{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:40:14Z","timestamp":1790707214487,"version":"4.1.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T00:00:00Z","timestamp":1481155200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"JSPS KAKENHI","award":["Grant Number 16K11679"],"award-info":[{"award-number":["Grant Number 16K11679"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Brain Res"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1007\/s00221-016-4852-9","type":"journal-article","created":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T11:23:45Z","timestamp":1481196225000},"page":"913-921","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Bilateral increases in ERK activation at the spinomedullary junction region by acute masseter muscle injury during temporomandibular joint inflammation in the rats"],"prefix":"10.1007","volume":"235","author":[{"given":"Masayuki","family":"Kurose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Imbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Nakatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mana","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noritaka","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritsuo","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Yamamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiko","family":"Senba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3519-9561","authenticated-orcid":false,"given":"Keiichiro","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,8]]},"reference":[{"key":"4852_CR1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.pain.2004.06.009","volume":"111","author":"H Adwanikar","year":"2004","unstructured":"Adwanikar H, Karim F, Gereau RWT (2004) Inflammation persistently enhances nocifensive behaviors mediated by spinal group I mGluRs through sustained ERK activation. Pain 111:125\u2013135","journal-title":"Pain"},{"key":"4852_CR2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0304-3959(93)90156-J","volume":"55","author":"AM Aloisi","year":"1993","unstructured":"Aloisi AM, Porro CA, Cavazzuti M, Baraldi P, Carli G (1993) \u2018Mirror pain\u2019 in the formalin test: behavioral and 2-deoxyglucose studies. Pain 55:267\u2013273","journal-title":"Pain"},{"key":"4852_CR3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.neulet.2006.02.003","volume":"399","author":"R Ambalavanar","year":"2006","unstructured":"Ambalavanar R, Moutanni A, Dessem D (2006) Inflammation of craniofacial muscle induces widespread mechanical allodynia. Neurosci Lett 399:249\u2013254","journal-title":"Neurosci Lett"},{"key":"4852_CR4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0304-3959(99)00246-8","volume":"85","author":"DA Bereiter","year":"2000","unstructured":"Bereiter DA, Bereiter DF (2000) Morphine and NMDA receptor antagonism reduce c-fos expression in spinal trigeminal nucleus produced by acute injury to the TMJ region. Pain 85:65\u201377","journal-title":"Pain"},{"key":"4852_CR5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.pain.2005.05.013","volume":"117","author":"DA Bereiter","year":"2005","unstructured":"Bereiter DA, Okamoto K, Bereiter DF (2005) Effect of persistent monoarthritis of the temporomandibular joint region on acute mustard oil-induced excitation of trigeminal subnucleus caudalis neurons in male and female rats. Pain 117:58\u201367","journal-title":"Pain"},{"key":"4852_CR6","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.jpain.2013.02.005","volume":"14","author":"Y Cao","year":"2013","unstructured":"Cao Y, Li K, Fu KY, Xie QF, Chiang CY, Sessle BJ (2013) Central sensitization and MAPKs are involved in occlusal interference-induced facial pain in rats. J Pain 14:793\u2013807","journal-title":"J Pain"},{"key":"4852_CR7","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1744-8069-8-78","volume":"8","author":"B Chai","year":"2012","unstructured":"Chai B, Guo W, Wei F, Dubner R, Ren K (2012) Trigeminal-rostral ventromedial medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury. Mol Pain 8:78","journal-title":"Mol Pain"},{"key":"4852_CR8","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1097\/j.pain.0000000000000280","volume":"156","author":"CF Cheng","year":"2015","unstructured":"Cheng CF, Cheng JK, Chen CY, Rau RH, Chang YC, Tsaur ML (2015) Nerve growth factor-induced synapse-like structures in contralateral sensory ganglia contribute to chronic mirror-image pain. Pain 156:2295\u20132309","journal-title":"Pain"},{"key":"4852_CR9","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0304-3940(89)90125-0","volume":"103","author":"P