{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:24:59Z","timestamp":1793247899059,"version":"4.5.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["5R01NS079626"],"award-info":[{"award-number":["5R01NS079626"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Brain Res"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1007\/s00221-017-5000-x","type":"journal-article","created":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T14:10:50Z","timestamp":1496326250000},"page":"2627-2638","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Inhibition of neuropathic hyperalgesia by intrathecal bone marrow stromal cells is associated with alteration of multiple soluble factors in cerebrospinal fluid"],"prefix":"10.1007","volume":"235","author":[{"given":"Gregory","family":"Fischer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfei","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quinn H.","family":"Hogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,1]]},"reference":[{"key":"5000_CR1","doi-asserted-by":"publisher","first-page":"129629","DOI":"10.1155\/2013\/129629","volume":"2013","author":"MT Abdel Aziz","year":"2013","unstructured":"Abdel Aziz MT et al (2013) Effect of mesenchymal stem cells and a novel curcumin derivative on Notch1 signaling in hepatoma cell line. Biomed Res Int 2013:129629","journal-title":"Biomed Res Int"},{"key":"5000_CR2","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1182\/blood-2004-04-1559","volume":"105","author":"S Aggarwal","year":"2005","unstructured":"Aggarwal S, Pittenger MF (2005) Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 105:1815\u20131822","journal-title":"Blood"},{"key":"5000_CR3","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.jneuroim.2008.01.005","volume":"195","author":"MM Backonja","year":"2008","unstructured":"Backonja MM et al (2008) Altered cytokine levels in the blood and cerebrospinal fluid of chronic pain patients. J Neuroimmunol 195:157\u2013163","journal-title":"J Neuroimmunol"},{"key":"5000_CR4","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1089\/ten.tea.2013.0196","volume":"20","author":"JJ Bara","year":"2014","unstructured":"Bara JJ et al (2014) Bone marrow-derived mesenchymal stem cells become antiangiogenic when chondrogenically or osteogenically differentiated: implications for bone and cartilage tissue engineering. Tissue Eng Part A 20:147\u2013159","journal-title":"Tissue Eng Part A"},{"key":"5000_CR5","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","volume":"139","author":"AI Basbaum","year":"2009","unstructured":"Basbaum AI et al (2009) Cellular and molecular mechanisms of pain. Cell 139:267\u2013284","journal-title":"Cell"},{"key":"5000_CR6","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1089\/ten.2006.12.2263","volume":"12","author":"P Batten","year":"2006","unstructured":"Batten P et al (2006) Human mesenchymal stem cells induce T cell anergy and downregulate T cell allo-responses via the TH2 pathway: relevance to tissue engineering human heart valves. Tissue Eng 12:2263\u20132273","journal-title":"Tissue Eng"},{"key":"5000_CR7","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.1182\/blood-2004-07-2921","volume":"105","author":"S Beyth","year":"2005","unstructured":"Beyth S et al (2005) Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood 105:2214\u20132219","journal-title":"Blood"},{"key":"5000_CR8","first-page":"153","volume":"82","author":"JB Brierley","year":"1948","unstructured":"Brierley JB, Field EJ (1948) The connexions of the spinal sub-arachnoid space with the lymphatic system. J Anat 82:153\u2013166","journal-title":"J Anat"},{"key":"5000_CR9","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","volume":"53","author":"SR Chaplan","year":"1994","unstructured":"Chaplan SR et al (1994) Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53:55\u201363","journal-title":"J Neurosci Methods"},{"key":"5000_CR10","doi-asserted-by":"publisher","first-page":"3226","DOI":"10.1172\/JCI80883","volume":"125","author":"G Chen","year":"2015","unstructured":"Chen G et al (2015) Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-beta secretion. J Clin Investig 125:3226\u20133240","journal-title":"J Clin