{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:46:54Z","timestamp":1791827214799,"version":"4.3.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC U23B20169"],"award-info":[{"award-number":["NSFC U23B20169"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science and Technology Major Project of China","award":["2025ZD1701500"],"award-info":[{"award-number":["2025ZD1701500"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anal Bioanal Chem"],"DOI":"10.1007\/s00216-026-06864-w","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:07:08Z","timestamp":1791824828000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Selective N-pyridinium derivatization for molecular characterization of neutral oxygenated compounds in fossil fuels by high-resolution mass spectrometry"],"prefix":"10.1007","author":[{"given":"Junyang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1363-1237","authenticated-orcid":false,"given":"Quan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"6864_CR1","doi-asserted-by":"publisher","first-page":"123297","DOI":"10.1016\/j.fuel.2022.123297","volume":"316","author":"Y Li","year":"2022","unstructured":"Li Y, Liao G, Wang Z, Su R, Ma S, Zhang H, et al. Molecular composition of low-temperature oxidation products in a simulated crude oil In-situ combustion. Fuel. 2022;316:123297.","journal-title":"Fuel"},{"key":"6864_CR2","doi-asserted-by":"publisher","first-page":"120834","DOI":"10.1016\/j.fuel.2021.120834","volume":"298","author":"L Yang","year":"2021","unstructured":"Yang L, Sheng JJ. Roles of alkanes, alcohols, and aldehydes for crude oil oxidation during the air injection process. Fuel. 2021;298:120834.","journal-title":"Fuel"},{"issue":"12","key":"6864_CR3","doi-asserted-by":"publisher","first-page":"7789","DOI":"10.1021\/acs.est.1c06149","volume":"56","author":"C Aeppli","year":"2022","unstructured":"Aeppli C, Mitchell DA, Keyes P, Beirne EC, McFarlin KM, Roman-Hubers AT, et al. Oil irradiation experiments document changes in oil properties, molecular composition, and dispersant effectiveness associated with oil photo-oxidation. Environ Sci Technol. 2022;56(12):7789\u201399.","journal-title":"Environ Sci Technol"},{"key":"6864_CR4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.oceaneng.2015.10.014","volume":"119","author":"M Afenyo","year":"2016","unstructured":"Afenyo M, Veitch B, Khan F. A state-of-the-art review of fate and transport of oil spills in open and ice-covered water. Ocean Eng. 2016;119:233\u201348.","journal-title":"Ocean Eng"},{"issue":"12","key":"6864_CR5","doi-asserted-by":"publisher","first-page":"6887","DOI":"10.1021\/acs.est.9b00908","volume":"53","author":"SF Niles","year":"2019","unstructured":"Niles SF, Chac\u00f3n-Pati\u00f1o ML, Chen H, McKenna AM, Blakney GT, Rodgers RP, et al. Molecular-level characterization of oil-soluble ketone\/aldehyde photo-oxidation products by Fourier transform ion cyclotron resonance mass spectrometry reveals similarity between microcosm and field samples. Environ Sci Technol. 2019;53(12):6887\u201394.","journal-title":"Environ Sci Technol"},{"issue":"8","key":"6864_CR6","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1080\/10408347.2022.2039093","volume":"53","author":"SA Wise","year":"2023","unstructured":"Wise SA, Rodgers RP, Reddy CM, Nelson RK, Kujawinski EB, Wade TL, et al. Advances in chemical analysis of oil spills since the Deepwater Horizon disaster. Crit Rev Anal Chem. 2023;53(8):1638\u201397.","journal-title":"Crit Rev Anal Chem"},{"issue":"3","key":"6864_CR7","first-page":"789","volume":"30","author":"D Cheng","year":"2014","unstructured":"Cheng D, Dou L, Xiao K, Wan L, Liu B. Origin of high acidity oils in the intensively inversed rift basin. Bongor Basin Acta Petrologica Sinica. 