{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:09:39Z","timestamp":1789628979134,"version":"build-2803163510"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"19","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Fundamental Research Funds for the Central Universities","award":["DUT24MS018"],"award-info":[{"award-number":["DUT24MS018"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["DUT26YG110"],"award-info":[{"award-number":["DUT26YG110"]}]},{"name":"the Natural Science Foundation of Liaoning Province","award":["2023-MSBA-018"],"award-info":[{"award-number":["2023-MSBA-018"]}]},{"name":"the Natural Science Foundation of Liaoning Province","award":["2025-MS-023"],"award-info":[{"award-number":["2025-MS-023"]}]},{"name":"\u201cOncology+\" Open project of Liaoning Cancer Hospital","award":["2024-ZLKF-33"],"award-info":[{"award-number":["2024-ZLKF-33"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anal Bioanal Chem"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s00216-026-06654-4","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:45:24Z","timestamp":1783943124000},"page":"6319-6333","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic integration of \u03bc-SPE and ammoniated adduct-based MRM for sensitive UPLC-MS\/MS quantification of PEG1000: a comparative study against in-source CID and application to zebrafish tissue distribution"],"prefix":"10.1007","volume":"418","author":[{"given":"Xinyue","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufei","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuye","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalin","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"6654_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctta.2026.100275","volume":"21","author":"N Das","year":"2026","unstructured":"Das N, Panda S, Praharaj MK. Comparative analysis of molecular interactions in PEG\u2013ethanol, PEG\u2013ethanol\u2013epoxy, and PEG\u2013ethanol\u2013epoxy\u2013TiO\u2082 systems at different temperatures for coating applications. Chem Thermodyn Therm Anal. 2026;21: 100275. https:\/\/doi.org\/10.1016\/j.ctta.2026.100275.","journal-title":"Chem Thermodyn Therm Anal"},{"key":"6654_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2026.117382","volume":"272","author":"M Liu","year":"2026","unstructured":"Liu M, Yu Y, Jing Y, Guo Y, Wang C, Xue H, Liu H, Yin L, Shi M. Comprehensive pharmacokinetic and tissue distribution study of \u03b1,\u03c9-dipropionic acid polyethylene glycol (PA-PEG\u2081\u2082-PA) in rats using a validated UPLC-MS\/MS method. J Pharm Biomed Anal. 2026;272: 117382. https:\/\/doi.org\/10.1016\/j.jpba.2026.117382.","journal-title":"J Pharm Biomed Anal"},{"key":"6654_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jafr.2026.102825","volume":"27","author":"C Zhou","year":"2026","unstructured":"Zhou C, Bozdar B, Ao Q, Hu X, Liu X, Li Y, Zhou X, Yang S, Li ZH. PEG-modified chitosan\u2013PVA binders regulate hydration dynamics and improve rapeseed pelleting performance. Journal of Agriculture and Food Research. 2026;27: 102825. https:\/\/doi.org\/10.1016\/j.jafr.2026.102825.","journal-title":"J Agric Food Res"},{"issue":"2","key":"6654_CR4","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1007\/s41664-025-00348-z","volume":"9","author":"M Shi","year":"2025","unstructured":"Shi M, Zhang N, Feng C, Tian J, Guo Y, Liu M, Xue H, You J, Zhang Y, Yin L. Development of a UHPLC-MS\/MS assay for determination of polypropylene glycol 4 K polymers coupled with micro-solid phase extraction and selection of [M + NH4]+ adduct strategy to enhance sensitivity. Journal of Analysis and Testing. 