{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:57:41Z","timestamp":1792425461825,"version":"4.5.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anal Bioanal Chem"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s00216-026-06455-9","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T08:55:28Z","timestamp":1774515328000},"page":"3435-3447","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Development of a highly sensitive electrochemical immunosensor and lateral flow immunoassay for enrofloxacin using optimized haptens"],"prefix":"10.1007","volume":"418","author":[{"given":"Zhenxian","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiliang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"6455_CR1","doi-asserted-by":"publisher","first-page":"127338","DOI":"10.1016\/j.envpol.2024.127338","volume":"387","author":"L Wen","year":"2025","unstructured":"Wen L, Dai J, Ma J, Li X, Yuan H, Duan L, Zhao C, Song J. Comprehensive profiling of quinolone antibiotics in the Bohai Sea: occurrence, source apportionment, and environmental risks. Environ Pollut. 2025;387:127338. https:\/\/doi.org\/10.1016\/j.envpol.2024.127338.","journal-title":"Environ Pollut"},{"key":"6455_CR2","doi-asserted-by":"publisher","first-page":"138393","DOI":"10.1016\/j.foodchem.2023.138393","volume":"441","author":"G Shen","year":"2024","unstructured":"Shen G, Ma Y, Zhang H, Wang F, Yang F, Ye H, Li R, Wang C, Tang Y. Novel fluorescence strategy based on G-quadruplex structure-switching aptamer for enrofloxacin detection in food and environmental samples. Food Chem. 2024;441:138393. https:\/\/doi.org\/10.1016\/j.foodchem.2023.138393.","journal-title":"Food Chem"},{"key":"6455_CR3","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.chemosphere.2014.07.018","volume":"119","author":"M Andrieu","year":"2015","unstructured":"Andrieu M, Rico A, Phu TM, Huong DTT, Phuong NT, Van den Brink PJ. Ecological risk assessment of the antibiotic enrofloxacin applied to Pangasius catfish farms in the Mekong Delta. Vietnam Chemosphere. 2015;119:407\u201314. https:\/\/doi.org\/10.1016\/j.chemosphere.2014.07.018.","journal-title":"Vietnam Chemosphere"},{"key":"6455_CR4","doi-asserted-by":"publisher","first-page":"344553","DOI":"10.1093\/mambio\/taae012","volume":"1374","author":"L Zhang","year":"2025","unstructured":"Zhang L, Yang J, Zhang J, Yang W, Liu X, Wang S, Kong X, Li J, Qu F. Resonance-matched terahertz metamaterials integrated with IRFE-MLR framework enabling specificity-enhanced detection of trace pefloxacin. Anal Chim Acta. 2025;1374:344553. https:\/\/doi.org\/10.1093\/mambio\/taae012.","journal-title":"Anal Chim Acta"},{"issue":"3","key":"6455_CR5","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1111\/j.1365-2885.2009.01131.x","volume":"33","author":"B San Mart\u00edn","year":"2010","unstructured":"San Mart\u00edn B, Cornejo J, Lapierre L, Irag\u00fcen D, P\u00e9rez F, Hidalgo H, Andr\u00e9 F. Withdrawal time of four pharmaceutical formulations of enrofloxacin in poultry according to different maximum residues limits. J Vet Pharmacol Ther. 2010;33(3):246\u201351. https:\/\/doi.org\/10.1111\/j.1365-2885.2009.01131.x.","journal-title":"J Vet Pharmacol Ther"},{"issue":"2","key":"6455_CR6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0001305","volume":"3","author":"R Mulchandani","year":"2023","unstructured":"Mulchandani R, Wang Y, Gilbert M, Van Boeckel TP. Global trends in antimicrobial use in food-producing animals: 2020 to 2030. PLOS Global Public Health. 