{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:16:31Z","timestamp":1793153791482,"version":"4.5.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Integrated Chemicals Mixtures Project (ICMP) of Environment and Climate Change Canada"},{"name":"Environment & Climate Change Canada"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anal Bioanal Chem"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s00216-026-06423-3","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T21:43:02Z","timestamp":1774474982000},"page":"3195-3209","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessing the performance of weak and strong ion exchange solid-phase extraction and data mining tools to identify congeners and transformation products in municipal wastewaters by non-targeted analysis"],"prefix":"10.1007","volume":"418","author":[{"given":"Emmanuel","family":"Eysseric","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gagnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Mark","family":"Hewitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley Anne","family":"Smyth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"6423_CR1","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1021\/acs.est.9b06379","volume":"54","author":"Z Wang","year":"2020","unstructured":"Wang Z, Walker GW, Muir DCG, Nagatani-Yoshida K. Toward a global understanding of chemical pollution: a first comprehensive analysis of national and regional chemical inventories. Environ Sci Technol. 2020;54:2575\u201384. https:\/\/doi.org\/10.1021\/acs.est.9b06379.","journal-title":"Environ Sci Technol"},{"key":"6423_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.125490","volume":"414","author":"Y Qian","year":"2021","unstructured":"Qian Y, Wang X, Wu G, Wang L, Geng J, Yu N, Wei S. Screening priority indicator pollutants in full-scale wastewater treatment plants by non-target analysis. J Hazard Mater. 2021;414: 125490. https:\/\/doi.org\/10.1016\/j.jhazmat.2021.125490.","journal-title":"J Hazard Mater"},{"key":"6423_CR3","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1039\/D0EM00463D","volume":"23","author":"KE Overdahl","year":"2021","unstructured":"Overdahl KE, Sutton R, Sun J, DeStefano NJ, Getzinger GJ, Ferguson PL. Assessment of emerging polar organic pollutants linked to contaminant pathways within an urban estuary using non-targeted analysis. Environ Sci Process Impacts. 2021;23:429\u201345. https:\/\/doi.org\/10.1039\/D0EM00463D.","journal-title":"Environ Sci Process Impacts"},{"key":"6423_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2022.116671","volume":"154","author":"M Paszkiewicz","year":"2022","unstructured":"Paszkiewicz M, Godlewska K, Lis H, Caban M, Bia\u0142k-Bieli\u0144ska A, Stepnowski P. Advances in suspect screening and non-target analysis of polar emerging contaminants in the environmental monitoring. TrAC Trends Anal Chem. 2022;154: 116671. https:\/\/doi.org\/10.1016\/j.trac.2022.116671.","journal-title":"TrAC Trends Anal Chem"},{"key":"6423_CR5","unstructured":"Environment and Climate Change Canada. Canadian environmental sustainability indicators: municipal wastewater treatment. 2023. Available at: www.canada.ca\/en\/environment-climate-change\/services\/environmental-indicators\/municipalwastewater-treatment.html."},{"key":"6423_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2021.122293","volume":"230","author":"E Eysseric","year":"2021","unstructured":"Eysseric E, Beaudry F, Gagnon C, Segura PA. Non-targeted screening of trace organic contaminants in surface waters by a multi-tool approach based on combinatorial analysis of tandem mass spectra and open access databases. Talanta. 2021;230: 122293. https:\/\/doi.org\/10.1016\/j.talanta.2021.122293.","journal-title":"Talanta"},{"key":"6423_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.153540","volume":"822","author":"E Eysseric","year":"2022","unstructured":"Eysseric E, Gagnon C, Segura PA. Identifying congeners and transformation products of organic contaminants within complex chemical mixtures in impacted surface waters with a top-down non-targeted screening workflow. Sci Total Environ. 