{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:25:25Z","timestamp":1791066325813,"version":"4.1.0"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T00:00:00Z","timestamp":1389052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Brain Res"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1007\/s00221-013-3806-8","type":"journal-article","created":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T14:22:01Z","timestamp":1389018121000},"page":"935-946","source":"Crossref","is-referenced-by-count":14,"title":["Chronic escitalopram treatment caused dissociative adaptation in serotonin (5-HT) 2C receptor antagonist-induced effects in REM sleep, wake and theta wave activity"],"prefix":"10.1007","volume":"232","author":[{"given":"Di\u00e1na","family":"Kostyalik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zita","family":"K\u00e1tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szilvia","family":"Vas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorottya","family":"Pap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Petschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter","family":"Moln\u00e1r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"Gyerty\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lajos","family":"Kalm\u00e1r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"T\u00f3thfalusi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyorgy","family":"Bagdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,1,7]]},"reference":[{"key":"3806_CR1","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/0028-3908(95)00138-7","volume":"34","author":"D Abramowski","year":"1995","unstructured":"Abramowski D, Rigo M, Duc D, Hoyer D, Staufenbiel M (1995) Localization of the 5-hydroxytryptamine2C receptor protein in human and rat brain using specific antisera. Neuropharmacology 34:1635\u20131645","journal-title":"Neuropharmacology"},{"key":"3806_CR2","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S1087-0792(01)90200-X","volume":"6","author":"J Adrien","year":"2002","unstructured":"Adrien J (2002) Neurobiological bases for the relation between sleep and depression. Sleep Med Rev 6:341\u2013351","journal-title":"Sleep Med Rev"},{"key":"3806_CR3","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1523\/JNEUROSCI.01-08-00876.1981","volume":"1","author":"G Aston-Jones","year":"1981","unstructured":"Aston-Jones G, Bloom FE (1981) Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle. J Neurosci 1:876\u2013886","journal-title":"J Neurosci"},{"key":"3806_CR4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0014-2999(95)00279-T","volume":"282","author":"CS Aulakh","year":"1995","unstructured":"Aulakh CS, Mazzola-Pomietto P, Murphy DL (1995) Long-term antidepressant treatments alter 5-HT2A and 5-HT2C receptor-mediated hyperthermia in Fawn-Hooded rats. Eur J Pharmacol 282:65\u201370","journal-title":"Eur J Pharmacol"},{"key":"3806_CR5","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1749-6632.1998.tb09009.x","volume":"851","author":"G Bagdy","year":"1998","unstructured":"Bagdy G (1998) Serotonin, anxiety, and stress hormones: focus on 5-HT receptor subtypes, species and gender differences. Ann N Y Acad Sci 851:357\u2013363","journal-title":"Ann N Y Acad Sci"},{"key":"3806_CR6","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1017\/S1461145701002632","volume":"4","author":"G Bagdy","year":"2001","unstructured":"Bagdy G, Graf M, Anheuer ZE, Modos EA, Kantor S (2001) Anxiety-like effects induced by acute fluoxetine, sertraline or m-CPP treatment are reversed by pretreatment with the 5-HT2C receptor antagonist SB-242084 but not the 5-HT1A receptor antagonist WAY-100635. Int J Neuropsychopharmacol 4:399\u2013408. doi: 10.1017\/S1461145701002632","journal-title":"Int J