2023;3(2): e0001305. https:\/\/doi.org\/10.1371\/journal.pgph.0001305.","journal-title":"PLOS Global Public Health"},{"issue":"9","key":"6455_CR7","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1080\/10408444.2021.2024496","volume":"51","author":"S Badawy","year":"2021","unstructured":"Badawy S, Yang Y, Liu Y, Marawan MA, Ares I, Martinez MA, Mart\u00ednez-Larra\u00f1aga MR, Wang X, Anad\u00f3n A, Mart\u00ednez M. Toxicity induced by ciprofloxacin and enrofloxacin: oxidative stress and metabolism. Crit Rev Toxicol. 2021;51(9):754\u201387. https:\/\/doi.org\/10.1080\/10408444.2021.2024496.","journal-title":"Crit Rev Toxicol"},{"issue":"13","key":"6455_CR8","doi-asserted-by":"publisher","first-page":"20017","DOI":"10.1007\/s11356-024-32340-y","volume":"31","author":"J Fu\u010d\u00edk","year":"2024","unstructured":"Fu\u010d\u00edk J, Amrichov\u00e1 A, Brabcov\u00e1 K, Karp\u00ed\u0161kov\u00e1 R, Kol\u00e1\u010dkov\u00e1 I, Pokludov\u00e1 L, Pol\u00e1kov\u00e1 \u0160, Mravcov\u00e1 L. Fate of fluoroquinolones in field soil environment after incorporation of poultry litter from a farm with enrofloxacin administration via drinking water. Environ Sci Pollut Res. 2024;31(13):20017\u201332. https:\/\/doi.org\/10.1007\/s11356-024-32340-y.","journal-title":"Environ Sci Pollut Res"},{"issue":"1","key":"6455_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/foods13010031","volume":"13","author":"Z Li","year":"2023","unstructured":"Li Z, Jin Y, Wang X, Xu L, Teng L, Fu K, Li B, Li Y, Huang Y, Ma N, Cui F, Chai T. Health risk assessment of antibiotic pollutants in large yellow croakers from Zhejiang aquaculture sites. Foods. 2023;13(1): 31. https:\/\/doi.org\/10.3390\/foods13010031.","journal-title":"Foods"},{"key":"6455_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.170558","volume":"920","author":"TT Wang","year":"2024","unstructured":"Wang TT, Shao S, Fan SD, Tang WQ, Miao JW, Wang S, Cao XC, Liu C, Ying GG, Chen ZB, Zhou HL, Diao XP, Mo L. Occurrence, distribution, and risk assessment of antibiotics in a typical aquaculture area around the Dongzhai Harbor mangrove forest on Hainan Island. Sci Total Environ. 2024;920: 170558. https:\/\/doi.org\/10.1016\/j.scitotenv.2024.170558.","journal-title":"Sci Total Environ"},{"issue":"1","key":"6455_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/foods13010153","volume":"13","author":"K Y\u00e9venes","year":"2024","unstructured":"Y\u00e9venes K, Ib\u00e1\u00f1ez MJ, Pokrant E, Flores A, Maturana M, Maddaleno A, Cornejo J. A suitable HPLC-MS\/MS methodology for the detection of oxytetracycline, enrofloxacin, and sulfachloropyridazine residues in lettuce plants. Foods. 2024;13(1): 153. https:\/\/doi.org\/10.3390\/foods13010153.","journal-title":"Foods"},{"issue":"1","key":"6455_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29010252","volume":"29","author":"Y Guo","year":"2024","unstructured":"Guo Y, Hong L, Gao P, Liu S, Zhu Y, Xie X, Zhang G, Xie K. Development of a QuEChERS-HPLC-FLD procedure for the simultaneous detection of residues of florfenicol, its metabolite florfenicol amine, and three fluoroquinolones in eggs. Molecules. 2024;29(1): 252. https:\/\/doi.org\/10.3390\/molecules29010252.","journal-title":"Molecules"},{"key":"6455_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2024.116205","volume":"254","author":"Y Hu","year":"2024","unstructured":"Hu Y, Chen X, Wang K, Jiang C, Liu W, Zhang S, Zheng M, Zhou Y, Xiao Y, Liu Y. Fluorescent responsive membrane based on terbium coordination polymer and carbon dots with AIE effect for rapid and visual detection of fluoroquinolone. Biosens Bioelectron. 