2022;822: 153540. https:\/\/doi.org\/10.1016\/j.scitotenv.2022.153540.","journal-title":"Sci Total Environ"},{"key":"6423_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.142688","volume":"755","author":"I Perkons","year":"2021","unstructured":"Perkons I, Rusko J, Zacs D, Bartkevics V. Rapid determination of pharmaceuticals in wastewater by direct infusion HRMS using target and suspect screening analysis. Sci Total Environ. 2021;755: 142688. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.142688.","journal-title":"Sci Total Environ"},{"key":"6423_CR9","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.chemosphere.2019.05.147","volume":"232","author":"MC Campos-Ma\u00f1as","year":"2019","unstructured":"Campos-Ma\u00f1as MC, Plaza-Bola\u00f1os P, Mart\u00ednez-Piernas AB, S\u00e1nchez-P\u00e9rez JA, Ag\u00fcera A. Determination of pesticide levels in wastewater from an agro-food industry: target, suspect and transformation product analysis. Chemosphere. 2019;232:152\u201363. https:\/\/doi.org\/10.1016\/j.chemosphere.2019.05.147.","journal-title":"Chemosphere"},{"key":"6423_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.124102","volume":"404","author":"M \u010celi\u0107","year":"2021","unstructured":"\u010celi\u0107 M, Ja\u00e9n-Gil A, Brice\u00f1o-Guevara S, Rodr\u00edguez-Mozaz S, Gros M, Petrovi\u0107 M. Extended suspect screening to identify contaminants of emerging concern in riverine and coastal ecosystems and assessment of environmental risks. J Hazard Mater. 2021;404: 124102. https:\/\/doi.org\/10.1016\/j.jhazmat.2020.124102.","journal-title":"J Hazard Mater"},{"key":"6423_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.123706","volume":"402","author":"Y Choi","year":"2021","unstructured":"Choi Y, Lee J-H, Kim K, Mun H, Park N, Jeon J. Identification, quantification, and prioritization of new emerging pollutants in domestic and industrial effluents, Korea: application of LC-HRMS based suspect and non-target screening. J Hazard Mater. 2021;402: 123706. https:\/\/doi.org\/10.1016\/j.jhazmat.2020.123706.","journal-title":"J Hazard Mater"},{"key":"6423_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.114092","volume":"261","author":"JK Challis","year":"2020","unstructured":"Challis JK, Almirall XO, Helm PA, Wong CS. Performance of the organic-diffusive gradients in thin-films passive sampler for measurement of target and suspect wastewater contaminants. Environ Pollut. 2020;261: 114092. https:\/\/doi.org\/10.1016\/j.envpol.2020.114092.","journal-title":"Environ Pollut"},{"key":"6423_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.134218","volume":"699","author":"R Wielens Becker","year":"2020","unstructured":"Wielens Becker R, Ib\u00e1\u00f1ez M, Cuervo Lumbaque E, Wilde ML, Flores da Rosa T, Hern\u00e1ndez F, Sirtori C. Investigation of pharmaceuticals and their metabolites in Brazilian hospital wastewater by LC-QTOF MS screening combined with a preliminary exposure and in silico risk assessment. Sci Total Environ. 2020;699: 134218. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.134218.","journal-title":"Sci Total Environ"},{"key":"6423_CR14","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.scitotenv.2019.06.057","volume":"687","author":"A Ccanccapa-Cartagena","year":"2019","unstructured":"Ccanccapa-Cartagena A, Pico Y, Ortiz X, Reiner EJ. Suspect, non-target and target screening of emerging pollutants using data independent acquisition: assessment of a Mediterranean River basin. Sci Total Environ. 2019;687:355\u201368. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.06.057.","journal-title":"Sci Total Environ"},{"key":"6423_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2019.115204","volume":"168","author":"N Zwart","year":"2020","unstructured":"Zwart N, Jonker W, Broek R, de Boer J, Somsen G, Kool J, Hamers T, Houtman CJ, Lamoree MH. Identification of mutagenic and endocrine disrupting compounds in surface water and wastewater treatment plant effluents using high-resolution effect-directed analysis. Water Res. 2020;168: 115204. https:\/\/doi.org\/10.1016\/j.watres.2019.115204.","journal-title":"Water Res"},{"key":"6423_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2019.121712","volume":"387","author":"P Gago-Ferrero","year":"2020","unstructured":"Gago-Ferrero P, Bletsou AA, Damalas DE, Aalizadeh R, Alygizakis NA, Singer HP, Hollender J, Thomaidis NS. Wide-scope target screening of >2000 emerging contaminants in wastewater samples with UPLC-Q-ToF-HRMS\/MS and smart evaluation of its performance through the validation of 195 selected representative analytes. J Hazard Mater. 2020;387: 121712. https:\/\/doi.org\/10.1016\/j.jhazmat.2019.121712.","journal-title":"J Hazard Mater"},{"key":"6423_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.114493","volume":"263","author":"W Liu","year":"2020","unstructured":"Liu W, Yao H, Xu W, Liu G, Wang X, Tu Y, Shi P, Yu N, Li A, Wei S. Suspect screening and risk assessment of pollutants in the wastewater from a chemical industry park in China. Environ Pollut. 2020;263: 114493. https:\/\/doi.org\/10.1016\/j.envpol.2020.114493.","journal-title":"Environ Pollut"},{"key":"6423_CR18","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12302-023-00779-4","volume":"35","author":"J Hollender","year":"2023","unstructured":"Hollender J, Schymanski EL, Ahrens L, Alygizakis N, B\u00e9en F, Bijlsma L, Brunner AM, Celma A, Fildier A, Fu Q, Gago-Ferrero P, Gil-Solsona R, Haglund P, Hansen M, Kaserzon S, Kruve A, Lamoree M, Margoum C, Meijer J, Merel S, Rauert C, Rostkowski P, Samanipour S, Schulze B, Schulze T, Singh RR, Slobodnik J, Steininger-Mairinger T, Thomaidis NS, Togola A, Vorkamp K, Vulliet E, Zhu L, Krauss M. NORMAN guidance on suspect and non-target screening in environmental monitoring. Environ Sci Eur. 2023;35:75. https:\/\/doi.org\/10.1186\/s12302-023-00779-4.","journal-title":"Environ Sci Eur"},{"key":"6423_CR19","doi-asserted-by":"publisher","first-page":"4154","DOI":"10.1007\/s11356-023-30972-0","volume":"31","author":"S Motteau","year":"2023","unstructured":"Motteau S, Deborde M, Gombert B, Karpel Vel Leitner N. Non-target analysis for water characterization: wastewater treatment impact and selection of relevant features. Environ Sci Pollut Res. 2023;31:4154\u201373. https:\/\/doi.org\/10.1007\/s11356-023-30972-0.","journal-title":"Environ Sci Pollut Res"},{"key":"6423_CR20","doi-asserted-by":"publisher","first-page":"6855","DOI":"10.1007\/s00216-022-04250-w","volume":"414","author":"M Musatadi","year":"2022","unstructured":"Musatadi M, Caballero C, Mijangos L, Prieto A, Olivares M, Zuloaga O. From target analysis to suspect and non-target screening of endocrine-disrupting compounds in human urine. Anal Bioanal Chem. 2022;414:6855\u201369. https:\/\/doi.org\/10.1007\/s00216-022-04250-w.","journal-title":"Anal Bioanal Chem"},{"key":"6423_CR21","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1038\/nbt.3597","volume":"34","author":"M Wang","year":"2016","unstructured":"Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu W-T, Cr\u00fcsemann M, Boudreau PD, Esquenazi E, Sandoval-Calder\u00f3n M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu C-C, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw C-C, Yang Y-L, Humpf H-U, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, Boya PCA, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O\u2019Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodr\u00edguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard P-M, Phapale P, Nothias L-F, Alexandrov T, Litaudon M, Wolfender J-L, Kyle JE, Metz TO, Peryea T, Nguyen D-T, VanLeer D, Shinn P, Jadhav A, M\u00fcller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson B\u00d8, Pogliano K, Linington RG, Guti\u00e9rrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nat Biotechnol. 