{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T04:22:36Z","timestamp":1775708556771,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Program for HUST Academic Frontier Youth Team","award":["2019QYTD09"],"award-info":[{"award-number":["2019QYTD09"]}]},{"name":"National Natural Science Foundation of Hubei Province","award":["2021CFB335"],"award-info":[{"award-number":["2021CFB335"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anal Bioanal Chem"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s00216-026-06371-y","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T02:34:14Z","timestamp":1770690854000},"page":"2427-2438","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cysteine carbon dots\/Au3+ system for dual-mode detection of epinephrine and discrimination of different catecholamines with PCA"],"prefix":"10.1007","volume":"418","author":[{"given":"Yi-Zhong","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"6371_CR1","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1038\/s12276-024-01296-x","volume":"56","author":"JS Lou","year":"2024","unstructured":"Lou JS, Su M, Wang J, Do HN, Miao Y, Huang XY. Distinct binding conformations of epinephrine with alpha- and beta-adrenergic receptors. Exp Mol Med. 2024;56:1952\u201366.","journal-title":"Exp Mol Med"},{"key":"6371_CR2","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.ando.2020.03.012","volume":"82","author":"J Motiejunaite","year":"2021","unstructured":"Motiejunaite J, Amar L, Vidal-Petiot E. Adrenergic receptors and cardiovascular effects of catecholamines. Ann Endocrinol Paris. 2021;82:193\u20137.","journal-title":"Ann Endocrinol Paris"},{"key":"6371_CR3","doi-asserted-by":"publisher","first-page":"115147","DOI":"10.1016\/j.celrep.2024.115147","volume":"44","author":"JG Pagiazitis","year":"2025","unstructured":"Pagiazitis JG, Delestree N, Sowoidnich L, Sivakumar N, Simon CM, Chatzisotiriou A, et al. Catecholaminergic dysfunction drives postural and locomotor deficits in a mouse model of spinal muscular atrophy. Cell Rep. 2025;44:115147.","journal-title":"Cell Rep"},{"key":"6371_CR4","doi-asserted-by":"publisher","first-page":"e2120725","DOI":"10.1001\/jamanetworkopen.2021.20725","volume":"4","author":"J Soar","year":"2021","unstructured":"Soar J, Berg KM. Early epinephrine administration for cardiac arrest. JAMA Netw Open. 2021;4:e2120725.","journal-title":"JAMA Netw Open"},{"key":"6371_CR5","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.anai.2023.09.015","volume":"132","author":"DBK Golden","year":"2024","unstructured":"Golden DBK, Wang J, Waserman S, Akin C, Campbell RL, Ellis AK, et al. Anaphylaxis: A 2023 practice parameter update. Ann Allergy Asthma Im. 2024;132:124\u201376.","journal-title":"Ann Allergy Asthma Im"},{"key":"6371_CR6","doi-asserted-by":"publisher","first-page":"1433582","DOI":"10.3389\/fendo.2024.1433582","volume":"15","author":"JS Saavedra T","year":"2024","unstructured":"Saavedra T JS, Nati-Castillo HA, Cometa LAV, Rivera-Mart\u00ednez WA, Asprilla J, Casta\u00f1o-Giraldo CM, et al. Pheochromocytoma: an updated scoping review from clinical presentation to management and treatment. Front Endocrinol. 2024;15:1433582.","journal-title":"Front Endocrinol"},{"key":"6371_CR7","doi-asserted-by":"publisher","first-page":"137590","DOI":"10.1016\/j.neulet.2023.137590","volume":"819","author":"R Hajisoltani","year":"2024","unstructured":"Hajisoltani R, Meftahi GH. Epinephrine injected into the basolateral amygdala affects anxiety-like behavior and memory performance in stressed rats. Neurosci Lett. 2024;819:137590.","journal-title":"Neurosci Lett"},{"key":"6371_CR8","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/s41398-022-01901-5","volume":"12","author":"K Henjum","year":"2022","unstructured":"Henjum K, Watne LO, Godang K, Halaas NB, Eldholm RS, Blennow K, et al. Cerebrospinal fluid catecholamines in Alzheimer\u2019s disease patients with and without biological disease. Transl Psychiatry. 