{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:08:00Z","timestamp":1792782480568,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Research Project of Jiangsu Geriatric Society","award":["JGS2026QN006"],"award-info":[{"award-number":["JGS2026QN006"]}]},{"name":"Nantong Pharmaceutical Association \u201cYangZiJiang\u201d Pharmaceutical Research Project","award":["ntyxky2507"],"award-info":[{"award-number":["ntyxky2507"]}]},{"name":"Jiangsu Pharmaceutical Association \u201cYaoYanXinSheng\u201d Pharmaceutical Research Project","award":["202564063"],"award-info":[{"award-number":["202564063"]}],"id":[{"id":"https:\/\/ror.org\/01c3kcb55","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Research Project of Nantong Municipal Health Commission","award":["QNZ2024023"],"award-info":[{"award-number":["QNZ2024023"]}],"id":[{"id":"https:\/\/ror.org\/0578pqz98","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anal Bioanal Chem"],"DOI":"10.1007\/s00216-026-06852-0","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:37:30Z","timestamp":1791268650000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polymeric deep eutectic solvents-functionalized carbon nanotubes: a synergistic buffer additive for enhanced enantioseparation in capillary electrophoresis"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5916-2918","authenticated-orcid":false,"given":"Chengchen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunli","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"6852_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2021.116332","volume":"143","author":"B Chankvetadze","year":"2021","unstructured":"Chankvetadze B. Application of enantioselective separation techniques to bioanalysis of chiral drugs and their metabolites. TrAC Trends Anal Chem. 2021;143:116332.","journal-title":"TrAC Trends Anal Chem"},{"key":"6852_CR2","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1093\/toxsci\/kfp097","volume":"110","author":"SW Smith","year":"2009","unstructured":"Smith SW. Chiral toxicology: it\u2019s the same thing...only different. Toxicol Sci. 2009;110:4\u201330.","journal-title":"Toxicol Sci"},{"key":"6852_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2023.464611","volume":"1715","author":"J Urdiain-Arraiza","year":"2024","unstructured":"Urdiain-Arraiza J, Desguin B. Versatile capillary electrophoresis method for the direct chiral separation of aliphatic and aromatic \u03b1-hydroxy acids, \u03b2-hydroxy acids and polyhydroxy acids using vancomycin as chiral selector. J Chromatogr A. 2024;1715:464611.","journal-title":"J Chromatogr A"},{"key":"6852_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2022.463381","volume":"1679","author":"L Qi","year":"2022","unstructured":"Qi L, Qiao J. Progress of chiral ligand-exchange capillary electrophoresis for enantioseparation. J Chromatogr A. 2022;1679:463381.","journal-title":"J Chromatogr A"},{"key":"6852_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.70172","volume":"48","author":"W Hu","year":"2025","unstructured":"Hu W, Liu H. Maltodextrin-based deep eutectic solvent as a chiral selector for enantioseparation of azole antifungal drugs in capillary electrophoresis. J Sep Sci. 2025;48:e70172.","journal-title":"J Sep Sci"},{"key":"6852_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2023.341496","volume":"1274","author":"H Liu","year":"2023","unstructured":"Liu H, Chen J, Chen M, Wang J, Qiu H. Recent development of chiral ionic liquids for enantioseparation in liquid chromatography and capillary electrophoresis: a review. Anal Chim Acta. 2023;1274:341496.","journal-title":"Anal Chim Acta"},{"key":"6852_CR7","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1007\/s00604-024-06773-8","volume":"191","author":"P Miao","year":"2024","unstructured":"Miao P, Zhu D, Du S, Du Y. Synergistic enantioseparation system based on a novel nanomaterial synthesized by chiral metal-organic framework and chiral molecularly imprinted polymer in capillary electrochromatography. Microchim Acta. 2024;191:686.","journal-title":"Microchim Acta"},{"key":"6852_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2020.105763","volume":"161","author":"RB Yu","year":"2021","unstructured":"Yu RB, Quirino JP. Cyclodextrins as mobile phase additives in open-tubular admicellar electrochromatography for achiral and chiral separations. Microchem J. 2021;161:105763.","journal-title":"Microchem