2016;34:828\u201337. https:\/\/doi.org\/10.1038\/nbt.3597.","journal-title":"Nat Biotechnol"},{"key":"6423_CR22","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1038\/s41592-020-0933-6","volume":"17","author":"L-F Nothias","year":"2020","unstructured":"Nothias L-F, Petras D, Schmid R, D\u00fchrkop K, Rainer J, Sarvepalli A, Protsyuk I, Ernst M, Tsugawa H, Fleischauer M, Aicheler F, Aksenov AA, Alka O, Allard P-M, Barsch A, Cachet X, Caraballo-Rodriguez AM, Da Silva RR, Dang T, Garg N, Gauglitz JM, Gurevich A, Isaac G, Jarmusch AK, Kamen\u00edk Z, Kang KB, Kessler N, Koester I, Korf A, Le Gouellec A, Ludwig M, Martin HC, McCall L-I, McSayles J, Meyer SW, Mohimani H, Morsy M, Moyne O, Neumann S, Neuweger H, Nguyen NH, Nothias-Esposito M, Paolini J, Phelan VV, Pluskal T, Quinn RA, Rogers S, Shrestha B, Tripathi A, van der Hooft JJJ, Vargas F, Weldon KC, Witting M, Yang H, Zhang Z, Zubeil F, Kohlbacher O, B\u00f6cker S, Alexandrov T, Bandeira N, Wang M, Dorrestein PC. Feature-based molecular networking in the GNPS analysis environment. Nat Methods. 2020;17:905\u20138. https:\/\/doi.org\/10.1038\/s41592-020-0933-6.","journal-title":"Nat Methods"},{"key":"6423_CR23","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1021\/np400413s","volume":"76","author":"JY Yang","year":"2013","unstructured":"Yang JY, Sanchez LM, Rath CM, Liu X, Boudreau PD, Bruns N, Glukhov E, Wodtke A, de Felicio R, Fenner A, Wong WR, Linington RG, Zhang L, Debonsi HM, Gerwick WH, Dorrestein PC. Molecular networking as a dereplication strategy. J Nat Prod. 2013;76:1686\u201399. https:\/\/doi.org\/10.1021\/np400413s.","journal-title":"J Nat Prod"},{"key":"6423_CR24","doi-asserted-by":"publisher","first-page":"5291","DOI":"10.1007\/s00216-021-03500-7","volume":"413","author":"D Oberleitner","year":"2021","unstructured":"Oberleitner D, Schmid R, Schulz W, Bergmann A, Achten C. Feature-based molecular networking for identification of organic micropollutants including metabolites by non-target analysis applied to riverbank filtration. Anal Bioanal Chem. 2021;413:5291\u2013300. https:\/\/doi.org\/10.1007\/s00216-021-03500-7.","journal-title":"Anal Bioanal Chem"},{"key":"6423_CR25","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1021\/es5002105","volume":"48","author":"EL Schymanski","year":"2014","unstructured":"Schymanski EL, Jeon J, Gulde R, Fenner K, Ruff M, Singer HP, Hollender J. Identifying small molecules via high resolution mass spectrometry: communicating confidence. Environ Sci Technol. 2014;48:2097\u20138. https:\/\/doi.org\/10.1021\/es5002105.","journal-title":"Environ Sci Technol"},{"key":"6423_CR26","doi-asserted-by":"publisher","first-page":"6808","DOI":"10.1021\/acs.est.2c08200","volume":"57","author":"B Bonnefille","year":"2023","unstructured":"Bonnefille B, Karlsson O, Rian MB, Raqib R, Parvez F, Papazian S, Islam MS, Martin JW. Nontarget analysis of polluted surface waters in Bangladesh using open science workflows. Environ Sci Technol. 2023;57:6808\u201324. https:\/\/doi.org\/10.1021\/acs.est.2c08200.","journal-title":"Environ Sci Technol"},{"key":"6423_CR27","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s42834-024-00221-1","volume":"34","author":"Y-J Chen","year":"2024","unstructured":"Chen Y-J, Yang J-S, Lin AY-C. Comprehensive nontargeted analysis of fluorosurfactant byproducts and reaction products in wastewater from semiconductor manufacturing. Sustain Environ Res. 2024;34:14. https:\/\/doi.org\/10.1186\/s42834-024-00221-1.","journal-title":"Sustain Environ Res"},{"key":"6423_CR28","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1021\/acs.est.3c04435","volume":"58","author":"Y-J Chen","year":"2024","unstructured":"Chen Y-J, Wang R-D, Shih Y-L, Chin H-Y, Lin AY-C. Emerging perfluorobutane sulfonamido derivatives as a new trend of surfactants used in the semiconductor industry. Environ Sci Technol. 