Investig"},{"key":"5000_CR11","first-page":"803","volume":"6","author":"AK Clark","year":"2013","unstructured":"Clark AK, Old EA, Malcangio M (2013) Neuropathic pain and cytokines: current perspectives. J Pain Res 6:803\u2013814","journal-title":"J Pain Res"},{"key":"5000_CR12","doi-asserted-by":"publisher","first-page":"C675","DOI":"10.1152\/ajpcell.00437.2007","volume":"294","author":"PR Crisostomo","year":"2008","unstructured":"Crisostomo PR et al (2008) Human mesenchymal stem cells stimulated by TNF-alpha, LPS, or hypoxia produce growth factors by an NF kappa B\u2014but not JNK-dependent mechanism. Am J Physiol Cell Physiol 294:C675\u2013C682","journal-title":"Am J Physiol Cell Physiol"},{"key":"5000_CR13","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0304-3959(00)00276-1","volume":"87","author":"I Decosterd","year":"2000","unstructured":"Decosterd I, Woolf CJ (2000) Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain 87:149\u2013158","journal-title":"Pain"},{"key":"5000_CR14","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1002\/eji.201242643","volume":"43","author":"B Del Papa","year":"2013","unstructured":"Del Papa B et al (2013) Notch1 modulates mesenchymal stem cells mediated regulatory T-cell induction. Eur J Immunol 43:182\u2013187","journal-title":"Eur J Immunol"},{"key":"5000_CR15","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","volume":"20","author":"WJ Dixon","year":"1980","unstructured":"Dixon WJ (1980) Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol 20:441\u2013462","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"5000_CR16","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","volume":"8","author":"M Dominici","year":"2006","unstructured":"Dominici M et al (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8:315\u2013317","journal-title":"Cytotherapy"},{"key":"5000_CR17","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1016\/j.pain.2012.01.008","volume":"153","author":"S Franchi","year":"2012","unstructured":"Franchi S et al (2012) Intravenous neural stem cells abolish nociceptive hypersensitivity and trigger nerve regeneration in experimental neuropathy. Pain 153:850\u2013861","journal-title":"Pain"},{"key":"5000_CR18","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1002\/stem.667","volume":"29","author":"W Guo","year":"2011","unstructured":"Guo W et al (2011) Bone marrow stromal cells produce long-term pain relief in rat models of persistent pain. Stem Cells 29:1294\u20131303","journal-title":"Stem Cells"},{"key":"5000_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/ar.1091710102","volume":"171","author":"WA Himango","year":"1971","unstructured":"Himango WA, Low FN (1971) The fine structure of a lateral recess of the subarachnoid space in the rat. Anat Rec 171:1\u201319","journal-title":"Anat Rec"},{"key":"5000_CR20","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0014-2999(03)01753-9","volume":"470","author":"HA Hofmann","year":"2003","unstructured":"Hofmann HA et al (2003) Pharmacological sensitivity and gene expression analysis of the tibial nerve injury model of neuropathic pain. Eur J Pharmacol 470:17\u201325","journal-title":"Eur J Pharmacol"},{"key":"5000_CR21","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1097\/00000542-200408000-00030","volume":"101","author":"Q Hogan","year":"2004","unstructured":"Hogan Q et al (2004) Detection of neuropathic pain in a rat model of peripheral nerve injury. Anesthesiology 101:476\u2013487","journal-title":"Anesthesiology"},{"key":"5000_CR22","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/j.bbmt.2015.05.008","volume":"21","author":"M Hosseini","year":"2015","unstructured":"Hosseini M et al (2015) The effect of bone marrow-derived mesenchymal stem cell transplantation on allodynia and hyperalgesia in neuropathic animals: a systematic review with meta-analysis. Biol Blood Marrow Transplant 21:1537\u20131544","journal-title":"Biol Blood Marrow Transplant"},{"key":"5000_CR23","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/icb.2012.64","volume":"91","author":"SA Jacobs","year":"2013","unstructured":"Jacobs SA et al (2013) Immunological characteristics of human mesenchymal stem cells and multipotent adult progenitor