2024;254: 116205. https:\/\/doi.org\/10.1016\/j.bios.2024.116205.","journal-title":"Biosens Bioelectron"},{"key":"6455_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.131016","volume":"370","author":"C Aymard","year":"2022","unstructured":"Aymard C, Kanso H, Serrano MJ, Pag\u00e1n R, Noguer T, Istamboulie G. Development of a new dual electrochemical immunosensor for a rapid and sensitive detection of enrofloxacin in meat samples. Food Chem. 2022;370: 131016. https:\/\/doi.org\/10.1016\/j.foodchem.2021.131016.","journal-title":"Food Chem"},{"issue":"1","key":"6455_CR15","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.talanta.2009.03.004","volume":"79","author":"CC Wu","year":"2009","unstructured":"Wu CC, Lin CH, Wang WS. Development of an enrofloxacin immunosensor based on label-free electrochemical impedance spectroscopy. Talanta. 2009;79(1):62\u20137. https:\/\/doi.org\/10.1016\/j.talanta.2009.03.004.","journal-title":"Talanta"},{"key":"6455_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.130615","volume":"445","author":"X Zhang","year":"2023","unstructured":"Zhang X, Bai Y, Tang Q, Liu M, Nan L, Wen K, Yu X, Yu W, Shen J, Wang Z. Development of epitopephore-based rational hapten design strategy: a combination of theoretical evidence and experimental validation. J Hazard Mater. 2023;445: 130615. https:\/\/doi.org\/10.1016\/j.jhazmat.2022.130615.","journal-title":"J Hazard Mater"},{"key":"6455_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2022.340699","volume":"1239","author":"Y Bai","year":"2023","unstructured":"Bai Y, Liu R, Dou L, Wu W, Yu W, Wen K, Yu X, Shen J, Wang Z. The influence of hapten spacer arm length on antibody response and immunoassay development. Anal Chim Acta. 2023;1239: 340699. https:\/\/doi.org\/10.1016\/j.aca.2022.340699.","journal-title":"Anal Chim Acta"},{"key":"6455_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2023.124852","volume":"265","author":"C Liu","year":"2023","unstructured":"Liu C, Lin H, Cao L, Wang K, Sui J. Characterization, specific recognition, and the performance in fish matrix of a shark-derived single-domain antibody against enrofloxacin. Talanta. 2023;265: 124852. https:\/\/doi.org\/10.1016\/j.talanta.2023.124852.","journal-title":"Talanta"},{"issue":"20","key":"6455_CR19","doi-asserted-by":"publisher","first-page":"5255","DOI":"10.1007\/s00216-018-1482-z","volume":"411","author":"J Mi","year":"2019","unstructured":"Mi J, Dong X, Zhang X, Li C, Wang J, Mujtaba MG, Zhang S, Wen K, Yu X, Wang Z. Novel hapten design, antibody recognition mechanism study, and a highly sensitive immunoassay for diethylstilbestrol in shrimp. Anal Bioanal Chem. 2019;411(20):5255\u201365. https:\/\/doi.org\/10.1007\/s00216-018-1482-z.","journal-title":"Anal Bioanal Chem"},{"issue":"7","key":"6455_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/biom10070986","volume":"10","author":"L Yang","year":"2020","unstructured":"Yang L, Zhang X, Shen D, Yu X, Li Y, Wen K, Shen J, Wang Z. Hapten design and monoclonal antibody to fluoroacetamide, a small and highly toxic chemical. Biomolecules. 2020;10(7): 986. https:\/\/doi.org\/10.3390\/biom10070986.","journal-title":"Biomolecules"},{"key":"6455_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.134100","volume":"469","author":"J Li","year":"2024","unstructured":"Li J, Jiang L, Shu Y, Song S, Xu L, Kuang H, Xu C, Guo L. Quantitative immunochromatographic assay for rapid and cost-effective on-site detection of benzo[a]pyrene in oilfield chemicals. J Hazard Mater. 