Neuropsychopharmacol"},{"key":"3806_CR7","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1471-4159.2006.04277.x","volume":"100","author":"G Bagdy","year":"2007","unstructured":"Bagdy G, Kecskemeti V, Riba P, Jakus R (2007) Serotonin and epilepsy. J Neurochem 100:857\u2013873. doi: 10.1111\/j.1471-4159.2006.04277.x","journal-title":"J Neurochem"},{"key":"3806_CR8","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0026-895X(25)13249-5","volume":"44","author":"EL Barker","year":"1993","unstructured":"Barker EL, Sanders-Bush E (1993) 5-hydroxytryptamine1C receptor density and mRNA levels in choroid plexus epithelial cells after treatment with mianserin and (\u2212)-1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane. Mol Pharmacol 44:725\u2013730","journal-title":"Mol Pharmacol"},{"key":"3806_CR9","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0028-3908(99)00010-6","volume":"38","author":"NM Barnes","year":"1999","unstructured":"Barnes NM, Sharp T (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38:1083\u20131152","journal-title":"Neuropharmacology"},{"key":"3806_CR10","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF02244313","volume":"105","author":"HH Berendsen","year":"1991","unstructured":"Berendsen HH, Broekkamp CL (1991) Attenuation of 5-HT1A and 5-HT2 but not 5-HT1C receptor mediated behaviour in rats following chronic treatment with 5-HT receptor agonists, antagonists or anti-depressants. Psychopharmacology 105:219\u2013224","journal-title":"Psychopharmacology"},{"key":"3806_CR11","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/S0028-3908(99)00191-4","volume":"39","author":"LJ Bristow","year":"2000","unstructured":"Bristow LJ, O\u2019Connor D, Watts R, Duxon MS, Hutson PH (2000) Evidence for accelerated desensitisation of 5-HT(2C) receptors following combined treatment with fluoxetine and the 5-HT(1A) receptor antagonist, WAY 100,635, in the rat. Neuropharmacology 39:1222\u20131236","journal-title":"Neuropharmacology"},{"key":"3806_CR12","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1124\/mol.107.041574","volume":"73","author":"B Chanrion","year":"2008","unstructured":"Chanrion B, Mannoury la Cour C, Gavarini S et al (2008) Inverse agonist and neutral antagonist actions of antidepressants at recombinant and native 5-hydroxytryptamine2C receptors: differential modulation of cell surface expression and signal transduction. Mol Pharmacol 73:748\u2013757. doi: 10.1124\/mol.107.041574","journal-title":"Mol Pharmacol"},{"key":"3806_CR13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0028-3908(99)00086-6","volume":"39","author":"DA Clemett","year":"2000","unstructured":"Clemett DA, Punhani T, Duxon MS, Blackburn TP, Fone KC (2000) Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS. Neuropharmacology 39:123\u2013132","journal-title":"Neuropharmacology"},{"key":"3806_CR14","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1523\/JNEUROSCI.0112-04.2004","volume":"24","author":"P Deurwaerdere De","year":"2004","unstructured":"De Deurwaerdere P, Navailles S, Berg KA, Clarke WP, Spampinato U (2004) Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens. J Neurosci 24:3235\u20133241. doi: 10.1523\/JNEUROSCI.0112-04.2004","journal-title":"J Neurosci"},{"key":"3806_CR15","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/S0028-3908(99)00268-3","volume":"39","author":"A Dekeyne","year":"2000","unstructured":"Dekeyne A, Denorme B, Monneyron S, Millan MJ (2000) Citalopram reduces social interaction in rats by activation of serotonin (5-HT)(2C) receptors. Neuropharmacology 39:1114\u20131117","journal-title":"Neuropharmacology"},{"key":"3806_CR16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0306-4522(00)00561-3","volume":"103","author":"G Giovanni Di","year":"2001","unstructured":"Di