{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:42:33Z","timestamp":1792467753598,"version":"4.5.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["11SDG7270016"],"award-info":[{"award-number":["11SDG7270016"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["8UL1TR000055"],"award-info":[{"award-number":["8UL1TR000055"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["1UL1RR031973"],"award-info":[{"award-number":["1UL1RR031973"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Brain Res"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1007\/s00221-015-4527-y","type":"journal-article","created":{"date-parts":[[2015,12,20]],"date-time":"2015-12-20T23:16:04Z","timestamp":1450653364000},"page":"985-995","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Delayed grip relaxation and altered modulation of intracortical inhibition with aging"],"prefix":"10.1007","volume":"234","author":[{"given":"Binal","family":"Motawar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Stinear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail W.","family":"Lauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viswanathan","family":"Ramakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na Jin","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,21]]},"reference":[{"key":"4527_CR1","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1152\/jn.1998.80.3.1373","volume":"80","author":"A Adam","year":"1998","unstructured":"Adam A, Luca CJD, Erim Z (1998) Hand dominance and motor unit firing behavior. J Neurophysiol 80:1373\u20131382","journal-title":"J Neurophysiol"},{"key":"4527_CR2","doi-asserted-by":"publisher","first-page":"8308","DOI":"10.1523\/JNEUROSCI.2744-12.2013","volume":"33","author":"PJ Arduin","year":"2013","unstructured":"Arduin PJ, Fregnac Y, Shulz DE, Ego-Stengel V (2013) \u201cMaster\u201d neurons induced by operant conditioning in rat motor cortex during a brain-machine interface task. J Neurosci 33:8308\u20138320","journal-title":"J Neurosci"},{"key":"4527_CR3","volume-title":"Biofeedback: principles and practice for clinicians","author":"JV Basmajian","year":"1989","unstructured":"Basmajian JV (1989) Biofeedback: principles and practice for clinicians. Williams & Wilkins, Baltimore"},{"key":"4527_CR4","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.neures.2005.09.002","volume":"53","author":"T Begum","year":"2005","unstructured":"Begum T, Mima T, Oga T, Hara H, Satow T, Ikeda A, Nagamine T, Fukuyama H, Shibasaki H (2005) Cortical mechanisms of unilateral voluntary motor inhibition in humans. Neurosci Res 53:428\u2013435","journal-title":"Neurosci Res"},{"key":"4527_CR5","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.brs.2008.06.005","volume":"1","author":"A Berardelli","year":"2008","unstructured":"Berardelli A, Abbruzzese G, Chen R, Orth M, Ridding MC, Stinear C, Suppa A, Trompetto C, Thompson PD (2008) Consensus paper on short-interval intracortical inhibition and other transcranial magnetic stimulation intracortical paradigms in movement disorders. Brain Stimul 1:183\u2013191","journal-title":"Brain Stimul"},{"key":"4527_CR6","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1111\/j.1460-9568.2008.06090.x","volume":"27","author":"K Boros","year":"2008","unstructured":"Boros K, Poreisz C, Munchau A, Paulus W, Nitsche MA (2008) Premotor transcranial direct current stimulation (tDCS) affects primary motor excitability in humans. Eur J Neurosci 27:1292\u20131300","journal-title":"Eur J Neurosci"},{"key":"4527_CR7","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/0013-4694(90)90002-2","volume":"76","author":"B Brouwer","year":"1990","unstructured":"Brouwer B, Ashby P (1990) Corticospinal projections to upper and lower limb spinal motoneurons in man. Electroencephalogr Clin Neurophysiol 