J"},{"key":"6852_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2022.119782","volume":"362","author":"X Ma","year":"2022","unstructured":"Ma X, Cao J, Yu J, Cai L. Evaluation of an ionic liquid chiral selector based on sulfobutylether-\u03b2-cyclodextrin in capillary electrophoresis. J Mol Liq. 2022;362:119782.","journal-title":"J Mol Liq"},{"key":"6852_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2019.460519","volume":"1609","author":"S Ren","year":"2020","unstructured":"Ren S, Xue S, Sun X, Rui M, Wang L, Zhang Q. Investigation of the synergistic effect of chiral ionic liquids as additives in non-aqueous capillary electrophoresis for enantioseparation. J Chromatogr A. 2020;1609:460519.","journal-title":"J Chromatogr A"},{"key":"6852_CR11","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1002\/elps.201900067","volume":"40","author":"Y Mu","year":"2019","unstructured":"Mu Y, Wu X, Huang Y, Liu Z. Investigation of deep eutectic solvents as additives to \u03b2-CD for enantiomeric separations of zopiclone, salbutamol, and amlodipine by CE. Electrophoresis. 2019;40:1992\u20135.","journal-title":"Electrophoresis"},{"key":"6852_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2020.105669","volume":"160","author":"S Salido-Fortuna","year":"2021","unstructured":"Salido-Fortuna S, Casado N, Castro-Puyana M, Marina ML. Use of choline chloride-D-sorbitol deep eutectic solvent as additive in cyclodextrin-electrokinetic chromatography for the enantiomeric separation of lacosamide. Microchem J. 2021;160:105669.","journal-title":"Microchem J"},{"key":"6852_CR13","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1007\/s00216-024-05138-7","volume":"416","author":"X Ma","year":"2024","unstructured":"Ma X, Wang Q, Cai L, Xiao M. Evaluation of deep eutectic solvents chiral selectors based on lactobionic acid in capillary electrophoresis. Anal Bioanal Chem. 2024;416:1417\u201325.","journal-title":"Anal Bioanal Chem"},{"key":"6852_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2020.104623","volume":"154","author":"M Sajid","year":"2020","unstructured":"Sajid M, Plotka-Wasylka J. Nanoparticles: synthesis, characteristics, and applications in analytical and other sciences. Microchem J. 2020;154:104623.","journal-title":"Microchem J"},{"key":"6852_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2021.106613","volume":"169","author":"X Sun","year":"2021","unstructured":"Sun X, Ding Y, Niu B, Chen Q. Evaluation of a composite nanomaterial consist of gold nanoparticles and graphene-carbon nitride as capillary electrochromatography stationary phase for enantioseparation. Microchem J. 2021;169:106613.","journal-title":"Microchem J"},{"issue":"4","key":"6852_CR16","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1007\/s00604-019-3318-8","volume":"186","author":"X Yang","year":"2019","unstructured":"Yang X, Sun X, Feng Z, Du Y, Chen J, Ma X, et al. Open-tubular capillary electrochromatography with \u03b2-cyclodextrin-functionalized magnetic nanoparticles as stationary phase for enantioseparation of dansylated amino acids. Mikrochim Acta. 2019;186:244.https:\/\/doi.org\/10.1007\/s00604-019-3318-8","journal-title":"Mikrochim Acta"},{"key":"6852_CR17","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.chroma.2018.11.026","volume":"1587","author":"X Xiao","year":"2019","unstructured":"Xiao X, Wu J, Li Z, Jia L. Enantioseparation and sensitive analysis of ofloxacin by poly(3,4-dihydroxyphenylalanine) functionalized magnetic nanoparticles-based solid phase extraction in combination with on-line concentration capillary electrophoresis. J Chromatogr A. 2019;1587:14\u201323.","journal-title":"J Chromatogr A"},{"key":"6852_CR18","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.chroma.2017.02.012","volume":"1490","author":"M Silva","year":"2017","unstructured":"Silva M, Perez-Quintanilla D, Morante-Zarcero S, Sierra I, Marina ML, Aturki Z, et al. Ordered mesoporous silica functionalized with \u03b2-cyclodextrin derivative for stereoisomer separation of flavanones and flavanone glycosides by nano-liquid chromatography and capillary electrochromatography. J Chromatogr A. 2017;1490:166\u201376.","journal-title":"J Chromatogr A"},{"key":"6852_CR19","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/s00604-018-3163-1","volume":"186","author":"X Sun","year":"2019","unstructured":"Sun X, Du Y, Zhao S, Huang Z, Feng Z. Enantioseparation of propranolol, amlodipine and metoprolol by electrochromatography using an open tubular