Giovanni G, Di Matteo V, La Grutta V, Esposito E (2001) m-Chlorophenylpiperazine excites non-dopaminergic neurons in the rat substantia nigra and ventral tegmental area by activating serotonin-2C receptors. Neuroscience 103:111\u2013116","journal-title":"Neuroscience"},{"key":"3806_CR17","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.2174\/092986706778521805","volume":"13","author":"G Giovanni Di","year":"2006","unstructured":"Di Giovanni G, Di Matteo V, Pierucci M, Benigno A, Esposito E (2006) Serotonin involvement in the basal ganglia pathophysiology: could the 5-HT2C receptor be a new target for therapeutic strategies? Curr Med Chem 13:3069\u20133081. doi: 10.1523\/JNEUROSCI.3895-04.2005","journal-title":"Curr Med Chem"},{"key":"3806_CR18","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0893-133X(01)00314-1","volume":"26","author":"B Feige","year":"2002","unstructured":"Feige B, Voderholzer U, Riemann D, Dittmann R, Hohagen F, Berger M (2002) Fluoxetine and sleep EEG: effects of a single dose, subchronic treatment, and discontinuation in healthy subjects. Neuropsychopharmacology 26:246\u2013258. doi: 10.1016\/S0893-133X(01)00314-1","journal-title":"Neuropsychopharmacology"},{"key":"3806_CR19","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0304-3940(99)00015-4","volume":"261","author":"J Filakovszky","year":"1999","unstructured":"Filakovszky J, Gerber K, Bagdy G (1999) A serotonin-1A receptor agonist and an N-methyl-d-aspartate receptor antagonist oppose each others effects in a genetic rat epilepsy model. Neurosci Lett 261:89\u201392","journal-title":"Neurosci Lett"},{"key":"3806_CR20","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.brainresbull.2009.03.002","volume":"79","author":"SM Fogel","year":"2009","unstructured":"Fogel SM, Smith CT, Beninger RJ (2009) Evidence for 2-stage models of sleep and memory: learning-dependent changes in spindles and theta in rats. Brain Res Bull 79:445\u2013451. doi: 10.1016\/j.brainresbull.2009.03.002","journal-title":"Brain Res Bull"},{"key":"3806_CR21","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1038\/sj.bjp.0701798","volume":"123","author":"KC Fone","year":"1998","unstructured":"Fone KC, Austin RH, Topham IA, Kennett GA, Punhani T (1998) Effect of chronic m-CPP on locomotion, hypophagia, plasma corticosterone and 5-HT2C receptor levels in the rat. Br J Pharmacol 123:1707\u20131715. doi: 10.1038\/sj.bjp.0701798","journal-title":"Br J Pharmacol"},{"key":"3806_CR22","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0893-133X(02)00353-6","volume":"27","author":"MG Frank","year":"2002","unstructured":"Frank MG, Stryker MP, Tecott LH (2002) Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor. Neuropsychopharmacology 27:869\u2013873. doi: 10.1016\/S0893-133X(02)00353-6","journal-title":"Neuropsychopharmacology"},{"key":"3806_CR23","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/0091-3057(94)90244-5","volume":"49","author":"G Gandolfo","year":"1994","unstructured":"Gandolfo G, Scherschlicht R, Gottesmann C (1994) Benzodiazepines promote the intermediate stage at the expense of paradoxical sleep in the rat. Pharmacol Biochem Behav 49:921\u2013927","journal-title":"Pharmacol Biochem Behav"},{"key":"3806_CR24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.neulet.2004.01.072","volume":"359","author":"M Graf","year":"2004","unstructured":"Graf M, Jakus R, Kantor S, Levay G, Bagdy G (2004) Selective 5-HT1A and 5-HT7 antagonists decrease epileptic activity in the WAG\/Rij rat model of absence epilepsy. Neurosci Lett 359:45\u201348. doi: 10.1016\/j.neulet.2004.01.072","journal-title":"Neurosci Lett"},{"key":"3806_CR25","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1124\/jpet.103.051169","volume":"306","author":"M