76:509\u2013519","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"4527_CR8","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1113\/jphysiol.2004.064774","volume":"558","author":"A Buccolieri","year":"2004","unstructured":"Buccolieri A, Abbruzzese G, Rothwell JC (2004) Relaxation from a voluntary contraction is preceded by increased excitability of motor cortical inhibitory circuits. J Physiol 558:685\u2013695","journal-title":"J Physiol"},{"key":"4527_CR11","doi-asserted-by":"publisher","first-page":"3371","DOI":"10.1152\/jn.01334.2005","volume":"95","author":"JP Coxon","year":"2006","unstructured":"Coxon JP, Stinear CM, Byblow WD (2006) Intracortical inhibition during volitional inhibition of prepared action. J Neurophysiol 95:3371\u20133383","journal-title":"J Neurophysiol"},{"issue":"Pt 7","key":"4527_CR12","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1093\/brain\/122.7.1327","volume":"122","author":"AM de Noordhout","year":"1999","unstructured":"de Noordhout AM, Rapisarda G, Bogacz D, Gerard P, De Pasqua V, Pennisi G, Delwaide PJ (1999) Corticomotoneuronal synaptic connections in normal man: an electrophysiological study. Brain 122(Pt 7):1327\u20131340","journal-title":"Brain"},{"key":"4527_CR13","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1037\/0882-7974.21.1.62","volume":"21","author":"G Der","year":"2006","unstructured":"Der G, Deary IJ (2006) Age and sex differences in reaction time in adulthood: results from the United Kingdom Health and Lifestyle Survey. Psychol Aging 21:62\u201373","journal-title":"Psychol Aging"},{"key":"4527_CR14","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1113\/jphysiol.2004.061747","volume":"564","author":"V Di Lazzaro","year":"2005","unstructured":"Di Lazzaro V, Oliviero A, Saturno E, Dileone M, Pilato F, Nardone R, Ranieri F, Musumeci G, Fiorilla T, Tonali P (2005) Effects of lorazepam on short latency afferent inhibition and short latency intracortical inhibition in humans. J Physiol 564:661\u2013668","journal-title":"J Physiol"},{"key":"4527_CR15","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1113\/jphysiol.2006.114694","volume":"575","author":"V Di Lazzaro","year":"2006","unstructured":"Di Lazzaro V, Pilato F, Dileone M, Ranieri F, Ricci V, Profice P, Bria P, Tonali PA, Ziemann U (2006) GABAA receptor subtype specific enhancement of inhibition in human motor cortex. J Physiol 575:721\u2013726","journal-title":"J Physiol"},{"key":"4527_CR16","doi-asserted-by":"publisher","first-page":"3555","DOI":"10.1152\/jn.00348.2005","volume":"94","author":"J Duclay","year":"2005","unstructured":"Duclay J, Martin A (2005) Evoked H-reflex and V-wave responses during maximal isometric, concentric, and eccentric muscle contraction. J Neurophysiol 94:3555\u20133562","journal-title":"J Neurophysiol"},{"key":"4527_CR17","doi-asserted-by":"publisher","first-page":"P179","DOI":"10.1093\/geronj\/49.4.P179","volume":"49","author":"JL Fozard","year":"1994","unstructured":"Fozard JL, Vercryssen M, Reynolds SL, Hancock PA, Quilter RE (1994) Age differences and changes in reaction time: the Baltimore Longitudinal Study of Aging. Journal of gerontology 49:P179\u2013P189","journal-title":"Journal of gerontology"},{"issue":"1484","key":"4527_CR18","first-page":"e1414","volume":"33","author":"H Fujiyama","year":"2012","unstructured":"Fujiyama H, Hinder MR, Schmidt MW, Garry MI, Summers JJ (2012) Age-related differences in corticospinal excitability and inhibition during coordination of upper and lower limbs. Neurobiol Aging 33(1484):e1414\u2013e1481","journal-title":"Neurobiol Aging"},{"key":"4527_CR20","doi-asserted-by":"publisher","first-page":"9039","DOI":"10.1523\/JNEUROSCI.4094-12.2013","volume":"33","author":"KF Heise","year":"2013","unstructured":"Heise KF, Zimerman M, Hoppe J, Gerloff C, Wegscheider K, Hummel FC (2013) The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance. J