2024;469: 134100. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.134100.","journal-title":"J Hazard Mater"},{"issue":"16","key":"6455_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165748","volume":"21","author":"Z Bogn\u00e1r","year":"2020","unstructured":"Bogn\u00e1r Z, Gyurcs\u00e1nyi RE. Aptamers against immunoglobulins: design, selection and bioanalytical applications. Int J Mol Sci. 2020;21(16): 5748. https:\/\/doi.org\/10.3390\/ijms21165748.","journal-title":"Int J Mol Sci"},{"key":"6455_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2023.124838","volume":"265","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, Luan Y, Ru S, Teng H, Li Y, Liu M, Wang J. A novel electrochemical aptasensor for ultrasensitive detection of herbicide prometryn based on its highly specific aptamer and Ag@Au nanoflowers. Talanta. 2023;265: 124838. https:\/\/doi.org\/10.1016\/j.talanta.2023.124838.","journal-title":"Talanta"},{"issue":"2","key":"6455_CR24","doi-asserted-by":"publisher","first-page":"2564","DOI":"10.1021\/acsomega.2c06933","volume":"8","author":"J Chuiprasert","year":"2023","unstructured":"Chuiprasert J, Srinives S, Boontanon N, Polprasert C, Ramungul N, Lertthanaphol N, Karawek A, Boontanon SK. Electrochemical sensor based on a composite of reduced graphene oxide and molecularly imprinted copolymer of polyaniline\u2013poly(o-phenylenediamine) for ciprofloxacin determination: fabrication, characterization, and performance evaluation. ACS Omega. 2023;8(2):2564\u201374. https:\/\/doi.org\/10.1021\/acsomega.2c06933.","journal-title":"ACS Omega"},{"issue":"6","key":"6455_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/foods13060941","volume":"13","author":"X Bao","year":"2024","unstructured":"Bao X, Wang S, Hao Q, Bai Y, Li S, Zhang S, Zhang L, Kang X, Lyu M, Wang S. Enrofloxacin rapid detection in aquatic foods: based on DNA aptamer sensor. Foods. 2024;13(6): 941. https:\/\/doi.org\/10.3390\/foods13060941.","journal-title":"Foods"},{"issue":"17","key":"6455_CR26","doi-asserted-by":"publisher","first-page":"3801","DOI":"10.1007\/s00216-019-01870-7","volume":"411","author":"Y Huang","year":"2019","unstructured":"Huang Y, Liang G, Lin T, Hou L, Ye F, Zhao S. Magnetic Cu\/Fe\u2083O\u2084@FeOOH with intrinsic HRP-like activity at nearly neutral pH for one-step biosensing. Anal Bioanal Chem. 2019;411(17):3801\u201310. https:\/\/doi.org\/10.1007\/s00216-019-01870-7.","journal-title":"Anal Bioanal Chem"},{"issue":"12","key":"6455_CR27","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/0039-9140(90)80172-P","volume":"37","author":"Y-X Ci","year":"1990","unstructured":"Ci Y-X, Wang F. Studies on catalytic fluorescence formation with peroxidase-like metallotetrakis(N-methylpyridiniumyl) porphyrins. Talanta. 1990;37(12):1133\u20136. https:\/\/doi.org\/10.1016\/0039-9140(90)80172-P.","journal-title":"Talanta"},{"key":"6455_CR28","doi-asserted-by":"publisher","first-page":"120995","DOI":"10.1016\/j.talanta.2020.120995","volume":"216","author":"X Huang","year":"2020","unstructured":"Huang X, Nan Z. Porous 2D FeS nanosheets as a peroxidase mimic for rapid determination of HO. Talanta. 