cells. Immunol Cell Biol 91:32\u201339","journal-title":"Immunol Cell Biol"},{"key":"5000_CR24","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1002\/acn3.186","volume":"2","author":"JA Kessler","year":"2015","unstructured":"Kessler JA et al (2015) Double-blind, placebo-controlled study of HGF gene therapy in diabetic neuropathy. Ann Clin Transl Neurol 2:465\u2013478","journal-title":"Ann Clin Transl Neurol"},{"key":"5000_CR25","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/1476-4598-9-129","volume":"9","author":"L Kucerova","year":"2010","unstructured":"Kucerova L et al (2010) Tumor cell behaviour modulation by mesenchymal stromal cells. Mol Cancer 9:129","journal-title":"Mol Cancer"},{"key":"5000_CR26","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.neuropharm.2014.10.020","volume":"96","author":"AJ Kwilasz","year":"2015","unstructured":"Kwilasz AJ et al (2015) The therapeutic potential of interleukin-10 in neuroimmune diseases. Neuropharmacology 96:55\u201369","journal-title":"Neuropharmacology"},{"key":"5000_CR27","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1172\/JCI36246C1","volume":"119","author":"D Labuz","year":"2009","unstructured":"Labuz D et al (2009) Immune cell-derived opioids protect against neuropathic pain in mice. J Clin Invest 119:278\u2013286","journal-title":"J Clin Invest"},{"key":"5000_CR28","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.bbi.2006.10.012","volume":"21","author":"A Ledeboer","year":"2007","unstructured":"Ledeboer A et al (2007) Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats. Brain Behav Immun 21:686\u2013698","journal-title":"Brain Behav Immun"},{"key":"5000_CR29","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s13287-015-0178-y","volume":"6","author":"MW Lee","year":"2015","unstructured":"Lee MW et al (2015) Strategies to improve the immunosuppressive properties of human mesenchymal stem cells. Stem Cell Res Ther 6:179","journal-title":"Stem Cell Res Ther"},{"key":"5000_CR30","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.3727\/096368913X667709","volume":"23","author":"X Liang","year":"2014","unstructured":"Liang X et al (2014) Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives. Cell Transplant 23:1045\u20131059","journal-title":"Cell Transplant"},{"key":"5000_CR31","doi-asserted-by":"publisher","unstructured":"Liu L, Duff K (2008) A technique for serial collection of cerebrospinal fluid from the cisterna magna in mouse. J Vis Exp JoVE 21:960. doi:\n                    10.3791\/960","DOI":"10.3791\/960"},{"key":"5000_CR32","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1523\/JNEUROSCI.22-13-05588.2002","volume":"22","author":"H Machelska","year":"2002","unstructured":"Machelska H et al (2002) Opioid control of inflammatory pain regulated by intercellular adhesion molecule-1. J Neurosci 22:5588\u20135596","journal-title":"J Neurosci"},{"key":"5000_CR33","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1006\/bcmd.2001.0424","volume":"27","author":"TC Mackenzie","year":"2001","unstructured":"Mackenzie TC, Flake AW (2001) Human mesenchymal stem cells persist, demonstrate site-specific multipotential differentiation, and are present in sites of wound healing and tissue regeneration after transplantation into fetal sheep. Blood Cells Mol Dis 27:601\u2013604","journal-title":"Blood Cells Mol Dis"},{"key":"5000_CR34","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s00011-009-0090-y","volume":"59","author":"F Mao","year":"2010","unstructured":"Mao F et al (2010) Immunosuppressive effects of mesenchymal stem cells in collagen-induced mouse arthritis. Inflamm Res 59:219\u2013225","journal-title":"Inflamm Res"},{"key":"5000_CR35","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.cytogfr.2009.10.002","volume":"20","author":"S Meirelles Lda","year":"2009","unstructured":"Meirelles Lda S et al (2009) Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine Growth Factor Rev 20:419\u2013427","journal-title":"Cytokine Growth Factor Rev"},{"key":"5000_CR36","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/j.addr.2010.09.013","volume":"62","author":"T Meyerrose","year":"2010","unstructured":"Meyerrose T et al (2010) Mesenchymal stem