Neurosci 33:9039\u20139049","journal-title":"J Neurosci"},{"key":"4527_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jneumeth.2008.02.012","volume":"171","author":"M Knikou","year":"2008","unstructured":"Knikou M (2008) The H-reflex as a probe: pathways and pitfalls. J Neurosci Methods 171:1\u201312","journal-title":"J Neurosci Methods"},{"key":"4527_CR22","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1113\/jphysiol.1993.sp019912","volume":"471","author":"T Kujirai","year":"1993","unstructured":"Kujirai T, Caramia MD, Rothwell JC, Day BL, Thompson PD, Ferbert A, Wroe S, Asselman P, Marsden CD (1993) Corticocortical inhibition in human motor cortex. J Physiol 471:501\u2013519","journal-title":"J Physiol"},{"key":"4527_CR23","first-page":"17","volume":"4","author":"J Langan","year":"2010","unstructured":"Langan J, Peltier SJ, Bo J, Fling BW, Welsh RC, Seidler RD (2010) Functional implications of age differences in motor system connectivity. Front Syst Neurosci 4:17","journal-title":"Front Syst Neurosci"},{"key":"4527_CR24","first-page":"11","volume":"50","author":"J Lexell","year":"1995","unstructured":"Lexell J (1995) Human aging, muscle mass, and fiber type composition. J Gerontol Ser A Biol Sci Med Sci 50:11\u201316","journal-title":"J Gerontol Ser A Biol Sci Med Sci"},{"key":"4527_CR25","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.neures.2011.04.004","volume":"70","author":"M Marneweck","year":"2011","unstructured":"Marneweck M, Loftus A, Hammond G (2011) Short-interval intracortical inhibition and manual dexterity in healthy aging. Neurosci Res 70:408\u2013414","journal-title":"Neurosci Res"},{"key":"4527_CR27","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/0301-0082(95)00012-K","volume":"46","author":"U Misgeld","year":"1995","unstructured":"Misgeld U, Bijak M, Jarolimek W (1995) A physiological role for GABAB receptors and the effects of baclofen in the mammalian central nervous system. Prog Neurobiol 46:423\u2013462","journal-title":"Prog Neurobiol"},{"key":"4527_CR28","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s00221-012-3173-x","volume":"221","author":"B Motawar","year":"2012","unstructured":"Motawar B, Hur P, Stinear J, Seo NJ (2012) Contribution of intracortical inhibition in voluntary muscle relaxation. Exp Brain Res 221:299\u2013308","journal-title":"Exp Brain Res"},{"key":"4527_CR30","first-page":"105","volume":"2","author":"K Ohlendieck","year":"2011","unstructured":"Ohlendieck K (2011) Proteomic Profiling of Fast-To-Slow Muscle Transitions during Aging. Frontiers in physiology 2:105","journal-title":"Frontiers in physiology"},{"key":"4527_CR31","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/0028-3932(71)90067-4","volume":"9","author":"RC Oldfield","year":"1971","unstructured":"Oldfield RC (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9:97\u2013113","journal-title":"Neuropsychologia"},{"key":"4527_CR32","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.neures.2006.02.002","volume":"55","author":"A Oliviero","year":"2006","unstructured":"Oliviero A, Profice P, Tonali PA, Pilato F, Saturno E, Dileone M, Ranieri F, Di Lazzaro V (2006) Effects of aging on motor cortex excitability. Neurosci Res 55:74\u201377","journal-title":"Neurosci Res"},{"key":"4527_CR33","doi-asserted-by":"publisher","first-page":"5147","DOI":"10.1113\/jphysiol.2008.158956","volume":"586","author":"E Ortu","year":"2008","unstructured":"Ortu E, Deriu F, Suppa A, Tolu E, Rothwell JC (2008) Effects of volitional contraction on intracortical inhibition and facilitation in the human motor cortex. J Physiol 586:5147\u20135159","journal-title":"J Physiol"},{"key":"4527_CR34","first-page":"268","volume":"39","author":"RM Palmieri","year":"2004","unstructured":"Palmieri RM, Ingersoll CD, Hoffman MA (2004) The hoffmann reflex: methodologic considerations