2025;9(2):272\u20138. https:\/\/doi.org\/10.1007\/s41664-025-00348-z.","journal-title":"Journal of Analysis and Testing"},{"key":"6654_CR5","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.chroma.2014.06.050","volume":"1356","author":"D Liu","year":"2014","unstructured":"Liu D, Zou X, Gao M, Gu M, Xiao H. Hydrophilic organic\/salt-containing aqueous two-phase solvent system for counter-current chromatography: a novel technique for separation of polar compounds. J Chromatogr A. 2014;1356:157\u201362. https:\/\/doi.org\/10.1016\/j.chroma.2014.06.050.","journal-title":"J Chromatogr A"},{"key":"6654_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2025.465661","volume":"1742","author":"Y Sun","year":"2025","unstructured":"Sun Y, Liu Q, Wang Z, Zhang J. Novel strategy for multi-critical quality attributes analysis of pharmaceutical excipient polyethylene glycol by UHPLC-Q-TOF\/MS. J Chromatogr A. 2025;1742:465661. https:\/\/doi.org\/10.1016\/j.chroma.2025.465661.","journal-title":"J Chromatogr A"},{"key":"6654_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2024.124141","volume":"1240","author":"T Wei","year":"2024","unstructured":"Wei T, Ni H. Establishing aqueous two-phase flotation coupled with preparative high performance liquid chromatography and its application for the purification of astragalin from Flaveria bidentis. J Chromatogr B. 2024;1240: 124141. https:\/\/doi.org\/10.1016\/j.jchromb.2024.124141.","journal-title":"J Chromatogr B"},{"key":"6654_CR8","doi-asserted-by":"publisher","first-page":"100473","DOI":"10.1016\/j.rsurfi.2025.100473","volume":"19","author":"MZ Ahmad","year":"2025","unstructured":"Ahmad MZ, Mustafa G, Abdel-Wahab BA, Pathak K, Das A, Sahariah JJ, Kalita P, Alam A, Borthakur PP. From bench to bedside: advancing liposomal doxorubicin for targeted cancer therapy. Results Surf Interfaces. 2025;19:100473. https:\/\/doi.org\/10.1016\/j.rsurfi.2025.100473.","journal-title":"Results Surf Interfaces"},{"issue":"10","key":"6654_CR9","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1016\/j.drudis.2014.06.002","volume":"19","author":"A Baumann","year":"2014","unstructured":"Baumann A, Tuerck D, Prabhu S, Dickmann L, Sims J. Pharmacokinetics, metabolism and distribution of PEGs and PEGylated proteins: quo vadis? Drug Discov Today. 2014;19(10):1623\u201331. https:\/\/doi.org\/10.1016\/j.drudis.2014.06.002.","journal-title":"Drug Discov Today"},{"key":"6654_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113372","volume":"217","author":"Y Fu","year":"2021","unstructured":"Fu Y, Ding Y, Zhang L, Zhang Y, Liu J, Yu P. Poly ethylene glycol (PEG)-related controllable and sustainable antidiabetic drug delivery systems. Eur J Med Chem. 2021;217: 113372. https:\/\/doi.org\/10.1016\/j.ejmech.2021.113372.","journal-title":"Eur J Med Chem"},{"issue":"1","key":"6654_CR11","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1124\/dmd.106.012419","volume":"35","author":"R Webster","year":"2007","unstructured":"Webster R, Didier E, Harris P, Siegel N, Stadler J, Tilbury L, Smith D. PEGylated proteins: evaluation of their safety in the absence of definitive metabolism studies. Drug Metab Dispos. 