2022;12:151.","journal-title":"Transl Psychiatry"},{"key":"6371_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neubiorev.2024.105733","volume":"162","author":"AJ Kim","year":"2024","unstructured":"Kim AJ, Senior J, Chen K. Catecholamines: influence on healthy aging and the progression of neurodegenerative diseases. Neurosci Biobehav Rev. 2024;162:1\u20133.","journal-title":"Neurosci Biobehav Rev"},{"key":"6371_CR10","doi-asserted-by":"publisher","first-page":"134009","DOI":"10.1016\/j.snb.2023.134009","volume":"390","author":"S Huang","year":"2023","unstructured":"Huang S, He MX, Jiang SJ, Su GH, Lu ZW, Liu T, et al. Electron-regulated WO3\/Mn3O4 bi-enzyme activity for colorimetric detection epinephrine with smartphones. Sens Actuators, B Chem. 2023;390:134009.","journal-title":"Sens Actuators, B Chem"},{"key":"6371_CR11","doi-asserted-by":"publisher","first-page":"8281","DOI":"10.1039\/D1QM01274F","volume":"5","author":"S Veeralingam","year":"2021","unstructured":"Veeralingam S, Badhulika S. BiVO4 nanofiber-based field-effect transistors for detection of epinephrine\/adrenaline hormones. Mater Chem Front. 2021;5:8281\u20139.","journal-title":"Mater Chem Front"},{"key":"6371_CR12","doi-asserted-by":"publisher","first-page":"9969","DOI":"10.1021\/acs.analchem.4c01309","volume":"96","author":"C Luo","year":"2024","unstructured":"Luo C, Chen YJ, Gu JX, Cai HH, Lin HJ, Jin ZG, et al. Activatable NIR fluorescence probe for epinephrine detection and bioimaging based on anionic heptamethine cyanine. Anal Chem. 2024;96:9969\u201374.","journal-title":"Anal Chem"},{"key":"6371_CR13","doi-asserted-by":"publisher","first-page":"117392","DOI":"10.1016\/j.bios.2025.117392","volume":"279","author":"L Zou","year":"2025","unstructured":"Zou L, Liu Y, Liu JW. Capture-SELEX of DNA aptamers for label-free detection of epinephrine and norepinephrine in urine. Biosens Bioelectron. 2025;279:117392.","journal-title":"Biosens Bioelectron"},{"key":"6371_CR14","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1007\/s00604-019-3801-2","volume":"186","author":"XY Hou","year":"2019","unstructured":"Hou XY, Huang W, Tong YK, Tian MM. Hollow dummy template imprinted boronate-modified polymers for extraction of norepinephrine, epinephrine and dopamine prior to quantitation by HPLC. Microchim Acta. 2019;186:686.","journal-title":"Microchim Acta"},{"key":"6371_CR15","doi-asserted-by":"publisher","first-page":"115906","DOI":"10.1016\/j.ab.2025.115906","volume":"4","author":"Z Wang","year":"2025","unstructured":"Wang Z, Ji Y, You N, Hu X, Du F, Liu G. Ultrasensitive detection of epinephrine by a Cd@HMCNs-based electrochemiluminescent sensor. Anal Biochem. 2025;4:115906.","journal-title":"Anal Biochem"},{"key":"6371_CR16","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.aca.2020.01.033","volume":"1105","author":"S Pang","year":"2020","unstructured":"Pang S, Liu SY. Dual-emission carbon dots for ratiometric detection of Fe3+ ions and acid phosphatase. Anal Chim Acta. 2020;1105:155\u201361.","journal-title":"Anal Chim Acta"},{"key":"6371_CR17","doi-asserted-by":"publisher","first-page":"144074","DOI":"10.1016\/j.foodchem.2025.144074","volume":"482","author":"H Chen","year":"2025","unstructured":"Chen H, Yang HY, Zheng Y, Li YY, Hu J, Yang XP, et al. Detection of doxycycline via a smartphone-assisted ratiometric fluorescence platform with cerium-nickel bimetallic nanoclusters. Food Chem. 2025;482:144074.","journal-title":"Food Chem"},{"key":"6371_CR18","doi-asserted-by":"publisher","first-page":"130595","DOI":"10.1016\/j.cej.2021.130595","volume":"425","author":"J An","year":"2021","unstructured":"An J, Shi YX, Fang JA, Hu YQ, Liu YF. Multichannel ratiometric fluorescence sensor arrays for rapid visual monitoring of epinephrine, norepinephrine, and levodopa. Chem Eng J. 2021;425:130595.","journal-title":"Chem Eng J"},{"key":"6371_CR19","doi-asserted-by":"publisher","first-page":"103182","DOI":"10.1016\/j.cis.2024.103182","volume":"328","author":"P Singh","year":"2024","unstructured":"Singh P, Bhankar V, Kumar S, Kumar K. Biomass-derived carbon dots as significant