and applications for use in sports medicine and athletic training research. J Athl Train 39:268\u2013277","journal-title":"J Athl Train"},{"key":"4527_CR35","first-page":"28","volume":"6","author":"S Papegaaij","year":"2014","unstructured":"Papegaaij S, Taube W, Baudry S, Otten E, Hortobagyi T (2014) Aging causes a reorganization of cortical and spinal control of posture. Front Aging Neurosci 6:28","journal-title":"Front Aging Neurosci"},{"key":"4527_CR36","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0304-3940(01)02239-X","volume":"313","author":"A Peinemann","year":"2001","unstructured":"Peinemann A, Lehner C, Conrad B, Siebner HR (2001) Age-related decrease in paired-pulse intracortical inhibition in the human primary motor cortex. Neurosci Lett 313:33\u201336","journal-title":"Neurosci Lett"},{"key":"4527_CR37","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1016\/j.clinph.2008.05.031","volume":"119","author":"SH Peurala","year":"2008","unstructured":"Peurala SH, Muller-Dahlhaus JF, Arai N, Ziemann U (2008) Interference of short-interval intracortical inhibition (SICI) and short-interval intracortical facilitation (SICF). Clin Neurophysiol 119:2291\u20132297","journal-title":"Clin Neurophysiol"},{"key":"4527_CR38","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1002\/mus.24279","volume":"51","author":"PC Raffalt","year":"2014","unstructured":"Raffalt PC, Alkjaer T, Simonsen EB (2014) Changes in soleus H-reflex during walking in middle-aged healthy subjects. Muscle Nerve 51:419\u2013425","journal-title":"Muscle Nerve"},{"key":"4527_CR39","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1016\/j.clinph.2010.12.037","volume":"122","author":"S Rossi","year":"2011","unstructured":"Rossi S, Hallett M, Rossini PM, Pascual-Leone A (2011) Screening questionnaire before TMS: an update. Clin Neurophysiol 122:1686","journal-title":"Clin Neurophysiol"},{"key":"4527_CR40","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/0013-4694(94)90029-9","volume":"91","author":"PM Rossini","year":"1994","unstructured":"Rossini PM, Barker AT, Berardelli A, Caramia MD, Caruso G, Cracco RQ, Dimitrijevic MR, Hallett M, Katayama Y, Lucking CH et al (1994) Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application. Report of an IFCN committee. Electroencephalogr Clin Neurophysiol 91:79\u201392","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"4527_CR41","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.clinph.2015.02.001","volume":"126","author":"PM Rossini","year":"2015","unstructured":"Rossini PM, Burke D, Chen R, Cohen LG, Daskalakis Z, Di Iorio R, Di Lazzaro V, Ferreri F, Fitzgerald PB, George MS, Hallett M, Lefaucheur JP, Langguth B, Matsumoto H, Miniussi C, Nitsche MA, Pascual-Leone A, Paulus W, Rossi S, Rothwell JC, Siebner HR, Ugawa Y, Walsh V, Ziemann U (2015) Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: basic principles and procedures for routine clinical and research application. An updated report from an I.F.C.N. Committee. Clin Neurophysiol 126:1071\u20131107","journal-title":"Clin Neurophysiol"},{"key":"4527_CR42","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/j.1469-7793.2001.0307l.x","volume":"530","author":"TD Sanger","year":"2001","unstructured":"Sanger TD, Garg RR, Chen R (2001) Interactions between two different inhibitory systems in the human motor cortex. J Physiol 530:307\u2013317","journal-title":"J Physiol"},{"key":"4527_CR43","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1007\/BF00237985","volume":"56","author":"M Schieppati","year":"1984","unstructured":"Schieppati M, Crenna P (1984) From activity to rest: gating of excitatory autogenetic afferences from the relaxing muscle in man. Exp Brain Res 56:448\u2013457","journal-title":"Exp Brain Res"},{"key":"4527_CR44","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0304-3940(85)90421-5","volume":"61","author":"M