2020;216:120995. https:\/\/doi.org\/10.1016\/j.talanta.2020.120995.","journal-title":"Talanta"},{"key":"6455_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1036826","volume":"9","author":"M Alhammadi","year":"2022","unstructured":"Alhammadi M, Yoo J, Sonwal S, Park SY, Umapathi R, Oh MH, Huh YS. A highly sensitive lateral flow immunoassay for the rapid and on-site detection of enrofloxacin in milk. Front Nutr. 2022;9: 1036826. https:\/\/doi.org\/10.3389\/fnut.2022.1036826.","journal-title":"Front Nutr"},{"key":"6455_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.922772","volume":"10","author":"AC Mirica","year":"2022","unstructured":"Mirica AC, Stan D, Chelcea IC, Mihailescu CM, Ofiteru A, Bocancia-Mateescu LA. Latest trends in lateral flow immunoassay (LFIA) detection labels and conjugation process. Front Bioeng Biotechnol. 2022;10: 922772. https:\/\/doi.org\/10.3389\/fbioe.2022.922772.","journal-title":"Front Bioeng Biotechnol"},{"issue":"11","key":"6455_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119600","volume":"24","author":"J Kim","year":"2023","unstructured":"Kim J, Shin MS, Shin J, Kim HM, Pham XH, Park SM, Kim DE, Kim YJ, Jun BH. Recent trends in lateral flow immunoassays with optical nanoparticles. Int J Mol Sci. 2023;24(11): 9600. https:\/\/doi.org\/10.3390\/ijms24119600.","journal-title":"Int J Mol Sci"},{"key":"6455_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2020.461739","volume":"1636","author":"V Marassi","year":"2021","unstructured":"Marassi V, Calabria D, Trozzi I, Zattoni A, Reschiglian P, Roda B. Comprehensive characterization of gold nanoparticles and their protein conjugates used as a label by hollow fiber flow field flow fractionation with photodiode array and fluorescence detectors and multiangle light scattering. J Chromatogr A. 2021;1636: 461739. https:\/\/doi.org\/10.1016\/j.chroma.2020.461739.","journal-title":"J Chromatogr A"},{"issue":"Pt 2","key":"6455_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.142054","volume":"465","author":"L Luo","year":"2025","unstructured":"Luo L, Zhang Y, Zhao X, Wu W, Fei J, Yu X, Wen K, Shen J, Pan Y, Wang Z. Rational hapten design, antibody preparation, and immunoassay development for rapid screening xylazine in biological samples. Food Chem. 2025;465(Pt 2): 142054. https:\/\/doi.org\/10.1016\/j.foodchem.2024.142054.","journal-title":"Food Chem"},{"issue":"4","key":"6455_CR34","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-025-05037-1","volume":"192","author":"J Li","year":"2025","unstructured":"Li J, Chen H, Shu Y, Jiang L, Gao W, Kuang H, Xu C, Guo L. Quantitative immunosensor for dibenz[a,h]anthracene on-site detection in oilfield chemicals based on computer-aided antibody. Mikrochim Acta. 2025;192(4): 245. https:\/\/doi.org\/10.1007\/s00604-025-05037-1.","journal-title":"Mikrochim Acta"},{"issue":"2","key":"6455_CR35","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1080\/03601234.2013.728916","volume":"48","author":"YZ Liu","year":"2013","unstructured":"Liu YZ, Zhao GX, Wang P, Liu J, Zhang HC, Wang JP. Production of the broad specific monoclonal antibody against sarafloxacin for rapid immunoscreening of 12 fluoroquinolones in meat. J Environ Sci Health B. 2013;48(2):139\u201346. https:\/\/doi.org\/10.1080\/03601234.2013.728916.","journal-title":"J Environ Sci Health B"},{"key":"6455_CR36","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.aca.2014.02.031","volume":"820","author":"Z Wang","year":"2014","unstructured":"Wang Z, Zhang H, Ni H, Zhang S, Shen J. Development of a highly sensitive and specific immunoassay for enrofloxacin based on heterologous coating haptens. Anal Chim Acta. 2014;820:152\u20138. https:\/\/doi.org\/10.1016\/j.aca.2014.02.031.","journal-title":"Anal Chim Acta"},{"key":"6455_CR37","doi-asserted-by":"publisher","first-page":"130357","DOI":"10.1016\/j.snb.2021.130357","volume":"345","author":"Z Zhang","year":"2021","unstructured":"Zhang