{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:21:55Z","timestamp":1791264115674,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2006,5,5]],"date-time":"2006-05-05T00:00:00Z","timestamp":1146787200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Brain Res"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1007\/s00221-006-0480-0","type":"journal-article","created":{"date-parts":[[2006,5,4]],"date-time":"2006-05-04T14:00:06Z","timestamp":1146751206000},"page":"443-452","source":"Crossref","is-referenced-by-count":48,"title":["The \u201chuman visceral homunculus\u201d to pain evoked in the oesophagus, stomach, duodenum and sigmoid colon"],"prefix":"10.1007","volume":"174","author":[{"given":"Asbj\u00f8rn Mohr","family":"Drewes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Dimcevski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saber A. K.","family":"Sami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Funch-Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khiem Dinh","family":"Huynh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenica","family":"Le Pera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Arendt-Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Valeriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,5,5]]},"reference":[{"key":"480_CR1","first-page":"217","volume-title":"Visceral pain","author":"AV Apkarian","year":"1995","unstructured":"Apkarian AV, Br\u00fcggemann J, Shi T, Airapetian LR (1995) A thalamic model for true and referred visceral pain. In: Gebhart GF (ed) Visceral pain. IASP Press, Seattle, pp 217\u2013259"},{"key":"480_CR2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0165-0173(96)00011-2","volume":"22","author":"JR Augustine","year":"1996","unstructured":"Augustine JR (1996) Circuitry and functional aspects of the insular lobe in primates including humans. Brain Res Rev 22:229\u2013244","journal-title":"Brain Res Rev"},{"key":"480_CR3","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0016-5085(97)70079-9","volume":"113","author":"Q Aziz","year":"1997","unstructured":"Aziz Q, Andersson JL, Valind S, Sundin A, Hamdy S, Jones AK, Foster ER, Langstrom B, Thompson DG (1997) Identification of human brain loci processing esophageal sensation using positron emission tomography. Gastroenterology 113:50\u201359","journal-title":"Gastroenterology"},{"key":"480_CR4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0168-5597(94)00297-R","volume":"96","author":"Q Aziz","year":"1995","unstructured":"Aziz Q, Furlong PL, Barlow J, Hobson A, Alani S, Bancewicz J, Ribbands M, Harding GF, Thompson DG (1995) Topographic mapping of cortical potentials evoked by distension of the human proximal and distal oesophagus. Electroencephalogr Clin Neurophysiol 96:219\u2013228","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"480_CR5","first-page":"261","volume-title":"Visceral pain. Progress in pain research and management","author":"DF Cechetto","year":"1995","unstructured":"Cechetto DF (1995) Supraspinal mechanisms of visceral representation. In: Gebhart GF (ed) Visceral pain. Progress in pain research and management. IASP Press, Seattle, pp 261\u2013290"},{"key":"480_CR6","unstructured":"Cervero F (1988) Visceral pain. In: Dubner R, Gebhart GF, Bond MR (eds) Pain research and clinical management, Proceedings of the 5th world congress on pain, vol. 3. Elsevier, Amsterdam, pp 216\u2013226"},{"key":"480_CR7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.neuro.26.041002.131022","volume":"26","author":"AD Craig","year":"2003","unstructured":"Craig AD (2003) Pain mechanisms: labeled lines versus convergence in central processing. Annu Rev Neurosci 26:1\u201330","journal-title":"Annu Rev Neurosci"},{"key":"480_CR8","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1572-0241.2003.07168.x","volume":"98","author":"SWG Derbyshire","year":"2003","unstructured":"Derbyshire SWG (2003) A systematic review of neuroimaging data during visceral stimulation. Am J Gastroenterol 98:12\u201320","journal-title":"Am J Gastroenterol"},{"key":"480_CR9","first-page":"G937","volume":"34","author":"KR DeVault","year":"1996","unstructured":"DeVault KR, Beacham S, Castell DO, Streletz LJ, Ditunno JF (1996) Esophageal