Schieppati","year":"1985","unstructured":"Schieppati M, Poloni M, Nardone A (1985) Voluntary muscle release is not accompanied by H-reflex inhibition in patients with upper moto neuron lesions. Neurosci Lett 61:177\u2013181","journal-title":"Neurosci Lett"},{"key":"4527_CR45","first-page":"59","volume":"5","author":"M Schieppati","year":"1986","unstructured":"Schieppati M, Nardone A, Musazzi M (1986) Modulation of the Hoffmann reflex by rapid muscle contraction or release. Hum Neurobiol 5:59\u201366","journal-title":"Hum Neurobiol"},{"key":"4527_CR47","doi-asserted-by":"publisher","first-page":"3108","DOI":"10.1152\/jn.91108.2008","volume":"101","author":"NJ Seo","year":"2009","unstructured":"Seo NJ, Rymer WZ, Kamper DG (2009) Delays in grip initiation and termination in persons with stroke: effects of arm support and active muscle stretch exercise. J Neurophysiol 101:3108\u20133115","journal-title":"J Neurophysiol"},{"key":"4527_CR49","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1212\/WNL.53.7.1458","volume":"53","author":"CD Smith","year":"1999","unstructured":"Smith CD, Umberger GH, Manning EL, Slevin JT, Wekstein DR, Schmitt FA, Markesbery WR, Zhang Z, Gerhardt GA, Kryscio RJ, Gash DM (1999) Critical decline in fine motor hand movements in human aging. Neurology 53:1458\u20131461","journal-title":"Neurology"},{"key":"4527_CR50","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.1093\/cercor\/bhp015","volume":"19","author":"MB Spraker","year":"2009","unstructured":"Spraker MB, Corcos DM, Vaillancourt DE (2009) Cortical and subcortical mechanisms for precisely controlled force generation and force relaxation. Cereb Cortex 19:2640\u20132650","journal-title":"Cereb Cortex"},{"key":"4527_CR51","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1152\/jn.91060.2008","volume":"101","author":"CJ Stagg","year":"2009","unstructured":"Stagg CJ, Wylezinska M, Matthews PM, Johansen-Berg H, Jezzard P, Rothwell JC, Bestmann S (2009) Neurochemical effects of theta burst stimulation as assessed by magnetic resonance spectroscopy. J Neurophysiol 101:2872\u20132877","journal-title":"J Neurophysiol"},{"key":"4527_CR52","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s00221-007-0989-x","volume":"182","author":"RB Stein","year":"2007","unstructured":"Stein RB, Estabrooks KL, McGie S, Roth MJ, Jones KE (2007) Quantifying the effects of voluntary contraction and inter-stimulus interval on the human soleus H-reflex. Exp Brain Res 182:309\u2013319","journal-title":"Exp Brain Res"},{"key":"4527_CR53","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.clinph.2012.07.005","volume":"124","author":"I Stetkarova","year":"2013","unstructured":"Stetkarova I, Kofler M (2013) Differential effect of baclofen on cortical and spinal inhibitory circuits. Clin Neurophysiol 124:339\u2013345","journal-title":"Clin Neurophysiol"},{"key":"4527_CR55","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3109\/00207458909002170","volume":"48","author":"U Tan","year":"1989","unstructured":"Tan U (1989) The H-reflex recovery curve from the wrist flexors: lateralization of motoneuronal excitability in relation to handedness in normal subjects. Int J Neurosci 48:271\u2013284","journal-title":"Int J Neurosci"},{"key":"4527_CR56","unstructured":"Tenteromano L, Amsterdam AJ, Brangaccio J, Sniffen J, Thompson AK (2012) Operant conditioning of the ankle dorsiflexor motor evoked potential (MEP) in people with and without CNS damage: Changes MEP size and silent period. In: Society for Neuroscience 42nd Annual Meeting, vol. 378.08 New Orleans, LA"},{"key":"4527_CR57","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/nrn1009","volume":"4","author":"AW Toga","year":"2003","unstructured":"Toga AW, Thompson PM (2003) Mapping brain asymmetry. Nat Rev Neurosci 4:37\u201348","journal-title":"Nat