Hajos","year":"2003","unstructured":"Hajos M, Hoffmann WE, Weaver RJ (2003) Regulation of septo-hippocampal activity by 5-hydroxytryptamine(2C) receptors. J Pharmacol Exp Ther 306:605\u2013615. doi: 10.1124\/jpet.103.051169","journal-title":"J Pharmacol Exp Ther"},{"key":"3806_CR26","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/syn.890140410","volume":"14","author":"PD Hrdina","year":"1993","unstructured":"Hrdina PD, Vu TB (1993) Chronic fluoxetine treatment upregulates 5-HT uptake sites and 5-HT2 receptors in rat brain: an autoradiographic study. Synapse 14:324\u2013331. doi: 10.1002\/syn.890140410","journal-title":"Synapse"},{"key":"3806_CR27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0031-9384(98)00125-5","volume":"65","author":"R Huber","year":"1998","unstructured":"Huber R, Deboer T, Schwierin B, Tobler I (1998) Effect of melatonin on sleep and brain temperature in the Djungarian hamster and the rat. Physiol Behav 65:77\u201382","journal-title":"Physiol Behav"},{"key":"3806_CR28","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1100\/tsw.2010.180","volume":"10","author":"NH Jensen","year":"2010","unstructured":"Jensen NH, Cremers TI, Sotty F (2010) Therapeutic potential of 5-HT2C receptor ligands. Sci World J 10:1870\u20131885. doi: 10.1100\/tsw.2010.180","journal-title":"Sci World J"},{"key":"3806_CR29","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0031-9384(00)00374-7","volume":"71","author":"S Kantor","year":"2000","unstructured":"Kantor S, Anheuer ZE, Bagdy G (2000) High social anxiety and low aggression in Fawn-Hooded rats. Physiol Behav 71:551\u2013557","journal-title":"Physiol Behav"},{"key":"3806_CR30","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0006-8993(02)02698-7","volume":"943","author":"S Kantor","year":"2002","unstructured":"Kantor S, Jakus R, Bodizs R, Halasz P, Bagdy G (2002) Acute and long-term effects of the 5-HT2 receptor antagonist ritanserin on EEG power spectra, motor activity, and sleep: changes at the light-dark phase shift. Brain Res 943:105\u2013111","journal-title":"Brain Res"},{"key":"3806_CR31","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/sj.bjp.0705887","volume":"142","author":"S Kantor","year":"2004","unstructured":"Kantor S, Jakus R, Balogh B, Benko A, Bagdy G (2004) Increased wakefulness, motor activity and decreased theta activity after blockade of the 5-HT2B receptor by the subtype-selective antagonist SB-215505. Br J Pharmacol 142:1332\u20131342. doi: 10.1038\/sj.bjp.0705887","journal-title":"Br J Pharmacol"},{"key":"3806_CR32","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1124\/jpet.105.086413","volume":"315","author":"S Kantor","year":"2005","unstructured":"Kantor S, Jakus R, Molnar E, Gyongyosi N, Toth A, Detari L, Bagdy G (2005) Despite similar anxiolytic potential, the 5-hydroxytryptamine 2C receptor antagonist SB-242084 [6-chloro-5-methyl-1-[2-(2-methylpyrid-3-yloxy)-pyrid-5-yl carbamoyl] indoline] and chlordiazepoxide produced differential effects on electroencephalogram power spectra. J Pharmacol Exp Ther 315:921\u2013930. doi: 10.1124\/jpet.105.086413","journal-title":"J Pharmacol Exp Ther"},{"key":"3806_CR33","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/BF02245708","volume":"113","author":"AJ Kennedy","year":"1993","unstructured":"Kennedy AJ, Gibson EL, O\u2019Connell MT, Curzon G (1993) Effects of housing, restraint and chronic treatments with mCPP and sertraline on behavioural responses to mCPP. Psychopharmacology 113:262\u2013268","journal-title":"Psychopharmacology"},{"key":"3806_CR34","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0028-3908(97)00038-5","volume":"36","author":"GA Kennett","year":"1997","unstructured":"Kennett GA, Wood MD, Bright F et al (1997) SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology 36:609\u2013620","journal-title":"Neuropharmacology"},{"key":"3806_CR35","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/978-3-7643-8561-3_15","volume-title":"Serotonin and sleep: molecular, functional and clinical aspects","author":"T Kitka","year":"2008","unstructured":"Kitka T, Bagdy G (2008) Effect of 5-HT2A\/2B\/2C receptor agonists and antagonists on sleep and waking in laboratory animals and humans. In: Monti JM, Jacobs BL, Nutt DJ (eds) Serotonin and sleep: molecular, functional and clinical aspects. Birkh\u00e4user, Basel, pp 387\u2013414"},{"key":"3806_CR36","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/hup.694","volume":"20","author":"M Lader","year":"2005","unstructured":"Lader M, Andersen HF, Baekdal T (2005) The effect of escitalopram on sleep problems in depressed patients. Hum Psychopharmacol 20:349\u2013354. doi: 10.1002\/hup.694","journal-title":"Hum Psychopharmacol"},{"key":"3806_CR37","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2174\/1568007043482598","volume":"3","author":"JE Leysen","year":"2004","unstructured":"Leysen JE (2004) 5-HT2 receptors. Curr Drug Targets CNS Neurol Disord 3:11\u201326","journal-title":"Curr Drug Targets CNS Neurol Disord"},{"key":"3806_CR38","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/S0022-3565(25)38429-6","volume":"266","author":"Q Li","year":"1993","unstructured":"Li Q, Brownfield MS, Battaglia G, Cabrera TM, Levy AD, Rittenhouse PA, van de Kar LD (1993) Long-term treatment with the antidepressants fluoxetine and desipramine potentiates endocrine responses to the serotonin agonists 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212) and (+-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI). J Pharmacol Exp Ther 266:836\u2013844","journal-title":"J Pharmacol Exp Ther"},{"key":"3806_CR39","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0022-3565(24)37669-4","volume":"286","author":"JR Martin","year":"1998","unstructured":"Martin JR, Bos M, Jenck F et al (1998) 5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential. J Pharmacol Exp Ther 286:913\u2013924","journal-title":"J Pharmacol Exp Ther"},{"key":"3806_CR40","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/S0024-3205(96)00400-6","volume":"59","author":"WB Mendelson","year":"1996","unstructured":"Mendelson WB (1996) Sleep induction by microinjection of pentobarbital into the medial preoptic area in rats. Life Sci 59:1821\u20131828","journal-title":"Life Sci"},{"key":"3806_CR41","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/sj.npp.1300109","volume":"28","author":"C Monaca","year":"2003","unstructured":"Monaca C, Boutrel B, Hen R, Hamon M, Adrien J (2003) 5-HT 1A\/1B receptor-mediated effects of the selective serotonin reuptake inhibitor, citalopram, on sleep: studies in 5-HT 1A and 5-HT 1B knockout mice. Neuropsychopharmacology 28:850\u2013856. doi: 10.1038\/sj.npp.1300109","journal-title":"Neuropsychopharmacology"},{"key":"3806_CR42","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1365-2869.1992.tb00033.x","volume":"1","author":"JM Monti","year":"1992","unstructured":"Monti JM, Jantos H (1992) Dose-dependent effects of the 5-HT1A receptor agonist 8-OH-DPAT on sleep and wakefulness in the rat. J Sleep Res 1:169\u2013175","journal-title":"J Sleep Res"},{"key":"3806_CR43","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.pnpbp.2006.02.013","volume":"30","author":"JM Monti","year":"2006","unstructured":"Monti JM, Jantos H (2006a) Effects of activation and blockade of 5-HT2A\/2C receptors in the dorsal raphe nucleus on sleep and waking in the rat. Prog Neuropsychopharmacol Biol Psychiatry 30:1189\u20131195. doi: 10.1016\/j.pnpbp.2006.02.013","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"3806_CR44","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ejphar.2006.09.027","volume":"553","author":"JM