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This study conducted for the purpose of metabolism investigation and method development complied with the Code of Ethics of the World Medical Association (1964 Declaration of Helsinki, including its later amendments). It had been reviewed by the Ethics Commission of the Medical Faculty of the Ruhr-Universit\u00e4t Bochum under the reg. no. 19-6687 \u2013 BR. After receiving the study design in written form, each participant gave written informed consent.Apart from that, we sourced ten spot urine samples from persons without occupational exposure to 2,4-DTBP in the occupational biomonitoring programmes of Currenta to spike individual urine specimens for the robustness measurements (\u201cRobustness and selectivity\u201d). The participants in these programmes are comprehensively informed by occupational physicians of the Department of Health Protection about the biomonitoring examinations at the Institute of Biomonitoring. Participation is strictly voluntary for each worker and requires his or her informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Edgar Leibold and Melanie Flach are employed by BASF SE. BASF SE is the registrant of the substance under EU REACH. All authors affiliated to Currenta or ChiroBlock declare no conflict of interest related to this work.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}