{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:04:23Z","timestamp":1740107063622,"version":"3.37.3"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Brain Res"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1007\/s00221-020-05912-w","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T10:02:56Z","timestamp":1598954576000},"page":"2539-2548","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["K channel blockage with 3,4-diaminopyridine potentiates the effect of L-DOPA on dopamine release in striatal slices prepared from 6-OHDA pre-treated rats"],"prefix":"10.1007","volume":"238","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8872-0074","authenticated-orcid":false,"given":"Zulfiye","family":"Gul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gozde","family":"Duyu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burcin","family":"Altinbas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Levent","family":"Buyukuysal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,1]]},"reference":[{"issue":"3","key":"5912_CR1","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1002\/mds.1090","volume":"16","author":"JE Ahlskog","year":"2001","unstructured":"Ahlskog JE, Muenter MD (2001) Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature. Mov Disord 16(3):448\u2013458. https:\/\/doi.org\/10.1002\/mds.1090","journal-title":"Mov Disord"},{"key":"5912_CR2","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1097\/FBP.0000000000000107","volume":"26","author":"S Aidi-Knani","year":"2015","unstructured":"Aidi-Knani S, Regaya I, Amalric M, Mourre C (2015) Kv4 channel blockade reduces motor and neuropsychiatric symptoms in rodent models of Parkinson\u2019s disease. Behav Pharmacol 26:91\u2013100. https:\/\/doi.org\/10.1097\/FBP.0000000000000107","journal-title":"Behav Pharmacol"},{"issue":"1","key":"5912_CR3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/s0223-5234(00)00103-3","volume":"35","author":"A Andreani","year":"2000","unstructured":"Andreani A, Leoni A, Locatelli A, Morigi R, Rambaldi M, Pietra C, Villetti G (2000) 4-Aminopyridine derivatives with antiamnesic activity. Eur J Med Chem 35(1):77\u201382. https:\/\/doi.org\/10.1016\/s0223-5234(00)00103-3","journal-title":"Eur J Med Chem"},{"issue":"1","key":"5912_CR4","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0006-8993(89)91281-x","volume":"486","author":"S Barnes","year":"1989","unstructured":"Barnes S, Whitham EM, Davies JA (1989) Effects of potassium channel blockade on endogenous glutamate release from cerebellar slices. Brain Res 486(1):89\u201394. https:\/\/doi.org\/10.1016\/0006-8993(89)91281-x","journal-title":"Brain Res"},{"key":"5912_CR5","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/syn.890050211","volume":"5","author":"JB Becker","year":"1990","unstructured":"Becker JB (1990) Direct effect of 17 beta-estradiol on striatum: Sex differences in dopamine release. Synapse 5:157\u2013164. https:\/\/doi.org\/10.1002\/syn.890050211","journal-title":"Synapse"},{"key":"5912_CR6","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1046\/j.1471-4159.2001.00608.x","volume":"79","author":"D Berg","year":"2001","unstructured":"Berg D, Gerlach M, Youdim MBH, Double KL, Zecca L, Riederer P, Becker G (2001) Brain iron and their relevance to Parkinson\u2019s disease. J Neurochem 79:225\u2013236. https:\/\/doi.org\/10.1046\/j.1471-4159.2001.00608.x","journal-title":"J Neurochem"},{"issue":"11","key":"5912_CR7","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1111\/j.2042-7158.1991.tb03485.xCitations:9","volume":"43","author":"A Boireau","year":"1991","unstructured":"Boireau A, Richard F, Olivier V, Aubeneau M, Miquet JM, Dub\u00e9dat P, Laduron P, Doble A, Blanchard JC (1991) Differential effects of potassium channel blockers on dopamine release from rat striatal slices. J Pharm Pharmacol 43(11):798\u2013801. https:\/\/doi.org\/10.1111\/j.2042-7158.1991.tb03485.xCitations:9","journal-title":"J Pharm Pharmacol"},{"issue":"6","key":"5912_CR8","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1007\/s00702-008-0025-8","volume":"115","author":"DJ Brooks","year":"2008","unstructured":"Brooks DJ, Leinonen M, Kuoppam\u00e4ki M, Nissinen H (2008) Five-year efficacy and safety of levodopa\/DDCI and entacapone in patients with Parkinson\u2019s disease. J Neural Transm 115(6):843\u2013849. https:\/\/doi.org\/10.1007\/s00702-008-0025-8Epub 2008 Feb 8","journal-title":"J Neural Transm"},{"issue":"2","key":"5912_CR9","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/0014-2999(95)00241-c","volume":"281","author":"RL Buyukuysal","year":"1995","unstructured":"Buyukuysal RL, Ulus IH, Aydin S, Kiran BK (1995) 3, 