Monti","year":"2006","unstructured":"Monti JM, Jantos H (2006b) Effects of the serotonin 5-HT2A\/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213, respectively, on sleep and waking in the rat. Eur J Pharmacol 553:163\u2013170. doi: 10.1016\/j.ejphar.2006.09.027","journal-title":"Eur J Pharmacol"},{"key":"3806_CR45","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1046\/j.1471-4159.1997.69031031.x","volume":"69","author":"RA Newton","year":"1997","unstructured":"Newton RA, Elliott JM (1997) Mianserin-induced down-regulation of human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors stably expressed in the human neuroblastoma cell line SH-SY5Y. J Neurochem 69:1031\u20131038","journal-title":"J Neurochem"},{"key":"3806_CR46","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0006-3223(01)01145-3","volume":"50","author":"MJ Owens","year":"2001","unstructured":"Owens MJ, Knight DL, Nemeroff CB (2001) Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine. Biol Psychiatry 50:345\u2013350","journal-title":"Biol Psychiatry"},{"key":"3806_CR47","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0169-328X(94)90223-2","volume":"23","author":"M Pompeiano","year":"1994","unstructured":"Pompeiano M, Palacios JM, Mengod G (1994) Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. Brain Res Mol Brain Res 23:163\u2013178","journal-title":"Brain Res Mol Brain Res"},{"key":"3806_CR48","doi-asserted-by":"crossref","first-page":"11231","DOI":"10.1523\/JNEUROSCI.1724-05.2005","volume":"25","author":"D Popa","year":"2005","unstructured":"Popa D, Lena C, Fabre V et al (2005) Contribution of 5-HT2 receptor subtypes to sleep-wakefulness and respiratory control, and functional adaptations in knock-out mice lacking 5-HT2A receptors. J Neurosci 25:11231\u201311238. doi: 10.1523\/JNEUROSCI.1724-05.2005","journal-title":"J Neurosci"},{"key":"3806_CR49","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/0306-3623(94)90150-3","volume":"25","author":"MR Pranzatelli","year":"1994","unstructured":"Pranzatelli MR, Tailor PT (1994) Modulation of brainstem 5-HT1C receptors by serotonergic drugs in the rat. Gen Pharmacol 25:1279\u20131284","journal-title":"Gen Pharmacol"},{"key":"3806_CR50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0922-4106(93)90052-B","volume":"244","author":"MR Pranzatelli","year":"1993","unstructured":"Pranzatelli MR, Murthy JN, Tailor PT (1993) Novel regulation of 5-HT1C receptors: down-regulation induced both by 5-HT1C\/2 receptor agonists and antagonists. Eur J Pharmacol 244:1\u20135","journal-title":"Eur J Pharmacol"},{"key":"3806_CR51","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1111\/j.1476-5381.1995.tb16684.x","volume":"116","author":"S Prisco","year":"1995","unstructured":"Prisco S, Esposito E (1995) Differential effects of acute and chronic fluoxetine administration on the spontaneous activity of dopaminergic neurones in the ventral tegmental area. Br J Pharmacol 116:1923\u20131931","journal-title":"Br J Pharmacol"},{"key":"3806_CR52","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0006-3223(98)00092-4","volume":"44","author":"AJ Rush","year":"1998","unstructured":"Rush AJ, Armitage R, Gillin JC et al (1998) Comparative effects of nefazodone and fluoxetine on sleep in outpatients with major depressive disorder. Biol Psychiatry 44:3\u201314","journal-title":"Biol Psychiatry"},{"key":"3806_CR53","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0304-3940(94)90635-1","volume":"171","author":"JJ Rutter","year":"1994","unstructured":"Rutter JJ, Gundlah C, Auerbach SB (1994) Increase in extracellular serotonin produced by uptake inhibitors is enhanced after chronic treatment with fluoxetine. Neurosci