2014;30(3):789\u2013800.","journal-title":"Bongor Basin Acta Petrologica Sinica"},{"key":"6864_CR8","doi-asserted-by":"publisher","first-page":"132429","DOI":"10.1016\/j.fuel.2024.132429","volume":"374","author":"H Hu","year":"2024","unstructured":"Hu H, Li S, Wang Y, Yang R, Wu J, Zhang W, et al. Molecular characterization of petroleum acids from diverse geological origins via n-Butylsilane reduction. Fuel. 2024;374:132429.","journal-title":"Fuel"},{"key":"6864_CR9","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/S0021-9673(01)90559-X","volume":"319","author":"TG Harvey","year":"1985","unstructured":"Harvey TG, Matheson TW, Pratt KC, Stanborough MS. Determination of carbonyl compounds in an Australian (Rundle) shale oil. J Chromatogr A. 1985;319:230\u20134.","journal-title":"J Chromatogr A"},{"issue":"9","key":"6864_CR10","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/S0146-6380(99)00085-6","volume":"30","author":"MB Fernandes","year":"1999","unstructured":"Fernandes MB, Elias VO, Cardoso JN, Carvalho MlS. Sources and fate of n-alkanols and sterols in sediments of the Amazon shelf. Org Geochem. 1999;30(9):1075\u201387.","journal-title":"Org Geochem"},{"issue":"10","key":"6864_CR11","doi-asserted-by":"publisher","first-page":"5770","DOI":"10.1021\/ef400961d","volume":"27","author":"A Alhassan","year":"2013","unstructured":"Alhassan A, Andersson JT. Ketones in fossil materials\u2014a mass spectrometric analysis of a crude oil and a coal tar. Energy Fuels. 2013;27(10):5770\u20138.","journal-title":"Energy Fuels"},{"issue":"10","key":"6864_CR12","doi-asserted-by":"publisher","first-page":"10674","DOI":"10.1021\/acs.energyfuels.7b01803","volume":"31","author":"LC Krajewski","year":"2017","unstructured":"Krajewski LC, Lobodin VV, Robbins WK, Jin P, Bota G, Marshall AG, et al. Method for isolation and detection of ketones formed from high-temperature naphthenic acid corrosion. Energy Fuels. 2017;31(10):10674\u20139.","journal-title":"Energy Fuels"},{"issue":"7","key":"6864_CR13","doi-asserted-by":"publisher","first-page":"3192","DOI":"10.1021\/ac203035k","volume":"84","author":"X Zhou","year":"2012","unstructured":"Zhou X, Shi Q, Zhang Y, Zhao S, Zhang R, Chung KH, et al. Analysis of saturated hydrocarbons by redox reaction with negative-ion electrospray Fourier transform ion cyclotron resonance mass spectrometry. Anal Chem. 2012;84(7):3192\u20139.","journal-title":"Anal Chem"},{"issue":"22","key":"6864_CR14","doi-asserted-by":"publisher","first-page":"18019","DOI":"10.1021\/acs.energyfuels.1c01671","volume":"35","author":"Q Shi","year":"2021","unstructured":"Shi Q, Zhang Y, Chung KH, Zhao S, Xu C. Molecular characterization of fossil and alternative fuels using electrospray ionization fourier transform ion cyclotron resonance mass spectrometry: recent advances and perspectives. Energy Fuels. 2021;35(22):18019\u201355.","journal-title":"Energy Fuels"},{"issue":"10","key":"6864_CR15","doi-asserted-by":"publisher","first-page":"8185","DOI":"10.1021\/acs.energyfuels.6b01597","volume":"30","author":"FA Rojas-Ruiz","year":"2016","unstructured":"Rojas-Ruiz FA, Orrego-Ruiz JA. Distribution of oxygen-containing compounds and its significance on total organic acid content in crude oils by ESI negative ion FT-ICR MS. Energy Fuels. 2016;30(10):8185\u201391.","journal-title":"Energy Fuels"},{"key":"6864_CR16","doi-asserted-by":"publisher","first-page":"123775","DOI":"10.1016\/j.fuel.2022.123775","volume":"319","author":"EV Barros","year":"2022","unstructured":"Barros EV, Filgueiras PR, Lacerda V, Rodgers RP, Rom\u00e3o W. Characterization of naphthenic acids in crude oil samples \u2013 a literature review. Fuel. 2022;319:123775.","journal-title":"Fuel"},{"issue":"6","key":"6864_CR17","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1021\/ef010111z","volume":"15","author":"K Qian","year":"2001","unstructured":"Qian K, Robbins WK, Hughey CA, Cooper HJ, Rodgers RP, Marshall AG. Resolution and identification of elemental compositions for more than 3000 crude acids in heavy petroleum by negative-ion microelectrospray high-field Fourier transform ion cyclotron resonance mass spectrometry. Energy Fuels. 