Clavelou","year":"1989","unstructured":"Clavelou P, Pajot J, Dallel R, Raboisson P (1989) Application of the formalin test to the study of orofacial pain in the rat. Neurosci Lett 103:349\u2013353","journal-title":"Neurosci Lett"},{"key":"4852_CR10","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.pain.2005.05.031","volume":"116","author":"CD Cruz","year":"2005","unstructured":"Cruz CD, Neto FL, Castro-Lopes J, McMahon SB, Cruz F (2005) Inhibition of ERK phosphorylation decreases nociceptive behaviour in monoarthritic rats. Pain 116:411\u2013419","journal-title":"Pain"},{"key":"4852_CR11","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1523\/JNEUROSCI.19-06-02394.1999","volume":"19","author":"N Danziger","year":"1999","unstructured":"Danziger N, Weil-Fugazza J, LeBars D, Bouhassira D (1999) Alteration of descending modulation of nociception during the course of monoarthritis. J Neurosci 19:2394\u20132400","journal-title":"J Neurosci"},{"key":"4852_CR12","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0166-2236(99)01481-2","volume":"22","author":"LF Donaldson","year":"1999","unstructured":"Donaldson LF (1999) Unilateral arthritis: contralateral effects. Trends Neurosci 22:495\u2013496","journal-title":"Trends Neurosci"},{"key":"4852_CR13","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1139\/y91-090","volume":"69","author":"R Dubner","year":"1991","unstructured":"Dubner R (1991) Basic mechanisms of pain associated with deep tissues. Can J Physiol Pharmacol 69:607\u2013609","journal-title":"Can J Physiol Pharmacol"},{"key":"4852_CR14","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0304-3940(83)90255-0","volume":"36","author":"M Fitzgerald","year":"1983","unstructured":"Fitzgerald M (1983) Influences of contralateral nerve and skin stimulation on neurones in the substantia gelatinosa of the rat spinal cord. Neurosci Lett 36:139\u2013143","journal-title":"Neurosci Lett"},{"key":"4852_CR15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2174\/1876386300902010011","volume":"2","author":"YJ Gao","year":"2009","unstructured":"Gao YJ, Ji RR (2009) c-Fos and pERK, which is a better marker for neuronal activation and central sensitization after noxious stimulation and tissue injury? Open Pain J 2:11\u201317","journal-title":"Open Pain J"},{"key":"4852_CR16","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/cne.903560311","volume":"356","author":"CB Hathaway","year":"1995","unstructured":"Hathaway CB, Hu JW, Bereiter DA (1995) Distribution of Fos-like immunoreactivity in the caudal brainstem of the rat following noxious chemical stimulation of the temporomandibular joint. J Comp Neurol 356:444\u2013456","journal-title":"J Comp Neurol"},{"key":"4852_CR17","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0304-3959(92)90131-T","volume":"48","author":"JW Hu","year":"1992","unstructured":"Hu JW, Sessle BJ, Raboisson P, Dallel R, Woda A (1992) Stimulation of craniofacial muscle afferents induces prolonged facilitatory effects in trigeminal nociceptive brain-stem neurones. Pain 48:53\u201360","journal-title":"Pain"},{"key":"4852_CR18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0006-8993(00)02015-1","volume":"861","author":"WJ Huang","year":"2000","unstructured":"Huang WJ, Wang BR, Yao LB et al (2000) Activity of p44\/42 MAP kinase in the caudal subnucleus of trigeminal spinal nucleus is increased following perioral noxious stimulation in the mouse. Brain Res 861:181\u2013185","journal-title":"Brain Res"},{"key":"4852_CR19","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1097\/01.brs.0000176239.72928.00","volume":"30","author":"RD Hubbard","year":"2005","unstructured":"Hubbard RD, Winkelstein BA (2005) Transient cervical nerve root compression in the rat induces bilateral forepaw allodynia and spinal glial activation: mechanical factors in painful neck injuries. Spine (Phila Pa 1976) 30:1924\u20131932","journal-title":"Spine (Phila Pa 1976)"},{"key":"4852_CR20","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.jbiomech.2007.09.026","volume":"41","author":"RD Hubbard","year":"2008","unstructured":"Hubbard RD, Chen Z, Winkelstein BA (2008) Transient cervical nerve root compression modulates pain: load thresholds for allodynia and sustained changes in spinal neuropeptide expression. J Biomech 41:677\u2013685","journal-title":"J Biomech"},{"key":"4852_CR21","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1159\/000047887","volume":"169","author":"H Imbe","year":"2001","unstructured":"Imbe H, Iwata