{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:34:54Z","timestamp":1777653294448,"version":"3.51.4"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2006,11,30]],"date-time":"2006-11-30T00:00:00Z","timestamp":1164844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,11,30]],"date-time":"2006-11-30T00:00:00Z","timestamp":1164844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Brain Res"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1007\/s00221-006-0779-x","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T20:42:48Z","timestamp":1164832968000},"page":"181-190","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Modulation of neuronal activity in CNS pain pathways following propofol administration in rats: Fos and EEG analysis"],"prefix":"10.1007","volume":"179","author":[{"given":"Ieko","family":"Kubota","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Tsuboi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emi","family":"Shoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Oi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,11,30]]},"reference":[{"key":"779_CR1","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1093\/bja\/66.2.185","volume":"66","author":"E Anker-Moller","year":"1991","unstructured":"Anker-Moller E, Spangsberg N, Arendt-Nielsen L, Schultz P, Kristensen MS, Bjerring P (1991) Subhypnotic doses of thiopentone and propofol cause analgesia to experimentally induced acute pain. Br J Anaesth 66:185\u2013188","journal-title":"Br J Anaesth"},{"key":"779_CR5","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/0306-4522(96)00038-3","volume":"73","author":"DA Bereiter","year":"1996","unstructured":"Bereiter DA, Bereiter DF (1996) N-Methyl-D-Aspartate and Non-N- Methyl-D-Aspartate receptor antagonism reduces Fos-like immunoreactivity in central trigeminal neurons after corneal stimulation in the rat. Neuroscience 73:249\u2013258","journal-title":"Neuroscience"},{"key":"779_CR6","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1006\/phrs.2001.0882","volume":"44","author":"M Bodo","year":"2001","unstructured":"Bodo M, Perjes G, Kalman E, Bacskai E, Berko K, Sarkadi A, Nagy I, Keim KL, Matysik FM, Csomor K, McCarron R, Zagvazdin Y, Rosenthal M, Morrissette C, Herendy E, Szporny L, Nagy Z (2001) Screening for cerebroprotective agents using an in vivo model of cerebral reversible depolarization in awake rats. Pharmacol Res 44:419\u2013429","journal-title":"Pharmacol Res"},{"key":"779_CR8","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1002\/cne.903120210","volume":"312","author":"E Bullitt","year":"1991","unstructured":"Bullitt E (1991) Somatotopy of spinal nociceptive processing. J Comp Neurol 312:279\u2013290","journal-title":"J Comp Neurol"},{"key":"779_CR9","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/BF00868808","volume":"242","author":"S Canavero","year":"1995","unstructured":"Canavero S, Bonicalzi V, Pagni CA, Castellano G, Merante R, Gentile S, Bradac GB, Bergui M, Benna P, Vighetti S (1995) Propofol analgesia in central pain: preliminary clinical observations. J Neurol 242:561\u2013567","journal-title":"J Neurol"},{"key":"779_CR10","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1097\/00000539-199603000-00007","volume":"82","author":"AW Doenicke","year":"1996","unstructured":"Doenicke AW, Roizen MF, Rau J, Kellermann W, Babl J (1996) Reducing pain during propofol injection: the role of the solvent. Anesth Analg 82:472\u2013474","journal-title":"Anesth Analg"},{"key":"779_CR11","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1097\/00000539-200210000-00021","volume":"95","author":"XP Dong","year":"2002","unstructured":"Dong XP, Xu TL (2002) The actions of propofol on gamma-aminobutyric acid-A and glycine receptors in acutely dissociated spinal dorsal horn neurons of the rat. Anesth Analg 95:907\u2013914","journal-title":"Anesth Analg"},{"key":"779_CR12","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/PL00005028","volume":"356","author":"E Dzoljic","year":"1997","unstructured":"Dzoljic E, van Leeuwen R, de Vries R, Dzoljic MR (1997) Vigilance and EEG power in rats: effects of potent inhibitors of the neuronal nitric oxide synthase. Naunyn Schmiedebergs Arch Pharmacol 356:56\u201361","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"779_CR13","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1007\/BF03011694","volume":"42","author":"A Ewen","year":"1995","unstructured":"Ewen A, Archer DP, Samanani N, Roth SH (1995) Hyperalgesia during sedation: effects of barbiturates and propofol in the rat. Can J Anaesth 42:532\u2013540","journal-title":"Can J Anaesth"},{"key":"779_CR17","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1097\/00000542-200411000-00017","volume":"101","author":"C Grasshoff","year":"2004","unstructured":"Grasshoff