2024;58:1648\u201358. https:\/\/doi.org\/10.1021\/acs.est.3c04435.","journal-title":"Environ Sci Technol"},{"key":"6423_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2023.464584","volume":"1715","author":"S Chu","year":"2024","unstructured":"Chu S, Letcher RJ. A targeted and non-targeted discovery screening approach for poly-and per-fluoroalkyl substances in model environmental biota samples. J Chromatogr A. 2024;1715: 464584. https:\/\/doi.org\/10.1016\/j.chroma.2023.464584.","journal-title":"J Chromatogr A"},{"key":"6423_CR30","doi-asserted-by":"publisher","first-page":"8518","DOI":"10.1021\/acs.est.4c01251","volume":"58","author":"EJ Vogel","year":"2024","unstructured":"Vogel EJ, Neyra M, Larsen DA, Zeng T. Target and nontarget screening to support capacity scaling for substance use assessment through a statewide wastewater surveillance network in New York. Environ Sci Technol. 2024;58:8518\u201330. https:\/\/doi.org\/10.1021\/acs.est.4c01251.","journal-title":"Environ Sci Technol"},{"key":"6423_CR31","doi-asserted-by":"publisher","first-page":"5022","DOI":"10.1007\/s11356-025-36007-0","volume":"32","author":"SB Gewurtz","year":"2025","unstructured":"Gewurtz SB, Auyeung AS, Teslic S, Smyth SA. Pharmaceuticals and personal care products in Canadian municipal wastewater and biosolids: occurrence, fate, and time trends 2010\u20132013 to 2022. Environ Sci Pollut Res. 2025;32:5022\u201339. https:\/\/doi.org\/10.1007\/s11356-025-36007-0.","journal-title":"Environ Sci Pollut Res"},{"key":"6423_CR32","doi-asserted-by":"publisher","unstructured":"Metzger B, Shoykhet K, Buckenmaier S (2022) Chemistry in a Bottle: Ester Formation in Acidified Mobile-Phase Solvents. LCGC N Am 411\u2013416.  https:\/\/doi.org\/10.56530\/lcgc.na.ns9481m3.","DOI":"10.56530\/lcgc.na.ns9481m3"},{"issue":"34","key":"6423_CR33","doi-asserted-by":"publisher","first-page":"12673","DOI":"10.1021\/acs.analchem.3c01202","volume":"95","author":"P Stincone","year":"2023","unstructured":"Stincone P, Pakkir Shah AK, Schmid R, Graves LG, Lambidis SP, Torres RR, Xia S-N, Minda V, Aron AT, Wang M, Hughes CC, Petras D. Evaluation of data-dependent MS\/MS acquisition parameters for non-targeted metabolomics and molecular networking of environmental samples: focus on the Q exactive platform. Anal Chem. 2023;95(34):12673\u201382. https:\/\/doi.org\/10.1021\/acs.analchem.3c01202.","journal-title":"Anal. Chem."},{"key":"6423_CR34","doi-asserted-by":"publisher","first-page":"13870","DOI":"10.1021\/acs.analchem.1c02621","volume":"93","author":"KT Peter","year":"2021","unstructured":"Peter KT, Phillips AL, Knolhoff AM, Gardinali PR, Manzano CA, Miller KE, Pristner M, Sabourin L, Sumarah MW, Warth B, Sobus JR. Nontargeted analysis study reporting tool: a framework to improve research transparency and reproducibility. Anal Chem. 2021;93:13870\u20139. https:\/\/doi.org\/10.1021\/acs.analchem.1c02621.","journal-title":"Anal Chem"},{"key":"6423_CR35","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/nmeth.3393","volume":"12","author":"H Tsugawa","year":"2015","unstructured":"Tsugawa H, Cajka T, Kind T, Ma Y, Higgins B, Ikeda K, Kanazawa M, VanderGheynst J, Fiehn O, Arita M. MS-DIAL: data-independent MS\/MS deconvolution for comprehensive metabolome analysis. Nat Methods. 2015;12:523\u20136. https:\/\/doi.org\/10.1038\/nmeth.3393.","journal-title":"Nat Methods"},{"key":"6423_CR36","doi-asserted-by":"publisher","first-page":"24000","DOI":"10.1021\/acs.est.5c08802","volume":"59","author":"MT M\u00f8ller","year":"2025","unstructured":"M\u00f8ller MT, Birch H, Sj\u00f8holm KK, Papazian S, Wennberg AC, Bonnefille B, Kronsbein PM, Kelland MA, Martin JW, Mayer P. Persistence-directed testing of chemicals discharged from offshore oil platforms combined with nontargeted analysis. Environ Sci Technol. 2025;59:24000\u201311. https:\/\/doi.org\/10.1021\/acs.est.5c08802.","journal-title":"Environ Sci Technol"},{"key":"6423_CR37","unstructured":"Waters Corporation. Oasis cartridges and 96-well plates care and use manual. 