sensation in spinal cord-injured patients: balloon distension and cerebral evoked potential recording. Am J Physiol 34:G937\u2013G941","journal-title":"Am J Physiol"},{"key":"480_CR10","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1080\/00365520310004399","volume":"38","author":"AM Drewes","year":"2003","unstructured":"Drewes AM, Gregersen H, Arendt-Nielsen L (2003) Experimental pain in gastroenterology: A reappraisal of human studies. Scand J Gastroenterol 38:1115\u20131130","journal-title":"Scand J Gastroenterol"},{"key":"480_CR11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.neulet.2003.12.101","volume":"358","author":"AM Drewes","year":"2004","unstructured":"Drewes AM, Rossel P, Le Pera D, Arendt-Nielsen L, Valeriani M (2004) Dipolar source modelling of brain potentials evoked by painful electrical stimulation of the human sigmoid colon. Neurosci Lett 358:45\u201348","journal-title":"Neurosci Lett"},{"key":"480_CR12","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neulet.2004.11.011","volume":"375","author":"AM Drewes","year":"2005","unstructured":"Drewes AM, Rossel P, Le Pera D, Arendt-Nielsen L, Valeriani M (2005) Cortical neuroplastic changes to painful colon stimulation in patients with irritable bowel syndrome. Neurosci Lett 375:157\u2013161","journal-title":"Neurosci Lett"},{"key":"480_CR13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0013-4694(95)00229-4","volume":"100","author":"H Franssen","year":"1996","unstructured":"Franssen H, Weusten BL, Wieneke GH, Smout AJ (1996) Source modeling of esophageal evoked potentials. Electroencephalogr Clin Neurophysiol 100:85\u201395","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"480_CR14","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1136\/gut.37.5.603","volume":"37","author":"O Frobert","year":"1995","unstructured":"Frobert O, Arendt-Nielsen L, Bak P, Funch-Jensen P, Bagger JP (1995) Oesophageal sensation assessed by electrical stimuli and brain evoked potentials\u2014a new model for visceral nociception. Gut 37:603\u2013609","journal-title":"Gut"},{"key":"480_CR15","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0168-5597(98)00016-1","volume":"108","author":"PL Furlong","year":"1998","unstructured":"Furlong PL, Aziz Q, Singh KD, Thompson DG, Hobson A, Harding GFA (1998) Cortical localisation of magnetic fields evoked by oesophageal distension. Electroencephalogr Clin Neurophysiol 108:234\u2013243","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"480_CR16","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/S1388-2457(99)00072-3","volume":"110","author":"M Hecht","year":"1999","unstructured":"Hecht M, Kober H, Claus D, Hilz M, Vieth J, Neundorfer B (1999) The electrical and magnetical cerebral responses evoked by electrical stimulation of the esophagus and the location of their cerebral sources. Clin Neurophysiol 110:1435\u20131444","journal-title":"Clin Neurophysiol"},{"key":"480_CR17","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1046\/j.1365-2982.2000.00231.x","volume":"12","author":"DI Hobday","year":"2000","unstructured":"Hobday DI, Hobson A, Furlong PL, Thompson DG, Aziz Q (2000) Comparison of cortical potentials evoked by mechanical and electrical stimulation of the rectum. Neurogastroenterol Motil 12:547\u2013554","journal-title":"Neurogastroenterol Motil"},{"key":"480_CR18","first-page":"G335","volume":"283","author":"DI Hobday","year":"2002","unstructured":"Hobday DI, Hobson AR, Sarkar S, Furlong PL, Thompson DG, Aziz Q (2002) Cortical processing of human gut sensation: an evoked potential study. Am J Physiol 283:G335\u2013G339","journal-title":"Am J Physiol"},{"key":"480_CR19","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1136\/gut.2003.035642","volume":"53","author":"AR Hobson","year":"2004","unstructured":"Hobson AR, Aziz Q (2004) Brain imaging and functional gastrointestinal disorders: has it helped our understanding? Gut 53:1198\u20131206","journal-title":"Gut"},{"key":"480_CR20","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1053\/j.gastro.2004.12.033","volume":"128","author":"AR Hobson","year":"2005","unstructured":"Hobson AR, Furlong PL, Worthen SF, Hillebrand A, Barnes GR, Singh KD, Aziz Q (2005) Real-time imaging of human