biological tools in the medicinal field: a review. Adv Colloid Interface Sci. 2024;328:103182.","journal-title":"Adv Colloid Interface Sci"},{"key":"6371_CR20","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1007\/s12274-022-4840-2","volume":"16","author":"BB Chen","year":"2023","unstructured":"Chen BB, Liu ML, Gao YT, Chang S, Qian RC, Li DW. Design and applications of carbon dots-based ratiometric fluorescent probes: a review. Nano Res. 2023;16:1064\u201383.","journal-title":"Nano Res"},{"key":"6371_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2024.136173","volume":"417","author":"JQ Du","year":"2024","unstructured":"Du JQ, Luo WC, Zhang JT, Li QY, Bao LN, Jiang M, et al. Machine learning-assisted fluorescence\/fluorescence colorimetric sensor array for discriminating amyloid fibrils. Sens Actuators B Chem. 2024;417: 136173.","journal-title":"Sens Actuators B Chem"},{"key":"6371_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbon.2024.119333","volume":"228","author":"LN Bao","year":"2024","unstructured":"Bao LN, Luo WC, Li QY, Zhang Y, Zhang ZT, Li X, et al. Chiral carbon dots based on ternary carbon sources: a multifunctional therapeutic agent for Cu2+-induced Alzheimer\u2019s disease. Carbon. 2024;228: 119333.","journal-title":"Carbon"},{"key":"6371_CR23","doi-asserted-by":"publisher","first-page":"17478","DOI":"10.1021\/acsami.6b04826","volume":"8","author":"ZC Liang","year":"2016","unstructured":"Liang ZC, Kang MJ, Payne GF, Wang XH, Sun RC. Probing energy and electron transfer mechanisms in fluorescence quenching of biomass carbon quantum dots. ACS Appl Mater Interfaces. 2016;8:17478\u201388.","journal-title":"ACS Appl Mater Interfaces"},{"key":"6371_CR24","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.aca.2016.02.037","volume":"917","author":"F Ghasemi","year":"2016","unstructured":"Ghasemi F, Hormozi-Nezhad MR, Mahmoudi M. Identification of catecholamine neurotransmitters using fluorescence sensor array. Anal Chim Acta. 2016;917:85\u201392.","journal-title":"Anal Chim Acta"},{"key":"6371_CR25","doi-asserted-by":"publisher","first-page":"8248","DOI":"10.1021\/acs.analchem.4c05618","volume":"97","author":"R Motamedi-Khozani","year":"2025","unstructured":"Motamedi-Khozani R, Abbasi-Moayed S, Hormozi-Nezhad MR. Single-component double-emissive ratiometric probe: toward machine learning driven detection and discrimination of neurological biomarkers. Anal Chem. 2025;97:8248\u201357.","journal-title":"Anal Chem"},{"key":"6371_CR26","doi-asserted-by":"publisher","first-page":"127463","DOI":"10.1016\/j.snb.2019.127463","volume":"305","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Ren W, Fan YZ, Luo HQ, Li NB. Chemically-modulated turn-on fluorescence for rapid and visual discrimination of norepinephrine and epinephrine and its application for dopamine-\u03b2-hydroxylase detection. Sens Actuators B Chem. 2020;305:127463.","journal-title":"Sens Actuators B Chem"},{"key":"6371_CR27","doi-asserted-by":"publisher","first-page":"127292","DOI":"10.1016\/j.talanta.2024.127292","volume":"285","author":"JJ Zhang","year":"2025","unstructured":"Zhang JJ, An J, Han YQ, Fang JA, Liu YF. Spermine induced in-situ synthesis of polychromatic carbon nanodots towards smartphone-readable ratiometric fluorescence sensing of multiple catecholamines. Talanta. 2025;285:127292.","journal-title":"Talanta"},{"key":"6371_CR28","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.aca.2018.12.030","volume":"1054","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Ren W, Fan YZ, Dong JX, Zhang H, Luo HQ, et al. Label-free fluorescent discrimination and detection of epinephrine and dopamine based on bioinspired in situ copolymers and excitation wavelength switch. Anal Chim Acta. 2019;1054:167\u201375.","journal-title":"Anal Chim Acta"},{"issue":"17","key":"6371_CR29","doi-asserted-by":"publisher","first-page":"10183","DOI":"10.1021\/la900958f","volume":"25","author":"Z Tao","year":"2009","unstructured":"Tao Z, Wang G, Goodisman J, Asefa T. Accelerated oxidation of epinephrine by silica nanoparticles. Langmuir. 