2024. Available at https:\/\/help.waters.com\/content\/dam\/waters\/ko\/support\/usermanuals\/2020\/715001391\/715001391en.pdf."},{"key":"6423_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2021.133408","volume":"293","author":"E Eysseric","year":"2022","unstructured":"Eysseric E, Gagnon C, Segura PA. Uncovering transformation products of four organic contaminants of concern by photodegradation experiments and analysis of real samples from a local river. Chemosphere. 2022;293: 133408. https:\/\/doi.org\/10.1016\/j.chemosphere.2021.133408.","journal-title":"Chemosphere"},{"key":"6423_CR39","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1021\/acs.estlett.1c00682","volume":"8","author":"JK Challis","year":"2021","unstructured":"Challis JK, Popick H, Prajapati S, Harder P, Giesy JP, McPhedran K, Brinkmann M. Occurrences of tire rubber\u2013derived contaminants in cold-climate urban runoff. Environ Sci Technol Lett. 2021;8:961\u20137. https:\/\/doi.org\/10.1021\/acs.estlett.1c00682.","journal-title":"Environ Sci Technol Lett"},{"key":"6423_CR40","doi-asserted-by":"publisher","first-page":"4909","DOI":"10.1007\/s00216-020-02653-1","volume":"412","author":"B Seiwert","year":"2020","unstructured":"Seiwert B, Kl\u00f6ckner P, Wagner S, Reemtsma T. Source-related smart suspect screening in the aqueous environment: search for tire-derived persistent and mobile trace organic contaminants in surface waters. Anal Bioanal Chem. 2020;412:4909\u201319. https:\/\/doi.org\/10.1007\/s00216-020-02653-1.","journal-title":"Anal Bioanal Chem"},{"key":"6423_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/fenvc.2023.1194664","volume":"4","author":"F Kryuchkov","year":"2023","unstructured":"Kryuchkov F, Foldvik A, Sandodden R, Uhlig S. Presence of 6PPD-quinone in runoff water samples from Norway using a new LC\u2013MS\/MS method. Front Environ Chem. 2023;4: 1194664. https:\/\/doi.org\/10.3389\/fenvc.2023.1194664.","journal-title":"Front Environ Chem"},{"key":"6423_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.164110","volume":"887","author":"Z-M Li","year":"2023","unstructured":"Li Z-M, Pal VK, Kannan P, Li W, Kannan K. 1,3-diphenylguanidine, benzothiazole, benzotriazole, and their derivatives in soils collected from northeastern United States. Sci Total Environ. 2023;887: 164110. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.164110.","journal-title":"Sci Total Environ"},{"key":"6423_CR43","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1126\/science.abd6951","volume":"371","author":"Z Tian","year":"2021","unstructured":"Tian Z, Zhao H, Peter KT, Gonzalez M, Wetzel J, Wu C, Hu X, Prat J, Mudrock E, Hettinger R, Cortina AE, Biswas RG, Kock FVC, Soong R, Jenne A, Du B, Hou F, He H, Lundeen R, Gilbreath A, Sutton R, Scholz NL, Davis JW, Dodd MC, Simpson A, McIntyre JK, Kolodziej EP. A ubiquitous tire rubber\u2013derived chemical induces acute mortality in coho salmon. Science. 2021;371:185\u20139. https:\/\/doi.org\/10.1126\/science.abd6951.","journal-title":"Science"},{"key":"6423_CR44","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.watres.2018.11.042","volume":"150","author":"D Zahn","year":"2019","unstructured":"Zahn D, Mucha P, Zilles V, Touffet A, Gallard H, Knepper TP, Fr\u00f6mel T. Identification of potentially mobile and persistent transformation products of REACH-registered chemicals and their occurrence in surface waters. Water Res. 2019;150:86\u201396. https:\/\/doi.org\/10.1016\/j.watres.2018.11.042.","journal-title":"Water Res"},{"key":"6423_CR45","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.envres.2018.11.040","volume":"169","author":"Y Ben","year":"2019","unstructured":"Ben Y, Fu C, Hu M, Liu L, Wong MH, Zheng C. Human health risk assessment of antibiotic resistance associated with antibiotic residues in the environment: a review. Environ Res. 2019;169:483\u201393. https:\/\/doi.org\/10.1016\/j.envres.2018.11.040.","journal-title":"Environ Res"},{"key":"6423_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2020.110543","volume":"196","author":"X