{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T19:03:59Z","timestamp":1780427039594,"version":"3.54.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004834","name":"Universitat Jaume I","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004834","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anal Bioanal Chem"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The increasing use of reclaimed water for agricultural irrigation raises concerns about the environmental accumulation of persistent contaminants, including gadolinium-based contrast agents (GBCAs). These compounds, widely used in medical imaging, are excreted unmetabolized and poorly removed by conventional wastewater treatment plants, leading to their release into aquatic environments and potential accumulation in soils and crops. In this study, a method was developed, validated, and applied\u2014for the first time\u2014for the determination of three commonly used GBCAs\u2014gadoteric acid, gadoteridol, and gadobutrol\u2014in clay soil. Quantification was achieved by ion chromatography coupled to inductively coupled plasma mass spectrometry (IC-ICP-MS). Suitable separation was accurately optimized using a mobile phase containing 30\u00a0mM EDTA and 20\u00a0mM NH\n                    <jats:sub>4<\/jats:sub>\n                    NO\n                    <jats:sub>3<\/jats:sub>\n                    at pH 9.8. Elution of all target species was achieved within 7.5\u00a0min. The method was evaluated using real clay soil samples from an agricultural field in Castell\u00f3 (Spain) fortified with selected GBCAs at various concentrations. Mild extraction with NH\n                    <jats:sub>4<\/jats:sub>\n                    NO\n                    <jats:sub>3<\/jats:sub>\n                    yielded recoveries below 50%, which allows assessment of the bioavailable fraction. To achieve quantitative recovery, a more severe alkaline extraction protocol using KOH was subsequently developed. The optimized procedure demonstrated excellent analytical performance, with LOD and LOQ below 2 and 5\u00a0ng\u00a0g\n                    <jats:sup>\u22121<\/jats:sup>\n                    , respectively. This methodology enabled the first quantitative determination of GBCAs in soil samples collected from municipal parks irrigated with reclaimed water. Furthermore, the KOH-based extraction was extended to the quantification of gadoteric acid in peat substrates from greenhouse-scale cultivation trials, yielding a mean recovery of 80% with a relative standard deviation (RSD) of 12%. The application of this method confirmed the accumulation of the contrast agent in peat irrigated with fortified tap water. These findings underscore the necessity for robust, matrix-specific analytical workflows to monitor the environmental fate of GBCAs and to accurately assess their potential transfer into the food chain.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s00216-026-06389-2","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T07:45:21Z","timestamp":1770795921000},"page":"2607-2617","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Determination of selected gadolinium-based contrast agents in soil: method validation and application"],"prefix":"10.1007","volume":"418","author":[{"given":"A. F.","family":"Roig-Navarro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Soria-Prieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Pitarch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Garc\u00eda-Cubedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"6389_CR1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s43621-024-00631-6","volume":"6","author":"AP Onyena","year":"2025","unstructured":"Onyena AP, Sam K. The blue revolution: sustainable water management for a thirsty world. Discover Sustain. 2025;6:63. https:\/\/doi.org\/10.1007\/s43621-024-00631-6.","journal-title":"Discover Sustain"},{"key":"6389_CR2","doi-asserted-by":"publisher","first-page":"144026","DOI":"10.1016\/j.scitotenv.2020.144026","volume":"760","author":"S Ofori","year":"2021","unstructured":"Ofori S, Puskacov\u00e1 A, Ruzickov\u00e1 I, Wanner J. Treated wastewater reuse for irrigation: pros and cons. Sci Total Environ. 2021;760:144026. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.144026.","journal-title":"Sci Total Environ"},{"key":"6389_CR3","doi-asserted-by":"publisher","unstructured":"Jodar-Abellan A, L\u00f3pez-Ortiz MI, Melgarejo-Moreno J. Wastewater treatment and water reuse in Spain. Current situation and perspectives. Water. 2019;11. https:\/\/doi.org\/10.3390\/w11081551.","DOI":"10.3390\/w11081551"},{"key":"6389_CR4","unstructured":"Communication from the Commission to the European Parliament, the Council, the European Economic and Social Committee and the Committee of the Regions A Blueprint to Safeguard Europe\u2019s Water Resources. COM\/2012\/0673 final.\u00a0https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/?uri=celex:52012DC0673."},{"key":"6389_CR5","unstructured":"Regulation (EU) 2020\/741 of the European Parliament and of the Council of 25 May 2020 on minimum requirements for water reuse. Official Journal of the European Union L177\/32\u201355. (n.d.).\u00a0https:\/\/eur-lex.europa.eu\/eli\/reg\/2020\/741."},{"key":"6389_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.resconrec.2021.105454","volume":"168","author":"A Singh","year":"2021","unstructured":"Singh A. A review of wastewater irrigation: environmental implications. Resour Conserv Recycl. 2021;168: 105454. https:\/\/doi.org\/10.1016\/j.resconrec.2021.105454.","journal-title":"Resour Conserv Recycl"},{"key":"6389_CR7","doi-asserted-by":"publisher","first-page":"160462","DOI":"10.1016\/j.scitotenv.2022.160462","volume":"859","author":"M Garc\u00eda-Valverde","year":"2023","unstructured":"Garc\u00eda-Valverde M, Aragon\u00e9s AM, And\u00fajar JS, Garc\u00eda MG, Mart\u00ednez-Bueno MJ, Fern\u00e1ndez-Alba AR. Long-term effects on the agroecosystem of using reclaimed water on commercial crops. Sci Total Environ. 2023;859:160462. https:\/\/doi.org\/10.1016\/j.scitotenv.2022.160462.","journal-title":"Sci Total Environ"},{"key":"6389_CR8","doi-asserted-by":"publisher","unstructured":"Sunyer-Cald\u00fa A, Sep\u00falveda-Ruiz P, Salgot M, Folch-S\u00e1nchez M, Barcelo D, Diaz-Cruz MS. Reclaimed water in agriculture: A plot-scale study assessing crop uptake of emerging contaminants and pathogens. J Environ Chem Eng. 2022 Dec 1;10(6):108831. https:\/\/doi.org\/10.1016\/j.jece.2022.108831.","DOI":"10.1016\/j.jece.2022.108831"},{"key":"6389_CR9","doi-asserted-by":"publisher","unstructured":"Kaegi R, Gogos A, Voegelin A, Hug SJ, Winkel LH, Buser AM, Berg M. Quantification of individual Rare Earth Elements from industrial sources in sewage sludge. Water Res X. 2021;11:100092.  https:\/\/doi.org\/10.1016\/j.wroa.2021.100092.","DOI":"10.1016\/j.wroa.2021.100092"},{"key":"6389_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/geosciences9020093","volume":"9","author":"P Ebrahimi","year":"2019","unstructured":"Ebrahimi P, Barbieri M. Gadolinium as an emerging microcontaminant in water resources: threats and opportunities. Geosciences. 2019;9: 93. https:\/\/doi.org\/10.3390\/geosciences9020093.","journal-title":"Geosciences"},{"key":"6389_CR11","doi-asserted-by":"publisher","unstructured":"Tomczuk M, Godlewska-Z\u02d9y\u0142kiewicz B, Bajguz A. Gadolinium in the environment: a double-edged sword for plant growth and ecosystem stability. Metabolites. 2025;15:415.  https:\/\/doi.org\/10.3390\/metabo15060415.","DOI":"10.3390\/metabo15060415"},{"key":"6389_CR12","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3390\/oceans4040026","volume":"4","author":"A Guerreiro","year":"2023","unstructured":"Guerreiro A, Brito P. Stability of the macrocyclic Gd-DOTA contrast agent (DOTAREM) under different estuarine environmental conditions. Oceans. 2023;4:381\u201393. https:\/\/doi.org\/10.3390\/oceans4040026.","journal-title":"Oceans"},{"key":"6389_CR13","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.watres.2016.01.012","volume":"91","author":"M Birka","year":"2016","unstructured":"Birka M, Roscher J, Holtkamp M, Sperling M, Karst U. Investigating the stability of gadolinium based contrast agents towards UV radiation. Water Res. 2016;91:244\u201350. https:\/\/doi.org\/10.1016\/j.watres.2016.01.012.","journal-title":"Water Res"},{"key":"6389_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.146273","volume":"781","author":"G Trapasso","year":"2021","unstructured":"Trapasso G, Chiesa S, Freitas R, Pereira E. What do we know about the ecotoxicological implications of the rare earth element gadolinium in aquatic ecosystems? Sci Total Environ. 