2009;25(17):10183\u20138.","journal-title":"Langmuir"},{"issue":"12","key":"6371_CR30","doi-asserted-by":"publisher","first-page":"3179","DOI":"10.1021\/acs.orglett.7b01198","volume":"19","author":"MK Meadows","year":"2017","unstructured":"Meadows MK, Roesner EK, Lynch VM, James TD, Anslyn EV. Boronic acid mediated coupling of catechols and N-Hydroxylamines: a bioorthogonal reaction to label peptides. Org Lett. 2017;19(12):3179\u201382.","journal-title":"Org Lett"},{"issue":"4","key":"6371_CR31","doi-asserted-by":"publisher","first-page":"2346","DOI":"10.1021\/acs.joc.8b03087","volume":"84","author":"ZM Robole","year":"2019","unstructured":"Robole ZM, Rahn KL, Lampkin BJ, Anand RK, VanVeller B. Tuning the electrochemical redox potentials of catechol with boronic acid derivatives. J Org Chem. 2019;84(4):2346\u201350.","journal-title":"J Org Chem"},{"key":"6371_CR32","doi-asserted-by":"publisher","first-page":"5040","DOI":"10.1021\/acs.langmuir.0c00731","volume":"36","author":"LL Hu","year":"2020","unstructured":"Hu LL, Gao N, Shan JK, Wang XY, Wang H, Yang XL, et al. Spectroscopic investigation and nanoscale characterization of epinephrine autooxidation under alkaline conditions. Langmuir. 2020;36:5040\u20137.","journal-title":"Langmuir"},{"key":"6371_CR33","doi-asserted-by":"publisher","first-page":"19268","DOI":"10.1021\/acs.jpcc.2c05843","volume":"126","author":"NG Khlebtsov","year":"2022","unstructured":"Khlebtsov NG, Khlebtsov BN, Kryuchkova EV, Zarkov SV, Burov AM. Universal determination of gold concentration in colloids with UV-vis spectroscopy. J Phys Chem C. 2022;126:19268\u201376.","journal-title":"The Journal of Physical Chemistry C"},{"key":"6371_CR34","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.snb.2015.09.105","volume":"223","author":"JJ Zhao","year":"2016","unstructured":"Zhao JJ, Zhao LM, Lan CQ, Zhao SL. Graphene quantum dots as effective probes for label-free fluorescence detection of dopamine. Sens Actuators B Chem. 2016;223:246\u201351.","journal-title":"Sens Actuators B Chem"},{"key":"6371_CR35","doi-asserted-by":"publisher","first-page":"349","DOI":"10.14336\/AD.2015.0330","volume":"6","author":"C Rangel-Barajas","year":"2015","unstructured":"Rangel-Barajas C, Coronel I, Flor\u00e1n B. Dopamine receptors and neurodegeneration. Aging Dis. 2015;6:349\u201368.","journal-title":"Aging Dis"},{"key":"6371_CR36","doi-asserted-by":"publisher","first-page":"8303","DOI":"10.1073\/pnas.0503069102","volume":"102","author":"PW Gold","year":"2005","unstructured":"Gold PW, Wong ML, Goldstein DS, Gold HK, Ronsaville DS, Esler M, et al. Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholia. Proc Natl Acad Sci USA. 2005;102:8303\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"key":"6371_CR37","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1016\/S0924-9338(15)31019-1","volume":"30","author":"G Hasler","year":"2015","unstructured":"Hasler G, Homan P, Neumeister A, Nugent AC, Charney DS, Drevets WC. Differenital behavioral and neural consequences of serotonin and catecholamine deficiency in depression: an experimental study. Eur Psychiat. 2015;30:1302.","journal-title":"Eur Psychiat"}],"container-title":["Analytical and Bioanalytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-026-06371-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00216-026-06371-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-026-06371-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T03:09:45Z","timestamp":1775704185000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00216-026-06371-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,10]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["6371"],"URL":"https:\/\/doi.org\/10.1007\/s00216-026-06371-y","relation":{},"ISSN":["1618-2642","1618-2650"],"issn-type":[{"value":"1618-2642","type":"print"},{"value":"1618-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,10]]},"assertion":[{"value":"12 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}