Lett 171:183\u2013186","journal-title":"Neurosci Lett"},{"key":"3806_CR54","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1124\/jpet.104.067306","volume":"310","author":"BD Schlag","year":"2004","unstructured":"Schlag BD, Lou Z, Fennell M, Dunlop J (2004) Ligand dependency of 5-hydroxytryptamine 2C receptor internalization. J Pharmacol Exp Ther 310:865\u2013870. doi: 10.1124\/jpet.104.067306","journal-title":"J Pharmacol Exp Ther"},{"key":"3806_CR55","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jchemneu.2004.03.010","volume":"29","author":"J Serrats","year":"2005","unstructured":"Serrats J, Mengod G, Cortes R (2005) Expression of serotonin 5-HT2C receptors in GABAergic cells of the anterior raphe nuclei. J Chem Neuroanat 29:83\u201391. doi: 10.1016\/j.jchemneu.2004.03.010","journal-title":"J Chem Neuroanat"},{"key":"3806_CR56","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1517\/14728222.8.1.15","volume":"8","author":"A Serretti","year":"2004","unstructured":"Serretti A, Artioli P, De Ronchi D (2004) The 5-HT2C receptor as a target for mood disorders. Expert Opin Ther Targets 8:15\u201323. doi: 10.1517\/14728222.8.1.15","journal-title":"Expert Opin Ther Targets"},{"key":"3806_CR57","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/BF02246410","volume":"126","author":"AL Sharpley","year":"1996","unstructured":"Sharpley AL, Williamson DJ, Attenburrow ME, Pearson G, Sargent P, Cowen PJ (1996) The effects of paroxetine and nefazodone on sleep: a placebo controlled trial. Psychopharmacology 126:50\u201354","journal-title":"Psychopharmacology"},{"key":"3806_CR58","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0091-3057(01)00702-X","volume":"71","author":"MI Smith","year":"2002","unstructured":"Smith MI, Piper DC, Duxon MS, Upton N (2002) Effect of SB-243213, a selective 5-HT(2C) receptor antagonist, on the rat sleep profile: a comparison to paroxetine. Pharmacol Biochem Behav 71:599\u2013605","journal-title":"Pharmacol Biochem Behav"},{"key":"3806_CR59","author":"E Sorman","year":"2011","unstructured":"Sorman E, Wang D, Hajos M, Kocsis B (2011) Control of hippocampal theta rhythm by serotonin: role of 5-HT2c receptors. Neuropharmacology. doi: 10.1016\/j.neuropharm.2011.01.029","journal-title":"Neuropharmacology"},{"key":"3806_CR60","author":"A Steiger","year":"2009","unstructured":"Steiger A, Kimura M (2009) Wake and sleep EEG provide biomarkers in depression. J Psychiatr Res. doi: 10.1016\/j.jpsychires.2009.08.013","journal-title":"J Psychiatr Res"},{"key":"3806_CR61","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0028-3908(98)00176-2","volume":"38","author":"CT To","year":"1999","unstructured":"To CT, Bagdy G (1999) Anxiogenic effect of central CCK administration is attenuated by chronic fluoxetine or ipsapirone treatment. Neuropharmacology 38:279\u2013282","journal-title":"Neuropharmacology"},{"key":"3806_CR62","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1097\/00001756-199902250-00020","volume":"10","author":"CT To","year":"1999","unstructured":"To CT, Anheuer ZE, Bagdy G (1999) Effects of acute and chronic fluoxetine treatment of CRH-induced anxiety. NeuroReport 10:553\u2013555","journal-title":"NeuroReport"},{"key":"3806_CR63","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/0006-8993(89)90573-8","volume":"485","author":"FC Tortella","year":"1989","unstructured":"Tortella FC, Echevarria E, Pastel RH, Cox B, Blackburn TP (1989) Suppressant effects of selective 5-HT2 antagonists on rapid eye movement sleep in rats. Brain Res 485:294\u2013300","journal-title":"Brain Res"},{"key":"3806_CR64","doi-asserted-by":"crossref","first-page":"PL187","DOI":"10.1016\/0024-3205(93)90116-K","volume":"52","author":"JH Trouvin","year":"1993","unstructured":"Trouvin JH, Gardier AM, Chanut