C, Antkowiak B (2004) Propofol and sevoflurane depress spinal neurons in vitro via different molecular targets. Anesthesiology 101:1167\u20131176","journal-title":"Anesthesiology"},{"key":"779_CR18","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1097\/00000542-199410000-00026","volume":"81","author":"M Hara","year":"1994","unstructured":"Hara M, Kai Y, Ikemoto Y (1994) Enhancement by propofol of the gamma-aminobutyric acidA response in dissociated hippocampal pyramidal neurons of the rat. Anesthesiology 81:988\u2013994","journal-title":"Anesthesiology"},{"key":"779_CR19","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1002\/cne.903560311","volume":"356","author":"CB Hathaway","year":"1995","unstructured":"Hathaway CB, Hu JW, Bereiter D (1995) Distribution of Fos-like immunoreactivity in the caudal brainstem of the rat following noxious chemical stimulation of the temporomandibular joint. J Comp Neurol 356:444\u2013456","journal-title":"J Comp Neurol"},{"key":"779_CR20","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1113\/jphysiol.2004.070540","volume":"560","author":"B Heinke","year":"2004","unstructured":"Heinke B, Ruscheweyh R, Forsthuber L, Wunderbaldinger G, Sandkuhler J (2004) Physiological, neurochemical and morphological properties of a subgroup of GABAergic spinal lamina II neurones identified by expression of green fluorescent protein in mice. J Physiol 560:249\u2013266","journal-title":"J Physiol"},{"key":"779_CR21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1152\/jn.1984.52.1.39","volume":"52","author":"JW Hu","year":"1984","unstructured":"Hu JW, Sessle BJ (1984) Comparison of responses of cutaneous nociceptive and nonnociceptive brain stem neurons in trigeminal subnucleus caudalis (medullary dorsal horn) and subnucleus oralis to natural and electrical stimulation of tooth pulp. J Neurophysiol 52:39\u201353","journal-title":"J Neurophysiol"},{"key":"779_CR22","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1038\/328632a0","volume":"328","author":"SP Hunt","year":"1987","unstructured":"Hunt SP, Pini A, Even G (1987) Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature 328:632\u2013634","journal-title":"Nature"},{"key":"779_CR23","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0304-3959(98)00213-9","volume":"80","author":"F Ichinose","year":"1999","unstructured":"Ichinose F, Miyazaki M, Goto T, Takahashi H, Terui K, Niimi Y, Uezono S, Morita S, Yanagida H (1999) Electroencephalographic responses to the formalin test in rats. Pain 80:251\u2013256","journal-title":"Pain"},{"key":"779_CR24","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0006-8993(99)01913-7","volume":"845","author":"H Imbe","year":"1999","unstructured":"Imbe H, Dubner R, Ren K (1999) Masseteric inflammation-induced Fos protein expression in the trigeminal interpolaris\/caudalis transition zone: contribution of somatosensory-vagal-adrenal integration. Brain Res 845:165\u2013175","journal-title":"Brain Res"},{"key":"779_CR26","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.expneurol.2004.08.027","volume":"190","author":"A Jansson","year":"2004","unstructured":"Jansson A, Olin K, Yoshitake T, Hagman B, Herrington MK, Kehr J, Permert J (2004) Effects of isoflurane on prefrontal acetylcholine release and hypothalamic Fos response in young adult and aged rats. Exp Neurol 190:535\u2013543","journal-title":"Exp Neurol"},{"key":"779_CR27","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1097\/00000542-199209001-01148","volume":"77","author":"BA Jewett","year":"1992","unstructured":"Jewett BA, Gibbs LM, Tarasiuk A, Kendig JJ (1992) Propofol and barbiturate depression of spinal nociceptive neurotransmission. Anesthesiology 77:1148\u20131154","journal-title":"Anesthesiology"},{"key":"779_CR28","first-page":"303","volume":"28","author":"B Kay","year":"1977","unstructured":"Kay B, Rolly G (1977) I.C.I. 35868, a new intravenous induction agent. Acta Anaesthesiol Belg 28:303\u2013316","journal-title":"Acta Anaesthesiol Belg"},{"key":"779_CR29","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.neuroscience.2004.11.007","volume":"131","author":"T Kushikata","year":"2005","unstructured":"Kushikata T, Hirota K, Kotani N, Yoshida H, Kudo M, Matsuki A (2005) Isoflurane increases norepinephrine release in the rat preoptic area and the posterior hypothalamus in vivo and in vitro: relevance to thermoregulation during anesthesia. Neuroscience 131:79\u201386","journal-title":"Neuroscience"},{"key":"779_CR30","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/0006-8993(94)90491-X","volume":"654","author":"Q Lin","year":"1994","unstructured":"Lin Q, Peng Y, Wills WD (1994) Glycine and GABAA antagonists reduse the inhibition of primate spinothalamic tract neurons produced by stimulation