2001;15(6):1505\u201311.","journal-title":"Energy Fuels"},{"key":"6864_CR18","doi-asserted-by":"publisher","first-page":"134888","DOI":"10.1016\/j.fuel.2025.134888","volume":"392","author":"F Kong","year":"2025","unstructured":"Kong F, Zhang Y, Liu Y, Zhang Y, Shi Q, Zhang L. Structural speciation of oxygen-containing compounds in fossil fuels using hydrogen\/deuterium exchange ESI high-resolution mass spectrometry. Fuel. 2025;392:134888.","journal-title":"Fuel"},{"issue":"34","key":"6864_CR19","doi-asserted-by":"publisher","first-page":"8973","DOI":"10.1002\/anie.201304249","volume":"52","author":"S Tittebrandt","year":"2013","unstructured":"Tittebrandt S, Edelson-Averbukh M, Spengler B, Lehmann WD. ESI hydrogen\/deuterium exchange can count chemical forms of heteroatom-bound hydrogen. Angew Chem Int Ed Engl. 2013;52(34):8973\u20135.","journal-title":"Angew Chem Int Ed Engl"},{"issue":"4","key":"6864_CR20","doi-asserted-by":"publisher","first-page":"4662","DOI":"10.1021\/acs.energyfuels.7b03630","volume":"32","author":"X Chen","year":"2018","unstructured":"Chen X, Xu C, Zhang W, Ma C, Liu X, Zhao S, et al. Separation and molecular characterization of ketones in a low-temperature coal tar. Energy Fuels. 2018;32(4):4662\u201370.","journal-title":"Energy Fuels"},{"key":"6864_CR21","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.aca.2014.08.027","volume":"849","author":"Y Cao","year":"2014","unstructured":"Cao Y, Guan Q, Sun T, Wang H, Leng J, Guo Y. N-Alkylpyridinium quaternization combined with liquid chromatography\u2013electrospray ionization-tandem mass spectrometry: a highly sensitive method to quantify fatty alcohols in thyroid tissues. Anal Chim Acta. 2014;849:19\u201326.","journal-title":"Anal Chim Acta"},{"issue":"10","key":"6864_CR22","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1002\/jms.3265","volume":"48","author":"H Wang","year":"2013","unstructured":"Wang H, Wang H, Zhang L, Zhang J, Leng J, Cai T, et al. N-Alkylpyridinium quaternization for assisting electrospray ionization of sterols in oil by quadrupole-time of flight mass spectrometry: NAPIQ for detecting sterols in oil by ESI-MS. J Mass Spectrom. 2013;48(10):1101\u20138.","journal-title":"J Mass Spectrom"},{"issue":"1","key":"6864_CR23","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.aca.2011.09.019","volume":"707","author":"H Wang","year":"2011","unstructured":"Wang H, Wang H, Zhang L, Zhang J, Leng J, Cai T, et al. Improvement and extension of the application scope for matrix-assisted laser desorption\/ionization mass spectrometric analysis-oriented N-alkylpyridinium isotope quaternization. Anal Chim Acta. 2011;707(1):100\u20136.","journal-title":"Anal Chim Acta"},{"issue":"1","key":"6864_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.aca.2011.02.017","volume":"690","author":"H Wang","year":"2011","unstructured":"Wang H, Wang H, Zhang L, Zhang J, Guo Y. N-alkylpyridinium isotope quaternization for matrix-assisted laser desorption\/ionization Fourier transform mass spectrometric analysis of cholesterol and fatty alcohols in human hair. Anal Chim Acta. 2011;690(1):1\u20139.","journal-title":"Anal Chim Acta"},{"key":"6864_CR25","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.aca.2016.05.032","volume":"937","author":"Y Cao","year":"2016","unstructured":"Cao Y, Guan Q, Sun T, Qi W, Guo Y. Charged tag founded in N-(1-chloroalkyl)pyridinium quaternization for quantification of fatty aldehydes. Anal Chim Acta. 2016;937:80\u20136.","journal-title":"Anal Chim Acta"},{"issue":"1","key":"6864_CR26","doi-asserted-by":"publisher","first-page":"20 A","DOI":"10.1021\/ac053302y","volume":"77","author":"RP Rodgers","year":"2005","unstructured":"Rodgers RP, Schaub TM, Marshall AG. Petroleomics: MS returns to its roots. Anal Chem. 2005;77(1):20 A-A27.","journal-title":"Anal Chem"},{"issue":"12","key":"6864_CR27","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1074\/mcp.T500030-MCP200","volume":"4","author":"JV Olsen","year":"2005","unstructured":"Olsen JV, de Godoy LMF, Li G, Macek B, Mortensen P, Pesch R, et al. Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap. Mol Cell Proteomics. 2005;4(12):2010\u201321.","journal-title":"Mol Cell Proteomics"},{"issue":"3","key":"6864_CR28","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1021\/jasms.4c00442","volume":"36","author":"J Chen","year":"2025","unstructured":"Chen J, He C, Wu J, Zhang Y, Shi Q. HRMS-Viewer: software for high resolution mass spectrometry formula assignment and data visualization. J Am Soc Mass Spectrom. 