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These materials, obtained by polymerization of high internal phase emulsions with different composition, were used in a miniaturized setting (\u00b5SPE), preliminarily in synthetic urine samples enriched with 200\u00a0ng\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    of each selected compound. It was found that the polyethylene glycol (PEG)-modified polymer combines good analytical performance, in terms of extraction efficiency (76\u2013100% for most analytes), from 1\u00a0mL samples and single-fraction elution in pure ethanol. Recovery was assessed in untreated real urine (1\u00a0mL, pH\u2009~\u20093.5) at three quality control levels (50, 200, 500\u00a0ng\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) observing inter-day RSD below 20% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093). The polymer exhibited a service life of at least ten sorption\/desorption cycles, a further strength point of this sample treatment ascertained by greenness metrics. This streamlined procedure also provided satisfactory sample clean-up, with a negligible matrix-effect, as observed in HPLC-MS\/MS. An ad hoc chromatographic method was developed to enable the simultaneous separation and quantification of all targets in a single run. Good linearity was observed in the range 10\u2013600\u00a0ng\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    (R\n                    <jats:sup>2<\/jats:sup>\n                    \u2009&gt;\u20090.9919) with suitable sensitivity (a few ng mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) to future application for monitoring these endogenous compounds.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s00216-026-06535-w","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:58:17Z","timestamp":1777928297000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantification of gastric cancer biomarkers in the urine matrix by high internal phase emulsion polymer-based \u00b5solid-phase extraction followed by HPLC-MS\/MS"],"prefix":"10.1007","author":[{"given":"Francesca","family":"Merlo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Invernizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Salerno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Calleri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Profumo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6924-7170","authenticated-orcid":false,"given":"Andrea","family":"Speltini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"6535_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2021.462422","volume":"1653","author":"J Lyu","year":"2021","unstructured":"Lyu J, Li H, Yin D, Zhao M, Sun Q, Guo M. 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For this type of study without sensitive data and randomized between products not intended for clinical use, there is no intervention by the Ethics Committee. Approval from the Ethics Committee would be required in case donation or additional samples are specifically obtained for defined research. Informed consent was obtained from all healthy adults who voluntarily provided the urine samples.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and informed consent"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}