in periaqueductal gray. Brain Res 654:286\u2013302","journal-title":"Brain Res"},{"key":"779_CR31","doi-asserted-by":"publisher","first-page":"41369","DOI":"10.1074\/jbc.M206768200","volume":"277","author":"H Lu","year":"2002","unstructured":"Lu H, Xu TL (2002) The general anesthetic pentobarbital slows desensitization and deactivation of the glycine receptor in the rat spinal dorsal horn neurons. J Biol Chem 277:41369\u201341378","journal-title":"J Biol Chem"},{"key":"779_CR32","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1097\/00000542-199606000-00018","volume":"84","author":"MB MacIver","year":"1996","unstructured":"MacIver MB, Mandema JW, Stanski DR, Bland BH (1996) Thiopental uncouples hippocampal and cortical synchronized electroencephalographic activity. Anesthesiology 84:1411\u20131424","journal-title":"Anesthesiology"},{"key":"779_CR33","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1111\/j.1365-2044.1985.tb10615.x","volume":"40","author":"MJ McCulloch","year":"1985","unstructured":"McCulloch MJ, Less NW (1985) Assessment and modification of pain on induction with propofol (Diprivan). Anaesthegia 40:1117\u20131120","journal-title":"Anaesthegia"},{"key":"779_CR35","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1213\/01.ANE.0000065545.58026.23","volume":"97","author":"M Naguib","year":"2003","unstructured":"Naguib M, Schmid PG III, Baker MT (2003) The electroencephalographic effects of IV anesthetic doses of melatonin: comparative studies with thiopental and propofol. Anesth Analg 97:238\u2013243","journal-title":"Anesth Analg"},{"key":"779_CR36","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1365-2044.1991.tb09323.x","volume":"46","author":"ME Nicol","year":"1991","unstructured":"Nicol ME, Moriarty J, Edwards J, Robbie DS, A\u2019Hern RP (1991) Modification of pain on injection of propofol\u2014a comparison between lignocaineand procaine. Anaesthesia. 46:67\u201369","journal-title":"Anaesthesia."},{"key":"779_CR37","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S0304-3959(01)00403-1","volume":"95","author":"H Nomura","year":"2002","unstructured":"Nomura H, Ogawa A, Tashiro A, Morimoto T, Hu JW, Iwata K (2002) Induction of Fos protein-like immunoreactivity in the trigeminal spinal nucleus caudalis and upper cervical cord following noxious and non-noxious mechanical stimulation of the whisker pad of the rat with an inferior alveolar nerve transection. Pain 95:225\u2013238","journal-title":"Pain"},{"key":"779_CR38","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1023\/B:NEAB.0000018753.29627.02","volume":"34","author":"NS Novikova","year":"2004","unstructured":"Novikova NS, Kazakova TB, Rogers V, Korneva EA (2004) Expression of the c-fos gene in spinal cord and brain cells in rats subjected to stress in conditions of exposure to various types of halothane anesthesia. Neurosci Behav Physiol 34:407\u2013412","journal-title":"Neurosci Behav Physiol"},{"key":"779_CR40","volume-title":"The rat brain in stereotaxic coordinates","author":"G Paxinos","year":"1998","unstructured":"Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates. 4th edn. Academic Press, San Diego, CA","edition":"4th edn."},{"key":"779_CR41","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/bja\/77.2.165","volume":"77","author":"S Petersen-Felix","year":"1996","unstructured":"Petersen-Felix S, Arendt-Nielsen L, Bak P, Fischer M, Zbinden AM (1996) Psychophysical and electrophysiological responses to experimental pain may be influenced by sedation: comparison of the effects of a hypnotic (propofol) and an analgesic (alfentanil). Br J Anaesth 77:165\u2013171","journal-title":"Br J Anaesth"},{"key":"779_CR42","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1002\/cne.903020213","volume":"302","author":"DB Reichling","year":"1990","unstructured":"Reichling DB, Basbaum AI (1990) Contribution of brainstem GABAergic circuitry to descending antinociceptive controls: I. GABA-immunoreactive projection neurons in the periaqueductal gray and nucleus raphe magnus. J Comp Neurol 302:370\u2013377","journal-title":"J Comp Neurol"},{"key":"779_CR43","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/0014-2999(89)90667-5","volume":"160","author":"J Sandkuhler","year":"1989","unstructured":"Sandkuhler J, Willmann E, Fu QG (1989) Blockade of GABAA receptors in the midbrain periaqueductal gray abolishes nociceptive spinal dorsal horn neuronal activity. Eur J Pharmacol 160:163\u2013166","journal-title":"Eur J Pharmacol"},{"key":"779_CR44","first-page":"213","volume":"47","author":"E Sanna","year":"1995","unstructured":"Sanna E, Garau F, Harris RA (1995) Novel properties of homomeric beta 1 gamma-aminobutyric acid type A receptors: actions of the anesthetics propofol and pentobarbital. Mol Pharmacol 