capillary modified with \u03b2-cyclodextrin and poly(glycidylmethacrylate) nanoparticles. Microchim Acta. 2019;186:128.","journal-title":"Microchim Acta"},{"key":"6852_CR20","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s00604-016-2014-1","volume":"184","author":"Z Liu","year":"2017","unstructured":"Liu Z, Du Y, Feng Z. Enantioseparation of drugs by capillary electrochromatography using a stationary phase covalently modified with graphene oxide. Microchim Acta. 2017;184:583\u201393.","journal-title":"Microchim Acta"},{"key":"6852_CR21","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.1002\/elps.200600773","volume":"28","author":"Y Moliner-Martinez","year":"2007","unstructured":"Moliner-Martinez Y, Cardenas S, Valcarcel M. Evaluation of carbon nanostructures as chiral selectors for direct enantiomeric separation of ephedrines by EKC. Electrophoresis. 2007;28:2573\u20139.","journal-title":"Electrophoresis"},{"key":"6852_CR22","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.trac.2005.11.008","volume":"25","author":"M Trojanowicz","year":"2006","unstructured":"Trojanowicz M. Analytical applications of carbon nanotubes: a review. TrAC-Trend Anal Chem. 2006;25:480\u20139.","journal-title":"TrAC-Trend Anal Chem"},{"key":"6852_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2019.120215","volume":"206","author":"R Ni","year":"2020","unstructured":"Ni R, Wang Y, Wei X, Chen J, Meng J, Xu F, et al. Magnetic carbon nanotube modified with polymeric deep eutectic solvent for the solid phase extraction of bovine serum albumin. Talanta. 2020;206:120215.","journal-title":"Talanta"},{"key":"6852_CR24","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1016\/j.carbon.2005.02.036","volume":"43","author":"SE Moulton","year":"2005","unstructured":"Moulton SE, Minett AI, Murphy R, Ryan KP, McCarthy D, Coleman JN, et al. Biomolecules as selective dispersants for carbon nanotubes. Carbon. 2005;43:1879\u201384.","journal-title":"Carbon"},{"key":"6852_CR25","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/nmat877","volume":"2","author":"M Zheng","year":"2003","unstructured":"Zheng M, Jagota A, Semke ED, Diner BA, Mclean RS, Lustig SR, et al. DNA-assisted dispersion and separation of carbon nanotubes. Nat Mater. 2003;2:338\u201342.","journal-title":"Nat Mater"},{"key":"6852_CR26","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.seppur.2015.11.002","volume":"156","author":"YAJ Al-Hamadani","year":"2015","unstructured":"Al-Hamadani YAJ, Chu KH, Son A, Heo J, Her N, Jang M, et al. Stabilization and dispersion of carbon nanomaterials in aqueous solutions: a review. Sep Purif Technol. 2015;156:861\u201374.","journal-title":"Sep Purif Technol"},{"key":"6852_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2022.340693","volume":"1239","author":"A Li","year":"2023","unstructured":"Li A, Xue S, Xu Y, Ding S, Wen D, Zhang Q. A feasibility study on the use of hydrophobic eutectic solvents as pseudo-stationary phases in capillary electrophoresis for chiral separations. Anal Chim Acta. 2023;1239:340693.","journal-title":"Anal Chim Acta"},{"key":"6852_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2020.121419","volume":"220","author":"S Deng","year":"2020","unstructured":"Deng S, Pan J, Wang M, Huang Y, Xia Z. Study on improvement of chiral separation of capillary electrophoresis based on cyclodextrin by deep eutectic solvents. Talanta. 2020;220:121419.","journal-title":"Talanta"},{"key":"6852_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2023.115748","volume":"236","author":"R Liu","year":"2023","unstructured":"Liu R, Gu B, Chen M, Ye J, Chu Q. Deep eutectic solvents combined with beta-cyclodextrin derivatives for chiral separation of typical adrenergic receptor agonists by capillary electrophoresis with amperometric detection. J Pharm Biomed Anal. 2023;236:115748.","journal-title":"J Pharm Biomed Anal"},{"key":"6852_CR30","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1002\/elps.202400092","volume":"45","author":"KA Loannou","year":"2024","unstructured":"Loannou KA, Georgiou MN, Ioannou GD, Christou A, Stavrou IJ, Schmid MG, et al. Enantiomeric separation of nefopam and cathinone derivatives using a supramolecular deep eutectic solvent as a chiral selector in capillary electrophoresis. Electrophoresis. 