cortical activity evoked by painful esophageal stimulation. Gastroenterology 128:610\u2013619","journal-title":"Gastroenterology"},{"key":"480_CR21","first-page":"G139","volume":"279","author":"AR Hobson","year":"2000","unstructured":"Hobson AR, Sarkar S, Furlong PL, Thompson DG, Aziz Q (2000) A cortical evoked potential study of afferents mediating human esophageal sensation. Am J Physiol 279:G139\u2013G147","journal-title":"Am J Physiol"},{"key":"480_CR22","first-page":"203","volume":"25","author":"S Hollerbach","year":"1997","unstructured":"Hollerbach S, Tougas G, Frieling T, Enck P, Fitzpatrick D, Upton AR, Kamath MV (1997) Cerebral evoked responses to gastrointestinal stimulation in humans. Crit Rev Biomed Eng 25:203\u2013242","journal-title":"Crit Rev Biomed Eng"},{"key":"480_CR23","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1023\/A:1026667123187","volume":"43","author":"S Hollerbach","year":"1998","unstructured":"Hollerbach S, Hudoba P, Fitzpatrick D, Hunt R, Upton AR, Tougas G (1998) Cortical evoked responses following esophageal balloon distension and electrical stimulation in healthy volunteers. Dig Dis Sci 43:2558\u20132566","journal-title":"Dig Dis Sci"},{"key":"480_CR24","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1152\/jn.1991.65.5.1067","volume":"65","author":"W J\u00e4nig","year":"1991","unstructured":"J\u00e4nig W, Koltzenburg M (1991) Receptive properties of sacral primary afferent neurons supplying the colon. J Neurophysiol 65:1067\u20131077","journal-title":"J Neurophysiol"},{"key":"480_CR25","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1109\/TBME.2005.844044","volume":"52","author":"MV Kamath","year":"2005","unstructured":"Kamath MV, Hollerbach S, Spaziani R, Shine G, Upton AR, Tougas G (2005) Optimal electrical stimulation modality for cortical esophageal evoked potentials: transmural or intraesophageal? IEEE Trans Biomed Eng 52:736\u2013739","journal-title":"IEEE Trans Biomed Eng"},{"key":"480_CR26","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1053\/gast.2001.21201","volume":"120","author":"U Ladabaum","year":"2001","unstructured":"Ladabaum U, Minoshima S, Hasler WL, Cross D, Chey WD, Owyang C (2001) Gastric distention correlates with activation of multiple cortical and subcortical regions. Gastroenterology 120:369\u2013376","journal-title":"Gastroenterology"},{"key":"480_CR27","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/0016-5085(94)90809-5","volume":"107","author":"T Lembo","year":"1994","unstructured":"Lembo T, Munakata J, Mertz H, Niazi N, Kodner A, Nikas V, Mayer EA (1994) Evidence for the hypersensitivity of lumbar splanchnic afferents in irritable bowel syndrome. Gastroenterology 107:1686\u20131696","journal-title":"Gastroenterology"},{"key":"480_CR28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/hbm.10024","volume":"16","author":"AK Liu","year":"2002","unstructured":"Liu AK, Dale AM, Belliveau JW (2002) Monte Carlo simulation studies of EEG and MEG localization accuracy. Hum Brain Mapp 16:47\u201362","journal-title":"Hum Brain Mapp"},{"key":"480_CR29","doi-asserted-by":"crossref","first-page":"G927","DOI":"10.1152\/ajpcell.1992.262.4.C927","volume":"262","author":"V Loening-Baucke","year":"1992","unstructured":"Loening-Baucke V, Read NW, Yamada T (1992) Further evaluation of the afferent nervous pathways from the rectum. Am J Physiol 262:G927\u2013G933","journal-title":"Am J Physiol"},{"key":"480_CR30","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1046\/j.1365-2982.1999.00155.x","volume":"11","author":"R Loose","year":"1999","unstructured":"Loose R, Schnitzler A, Sarkar S, Volkmann J, Frieling T, Freund HJ, Witte OW, Enck P (1999) Cortical activation during oesophageal stimulation: a neuromagnetic study. Neurogastroenterol Mot 11:163\u2013171","journal-title":"Neurogastroenterol Mot"},{"key":"480_CR31","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0987-7053(99)80040-9","volume":"29","author":"I Merlet","year":"1999","unstructured":"Merlet I, Garcia-Larrea L, Froment JC, Mauguiere F (1999) Simplified projection of EEG dipole sources onto human brain anatomy. Clin Neurophysiol 29:39\u201352","journal-title":"Clin