2021;781: 146273. https:\/\/doi.org\/10.1016\/j.scitotenv.2021.146273.","journal-title":"Sci Total Environ"},{"key":"6389_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconhyd.2022.104057","volume":"250","author":"IE Oluwasola","year":"2022","unstructured":"Oluwasola IE, Ahmad AL, Shoparwe NF, Ismail S. Gadolinium based contrast agents (GBCAs): uniqueness, aquatic toxicity concerns, and prospective remediation. J Contam Hydrol. 2022;250: 104057. https:\/\/doi.org\/10.1016\/j.jconhyd.2022.104057.","journal-title":"J Contam Hydrol"},{"issue":"6","key":"6389_CR16","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1002\/etc.4116","volume":"37","author":"J Rogowska","year":"2018","unstructured":"Rogowska J, Olkowska E, Ratajczyk W, Wolska L. Gadolinium as a new emerging contaminant of aquatic environments. Environ Toxicol Chem. 2018;37(6):1523\u201334. https:\/\/doi.org\/10.1002\/etc.4116.","journal-title":"Environ Toxicol Chem"},{"key":"6389_CR17","doi-asserted-by":"publisher","unstructured":"Bringas A, Bringas E, Iba\u00f1ez R, San Rom\u00e1n MF. Tracing Gadolinium levels throughout wastewater treatment: Insights from a yearly assessment in northern Spain. Sci Total Environ. 2024;948:174819.  https:\/\/doi.org\/10.1016\/j.scitotenv.2024.174819.","DOI":"10.1016\/j.scitotenv.2024.174819"},{"key":"6389_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2025.179255","volume":"975","author":"K Inoue","year":"2025","unstructured":"Inoue K, Natarajan T, Isoda R, Fukushi M, Sahoo SK. Anthropogenic gadolinium contamination assessment in sewage, river, and tap water samples from the urban Osaka area, Japan. Sci Total Environ. 2025;975: 179255. https:\/\/doi.org\/10.1016\/j.scitotenv.2025.179255.","journal-title":"Sci Total Environ"},{"key":"6389_CR19","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/j.scitotenv.2019.07.075","volume":"687","author":"K Schmidt","year":"2019","unstructured":"Schmidt K, Bau M, Merschel G, Tepe N. Anthropogenic gadolinium in tap water and in tap water-based beverages from fast-food franchises in six major cities in Germany. Sci Total Environ. 2019;687:1401\u20138. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.07.075.","journal-title":"Sci Total Environ"},{"key":"6389_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202404411","volume":"12","author":"V Pichler","year":"2025","unstructured":"Pichler V, Martinho RP, Temming L, Segers T, Wurm FR, Koshkina O. The environmental impact of medical imaging agents and the roadmap to sustainable medical imaging. Adv Sci. 2025;12: 2404411. https:\/\/doi.org\/10.1002\/advs.202404411.","journal-title":"Adv Sci"},{"key":"6389_CR21","doi-asserted-by":"publisher","first-page":"2884","DOI":"10.1021\/es803278n","volume":"43","author":"J K\u00fcnnemeyer","year":"2009","unstructured":"K\u00fcnnemeyer J, Terborg L, Meermann B, Brauckmann C, M\u00f6ller I, Scheffer A, Karst U. Speciation analysis of Gadolinium chelates in hospital effluents and wastewater treatment plant sewage by a novel HILIC\/ICP-MS method. Environ Sci Technol. 2009;43:2884\u201390. https:\/\/doi.org\/10.1021\/es803278n.","journal-title":"Environ Sci Technol"},{"key":"6389_CR22","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1039\/b919959d","volume":"25","author":"CSK Raju","year":"2010","unstructured":"Raju CSK, Cossmer A, Scharf H, Panne U, L\u00fcck D. Speciation of gadolinium-based MRI contrast agents in environmental water samples using hydrophilic interaction chromatography hyphenated with inductively coupled plasma mass spectrometry. J Anal At Spectrom. 2010;25:55\u201361. https:\/\/doi.org\/10.1039\/b919959d.","journal-title":"J Anal At Spectrom"},{"key":"6389_CR23","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1007\/s00216-014-8368-5","volume":"407","author":"U Lindner","year":"2015","unstructured":"Lindner U, Lingott J, Richter S, Jiang W, Jakubowski N, Panne U. Analysis of Gadolinium-based contrast agents in tap water with a new hydrophilic interaction chromatography (ZIC-cHILIC) hyphenated with inductively coupled plasma mass spectrometry. Anal Bioanal Chem. 2015;407:2415\u201322. https:\/\/doi.org\/10.1007\/s00216-014-8368-5.","journal-title":"Anal Bioanal Chem"},{"key":"6389_CR24","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1039\/d0ja00493f","volume":"36","author":"M Horstmann","year":"2021","unstructured":"Horstmann M, Gonzalez De Vega R, Bishop DP, Karst U, Doble PA, Clases D. Determination of gadolinium MRI contrast agents in fresh and oceanic waters of Australia employing micro-solid phase extraction, HILIC-ICP-MS and bandpass mass filtering. J Anal At Spectrom. 