2007;35(1):9\u201316. https:\/\/doi.org\/10.1124\/dmd.106.012419.","journal-title":"Drug Metab Dispos"},{"key":"6654_CR12","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.chroma.2019.03.069","volume":"1599","author":"D Bo\u00dfmann","year":"2019","unstructured":"Bo\u00dfmann D, Bartling B, de Vries I, Winkler J, Neumann H, Lammers F, Beutel S, Scheper T. Charged aerosol detector HPLC as a characterization and quantification application of biopharmaceutically relevant polysialic acid from E. coli K1. J Chromatogr A. 2019;1599:85\u201394. https:\/\/doi.org\/10.1016\/j.chroma.2019.03.069.","journal-title":"J Chromatogr A"},{"key":"6654_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2023.464366","volume":"1708","author":"P Kubica","year":"2023","unstructured":"Kubica P, Kalogiouri NP, Kabir A, Furton KG, Samanidou VF. Optimization of a fabric phase sorptive extraction protocol for the isolation of six bisphenols from juice pouches to be analysed by high performance liquid chromatography coupled with diode array detector. J Chromatogr A. 2023;1708: 464366. https:\/\/doi.org\/10.1016\/j.chroma.2023.464366.","journal-title":"J Chromatogr A"},{"issue":"34","key":"6654_CR14","doi-asserted-by":"publisher","first-page":"5757","DOI":"10.1016\/j.chroma.2011.06.099","volume":"1218","author":"A Sarafraz-Yazdi","year":"2011","unstructured":"Sarafraz-Yazdi A, Amiri A, Rounaghi G, Hosseini HE. A novel solid-phase microextraction using coated fiber based sol\u2013gel technique using poly(ethylene glycol) grafted multi-walled carbon nanotubes for determination of benzene, toluene, ethylbenzene and o-xylene in water samples with gas chromatography-flam ionization detector. J Chromatogr A. 2011;1218(34):5757\u201364. https:\/\/doi.org\/10.1016\/j.chroma.2011.06.099.","journal-title":"J Chromatogr A"},{"key":"6654_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2023.464070","volume":"1701","author":"P Zimoch","year":"2023","unstructured":"Zimoch P, Rumanek T, Ko\u0142odziej M, Pi\u0105tkowski W, Antos D. Coupling of chromatography and precipitation for adjusting acidic variant content in a monoclonal antibody pool. J Chromatogr A. 2023;1701: 464070. https:\/\/doi.org\/10.1016\/j.chroma.2023.464070.","journal-title":"J Chromatogr A"},{"key":"6654_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123854","volume":"328","author":"T-Y Chen","year":"2026","unstructured":"Chen T-Y, Chang C-Y, Xu L, Wen T-C, Lin Y-H, Peng C-L, Yeh Y-Q, Chen C-H, Tsai IL, Chuang K-H, Wu S-H. Short-chain dense brush PEGylation on rigid nanocarriers overcomes anti-PEG antibody recognition for immune-stealth drug delivery. Biomaterials. 2026;328: 123854. https:\/\/doi.org\/10.1016\/j.biomaterials.2025.123854.","journal-title":"Biomaterials"},{"key":"6654_CR17","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.jconrel.2024.01.016","volume":"366","author":"A Hyldbakk","year":"2024","unstructured":"Hyldbakk A, Hansen T, Hak S, Borgos SEF. Polyethylene glycol (PEG) as a broad applicability marker for LC\u2013MS\/MS-based biodistribution analysis of nanomedicines. J Control Release. 2024;366:611\u201320. https:\/\/doi.org\/10.1016\/j.jconrel.2024.01.016.","journal-title":"J Control Release"},{"issue":"7","key":"6654_CR18","doi-asserted-by":"publisher","first-page":"3156","DOI":"10.1016\/j.apsb.2022.01.014","volume":"12","author":"T Ren","year":"2022","unstructured":"Ren T, Li R, Zhao L, Fawcett JP, Sun D, Gu J. Biological fate and interaction with cytochromes P450 of the nanocarrier material, d-\u03b1-tocopheryl polyethylene glycol 1000 succinate. Acta Pharm Sin B. 2022;12(7):3156\u201366. https:\/\/doi.org\/10.1016\/j.apsb.2022.01.014.","journal-title":"Acta Pharm Sin B"},{"issue":"5","key":"6654_CR19","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.jasms.2010.01.011","volume":"21","author":"X Lu","year":"2010","unstructured":"Lu X, Gough PC, DeFelippis MR, Huang L. Elucidation of PEGylation site with a combined approach of in-source fragmentation and CID MS\/MS. J Am Soc Mass Spectrom. 