Z, Ru S, Wang J, Wang D, Zhao L, Teng H, Dai Z, Zhang W, Yang A. Ultrasensitive label-free electrochemical immunosensors for detecting marine medaka (Oryzias melastigma) vitellogenin based on novel Cu\u2082O\u2013BSA nanoparticles and anti-lipovitellin monoclonal antibody. Sens Actuators B Chem. 2021;345:130357. https:\/\/doi.org\/10.1016\/j.snb.2021.130357.","journal-title":"Sens Actuators B Chem"},{"issue":"1","key":"6455_CR38","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-023-06116-z","volume":"192","author":"C Wu","year":"2024","unstructured":"Wu C, Dai M, Qin X, Liu G, Zhang H. Gold nanoclusters decorated hollow ZIF-8 encapsulating iron-catecholates as oxidase mimetics for ratiometric colorimetric detection of nitrite. Mikrochim Acta. 2024;192(1): 23. https:\/\/doi.org\/10.1007\/s00604-023-06116-z.","journal-title":"Mikrochim Acta"},{"issue":"1-2","key":"6455_CR39","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jim.2010.03.014","volume":"358","author":"FB Gomes","year":"2010","unstructured":"Gomes FB, Riedstra S, Ferreira JP. Development of an immunoassay for ciprofloxacin based on phage-displayed antibody fragments. J Immunol Methods. 2010;358(1\u20132):17\u201322. https:\/\/doi.org\/10.1016\/j.jim.2010.03.014.","journal-title":"J Immunol Methods"},{"key":"6455_CR40","doi-asserted-by":"publisher","first-page":"137700","DOI":"10.1016\/j.jhazmat.2024.137700","volume":"489","author":"Y Li","year":"2025","unstructured":"Li Y, Liu Z, Luo H, Tang Y, Pan L, Zhang S, Huang XA, Wen J, Chen J, Lei H. Broad-spectrum antibody against thiazides and degraded salamide and immunoassay establishment for simultaneous detection. J Hazard Mater. 2025;489:137700. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.137700.","journal-title":"J Hazard Mater"},{"key":"6455_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2019.125379","volume":"303","author":"S Hu","year":"2020","unstructured":"Hu S, Huang Z, Wang C, Peng J, Lai WH. Using hapten cross-reactivity to screen heterologous competitive antigens for improving the sensitivity of ELISA. Food Chem. 2020;303: 125379. https:\/\/doi.org\/10.1016\/j.foodchem.2019.125379.","journal-title":"Food Chem"},{"key":"6455_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.133221","volume":"465","author":"J Xiao","year":"2024","unstructured":"Xiao J, Qin L, Zhao D, Huang N, Xu W, Zhang L, Pan X, Han S, Ding M, Li L, Le T, Peng D. Monospecific and ultrasensitive detection of ofloxacin: a computational chemistry-assisted hapten screening strategy and analysis of molecular recognition mechanism. J Hazard Mater. 2024;465: 133221. https:\/\/doi.org\/10.1016\/j.jhazmat.2023.133221.","journal-title":"J Hazard Mater"},{"key":"6455_CR43","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.saa.2017.12.062","volume":"194","author":"H Mu","year":"2018","unstructured":"Mu H, Xu Z, Liu Y, Sun Y, Wang B, Sun X, Wang Z, Eremin S, Zherdev AV, Dzantiev BB, Lei H. Probing the stereoselective interaction of ofloxacin enantiomers with corresponding monoclonal antibodies by multiple spectrometry. Spectrochim Acta A Mol Biomol Spectrosc. 