cells for the sustained in vivo delivery of bioactive factors. Adv Drug Deliv Rev 62:1167\u20131174","journal-title":"Adv Drug Deliv Rev"},{"key":"5000_CR37","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1017\/S1740925X07000488","volume":"2","author":"ED Milligan","year":"2006","unstructured":"Milligan ED et al (2006) Intrathecal polymer-based interleukin-10 gene delivery for neuropathic pain. Neuron Glia Biol 2:293\u2013308","journal-title":"Neuron Glia Biol"},{"key":"5000_CR38","doi-asserted-by":"publisher","first-page":"12533","DOI":"10.1523\/JNEUROSCI.2840-11.2011","volume":"31","author":"S Nadeau","year":"2011","unstructured":"Nadeau S et al (2011) Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1beta and TNF: implications for neuropathic pain. J Neurosci 31:12533\u201312542","journal-title":"J Neurosci"},{"key":"5000_CR39","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1126\/science.284.5411.143","volume":"284","author":"MF Pittenger","year":"1999","unstructured":"Pittenger MF et al (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284:143\u2013147","journal-title":"Science"},{"key":"5000_CR40","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/gt.2014.96","volume":"22","author":"J Pleticha","year":"2015","unstructured":"Pleticha J et al (2015) High cerebrospinal fluid levels of interleukin-10 attained by AAV in dogs. Gene Ther 22:202\u2013208","journal-title":"Gene Ther"},{"key":"5000_CR41","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.4049\/jimmunol.0902023","volume":"184","author":"G Ren","year":"2010","unstructured":"Ren G et al (2010) Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression. J Immunol 184:2321\u20132328","journal-title":"J Immunol"},{"key":"5000_CR42","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1006\/geno.2000.6114","volume":"64","author":"JM Salbaum","year":"2000","unstructured":"Salbaum JM, Kappen C (2000) Cloning and expression of nope, a new mouse gene of the immunoglobulin superfamily related to guidance receptors. Genomics 64:15\u201323","journal-title":"Genomics"},{"key":"5000_CR43","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s12974-014-0157-8","volume":"11","author":"S Schafer","year":"2014","unstructured":"Schafer S et al (2014) Influence of intrathecal delivery of bone marrow-derived mesenchymal stem cells on spinal inflammation and pain hypersensitivity in a rat model of peripheral nerve injury. J Neuroinflamm 11:157","journal-title":"J Neuroinflamm"},{"key":"5000_CR44","doi-asserted-by":"publisher","first-page":"3099","DOI":"10.2337\/db08-0031","volume":"57","author":"T Shibata","year":"2008","unstructured":"Shibata T et al (2008) Transplantation of bone marrow-derived mesenchymal stem cells improves diabetic polyneuropathy in rats. Diabetes 57:3099\u20133107","journal-title":"Diabetes"},{"key":"5000_CR45","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1007\/s00018-009-0202-4","volume":"67","author":"D Siniscalco","year":"2010","unstructured":"Siniscalco D et al (2010) Intra-brain microinjection of human mesenchymal stem cells decreases allodynia in neuropathic mice. Cell Mol Life Sci CMLS 67:655\u2013669","journal-title":"Cell Mol Life Sci CMLS"},{"key":"5000_CR46","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1756-6606-5-23","volume":"5","author":"YY Sun","year":"2012","unstructured":"Sun YY et al (2012) The spinal notch signaling pathway plays a pivotal role in the development of neuropathic pain. Mol Brain 5:23","journal-title":"Mol Brain"},{"key":"5000_CR47","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.neulet.2008.05.081","volume":"440","author":"K Temporin","year":"2008","unstructured":"Temporin K et al (2008) Interleukin-1 beta promotes sensory nerve regeneration after sciatic nerve injury. Neurosci Lett 440:130\u2013133","journal-title":"Neurosci Lett"},{"key":"5000_CR48","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1002\/stem.459","volume":"28","author":"J Tolar","year":"2010","unstructured":"Tolar J et al (2010) Concise review: hitting the right spot with mesenchymal stromal cells. Stem Cells 28:1446\u20131455","journal-title":"Stem Cells"},{"key":"5000_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.addr.2014.10.007","volume":"82\u201383","author":"C