2010;21(5):810\u20138. https:\/\/doi.org\/10.1016\/j.jasms.2010.01.011.","journal-title":"J Am Soc Mass Spectrom"},{"key":"6654_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2019.121716","volume":"1125","author":"M Shi","year":"2019","unstructured":"Shi M, Jiang H, Yin L, Liu Y, Xu M. Development of an UPLC-MS\/MS method coupled with in-source CID for quantitative analysis of PEG-PLA copolymer and its application to a pharmacokinetic study in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2019;1125: 121716. https:\/\/doi.org\/10.1016\/j.jchromb.2019.121716.","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"6654_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2023.341375","volume":"1267","author":"M Shi","year":"2023","unstructured":"Shi M, Zheng X, Jiang H, Ge Y, Zhang N, Duan X, Liu Y, Xue H, You J, Yin L. Unraveling the in vivo biological fate of mPEG2000-PDLLA2500-COOH diblock copolymers by LC-MS\/MS based on CID in source technique. Anal Chim Acta. 2023;1267: 341375. https:\/\/doi.org\/10.1016\/j.aca.2023.341375.","journal-title":"Anal Chim Acta"},{"key":"6654_CR22","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.jpba.2017.06.053","volume":"145","author":"H Sun","year":"2017","unstructured":"Sun H, Zhang Q, Zhang Z, Tong J, Chu D, Gu J. Simultaneous quantitative analysis of polyethylene glycol (PEG), PEGylated paclitaxel and paclitaxel in rats by MS\/MSALL technique with hybrid quadrupole time-of-flight mass spectrometry. J Pharm Biomed Anal. 2017;145:255\u201361. https:\/\/doi.org\/10.1016\/j.jpba.2017.06.053.","journal-title":"J Pharm Biomed Anal"},{"key":"6654_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2024.114276","volume":"184","author":"S-T Chin","year":"2024","unstructured":"Chin S-T, Boughton BA, Gay MCL, Russell AC, Wang Y, Nambiar V, McHenry MP, Holmes E, Nicholson JK, Loo RL. Unravelling inulin molecules in food sources using a matrix-assisted laser desorption\/ionization magnetic resonance mass spectrometry (MALDI-MRMS) pipeline. Food Res Int. 2024;184: 114276. https:\/\/doi.org\/10.1016\/j.foodres.2024.114276.","journal-title":"Food Res Int"},{"key":"6654_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.105258","volume":"62","author":"R Du","year":"2024","unstructured":"Du R, Liu Y, Ye Z, Zhang J, Li C, Liu Y. LC-MRM-MS-based lipidomics reveals differences in the digestion, absorption, and metabolism of phosphatidylcholines from egg, soy, and krill in vivo. Food Biosci. 2024;62: 105258. https:\/\/doi.org\/10.1016\/j.fbio.2024.105258.","journal-title":"Food Biosci"},{"issue":"4","key":"6654_CR25","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1021\/acs.jproteome.3c00557","volume":"23","author":"DO Qasrawi","year":"2024","unstructured":"Qasrawi DO, Al-Ghabkari A, Khan RM, Petrotchenko EV, Montero-Odasso M, Borchers CH. A simplified proteomics LC-MRM-MS assay for determination of apoE genotypes in plasma samples. J Proteome Res. 2024;23(4):1144\u20139. https:\/\/doi.org\/10.1021\/acs.jproteome.3c00557.","journal-title":"J Proteome Res"},{"key":"6654_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2026.144863","volume":"396","author":"C Yu","year":"2026","unstructured":"Yu C, Stevenson G, Crough R, De Araujo J, Yates A. A clean-up method to remove taurine conjugated bile acid isomers interference for perfluorooctane sulfonate (PFOS) analysis in biotic matrices by isotope dilution LC-MS\/MS and investigation of other MRMs interference. Chemosphere. 