2025;36(3):565\u201372.","journal-title":"J Am Soc Mass Spectrom"},{"issue":"5","key":"6864_CR29","doi-asserted-by":"publisher","first-page":"3612","DOI":"10.1016\/j.petsci.2024.02.019","volume":"21","author":"J-X Wu","year":"2024","unstructured":"Wu J-X, Li S-F, Li Q-F, Yan F, Zhou Q-L, Ma S, et al. Characterization of chemical composition of high viscosity heavy oils: macroscopic properties, and semi-quantitative analysis of molecular composition using high-resolution mass spectrometry. Pet Sci. 2024;21(5):3612\u201320.","journal-title":"Pet Sci"},{"issue":"5","key":"6864_CR30","doi-asserted-by":"publisher","first-page":"3769","DOI":"10.1021\/acs.energyfuels.3c05086","volume":"38","author":"S Li","year":"2024","unstructured":"Li S, Wu J, Chen J, Li Y, Hu M, Huang S, et al. Semiquantitative molecular characterization of crude oil. Energy Fuels. 2024;38(5):3769\u201383.","journal-title":"Energy Fuels"},{"issue":"12","key":"6864_CR31","doi-asserted-by":"publisher","first-page":"4292","DOI":"10.1021\/jo100276m","volume":"75","author":"AB Rudine","year":"2010","unstructured":"Rudine AB, Walter MG, Wamser CC. Reaction of dichloromethane with pyridine derivatives under ambient conditions. J Org Chem. 2010;75(12):4292\u20135.","journal-title":"J Org Chem"},{"key":"6864_CR32","first-page":"1","volume":"3","author":"JS Pizey","year":"1980","unstructured":"Pizey JS, Symeonides K. The reaction between ketones and thionyl chloride. Phosphorus Sulfur Relat Elem. 1980;3:1\u20138.","journal-title":"Phosphorus Sulfur Relat Elem"},{"issue":"8","key":"6864_CR33","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1021\/jo00948a026","volume":"38","author":"HM Relles","year":"1973","unstructured":"Relles HM. Thionyl chloride-pyridine chemistry. Synthesis and reactions of N-.alpha.-styrylpyridinium salts. J Org Chem. 1973;38(8):1570\u20134.","journal-title":"J Org Chem"},{"issue":"41","key":"6864_CR34","doi-asserted-by":"publisher","first-page":"7744","DOI":"10.1002\/anie.200700039","volume":"46","author":"J Atzrodt","year":"2007","unstructured":"Atzrodt J, Derdau V, Fey T, Zimmermann J. The renaissance of H\/D exchange. Angew Chem Int Ed Engl. 2007;46(41):7744\u201365.","journal-title":"Angew Chem Int Ed Engl"},{"key":"6864_CR35","unstructured":"Peters KE, Walters CC, Moldowan JM, Peters KE. The biomarker guide Volume 1 Biomarkers and isotopes in the environment and human history. 2. ed., reprinted with corrections, digitally printed version 2007 ed. Cambridge, UK: Cambridge Univ. Press; 2007 2007. 471 p."},{"issue":"1","key":"6864_CR36","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1021\/ef00031a011","volume":"6","author":"MM Boduszynski","year":"1992","unstructured":"Boduszynski MM, Altgelt KH. Composition of heavy petroleums. 4. Significance of the extended atmospheric equivalent boiling point (AEBP) scale. Energy Fuels. 1992;6(1):72\u20136.","journal-title":"Energy Fuels"},{"key":"6864_CR37","doi-asserted-by":"publisher","first-page":"122223","DOI":"10.1016\/j.talanta.2021.122223","volume":"229","author":"H-M Xiao","year":"2021","unstructured":"Xiao H-M, Zhao S, Fan R-T, Hussain D, Wang X. Simultaneous determination of short-chain fatty alcohols in aged oil and biodiesels by stable isotope labeling assisted liquid chromatography-mass spectrometry. Talanta. 2021;229:122223.","journal-title":"Talanta"}],"container-title":["Analytical and Bioanalytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-026-06864-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00216-026-06864-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-026-06864-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:07:10Z","timestamp":1791824830000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00216-026-06864-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,12]]},"references-count":37,"alternative-id":["6864"],"URL":"https:\/\/doi.org\/10.1007\/s00216-026-06864-w","relation":{},"ISSN":["1618-2642","1618-2650"],"issn-type":[{"value":"1618-2642","type":"print"},{"value":"1618-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,12]]},"assertion":[{"value":"11 August 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All authors have read and agreed to the published version of the manuscript.","order":1,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}