Liang","year":"2020","unstructured":"Liang X, Guan F, Chen B, Luo P, Guo C, Wu G, Ye Y, Zhou Q, Fang H. Spatial and seasonal variations of antibiotic resistance genes and antibiotics in the surface waters of Poyang Lake in China. Ecotoxicol Environ Saf. 2020;196: 110543. https:\/\/doi.org\/10.1016\/j.ecoenv.2020.110543.","journal-title":"Ecotoxicol Environ Saf"},{"key":"6423_CR47","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.chemosphere.2018.08.086","volume":"212","author":"M Wang","year":"2018","unstructured":"Wang M, Li J, Shi H, Miao D, Yang Y, Qian L, Gao S. Photolysis of atorvastatin in aquatic environment: influencing factors, products, and pathways. Chemosphere. 2018;212:467\u201375. https:\/\/doi.org\/10.1016\/j.chemosphere.2018.08.086.","journal-title":"Chemosphere"},{"key":"6423_CR48","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1016\/j.chemosphere.2012.10.039","volume":"90","author":"PC R\u00faa-G\u00f3mez","year":"2013","unstructured":"R\u00faa-G\u00f3mez PC, P\u00fcttmann W. Degradation of lidocaine, tramadol, venlafaxine and the metabolites O-desmethyltramadol and O-desmethylvenlafaxine in surface waters. Chemosphere. 2013;90:1952\u20139. https:\/\/doi.org\/10.1016\/j.chemosphere.2012.10.039.","journal-title":"Chemosphere"},{"key":"6423_CR49","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1289\/ehp.1104477","volume":"120","author":"ABA Boxall","year":"2012","unstructured":"Boxall ABA, Rudd MA, Brooks BW, Caldwell DJ, Choi K, Hickmann S, Innes E, Ostapyk K, Staveley JP, Verslycke T, Ankley GT, Beazley KF, Belanger SE, Berninger JP, Carriquiriborde P, Coors A, DeLeo PC, Dyer SD, Ericson JF, Gagn\u00e9 F, Giesy JP, Gouin T, Hallstrom L, Karlsson MV, Larsson DGJ, Lazorchak JM, Mastrocco F, McLaughlin A, McMaster ME, Meyerhoff RD, Moore R, Parrott JL, Snape JR, Murray-Smith R, Servos MR, Sibley PK, Straub JO, Szabo ND, Topp E, Tetreault GR, Trudeau VL, Van Der Kraak G. Pharmaceuticals and personal care products in the environment: what are the big questions? Environ Health Perspect. 2012;120:1221\u20139. https:\/\/doi.org\/10.1289\/ehp.1104477.","journal-title":"Environ Health Perspect"},{"key":"6423_CR50","doi-asserted-by":"publisher","first-page":"11505","DOI":"10.1021\/acs.est.7b02184","volume":"51","author":"J Hollender","year":"2017","unstructured":"Hollender J, Schymanski EL, Singer HP, Ferguson PL. Nontarget screening with high resolution mass spectrometry in the environment: ready to go? Environ Sci Technol. 2017;51:11505\u201312. https:\/\/doi.org\/10.1021\/acs.est.7b02184.","journal-title":"Environ Sci Technol"},{"key":"6423_CR51","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1016\/j.scitotenv.2018.04.079","volume":"635","author":"I-H Acir","year":"2018","unstructured":"Acir I-H, Guenther K. Endocrine-disrupting metabolites of alkylphenol ethoxylates \u2013 a critical review of analytical methods, environmental occurrences, toxicity, and regulation. Sci Total Environ. 2018;635:1530\u201346. https:\/\/doi.org\/10.1016\/j.scitotenv.2018.04.079.","journal-title":"Sci Total Environ"}],"container-title":["Analytical and Bioanalytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-026-06423-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00216-026-06423-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-026-06423-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T07:29:43Z","timestamp":1779434983000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00216-026-06423-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,25]]},"references-count":51,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["6423"],"URL":"https:\/\/doi.org\/10.1007\/s00216-026-06423-3","relation":{},"ISSN":["1618-2642","1618-2650"],"issn-type":[{"value":"1618-2642","type":"print"},{"value":"1618-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,25]]},"assertion":[{"value":"21 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}