2026;396: 144863. https:\/\/doi.org\/10.1016\/j.chemosphere.2026.144863.","journal-title":"Chemosphere"},{"key":"6654_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2026.117337","volume":"273","author":"MH Maria","year":"2026","unstructured":"Maria MH, Neng NR, Berg T. Simultaneous determination of three phosphatidylethanol homologues, 12 drugs and metabolites in whole blood by LC\u2013MS\/MS. J Pharm Biomed Anal. 2026;273: 117337. https:\/\/doi.org\/10.1016\/j.jpba.2026.117337.","journal-title":"J Pharm Biomed Anal"},{"key":"6654_CR28","doi-asserted-by":"publisher","unstructured":"Fu J, Shao Y, Shao H, Jingyuan G, Zhang T, Fen J, et al. Advanced LC\u2012MS\/MS method for the precise detection of dinocap phenol isomers in 23 plant-derived foods for ensuring food safety and sustainability. Talanta Open. 2026: 100638. https:\/\/doi.org\/10.1016\/j.talo.2026.100638.","DOI":"10.1016\/j.talo.2026.100638"},{"issue":"3","key":"6654_CR29","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1021\/acs.jproteome.5c00869","volume":"25","author":"SJ Caven","year":"2026","unstructured":"Caven SJ, Barlow CK, Goode RJA, Blundell SA, Valipour Kahrood H, Zhang H, Shah AD, Ho BK, Wybrow M, Czauderna T, Schittenhelm RB. MaSpeQC: an easy-to-use interactive pipeline to assess the performance of LC-MS\/MS instrumentation. J Proteome Res. 2026;25(3):1507\u201314. https:\/\/doi.org\/10.1021\/acs.jproteome.5c00869.","journal-title":"J Proteome Res"},{"key":"6654_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2026.466798","volume":"1773","author":"S Al","year":"2026","unstructured":"Al S, Dincel D, Kul A, Sagirli O. Advances in LC\u2013MS\/MS methods and sample preparation strategies for therapeutic drug monitoring of immunosuppressive drugs. J Chromatogr A. 2026;1773: 466798. https:\/\/doi.org\/10.1016\/j.chroma.2026.466798.","journal-title":"J Chromatogr A"},{"key":"6654_CR31","doi-asserted-by":"publisher","first-page":"100639","DOI":"10.1016\/j.talo.2026.100639","volume":"13","author":"Y Sedaghat","year":"2026","unstructured":"Sedaghat Y, Rajabi M, Asghari A, Silerio-V\u00e1zquez FdJ, Galiya F, Naseri A, Hosseini-Bandegharaei A. Magnetic CNTs\/MnO2\/chitin nanocomposite for preconcentration and detection of trace narcotics in biological samples using D-\u03bc-SPE method. Talanta Open. 2026;13:100639. https:\/\/doi.org\/10.1016\/j.talo.2026.100639.","journal-title":"Talanta Open"},{"issue":"2","key":"6654_CR32","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.jchromb.2006.06.039","volume":"843","author":"JX Shen","year":"2006","unstructured":"Shen JX, Tama CI, Hayes RN. Evaluation of automated micro solid phase extraction tips (\u03bc-SPE) for the validation of a LC\u2013MS\/MS bioanalytical method. J Chromatogr B. 2006;843(2):275\u201382. https:\/\/doi.org\/10.1016\/j.jchromb.2006.06.039.","journal-title":"J Chromatogr B"},{"key":"6654_CR33","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.jpba.2013.12.035","volume":"91","author":"C Montesano","year":"2014","unstructured":"Montesano C, Sergi M, Odoardi S, Simeoni MC, Compagnone D, Curini R. A \u03bc-SPE procedure for the determination of cannabinoids and their metabolites in urine by LC\u2013MS\/MS. J Pharm Biomed Anal. 2014;91:169\u201375. https:\/\/doi.org\/10.1016\/j.jpba.2013.12.035.","journal-title":"J Pharm Biomed Anal"},{"key":"6654_CR34","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.talanta.2017.02.019","volume":"167","author":"C Montesano","year":"2017","unstructured":"Montesano C, Vannutelli G, Piccirilli V, Sergi M, Compagnone D, Curini R. Application of a rapid \u03bc-SPE clean-up for multiclass quantitative analysis of sixteen new psychoactive substances in whole blood by LC\u2013MS\/MS. Talanta. 