Tran","year":"2015","unstructured":"Tran C, Damaser MS (2015) Stem cells as drug delivery methods: application of stem cell secretome for regeneration. Adv Drug Deliv Rev 82\u201383:1\u201311","journal-title":"Adv Drug Deliv Rev"},{"key":"5000_CR50","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/mt.2008.214","volume":"17","author":"T Tsuchihara","year":"2009","unstructured":"Tsuchihara T et al (2009) Nonviral retrograde gene transfer of human hepatocyte growth factor improves neuropathic pain-related phenomena in rats. Mol Ther 17:42\u201350","journal-title":"Mol Ther"},{"key":"5000_CR51","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.neuron.2012.02.008","volume":"73","author":"CA von Hehn","year":"2012","unstructured":"von Hehn CA, Baron R, Woolf CJ (2012) Deconstructing the neuropathic pain phenotype to reveal neural mechanisms. Neuron 73:638\u2013652","journal-title":"Neuron"},{"key":"5000_CR52","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.3324\/haematol.2008.001735","volume":"94","author":"R Wehner","year":"2009","unstructured":"Wehner R et al (2009) Mesenchymal stem cells efficiently inhibit the proinflammatory properties of 6-sulfo LacNAc dendritic cells. Haematologica 94:1151\u20131156","journal-title":"Haematologica"},{"key":"5000_CR53","doi-asserted-by":"publisher","first-page":"e101841","DOI":"10.1371\/journal.pone.0101841","volume":"9","author":"L Wen","year":"2014","unstructured":"Wen L et al (2014) Immunomodulatory effects of bone marrow-derived mesenchymal stem cells on pro-inflammatory cytokine-stimulated human corneal epithelial cells. PLoS One 9:e101841","journal-title":"PLoS One"},{"key":"5000_CR54","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jpain.2009.07.011","volume":"11","author":"HE Wu","year":"2010","unstructured":"Wu HE et al (2010) Learned avoidance from noxious mechanical simulation but not threshold semmes weinstein filament stimulation after nerve injury in rats. J Pain 11:280\u2013286","journal-title":"J Pain"},{"key":"5000_CR55","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12871-015-0021-0","volume":"15","author":"K Xie","year":"2015","unstructured":"Xie K et al (2015) Notch signaling activation is critical to the development of neuropathic pain. BMC Anesthesiol 15:41","journal-title":"BMC Anesthesiol"},{"key":"5000_CR56","first-page":"154","volume":"43","author":"Q Xu","year":"2013","unstructured":"Xu Q et al (2013) Intrathecal transplantation of neural stem cells appears to alleviate neuropathic pain in rats through release of GDNF. Ann Clin Lab Sci 43:154\u2013162","journal-title":"Ann Clin Lab Sci"},{"key":"5000_CR57","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/1744-8069-7-63","volume":"7","author":"H Yu","year":"2011","unstructured":"Yu H et al (2011) Lentiviral gene transfer into the dorsal root ganglion of adult rats. Mol Pain 7:63","journal-title":"Mol Pain"},{"key":"5000_CR58","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s12990-015-0002-9","volume":"11","author":"H Yu","year":"2015","unstructured":"Yu H et al (2015) Analgesia for neuropathic pain by dorsal root ganglion transplantation of genetically engineered mesenchymal stem cells: initial results. Mol Pain 11:5","journal-title":"Mol Pain"}],"container-title":["Experimental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00221-017-5000-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-017-5000-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-017-5000-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T09:54:50Z","timestamp":1589622890000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00221-017-5000-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,1]]},"references-count":58,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["5000"],"URL":"https:\/\/doi.org\/10.1007\/s00221-017-5000-x","relation":{},"ISSN":["0014-4819","1432-1106"],"issn-type":[{"value":"0014-4819","type":"print"},{"value":"1432-1106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,1]]},"assertion":[{"value":"6 January 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors indicated no potential conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}