2018;194:83\u201391. https:\/\/doi.org\/10.1016\/j.saa.2017.12.062.","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"issue":"24","key":"6455_CR44","doi-asserted-by":"publisher","first-page":"5927","DOI":"10.1007\/s00216-014-8035-x","volume":"406","author":"OB Torres","year":"2014","unstructured":"Torres OB, Jalah R, Rice KC, Li F, Antoline JF, Iyer MR, Jacobson AE, Boutaghou MN, Alving CR, Matyas GR. Characterization and optimization of heroin hapten-BSA conjugates: method development for the synthesis of reproducible hapten-based vaccines. Anal Bioanal Chem. 2014;406(24):5927\u201337. https:\/\/doi.org\/10.1007\/s00216-014-8035-x.","journal-title":"Anal Bioanal Chem"},{"key":"6455_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2020.111163","volume":"210","author":"KH Wu","year":"2020","unstructured":"Wu KH, Huang WC, Shyu RH, Chang SC. Silver nanoparticle-base lateral flow immunoassay for rapid detection of Staphylococcal enterotoxin B in milk and honey. J Inorg Biochem. 2020;210: 111163. https:\/\/doi.org\/10.1016\/j.jinorgbio.2020.111163.","journal-title":"J Inorg Biochem"},{"issue":"24","key":"6455_CR46","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27248846","volume":"27","author":"Y Tkachenko","year":"2022","unstructured":"Tkachenko Y, Niedzielski P. FTIR as a method for qualitative assessment of solid samples in geochemical research: a review. Molecules. 2022;27(24): 8846. https:\/\/doi.org\/10.3390\/molecules27248846.","journal-title":"Molecules"},{"issue":"11","key":"6455_CR47","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11111512","volume":"11","author":"S Yadoung","year":"2022","unstructured":"Yadoung S, Ishimatsu R, Xu ZL, Sringarm K, Pata S, Thongkham M, Chantara S, Pattarawarapan M, Hongsibsong S. Development of IgY-based indirect competitive ELISA for the detection of fluoroquinolone residues in chicken and pork samples. Antibiotics. 2022;11(11): 1512. https:\/\/doi.org\/10.3390\/antibiotics11111512.","journal-title":"Antibiotics"},{"issue":"12","key":"6455_CR48","doi-asserted-by":"publisher","first-page":"4471","DOI":"10.1021\/ac070064t","volume":"79","author":"Z Wang","year":"2007","unstructured":"Wang Z, Zhu Y, Ding S, He F, Beier RC, Li J, Jiang H, Feng C, Wan Y, Zhang S, Kai Z, Yang X, Shen J. Development of a monoclonal antibody-based broad-specificity ELISA for fluoroquinolone antibiotics in foods and molecular modeling studies of cross-reactive compounds. Anal Chem. 2007;79(12):4471\u201383. https:\/\/doi.org\/10.1021\/ac070064t.","journal-title":"Anal Chem"},{"issue":"8","key":"6455_CR49","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1177\/27.8.383822","volume":"27","author":"AJ O\u2019Beirne","year":"1979","unstructured":"O\u2019Beirne AJ, Cooper HR. Heterogeneous enzyme immunoassay. J Histochem Cytochem: Off J Histochem Soc. 1979;27(8):1148\u201362. https:\/\/doi.org\/10.1177\/27.8.383822.","journal-title":"J Histochem Cytochem: Off J Histochem Soc"},{"key":"6455_CR50","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.talanta.2013.05.009","volume":"116","author":"B Cao","year":"2013","unstructured":"Cao B, Yang H, Song J, Chang H, Li S, Deng A. Sensitivity and specificity enhanced enzyme-linked immunosorbent assay by rational hapten modification and heterogeneous antibody\/coating antigen combinations for the detection of melamine in milk, milk powder and feed samples. Talanta. 2013;116:173\u201380. https:\/\/doi.org\/10.1016\/j.talanta.2013.05.009.","journal-title":"Talanta"},{"issue":"3","key":"6455_CR51","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1084\/jem.124.3.293","volume":"124","author":"AA Amkraut","year":"1966","unstructured":"Amkraut AA, Garvey JS, Campbell DH. Competition of haptens. J Exp Med. 1966;124(3):293\u2013306. https:\/\/doi.org\/10.1084\/jem.124.3.293.","journal-title":"J Exp Med"},{"issue":"3","key":"6455_CR52","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-022-05185-w","volume":"189","author":"J