{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:06:46Z","timestamp":1761581206264,"version":"3.40.4"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T00:00:00Z","timestamp":1402358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Brain Res"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1007\/s00221-014-4004-z","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T18:32:20Z","timestamp":1402425140000},"page":"2699-2707","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The broad-spectrum antiemetic effects ETI-385 result from stimulation of 5-HT1A and 5-HT1D receptors"],"prefix":"10.1007","volume":"232","author":[{"given":"J. B.","family":"Lucot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E. L.","family":"Brame","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. L.","family":"Garrett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. H.","family":"Pfadenhauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. B.","family":"Fick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. R.","family":"Helton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,6,10]]},"reference":[{"key":"4004_CR1","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/bjc.1995.452","volume":"72","author":"AB Alfieri","year":"1995","unstructured":"Alfieri AB, Cubeddu LX (1995) Comparative efficacy of a single oral dose of ondansetron and of buspirone against cisplatin-induced emesis in cancer patients. Br J Cancer 72:1013\u20131015","journal-title":"Br J Cancer"},{"key":"4004_CR2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0014-2999(96)00275-0","volume":"307","author":"P Andrews","year":"1996","unstructured":"Andrews P, Torii Y, Saito H, Matsuki N (1996) The pharmacology of the emetic response to upper gastrointestinal tract stimulation in Suncus murinus. Eur J Pharmacol 307:305\u2013313","journal-title":"Eur J Pharmacol"},{"key":"4004_CR3","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/BF00168940","volume":"345","author":"WA Bax","year":"1992","unstructured":"Bax WA, Van Heuven-Nolsen D, Bos E, Simoons ML, Saxena PR (1992) 5-Hydroxytryptamine-induced contractions of the human isolated saphenous vein: involvement of 5-HT2 and 5-HT1D-like receptors, and a comparison with grafted veins. Naunyn Schmiedebergs Arch Pharmacol 345:500\u2013508","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"4004_CR4","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.pbb.2011.05.012","volume":"99","author":"RE Brame","year":"2011","unstructured":"Brame RE, Lucot JB (2011) Guamanian Suncus murinus responsiveness to emetic stimuli and the antiemetic effects of 8-OH-DPAT. Pharmacol Biochem Behav 99:381\u2013384","journal-title":"Pharmacol Biochem Behav"},{"key":"4004_CR5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0024-3205(96)00625-X","volume":"60","author":"Y Chen","year":"1997","unstructured":"Chen Y, Saito H, Matsuki N (1997) Ethanol-induced emesis in the house musk shrew, Suncus murinus. Life Sci 60:253\u2013261","journal-title":"Life Sci"},{"key":"4004_CR6","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/S0026-895X(25)11082-1","volume":"39","author":"LJ Cornfield","year":"1991","unstructured":"Cornfield LJ, Lambert G, Arvidsson LE, Mellin C, Vallgarda J, Hacksell U, Nelson DL (1991) Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogs at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase. Mol Pharmacol 39:780\u2013787","journal-title":"Mol Pharmacol"},{"key":"4004_CR7","first-page":"462","volume":"56","author":"GH Crampton","year":"1985","unstructured":"Crampton GH, Lucot JB (1985) A stimulator for laboratory studies of motion sickness in cats. Aviat Space Environ Med 56:462\u2013465","journal-title":"Aviat Space Environ Med"},{"key":"4004_CR8","first-page":"212","volume":"62","author":"GH Crampton","year":"1991","unstructured":"Crampton GH, Lucot JB (1991) Habituation of motion sickness in the cat. Aviat Space Environ Med 62:212\u2013215","journal-title":"Aviat Space Environ Med"},{"key":"4004_CR9","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.bcp.2006.05.008","volume":"72","author":"J Dabrowska","year":"2006","unstructured":"Dabrowska J, Brylinski M (2006) Stereoselectivity of 8-OH-DPAT toward the serotonin 5-HT1A receptor: biochemical and molecular modeling study. Biochem Pharmacol 72:498\u2013511","journal-title":"Biochem Pharmacol"},{"key":"4004_CR10","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/S0022-3565(24)37340-9","volume":"284","author":"VJ De","year":"1998","unstructured":"De VJ, Schohe-Loop