K, Zhou QQ, Zou S, Dubner R, Ren K (2001) Orofacial deep and cutaneous tissue inflammation and trigeminal neuronal activation. Implications for persistent temporomandibular pain. Cells Tissues Organs 169:238\u2013247","journal-title":"Cells Tissues Organs"},{"key":"4852_CR22","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1152\/jn.1999.82.3.1244","volume":"82","author":"K Iwata","year":"1999","unstructured":"Iwata K, Tashiro A, Tsuboi Y et al (1999) Medullary dorsal horn neuronal activity in rats with persistent temporomandibular joint and perioral inflammation. J Neurophysiol 82:1244\u20131253","journal-title":"J Neurophysiol"},{"key":"4852_CR23","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/16040","volume":"2","author":"RR Ji","year":"1999","unstructured":"Ji RR, Baba H, Brenner GJ, Woolf CJ (1999) Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat Neurosci 2:1114\u20131119","journal-title":"Nat Neurosci"},{"key":"4852_CR24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0896-6273(02)00908-X","volume":"36","author":"RR Ji","year":"2002","unstructured":"Ji RR, Samad TA, Jin SX, Schmoll R, Woolf CJ (2002) p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron 36:57\u201368","journal-title":"Neuron"},{"key":"4852_CR25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.brainresrev.2008.12.011","volume":"60","author":"RR Ji","year":"2009","unstructured":"Ji RR, Gereau RW, Malcangio M, Strichartz GR (2009) MAP kinase and pain. Brain Res Rev 60:135\u2013148","journal-title":"Brain Res Rev"},{"key":"4852_CR26","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0166-2236(98)01302-2","volume":"22","author":"M Koltzenburg","year":"1999","unstructured":"Koltzenburg M, Wall PD, McMahon SB (1999) Does the right side know what the left side is doing? Trends Neurosci 22:122\u2013127","journal-title":"Trends Neurosci"},{"key":"4852_CR27","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1523\/JNEUROSCI.05-05-01380.1985","volume":"5","author":"JD Levine","year":"1985","unstructured":"Levine JD, Dardick SJ, Basbaum AI, Scipio E (1985) Reflex neurogenic inflammation. I. Contribution of the peripheral nervous system to spatially remote inflammatory responses that follow injury. J Neurosci 5:1380\u20131386","journal-title":"J Neurosci"},{"key":"4852_CR28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0304-3959(93)90027-M","volume":"54","author":"S Mense","year":"1993","unstructured":"Mense S (1993) Nociception from skeletal muscle in relation to clinical muscle pain. Pain 54:241\u2013289","journal-title":"Pain"},{"key":"4852_CR29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(98)00048-3","volume":"57","author":"MJ Millan","year":"1999","unstructured":"Millan MJ (1999) The induction of pain: an integrative review. Prog Neurobiol 57:1\u2013164","journal-title":"Prog Neurobiol"},{"key":"4852_CR30","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/cne.902890303","volume":"289","author":"C Molander","year":"1989","unstructured":"Molander C, Xu Q, Rivero-Melian C, Grant G (1989) Cytoarchitectonic organization of the spinal cord in the rat: II. The cervical and upper thoracic cord. J Comp Neurol 289:375\u2013385","journal-title":"J Comp Neurol"},{"key":"4852_CR31","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0306-4522(99)00185-2","volume":"94","author":"FL Neto","year":"1999","unstructured":"Neto FL, Schradrack J, Ableitner A, Castro-Lopes JM, Bartenstein P, Zieglgansberger W, Tolle TR (1999) Supraspinal metabolic activity changes in the rat during adjuvant monoarthritis. Neuroscience 94:607\u2013621","journal-title":"Neuroscience"},{"key":"4852_CR32","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1002\/cne.21620","volume":"507","author":"N Noma","year":"2008","unstructured":"Noma N, Tsuboi Y, Kondo M et al (2008) Organization of pERK-immunoreactive cells in trigeminal spinal nucleus caudalis and upper cervical cord following capsaicin injection into oral and craniofacial regions in rats. J Comp Neurol 507:1428\u20131440","journal-title":"J Comp Neurol"},{"key":"4852_CR33","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1016\/j.lfs.2004.01.007","volume":"74","author":"K Obata","year":"2004","unstructured":"Obata K, Noguchi K (2004) MAPK activation in nociceptive neurons and pain hypersensitivity. Life Sci 74:2643\u20132653","journal-title":"Life Sci"},{"key":"4852_CR34","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2535\/ofaj.83.43","volume":"83","author":"SH Oh","year":"2006","unstructured":"Oh SH, Imbe H, Iwai-Liao Y (2006) TMJ inflammation increases Fos expression in the nucleus raphe magnus induced by subsequent formalin injection of the masseter or hindpaw of rats. Okajimas Folia Anat Jpn 83:43\u201352","journal-title":"Okajimas Folia Anat Jpn"},{"key":"4852_CR35","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.neulet.2004.06.017","volume":"367","author":"K Okamoto","year":"2004","unstructured":"Okamoto K, Imbe H, Tashiro A, Kumabe S, Senba E (2004) Blockade of peripheral 5HT3 receptor attenuates the formalin-induced nocifensive behavior in persistent temporomandibular joint inflammation of rat. Neurosci Lett 367:259\u2013263","journal-title":"Neurosci Lett"},{"key":"4852_CR36","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.neuroscience.2004.10.004","volume":"130","author":"K Okamoto","year":"2005","unstructured":"Okamoto K, Imbe H, Tashiro A, Kimura A, Donishi T, Tamai Y, Senba E (2005) The role of peripheral 5HT2A and 5HT1A receptors on the orofacial formalin test in rats with persistent temporomandibular joint inflammation. Neuroscience 130:465\u2013474","journal-title":"Neuroscience"},{"key":"4852_CR37","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s00221-005-0218-4","volume":"170","author":"K Okamoto","year":"2006","unstructured":"Okamoto K, Kimura A, Donishi T et al (2006) Persistent monoarthritis of the temporomandibular joint region enhances nocifensive behavior and lumbar spinal Fos expression after noxious stimulation to the hindpaw in rats. Exp Brain Res 170:358\u2013367","journal-title":"Exp Brain Res"},{"key":"4852_CR38","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.neuroscience.2007.05.012","volume":"147","author":"K Okamoto","year":"2007","unstructured":"Okamoto K, Imbe H, Kimura A, Donishi T, Tamai Y, Senba E (2007) Activation of central 5HT2A receptors reduces the craniofacial nociception of rats. Neuroscience 147:1090\u20131102","journal-title":"Neuroscience"},{"key":"4852_CR39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3959(02)00368-8","volume":"100","author":"K Ren","year":"2002","unstructured":"Ren K, Dubner R (2002) Descending modulation in persistent pain: an update. Pain 100:1\u20136","journal-title":"Pain"},{"key":"4852_CR40","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0304-3959(03)00095-2","volume":"102","author":"E Sarlani","year":"2003","unstructured":"Sarlani E, Greenspan JD (2003) Evidence for generalized hyperalgesia in temporomandibular disorders patients. Pain 102:221\u2013226","journal-title":"Pain"},{"key":"4852_CR41","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0304-3959(93)90183-P","volume":"55","author":"HG Schaible","year":"1993","unstructured":"Schaible HG, Grubb BD (1993) Afferent and spinal mechanisms of joint pain. Pain 55:5\u201354","journal-title":"Pain"},{"key":"4852_CR42","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1186\/ar121","volume":"2","author":"G Segond von Banchet","year":"2000","unstructured":"Segond von Banchet G, Petrow PK, Brauer R, Schaible H-G (2000) Monoarticular antigen-induced arthritis leads to pronounced bilateral upregulation of the expression of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion neurons of rats. Arthritis Res 2:424\u2013427","journal-title":"Arthritis Res"},{"key":"4852_CR43","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.pain.2006.02.032","volume":"123","author":"D Seino","year":"2006","unstructured":"Seino D, Tokunaga A, Tachibana T et al (2006) The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed knee joint. Pain 123:193\u2013203","journal-title":"Pain"},{"key":"4852_CR44","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1093\/rheumatology\/keg397","volume":"42","author":"N Shenker","year":"2003","unstructured":"Shenker N, Haigh R, Roberts E, Mapp P, Harris N, Blake D (2003) A review of contralateral responses to a unilateral inflammatory lesion. Rheumatology 42:1279\u20131286","journal-title":"Rheumatology"},{"key":"4852_CR45","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1744-8069-9-68","volume":"9","author":"S Simonic-Kocijan","year":"2013","unstructured":"Simonic-Kocijan S, Zhao X, Liu W, Wu Y, Uhac I, Wang K (2013) TRPV1 channel-mediated bilateral allodynia induced by unilateral masseter muscle inflammation in rats. Mol Pain 9:68","journal-title":"Mol Pain"},{"key":"4852_CR46","first-page":"225","volume":"21","author":"I Suzuki","year":"2007","unstructured":"Suzuki I, Harada T, Asano M et al (2007) Phosphorylation of ERK in trigeminal spinal nucleus neurons following passive jaw movement in rats with chronic