Neurophysiol"},{"key":"480_CR32","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1016\/j.clinph.2004.06.001","volume":"115","author":"CM Michel","year":"2004","unstructured":"Michel CM, Murray MM, Lantz G, Gonzalez S, Spinelli L, de Peralta RG (2004) EEG source imaging. Clin Neurophysiol 115:2195\u20132222","journal-title":"Clin Neurophysiol"},{"key":"480_CR33","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00221-003-1484-7","volume":"151","author":"P R\u00f6ssel","year":"2003","unstructured":"R\u00f6ssel P, Arendt-Nielsen L, Niddam D, Chen ACN, Drewes AM (2003) Short latency cerebral response evoked by painful electrical stimulation applied to the human sigmoid colon and to the convergent referred somatic pain area. Exp Brain Res 151:115\u2013122","journal-title":"Exp Brain Res"},{"key":"480_CR34","doi-asserted-by":"crossref","unstructured":"Sami SAK, R\u00f6ssel P, Dimcevski G, Nielsen KD, Funch-Jensen P, Valeriani M, Arendt-Nielsen L, Drewes AM (2006) Cortical changes to experimental sensitization of the human esophagus. Neuroscience (in press)","DOI":"10.1016\/j.neuroscience.2006.02.031"},{"key":"480_CR35","unstructured":"Scherg M (1990) Fundamentals of dipole source potential analysis. In: Grandoni F, Hoke M, Romani GL (eds) Auditory evoked magnetic fields and electric potentials, advances in audiology, vol. 6. Karger, Basel, pp 40\u201369"},{"key":"480_CR36","first-page":"484","volume-title":"Physiology of the gastrointestinal tract","author":"JN Sengupta","year":"1994","unstructured":"Sengupta JN, Gebhart GF (1994) Gastrointestinal afferent fibers and sensation. In: Johnson L (ed) Physiology of the gastrointestinal tract. Raven Press, New York, pp 484\u2013519"},{"key":"480_CR38","first-page":"G486","volume":"264","author":"G Tougas","year":"1993","unstructured":"Tougas G, Hudoba P, Fitzpatrick D, Hunt RH, Upton ARM (1993) Cerebral-evoked potential responses following direct vagal and esophageal electrical-stimulation in humans. Am J Physiol 264:G486\u2013G491","journal-title":"Am J Physiol"},{"key":"480_CR39","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/1097-4598(200103)24:3<325::AID-MUS1002>3.0.CO;2-0","volume":"24","author":"M Valeriani","year":"2001","unstructured":"Valeriani M, Le Pera D, Tonali P (2001) Characterizing somatosensory evoked potential sources with dipole models: advantages and limitations. Muscle Nerve 24:325\u2013339","journal-title":"Muscle Nerve"},{"key":"480_CR40","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S1350-4533(02)00036-X","volume":"24","author":"B Vanrumste","year":"2002","unstructured":"Vanrumste B, Van Hoey G, Van de Walle R, D\u2019Have MR, Lemahieu IA, Boon PA (2002) Comparison of performance of spherical and realistic head models in dipole localization from noisy EEG. Med Eng Phys 24:403\u2013418","journal-title":"Med Eng Phys"},{"key":"480_CR41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1475-925X-2-14","volume":"2","author":"K Whittingstall","year":"2003","unstructured":"Whittingstall K, Stroink G, Gates L, Connolly JF, Finley A (2003) Effects of dipole position, orientation and noise on the accuracy of EEG source localization. Biomed Eng Online 2:14","journal-title":"Biomed Eng Online"},{"key":"480_CR42","first-page":"384","volume":"100","author":"R Zaslansky","year":"1996","unstructured":"Zaslansky R, Sprecher E, Katz Y, Rozenberg B, Hemli JA, Yarnitsky D (1996) Pain-evoked potentials: what do they really measure? Electroencephalogr Clin Neurophysiol 100:384\u2013392","journal-title":"Electroencephalogr Clin Neurophysiol"}],"container-title":["Experimental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-006-0480-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00221-006-0480-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-006-0480-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T11:12:50Z","timestamp":1558696370000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00221-006-0480-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,5]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["480"],"URL":"https:\/\/doi.org\/10.1007\/s00221-006-0480-0","relation":{},"ISSN":["0014-4819","1432-1106"],"issn-type":[{"value":"0014-4819","type":"print"},{"value":"1432-1106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,5]]}}}