2024;45:1721\u20136.","journal-title":"Electrophoresis"},{"key":"6852_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2021.106815","volume":"171","author":"L Garc\u00eda-Cansino","year":"2021","unstructured":"Garc\u00eda-Cansino L, Marina ML, Garc\u00eda MA. Effect of ionic liquids and deep eutectic solvents on the enantiomeric separation of clopidogrel by cyclodextrin-electrokinetic chromatography. Quantitative analysis in pharmaceutical formulations using tetrabutylammonium L-aspartic acid combined with carboxymethyl-\u03b3-cyclodextrin. Microchem J. 2021;171:106815.","journal-title":"Microchem J"},{"key":"6852_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2021.118422","volume":"264","author":"Y Qian","year":"2021","unstructured":"Qian Y, Xu K, Ni R, Wang Y. Fabrication of a novel bio-sorbent based on magnetic \u03b2-cyclodextrin composites modified by polymeric deep eutectic solvent for the efficient separation of ovalbumin. Sep Purif Technol. 2021;264:118422.","journal-title":"Sep Purif Technol"},{"key":"6852_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2026.117372","volume":"223","author":"S Ji","year":"2026","unstructured":"Ji S, Xu J, Shen H, Ma X. Composite nanoparticles based on polymeric deep eutectic solvents modified by carboxymethyl-\u03b2-cyclodextrin, as chiral selectors for enantioseparation in capillary electrophoresis. Microchem J. 2026;223:117372.","journal-title":"Microchem J"},{"key":"6852_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2025.466143","volume":"1757","author":"Q Wang","year":"2025","unstructured":"Wang Q, Sheng T, Lu Y, Cai L, Ma X. Deep eutectic solvents modified carbon nanotubes as additives for enhanced enantioseparation in capillary electrophoresis. J Chromatogr A. 2025;1757:466143.","journal-title":"J Chromatogr A"},{"key":"6852_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2024.465599","volume":"1740","author":"Q Zhu","year":"2025","unstructured":"Zhu Q, Xu X, Xu J, Ma X. Cyclodextrins-based deep eutectic supramolecules as chiral selectors for enhanced enantioseparation in capillary electrophoresis. J Chromatogr A. 2025;1740:465599.","journal-title":"J Chromatogr A"},{"key":"6852_CR36","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1002\/elps.202000307","volume":"42","author":"J Urlaub","year":"2021","unstructured":"Urlaub J, Kaiser RP, Scherf-Clavel O, Bolm C, Holzgrabe U. Investigation of isomerization of dexibuprofen in a ball mill using chiral capillary electrophoresis. Electrophoresis. 2021;42:1790\u20139.","journal-title":"Electrophoresis"},{"key":"6852_CR37","doi-asserted-by":"publisher","first-page":"2900","DOI":"10.1002\/jssc.201400677","volume":"38","author":"T Yu","year":"2015","unstructured":"Yu T, Du Y, Chen J, Xu G, Yang K, Zhang Q, et al. Study on clarithromycin lactobionate based dual selector systems for the enantioseparation of basic drugs in capillary electrophoresis. J Sep Sci. 2015;38:2900\u20136.","journal-title":"J Sep Sci"},{"key":"6852_CR38","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.aca.2004.11.018","volume":"533","author":"JJB Nevado","year":"2005","unstructured":"Nevado JJB, Pe\u00f1alvo GC, Dorado RMR. Method development and validation for the separation and determination of omeprazole enantiomers in pharmaceutical preparations by capillary electrophoresis. Anal Chim Acta. 2005;533:127\u201333.","journal-title":"Anal Chim Acta"},{"key":"6852_CR39","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.chroma.2014.07.047","volume":"1360","author":"Y Liu","year":"2014","unstructured":"Liu Y, Shamsi SA. Combined use of chiral ionic liquid surfactants and neutralcyclodextrins: evaluation of ionic liquid head groups forenantioseparation of neutral compounds in capillary electrophoresis. J Chromatogr A. 2014;1360:296\u2013304.","journal-title":"J Chromatogr A"}],"container-title":["Analytical and Bioanalytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-026-06852-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00216-026-06852-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-026-06852-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:37:32Z","timestamp":1791268652000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00216-026-06852-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":39,"alternative-id":["6852"],"URL":"https:\/\/doi.org\/10.1007\/s00216-026-06852-0","relation":{},"ISSN":["1618-2642","1618-2650"],"issn-type":[{"value":"1618-2642","type":"print"},{"value":"1618-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]},"assertion":[{"value":"3 August 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}