Rev Neurosci"},{"key":"4527_CR58","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1523\/JNEUROSCI.19-09-03527.1999","volume":"19","author":"K Toma","year":"1999","unstructured":"Toma K, Honda M, Hanakawa T, Okada T, Fukuyama H, Ikeda A, Nishizawa S, Konishi J, Shibasaki H (1999) Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation: an event-related fMRI study. J Neurosci 19:3527\u20133534","journal-title":"J Neurosci"},{"key":"4527_CR59","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.biopsycho.2011.11.005","volume":"89","author":"MC van de Laar","year":"2012","unstructured":"van de Laar MC, van den Wildenberg WP, van Boxtel GJ, Huizenga HM, van der Molen MW (2012) Lifespan changes in motor activation and inhibition during choice reactions: a Laplacian ERP study. Biol Psychol 89:323\u2013334","journal-title":"Biol Psychol"},{"key":"4527_CR60","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1093\/ptj\/70.10.652","volume":"70","author":"SL Wolf","year":"1990","unstructured":"Wolf SL, Segal RL (1990) Conditioning of the spinal stretch reflex: implications for rehabilitation. Phys Ther 70:652\u2013656","journal-title":"Phys Ther"},{"key":"4527_CR61","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3389\/fnagi.2014.00079","volume":"6","author":"R Wolkorte","year":"2014","unstructured":"Wolkorte R, Kamphuis J, Zijdewind I (2014) Increased reaction times and reduced response preparation already starts at middle age. Front Aging Neurosci 6:79","journal-title":"Front Aging Neurosci"},{"key":"4527_CR62","first-page":"104","volume":"6","author":"T Wong","year":"2002","unstructured":"Wong T (2002) Aging of the cerebral cortex. McGill J Med 6:104\u2013113","journal-title":"McGill J Med"},{"key":"4527_CR63","first-page":"366","volume":"91","author":"PI Yakovlev","year":"1966","unstructured":"Yakovlev PI, Rakic P (1966) Patterns of decussation of bulbar pyramids and distribution of pyramidal tracts on two sides of the spinal cord. Trans Am Neurol Assoc 91:366\u2013367","journal-title":"Trans Am Neurol Assoc"},{"key":"4527_CR64","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s00421-002-0577-5","volume":"86","author":"EP Zehr","year":"2002","unstructured":"Zehr EP (2002) Considerations for use of the Hoffmann reflex in exercise studies. Eur J Appl Physiol 86:455\u2013468","journal-title":"Eur J Appl Physiol"},{"key":"4527_CR65","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/S0924-980X(98)00023-X","volume":"109","author":"U Ziemann","year":"1998","unstructured":"Ziemann U, Tergau F, Wischer S, Hildebrandt J, Paulus W (1998) Pharmacological control of facilitatory I-wave interaction in the human motor cortex. A paired transcranial magnetic stimulation study. Electroencephalogr Clin Neurophysiol 109:321\u2013330","journal-title":"Electroencephalogr Clin Neurophysiol"}],"container-title":["Experimental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-015-4527-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00221-015-4527-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-015-4527-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-015-4527-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T05:48:33Z","timestamp":1589608113000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00221-015-4527-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,21]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["4527"],"URL":"https:\/\/doi.org\/10.1007\/s00221-015-4527-y","relation":{},"ISSN":["0014-4819","1432-1106"],"issn-type":[{"value":"0014-4819","type":"print"},{"value":"1432-1106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,21]]},"assertion":[{"value":"2 September 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None of the authors have potential conflicts of interest to be disclosed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}