R, Heine HG, Greuel JM, Mauler F, Schmidt B, Sommermeyer H, Glaser T (1998) Characterization of the aminomethylchroman derivative BAY \u00d7 3702 as a highly potent 5-hydroxytryptamine1A receptor agonist. J Pharmacol Exp Ther 284:1082\u20131094","journal-title":"J Pharmacol Exp Ther"},{"key":"4004_CR11","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0014-2999(88)90789-3","volume":"147","author":"GF Francesco Di","year":"1988","unstructured":"Di Francesco GF, Petty MA, Fozard JR (1988) Antihypertensive effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in conscious dogs. Eur J Pharmacol 147:287\u2013290","journal-title":"Eur J Pharmacol"},{"key":"4004_CR12","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0022-3565(25)39565-0","volume":"267","author":"MM Foreman","year":"1993","unstructured":"Foreman MM, Fuller RW, Leander JD, Benvenga MJ, Wong DT, Nelson DL, Calligaro DO, Swanson SP, Lucot JB, Flaugh ME (1993) Preclinical studies on LY228729: a potent and selective serotonin1A agonist. J Pharmacol Exp Ther 267:58\u201371","journal-title":"J Pharmacol Exp Ther"},{"key":"4004_CR13","first-page":"463","volume":"46","author":"YK Gupta","year":"2002","unstructured":"Gupta YK, Sharma SS (2002) Involvement of 5-HT1A and 5-HT2 receptor in cisplatin induced emesis in dogs. Indian J Physiol Pharmacol 46:463\u2013467","journal-title":"Indian J Physiol Pharmacol"},{"key":"4004_CR14","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.pbb.2006.11.018","volume":"85","author":"FA Javid","year":"2006","unstructured":"Javid FA, Naylor RJ (2006) The effect of the 5-HT1A receptor agonist, 8-OH-DPAT, on motion-induced emesis in Suncus murinus. Pharmacol Biochem Behav 85:820\u2013826","journal-title":"Pharmacol Biochem Behav"},{"key":"4004_CR15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ejphar.2013.10.014","volume":"722","author":"KD Johnston","year":"2014","unstructured":"Johnston KD, Lu Z, Rudd JA (2014) Looking beyond 5-HT3 receptors: a review of the wider role of serotonin in the pharmacology of nausea and vomiting. Eur J Pharmacol 722:13\u201325","journal-title":"Eur J Pharmacol"},{"key":"4004_CR16","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1007\/s00228-012-1284-8","volume":"68","author":"P Kranke","year":"2012","unstructured":"Kranke P, Rohm KD, Diemunsch P, Gan TJ, Apfel CC, Eberhart L, Minkowitz HS, Wallenborn J, Chassard D, Lebuffe G, Fox GM, Tramer MR (2012) Intravenous buspirone for the prevention of postoperative nausea and vomiting. Eur J Clin Pharmacol 68:1465\u20131472","journal-title":"Eur J Clin Pharmacol"},{"key":"4004_CR17","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0091-3057(90)90335-F","volume":"37","author":"JB Lucot","year":"1990","unstructured":"Lucot JB (1990) Effects of serotonin antagonists on motion sickness and its suppression by 8-OH-DPAT in cats. Pharmacol Biochem Behav 37:283\u2013287","journal-title":"Pharmacol Biochem Behav"},{"key":"4004_CR18","first-page":"195","volume-title":"Mechanisms and control of emesis","author":"JB Lucot","year":"1992","unstructured":"Lucot JB (1992) Prevention of motion sickness by 5-HT1A agonists in cats1. In: Bianchi AL, Grelot L, Miller AD, King GL (eds) Mechanisms and control of emesis, vol 223. John Libbey Eurotext Ltd, London, pp 195\u2013201"},{"key":"4004_CR19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0014-2999(94)90756-0","volume":"253","author":"JB Lucot","year":"1994","unstructured":"Lucot JB (1994) Antiemetic effects of flesinoxan in cats: comparisons with 8-hydroxy-2-(di-n-propylamino)tetralin. Eur J Pharmacol 253:53\u201360","journal-title":"Eur J Pharmacol"},{"key":"4004_CR20","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0022-3565(25)24948-5","volume":"237","author":"JB Lucot","year":"1986","unstructured":"Lucot JB, Crampton GH (1986) Xylazine emesis, yohimbine and motion sickness susceptibility in the cat. J Pharmacol Exp Ther 237:450\u2013455","journal-title":"J Pharmacol Exp Ther"},{"key":"4004_CR21","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/j.1552-4604.1987.tb03003.x","volume":"27","author":"JB Lucot","year":"1987","unstructured":"Lucot JB, Crampton GH (1987a) Buspirone blocks cisplatin-induced emesis in cats. J Clin Pharmacol 27:817\u2013818","journal-title":"J Clin Pharmacol"},{"key":"4004_CR22","first-page":"989","volume":"58","author":"JB Lucot","year":"1987","unstructured":"Lucot JB, Crampton GH (1987b) Buspirone blocks motion sickness and xylazine-induced emesis in the cat. Aviat Space Environ Med 