Chen","year":"2022","unstructured":"Chen J, Tan L, Qu K, Cui Z, Wang J. Novel electrochemical sensor modified with molecularly imprinted polymers for determination of enrofloxacin in marine environment. Mikrochim Acta. 2022;189(3): 95. https:\/\/doi.org\/10.1007\/s00604-022-05185-w.","journal-title":"Mikrochim Acta"},{"key":"6455_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.electacta.2020.137609","volume":"368","author":"Y Song","year":"2021","unstructured":"Song Y, Xu M, Liu X, Li Z, Du M. A label-free enrofloxacin electrochemical aptasensor constructed by a semiconducting CoNi-based metal\u2013organic framework (MOF). Electrochim Acta. 2021;368: 137609. https:\/\/doi.org\/10.1016\/j.electacta.2020.137609.","journal-title":"Electrochim Acta"},{"key":"6455_CR54","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2022.340123","volume":"1221","author":"L Huang","year":"2022","unstructured":"Huang L, Zha S, Yu H, He Y, Li Y, Shen Y, Peng Y, Liu G, Fu Y. Chemical and electrochemical conversion of magnetic nanoparticles to Prussian blue for label-free and refreshment-enhanced electrochemical biosensing of enrofloxacin. Anal Chim Acta. 2022;1221: 340123. https:\/\/doi.org\/10.1016\/j.aca.2022.340123.","journal-title":"Anal Chim Acta"},{"issue":"6","key":"6455_CR55","doi-asserted-by":"publisher","first-page":"3856","DOI":"10.3168\/jds.2022-22781","volume":"106","author":"G Xue","year":"2023","unstructured":"Xue G, Wu M, Liu T, Fang X, Yin J, Lai W, Peng J. A multiple lateral flow immunoassay based on AuNP for the detection of 5 chemical contaminants in milk. J Dairy Sci. 2023;106(6):3856\u201367. https:\/\/doi.org\/10.3168\/jds.2022-22781.","journal-title":"J Dairy Sci"},{"key":"6455_CR56","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2023.341152","volume":"1257","author":"R Tian","year":"2023","unstructured":"Tian R, Ren Y, Wang T, Cao J, Li J, Deng A. A SERS-based lateral flow immunochromatographic assay using raman reporter mediated-gap AuNR@Au nanoparticles as the substrate for the detection of enrofloxacin in food samples. Anal Chim Acta. 2023;1257: 341152. https:\/\/doi.org\/10.1016\/j.aca.2023.341152.","journal-title":"Anal Chim Acta"}],"container-title":["Analytical and Bioanalytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-026-06455-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00216-026-06455-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-026-06455-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T07:29:51Z","timestamp":1779434991000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00216-026-06455-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,26]]},"references-count":56,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["6455"],"URL":"https:\/\/doi.org\/10.1007\/s00216-026-06455-9","relation":{},"ISSN":["1618-2642","1618-2650"],"issn-type":[{"value":"1618-2642","type":"print"},{"value":"1618-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,26]]},"assertion":[{"value":"21 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The fish used in this study were obtained from the Taishan Chilin Breeding Base. All animal procedures were approved and reviewed by the Animal Ethics and Welfare Committee of Taishan University. All methods were performed in accordance with the relevant institutional and national guidelines and regulations for the care and use of laboratory animals. Efforts were made to minimize animal suffering and to reduce the number of animals used.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}