temporomandibular joint inflammation. J Orofac Pain 21:225\u2013231","journal-title":"J Orofac Pain"},{"key":"4852_CR47","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1152\/jn.2001.86.5.2393","volume":"86","author":"S Takeshita","year":"2001","unstructured":"Takeshita S, Hirata H, Bereiter DA (2001) Intensity coding by TMJ-responsive neurons in superficial laminae of caudal medullary dorsal horn of the rat. J Neurophysiol 86:2393\u20132404","journal-title":"J Neurophysiol"},{"key":"4852_CR48","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/j.neuroscience.2009.09.058","volume":"164","author":"A Tashiro","year":"2009","unstructured":"Tashiro A, Okamoto K, Bereiter DA (2009) Chronic inflammation and estradiol interact through MAPK activation to affect TMJ nociceptive processing by trigeminal caudalis neurons. Neuroscience 164:1813\u20131820","journal-title":"Neuroscience"},{"key":"4852_CR49","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1177\/00220345980770061101","volume":"77","author":"JC Turp","year":"1998","unstructured":"Turp JC, Kowalski CJ, O\u2019Leary N, Stohler CS (1998) Pain maps from facial pain patients indicate a broad pain geography. J Dent Res 77:1465\u20131472","journal-title":"J Dent Res"},{"key":"4852_CR50","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1113\/jphysiol.1984.sp015475","volume":"356","author":"PD Wall","year":"1984","unstructured":"Wall PD, Woolf CJ (1984) Muscle but not cutaneous C-afferent input produces prolonged increases in the excitability of the flexion reflex in the rat. J Physiol 356:443\u2013458","journal-title":"J Physiol"},{"key":"4852_CR51","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1126\/science.288.5472.1765","volume":"288","author":"CJ Woolf","year":"2000","unstructured":"Woolf CJ, Salter MW (2000) Neuronal plasticity: increasing the gain in pain. Science 288:1765\u20131768","journal-title":"Science"},{"key":"4852_CR52","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.neuroscience.2014.03.056","volume":"269","author":"MA Worsley","year":"2014","unstructured":"Worsley MA, Allen CE, Billinton A, King AE, Boissonade FM (2014) Chronic tooth pulp inflammation induces persistent expression of phosphorylated ERK (pERK) and phosphorylated p38 (pp38) in trigeminal subnucleus caudalis. Neuroscience 269:318\u2013330","journal-title":"Neuroscience"},{"key":"4852_CR53","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.14219\/jada.archive.2000.0384","volume":"131","author":"EF Wright","year":"2000","unstructured":"Wright EF (2000) Referred craniofacial pain patterns in patients with temporomandibular disorder. J Am Dent Assoc 131:1307\u20131315","journal-title":"J Am Dent Assoc"},{"key":"4852_CR54","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neulet.2005.07.019","volume":"387","author":"CS Yang","year":"2005","unstructured":"Yang CS, Jung CY, Ju JS, Lee MK, Ahn DK (2005) Intracisternal administration of mitogen-activated protein kinase inhibitors reduced IL-1beta-induced mirror-image mechanical allodynia in the orofacial area of rats. Neurosci Lett 387:32\u201337","journal-title":"Neurosci Lett"},{"key":"4852_CR55","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/(SICI)1096-9861(19990920)412:2<276::AID-CNE7>3.0.CO;2-9","volume":"412","author":"Q Zhou","year":"1999","unstructured":"Zhou Q, Imbe H, Dubner R, Ren K (1999) Persistent Fos protein expression after orofacial deep or cutaneous tissue inflammation in rats: implications for persistent orofacial pain. J Comp Neurol 412:276\u2013291","journal-title":"J Comp Neurol"},{"key":"4852_CR56","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","volume":"16","author":"M Zimmermann","year":"1983","unstructured":"Zimmermann M (1983) Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16:109\u2013110","journal-title":"Pain"}],"container-title":["Experimental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-016-4852-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00221-016-4852-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-016-4852-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T06:11:30Z","timestamp":1568614290000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00221-016-4852-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,8]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["4852"],"URL":"https:\/\/doi.org\/10.1007\/s00221-016-4852-9","relation":{},"ISSN":["0014-4819","1432-1106"],"issn-type":[{"value":"0014-4819","type":"print"},{"value":"1432-1106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,8]]}}}