58:989\u2013991","journal-title":"Aviat Space Environ Med"},{"key":"4004_CR23","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0091-3057(89)90399-7","volume":"33","author":"JB Lucot","year":"1989","unstructured":"Lucot JB, Crampton GH (1989) 8-OH-DPAT suppresses vomiting in the cat elicited by motion, cisplatin or xylazine. Pharmacol Biochem Behav 33:627\u2013631","journal-title":"Pharmacol Biochem Behav"},{"key":"4004_CR24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2174\/1568007053544165","volume":"4","author":"HL Lutsep","year":"2005","unstructured":"Lutsep HL (2005) Repinotan, A 5-HT1A agonist, in the treatment of acute ischemic stroke. Curr Drug Targets CNS Neurol Disord 4:119\u2013120","journal-title":"Curr Drug Targets CNS Neurol Disord"},{"key":"4004_CR25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1254\/jjp.64.109","volume":"64","author":"F Okada","year":"1994","unstructured":"Okada F, Torii Y, Saito H, Matsuki N (1994) Antiemetic effects of serotonergic 5-HT1A-receptor agonists in Suncus murinus. Jpn J Pharmacol 64:109\u2013114","journal-title":"Jpn J Pharmacol"},{"key":"4004_CR26","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1016\/0014-2999(94)90048-5","volume":"262","author":"JA Rudd","year":"1994","unstructured":"Rudd JA, Jordan CC, Naylor RJ (1994) Profiles of emetic action of cisplatin in the ferret: a potential model of acute and delayed emesis. Eur J Pharmacol 262:R1\u2013R2","journal-title":"Eur J Pharmacol"},{"key":"4004_CR27","doi-asserted-by":"crossref","first-page":"D1083","DOI":"10.1093\/nar\/gks960","volume":"41","author":"JL Sharman","year":"2013","unstructured":"Sharman JL, Benson HE, Pawson AJ, Lukito V, Mpamhanga CP, Bombail V, Davenport AP, Peters JA, Spedding M, Harmar AJ (2013) IUPHAR-DB: updated database content and new features. Nucleic Acids Res 41:D1083\u2013D1088","journal-title":"Nucleic Acids Res"},{"key":"4004_CR28","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/BF02805991","volume":"127","author":"IM Vliet van","year":"1996","unstructured":"van Vliet IM, Westenberg HG, Den Boer JA (1996) Effects of the 5-HT1A receptor agonist flesinoxan in panic disorder. Psychopharmacology 127:174\u2013180","journal-title":"Psychopharmacology"},{"key":"4004_CR29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0016-5085(19)36357-7","volume":"22","author":"SC Wang","year":"1952","unstructured":"Wang SC, Borison HL (1952) A new concept of organization of the central emetic mechanism: recent studies on the sites of action of apomorphine, copper sulfate and cardiac glycosides. Gastroenterology 22:1\u201312","journal-title":"Gastroenterology"},{"key":"4004_CR30","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0091-3057(94)90438-3","volume":"49","author":"MC Wolff","year":"1994","unstructured":"Wolff MC, Leander JD (1994) Antiemetic effects of 5-HT1A agonists in the pigeon. Pharmacol Biochem Behav 49:385\u2013391","journal-title":"Pharmacol Biochem Behav"},{"key":"4004_CR31","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0091-3057(95)00142-J","volume":"52","author":"MC Wolff","year":"1995","unstructured":"Wolff MC, Leander JD (1995) Comparison of the antiemetic effects of a 5-HT1A agonist, LY228729, and 5-HT3 antagonists in the pigeon. Pharmacol Biochem Behav 52:571\u2013575","journal-title":"Pharmacol Biochem Behav"},{"key":"4004_CR32","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/(SICI)1098-2299(199701)40:1<17::AID-DDR2>3.0.CO;2-W","volume":"40","author":"MC Wolff","year":"1997","unstructured":"Wolff MC, Benvenga MJ, Calligary DO, Fuller RW, Gidda JS, Hemrick-Lueke S, Lucot JB, Nelson DL, Overshiner CD, Leander JD (1997) Pharmacological profile of LY301317, a potent and selective 5-HT1A agonist. Drug Dev Res 40:17\u201334","journal-title":"Drug Dev Res"}],"container-title":["Experimental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-014-4004-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00221-014-4004-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-014-4004-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T09:09:06Z","timestamp":1746263346000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00221-014-4004-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,10]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["4004"],"URL":"https:\/\/doi.org\/10.1007\/s00221-014-4004-z","relation":{},"ISSN":["0014-4819","1432-1106"],"issn-type":[{"type":"print","value":"0014-4819"},{"type":"electronic","value":"1432-1106"}],"subject":[],"published":{"date-parts":[[2014,6,10]]}}}