2021;36:767\u201375. https:\/\/doi.org\/10.1039\/d0ja00493f.","journal-title":"J Anal At Spectrom"},{"key":"6389_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2020.121531","volume":"222","author":"S Okabayashi","year":"2021","unstructured":"Okabayashi S, Kawane L, Mrabawani NY, Iwai T, Narukawa T, Tsuboi M, Chiba K. Speciation analysis of Gadolinium-based contrast agents using aqueous eluent-hydrophilic interaction liquid chromatography hyphenated with inductively coupled plasma-mass spectrometry. Talanta. 2021;222: 121531. https:\/\/doi.org\/10.1016\/j.talanta.2020.121531.","journal-title":"Talanta"},{"key":"6389_CR26","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1093\/chromsci\/bmw133","volume":"54","author":"P Haj\u00f3s","year":"2016","unstructured":"Haj\u00f3s P, Luk\u00e1cs D, Farsang E, Horv\u00e1th K. High performance anion chromatography of Gadolinium chelates. J Chromatogr Sci. 2016;54:1752\u201360. https:\/\/doi.org\/10.1093\/chromsci\/bmw133.","journal-title":"J Chromatogr Sci"},{"key":"6389_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2021.117836","volume":"207","author":"M Macke","year":"2021","unstructured":"Macke M, Quarles CD, Sperling M, Karst U. Fast and automated monitoring of gadolinium-based contrast agents in surface waters. Water Res. 2021;207: 117836. https:\/\/doi.org\/10.1016\/j.watres.2021.117836.","journal-title":"Water Res"},{"key":"6389_CR28","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1039\/d5ja00203f","volume":"40","author":"MD Costa","year":"2025","unstructured":"Costa MD, Dumoulin D, Lenski M, Garat A. Development of a HPIC-ICP-MS method for the quantification and speciation of gadolinium-based contrast media in surface waters. J Anal At Spectrom. 2025;40:2150\u201361. https:\/\/doi.org\/10.1039\/d5ja00203f.","journal-title":"J Anal At Spectrom"},{"key":"6389_CR29","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.1039\/D5JA00159E","volume":"40","author":"M Athmer","year":"2025","unstructured":"Athmer M, Marotz L, Karst U. Rapid and sensitive speciation analysis of established and emerging gadolinium-based contrast agents in the aquatic environment by IC-ICP-MS. J Anal At Spectrom. 2025;40:2138.","journal-title":"J Anal At Spectrom"},{"key":"6389_CR30","doi-asserted-by":"publisher","first-page":"11398","DOI":"10.1021\/acs.analchem.1c01100","volume":"93","author":"L Schlatt","year":"2021","unstructured":"Schlatt L, K\u00f6hrer A, Factor C, Robert P, Rasschaert M, Sperling M, Karst U. Mild dissolution\/recomplexation strategy for speciation analysis of gadolinium from MR contrast agents in bone tissues by means of HPLC-ICP-MS. Anal Chem. 2021;93:11398\u2013405. https:\/\/doi.org\/10.1021\/acs.analchem.1c01100.","journal-title":"Anal Chem"},{"key":"6389_CR31","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1007\/s00216-012-6643-x","volume":"405","author":"U Lindner","year":"2013","unstructured":"Lindner U, Lingott J, Richter S, Jakubowski N, Panne U. Speciation of gadolinium in surface water samples and plants by hydrophilic interaction chromatography hyphenated with inductively coupled plasma mass spectrometry. Anal Bioanal Chem. 2013;405:1865\u201373. https:\/\/doi.org\/10.1007\/s00216-012-6643-x.","journal-title":"Anal Bioanal Chem"},{"key":"6389_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.166909","volume":"905","author":"K Sommer","year":"2023","unstructured":"Sommer K, Reuter S, Elinkmann M, K\u00f6hrer A, Quarles CD Jr, Hippler M, Karst U. Species-dependent uptake of gadolinium in Chlamydomonas reinhardtii algae. Sci Total Environ. 2023;905: 166909. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.166909.","journal-title":"Sci Total Environ"},{"issue":"19","key":"6389_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911368","volume":"23","author":"VF Scurtu","year":"2022","unstructured":"Scurtu VF, Clapa D, Leopold LF, Ranga F, Iancu \u0218D, Cadi\u0219 AI, Coman V, Socaci SA, Mo\u021b AC, Coman C. Gadolinium accumulation and toxicity on in vitro grown Stevia rebaudiana: a case-study on Gadobutrol. Int J Mol Sci. 2022;23(19): 11368. https:\/\/doi.org\/10.3390\/ijms231911368.","journal-title":"Int J Mol Sci"},{"key":"6389_CR34","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.chemosphere.2015.09.044","volume":"144","author":"A Menahem","year":"2016","unstructured":"Menahem A, Dror I, Berkowitz B. Transport of gadolinium and arsenic-based pharmaceuticals in saturated soil under various redox conditions. Chemosphere. 2016;144:713\u201320. https:\/\/doi.org\/10.1016\/j.chemosphere.2015.09.044.","journal-title":"Chemosphere"},{"key":"6389_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2022.134528","volume":"300","author":"K Sommer","year":"2022","unstructured":"Sommer K, Sperling M, Karst U. Species-dependent interaction of Gd-based contrast agents with humic substances. Chemosphere. 2022;300: 134528. https:\/\/doi.org\/10.1016\/j.chemosphere.2022.134528.","journal-title":"Chemosphere"},{"key":"6389_CR36","unstructured":"EMA\u2019s final opinion confirms restrictions on use of linear gadolinium agents in body scans EMA\/457616\/2017. 2017.  https:\/\/www.ema.europa.eu\/en\/medicines\/human\/referrals\/gadolinium-containing-contrast-agents. Accessed 14 Oct 2024."},{"key":"6389_CR37","doi-asserted-by":"publisher","DOI":"10.1186\/s12880-021-00600-9","volume":"21","author":"J\u00c5 Jakobsen","year":"2021","unstructured":"Jakobsen J\u00c5, Quattrocchi CC, M\u00fcller FHH, Outteryck O, Alc\u00e1zar A, Reith W, Fraga P, Panebianco V, Sampedro A, Pietura R. Patterns of use, effectiveness and safety of gadolinium contrast agents: a European prospective cross-sectional multicentre observational study. BMC Med Imaging. 2021;21: 74. https:\/\/doi.org\/10.1186\/s12880-021-00600-9.","journal-title":"BMC Med Imaging"},{"key":"6389_CR38","unstructured":"https:\/\/www.aemps.gob.es\/informa\/notasinformativas\/medicamentosusohumano-3\/informacion-a-los-laboratorios-titulares-de-agentes-de-contraste-que-contienen-gadolinio-decision-de-la-comision-c2017-7941-final-de-fecha-23-11-2017-no-ema-emea-h-a-31-1437\/.  Accessed 14 Oct 2024."},{"key":"6389_CR39","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.chroma.2012.12.007","volume":"1292","author":"AM Botero-Coy","year":"2013","unstructured":"Botero-Coy AM, Ib\u00e1\u00f1ez M, Sancho JV, Hern\u00e1ndez F. Improvements in the analytical methodology for the residue determination of the herbicide glyphosate in soils by liquid chromatography coupled to mass spectrometry. J Chromatogr A. 2013;1292:132\u201341. https:\/\/doi.org\/10.1016\/j.chroma.2012.12.007.","journal-title":"J Chromatogr A"},{"key":"6389_CR40","unstructured":"Ellison SLR  and Williams A (Eds). Eurachem\/CITAC guide: quantifying uncertainty in analytical measurement, 3rd ed. 2012. Available from\u00a0https:\/\/www.eurachem.org\/index.php\/publications\/guides\/quam."},{"key":"6389_CR41","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/S0010-8545(99)00237-4","volume":"204","author":"A Bianchi","year":"2000","unstructured":"Bianchi A, Calabi L, Corana F, Fontana S, Losi P, Maiocchi A, Paleari L, Valtancoli B. Thermodynamic and structural properties of Gd(III) complexes with polyamino-polycarboxylic ligands: basic compounds for the development of MRI contrast agents. Coord Chem Rev. 2000;204:309\u201393. https:\/\/doi.org\/10.1016\/S0010-8545(99)00237-4.","journal-title":"Coord Chem Rev"}],"container-title":["Analytical and Bioanalytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-026-06389-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00216-026-06389-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-026-06389-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T03:06:59Z","timestamp":1776136019000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00216-026-06389-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,11]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["6389"],"URL":"https:\/\/doi.org\/10.1007\/s00216-026-06389-2","relation":{},"ISSN":["1618-2642","1618-2650"],"issn-type":[{"value":"1618-2642","type":"print"},{"value":"1618-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,11]]},"assertion":[{"value":"31 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}