47:213\u2013217","journal-title":"Mol Pharmacol"},{"key":"779_CR45","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/0169-328X(94)90141-4","volume":"24","author":"E Senba","year":"1994","unstructured":"Senba E, Umemoto S, Kawai Y, Noguchi K (1994) Differential expression of fos family and jun family mRNAs in the rat hypothalamo-pituitary-adrenal axis after immobilization stress. Brain Res Mol Brain Res 24:283\u2013294","journal-title":"Brain Res Mol Brain Res"},{"key":"779_CR46","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1113\/jphysiol.2001.012818","volume":"537","author":"JH Steinbach","year":"2001","unstructured":"Steinbach JH, Akk G (2001) Modulation of GABA(A) receptor channel gating by pentobarbital. J Physiol 537:715\u2013733","journal-title":"J Physiol"},{"key":"779_CR47","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1152\/jn.1993.70.5.1811","volume":"70","author":"AM Strassman","year":"1993","unstructured":"Strassman AM, Vos BP, Mineta Y, Naderi S, Borsook D, Burstein R (1993) Fos-like immunoreactivity in the superficial medullary dorsal horn induced by noxious and innocuous thermal stimulation of facial skin in the rat. J Neurophysiol 70:1811\u20131821","journal-title":"J Neurophysiol"},{"key":"779_CR48","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/S0306-4522(00)00121-4","volume":"98","author":"M Takemura","year":"2000","unstructured":"Takemura M, Shimada T, Shigenaga Y (2000) GABA(A) receptor-mediated effects on expression of c-Fos in rat trigeminal nucleus following high- and low-intensity afferent stimulation. Neuroscience 98:325\u2013332","journal-title":"Neuroscience"},{"key":"779_CR49","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/0304-3940(93)90414-G","volume":"160","author":"PP Tan","year":"1993","unstructured":"Tan PP, Shyr MH, Yang CH, Kuo TB, Pan WH, Chan SH (1993) Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat: intravenous infusion. Neurosci Lett 160:205\u2013208","journal-title":"Neurosci Lett"},{"key":"779_CR50","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1097\/00000542-199512000-00022","volume":"83","author":"H Uchida","year":"1995","unstructured":"Uchida H, Kishikawa K, Collins JG (1995) Effect of propofol on spinal dorsal horn neurons. Comparison with lack of ketamine effects. Anesthesiology 83:1312\u20131322","journal-title":"Anesthesiology"},{"key":"779_CR51","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/bja\/81.3.415","volume":"81","author":"PC Vijn","year":"1998","unstructured":"Vijn PC, Sneyd JR (1998) i.v. anaesthesia and EEG burst suppression in rats: bolus injections and closed-loop infusions. Br J Anaesth 81:415\u2013421","journal-title":"Br J Anaesth"},{"key":"779_CR53","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1111\/j.1365-2044.1995.tb04560.x","volume":"50","author":"OH Wilder-Smith","year":"1995","unstructured":"Wilder-Smith OH, Kolletzki M, Wilder-Smith CH (1995) Sedation with intravenous infusions of propofol or thiopentone. Effects on pain perception. Anaesthesia 50:218\u2013222","journal-title":"Anaesthesia"},{"key":"779_CR54","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1002\/(SICI)1096-9861(19990920)412:2<276::AID-CNE7>3.0.CO;2-9","volume":"412","author":"Q Zhou","year":"1999","unstructured":"Zhou Q, Imbe H, Dubner R, Ren K (1999) Persistent Fos protein expression after orofacial deep or cutaneous tissue inflammation in rats: implications for persistent orofacial pain. J Comp Neurol 412:276\u2013291","journal-title":"J Comp Neurol"},{"key":"779_CR55","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","volume":"16","author":"M Zimmerman","year":"1983","unstructured":"Zimmerman M (1983) Ethical guidelines for investigation of experimental pain in conscious animals. Pain 16:109\u2013110","journal-title":"Pain"}],"container-title":["Experimental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-006-0779-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00221-006-0779-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-006-0779-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-006-0779-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T21:19:32Z","timestamp":1652822372000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00221-006-0779-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,30]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["779"],"URL":"https:\/\/doi.org\/10.1007\/s00221-006-0779-x","relation":{},"ISSN":["0014-4819","1432-1106"],"issn-type":[{"value":"0014-4819","type":"print"},{"value":"1432-1106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,30]]},"assertion":[{"value":"11 April 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2006","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2006","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}