E, Pages N, Jacquot C (1993) Time course of brain serotonin metabolism after cessation of long-term fluoxetine treatment in the rat. Life Sci 52:PL187\u2013PL192","journal-title":"Life Sci"},{"key":"3806_CR65","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF02245142","volume":"107","author":"J Ulrichsen","year":"1992","unstructured":"Ulrichsen J, Partilla JS, Dax EM (1992) Long-term administration of m-chlorophenylpiperazine (mCPP) to rats induces changes in serotonin receptor binding, dopamine levels and locomotor activity without altering prolactin and corticosterone secretion. Psychopharmacology 107:229\u2013235","journal-title":"Psychopharmacology"},{"key":"3806_CR66","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1113\/jphysiol.2006.108514","volume":"573","author":"N Urbain","year":"2006","unstructured":"Urbain N, Creamer K, Debonnel G (2006) Electrophysiological diversity of the dorsal raphe cells across the sleep-wake cycle of the rat. J Physiol 573:679\u2013695. doi: 10.1113\/jphysiol.2006.108514","journal-title":"J Physiol"},{"key":"3806_CR67","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00702-012-0847-2","volume":"120","author":"S Vas","year":"2013","unstructured":"Vas S, Katai Z, Kostyalik D et al (2013) Differential adaptation of REM sleep latency, intermediate stage and theta power effects of escitalopram after chronic treatment. J Neural Transm 120:169\u2013176. doi: 10.1007\/s00702-012-0847-2","journal-title":"J Neural Transm"},{"key":"3806_CR68","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0306-4522(97)00239-X","volume":"81","author":"RP Vertes","year":"1997","unstructured":"Vertes RP, Kocsis B (1997) Brainstem-diencephalo-septohippocampal systems controlling the theta rhythm of the hippocampus. Neuroscience 81:893\u2013926","journal-title":"Neuroscience"},{"key":"3806_CR69","doi-asserted-by":"crossref","first-page":"927","DOI":"10.2165\/00003495-200565070-00003","volume":"65","author":"S Wilson","year":"2005","unstructured":"Wilson S, Argyropoulos S (2005) Antidepressants and sleep: a qualitative review of the literature. Drugs 65:927\u2013947","journal-title":"Drugs"},{"key":"3806_CR70","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.euroneuro.2003.11.004","volume":"14","author":"SJ Wilson","year":"2004","unstructured":"Wilson SJ, Bailey JE, Rich AS, Adrover M, Potokar J, Nutt DJ (2004) Using sleep to evaluate comparative serotonergic effects of paroxetine and citalopram. Eur Neuropsychopharmacol 14:367\u2013372. doi: 10.1016\/j.euroneuro.2003.11.004","journal-title":"Eur Neuropsychopharmacol"},{"key":"3806_CR71","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.pbb.2004.05.003","volume":"78","author":"M Yamauchi","year":"2004","unstructured":"Yamauchi M, Tatebayashi T, Nagase K, Kojima M, Imanishi T (2004) Chronic treatment with fluvoxamine desensitizes 5-HT2C receptor-mediated hypolocomotion in rats. Pharmacol Biochem Behav 78:683\u2013689. doi: 10.1016\/j.pbb.2004.05.003","journal-title":"Pharmacol Biochem Behav"}],"container-title":["Experimental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-013-3806-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00221-013-3806-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-013-3806-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T11:18:35Z","timestamp":1746098315000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00221-013-3806-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,7]]},"references-count":71,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["3806"],"URL":"https:\/\/doi.org\/10.1007\/s00221-013-3806-8","relation":{},"ISSN":["0014-4819","1432-1106"],"issn-type":[{"value":"0014-4819","type":"print"},{"value":"1432-1106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,7]]}}}