2017;167:260\u20137. https:\/\/doi.org\/10.1016\/j.talanta.2017.02.019.","journal-title":"Talanta"},{"issue":"2","key":"6654_CR35","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0021-9673(98)00622-0","volume":"822","author":"K Rissler","year":"1998","unstructured":"Rissler K, Wyttenbach N, B\u00f6rnsen KO. High-performance liquid chromatography of polyethylene glycols as their \u03b1,\u03c9-bis(1-naphthylurethane) derivatives and signal monitoring by fluorescence detection. J Chromatogr A. 1998;822(2):189\u2013206. https:\/\/doi.org\/10.1016\/S0021-9673(98)00622-0.","journal-title":"J Chromatogr A"},{"key":"6654_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.126933","volume":"326","author":"H Kim","year":"2020","unstructured":"Kim H, Park J, Suh H-J, Lee J, Lee C. Simultaneous analysis of polyethylene glycol in dietary supplement tablets using high-performance liquid chromatography and verification with liquid chromatography\u2013electrospray ionization mass spectrometry. Food Chem. 2020;326: 126933. https:\/\/doi.org\/10.1016\/j.foodchem.2020.126933.","journal-title":"Food Chem"},{"issue":"19","key":"6654_CR37","doi-asserted-by":"publisher","first-page":"7598","DOI":"10.1039\/D3GC02347H","volume":"25","author":"N Manousi","year":"2023","unstructured":"Manousi N, Wojnowski W, P\u0142otka-Wasylka J, Samanidou V. Blue applicability grade index (BAGI) and software: a new tool for the evaluation of method practicality. Green Chem. 2023;25(19):7598\u2013604. https:\/\/doi.org\/10.1039\/D3GC02347H.","journal-title":"Green Chem"},{"issue":"7","key":"6654_CR38","doi-asserted-by":"publisher","first-page":"101202","DOI":"10.1016\/j.jpha.2025.101202","volume":"15","author":"T Xin","year":"2025","unstructured":"Xin T, Yu L, Zhang W, Guo Y, Wang C, Li Z, You J, Xue H, Shi M, Yin L. Greenness evaluation metric for analytical methods and software. J Pharm Anal. 2025;15(7):101202. https:\/\/doi.org\/10.1016\/j.jpha.2025.101202.","journal-title":"J Pharm Anal"}],"container-title":["Analytical and Bioanalytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-026-06654-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00216-026-06654-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-026-06654-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:09:21Z","timestamp":1789625361000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00216-026-06654-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":38,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["6654"],"URL":"https:\/\/doi.org\/10.1007\/s00216-026-06654-4","relation":{},"ISSN":["1618-2642","1618-2650"],"issn-type":[{"value":"1618-2642","type":"print"},{"value":"1618-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,13]]},"assertion":[{"value":"9 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal procedures were carried out in strict adherence to guidelines approved by the Institutional Animal Care and Use Committee of Dalian University of Technology (Approval No. DUTSCEOLS250223-04).","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study followed the internationally recognized guidelines for the care and use of laboratory animals (National Research Council, 1996). All efforts were made to minimize animal suffering and to reduce the number of animals used.","order":3,"name":"Ethics","label":"Statement on animal welfare","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Adult wild-type AB strain zebrafish were sourced from Shandong Yixiyue Biotechnology Co., Ltd. (Weifang, China).","order":4,"name":"Ethics","label":"Source of biological material","group":{"name":"EthicsHeading","label":"Declarations"}}]}}