4-Diaminopyridine and choline increase in vivo acetylcholine release in rat striatum. Eur J Pharmacol 281(2):179\u2013185. https:\/\/doi.org\/10.1016\/0014-2999(95)00241-c","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"5912_CR10","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.neures.2008.07.005","volume":"62","author":"M Cansev","year":"2008","unstructured":"Cansev M, Ulus IH, Wang L, Maher TJ, Wurtman RJ (2008) Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson\u2019s disease. Neurosci Res 62(3):206\u2013209. https:\/\/doi.org\/10.1016\/j.neures.2008.07.005","journal-title":"Neurosci Res"},{"issue":"5","key":"5912_CR11","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1212\/WNL.41.5.622","volume":"41","author":"JM Cedarbaum","year":"1991","unstructured":"Cedarbaum JM, Gandy SE, Mcdowell FH (1991) Early initiation of Levodopa treatment does not promote the development of motor response fluctuations, Dyskinesias, or dementia in Parkinsons-disease. Neurology 41(5):622\u2013629. https:\/\/doi.org\/10.1212\/WNL.41.5.622","journal-title":"Neurology"},{"issue":"1","key":"5912_CR12","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0014-2999(88)90343-3","volume":"145","author":"G Damsma","year":"1988","unstructured":"Damsma G, Biessels PTM, Westerink BHC, De Vries JB, Horn AS (1988) Differential effects of 4-aminopyridine and 2,4-diaminopyridine in the in vivo release of acetylcholine and dopamine in freely moving rats measured by intrastriatal dialysis. Eur J Pharmacol 145(1):15\u201320. https:\/\/doi.org\/10.1016\/0014-2999(88)90343-3","journal-title":"Eur J Pharmacol"},{"issue":"6","key":"5912_CR13","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/s0896-6273(03)00568-3","volume":"39","author":"W Dauer","year":"2003","unstructured":"Dauer W, Przedborski S (2003) Parkinson\u2019s disease: mechanisms and models. Neuron 39(6):889\u2013909. https:\/\/doi.org\/10.1016\/s0896-6273(03)00568-3","journal-title":"Neuron"},{"issue":"7","key":"5912_CR14","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1007\/s11064-014-1301-7","volume":"39","author":"C Demircan","year":"2014","unstructured":"Demircan C, Gul Z, Buyukuysal RL (2014) High glutamate attenuates S100B and LDH outputs from rat cortical slices enhanced by either oxygen\u2013glucose deprivation or menadione. Neurochem Res 39(7):1232\u20131244. https:\/\/doi.org\/10.1007\/s11064-014-1301-7","journal-title":"Neurochem Res"},{"issue":"4","key":"5912_CR15","doi-asserted-by":"publisher","first-page":"407e21","DOI":"10.1111\/j.1472-8206.2009.00798.x","volume":"24","author":"D Devos","year":"2010","unstructured":"Devos D, Defebvre L, Bordet R (2010) Dopaminergic and non-dopaminergic pharmacological hypotheses for gait disorders in Parkinson\u2019s disease. Fundam Clin Pharmacol 24(4):407e21. https:\/\/doi.org\/10.1111\/j.1472-8206.2009.00798.x","journal-title":"Fundam Clin Pharmacol"},{"issue":"1","key":"5912_CR16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1001\/jamaneurol.2017.3299","volume":"75","author":"ER Dorsey","year":"2018","unstructured":"Dorsey ER, Bloem BR (2018) The Parkinson pandemic\u2014a call to action. JAMA Neurol 75(1):9\u201310. https:\/\/doi.org\/10.1001\/jamaneurol.2017.3299","journal-title":"JAMA Neurol"},{"issue":"45","key":"5912_CR17","doi-asserted-by":"publisher","first-page":"11652","DOI":"10.1523\/JNEUROSCI.2490-06.2006","volume":"26","author":"S Franciosi","year":"2006","unstructured":"Franciosi S, Ryu JK, Choi HB, Radov L, Kim SU, McLarnon JG (2006) Broad-spectrum effects of 4-aminopyridine to modulate amyloid \u03b21\u201342-induced cell signaling and functional responses in human microglia. J Neurosci 26(45):11652\u201311664. https:\/\/doi.org\/10.1523\/JNEUROSCI.2490-06.2006","journal-title":"J Neurosci"},{"issue":"11","key":"5912_CR18","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1007\/BF00970931","volume":"12","author":"GB Freeman","year":"1987","unstructured":"Freeman GB, Mykytyn V, Gibson GE (1987) Differential alteration of dopamine, acetylcholine, and glutamate release during anoxia and\/or 3,4-diaminopyridine treatment. Neurochem Res 12(11):1019\u20131027","journal-title":"Neurochem Res"},{"issue":"11","key":"5912_CR19","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/S1474-4422(17)30299-5","volume":"16","author":"GBD 2015 Neurological Disorders Collaborator Group","year":"2017","unstructured":"GBD 2015 Neurological Disorders Collaborator Group (2017) Global, regional, and national burden of neurological disorders during 1990\u20132015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Neurol 16(11):877\u2013897. https:\/\/doi.org\/10.1016\/S1474-4422(17)30299-5","journal-title":"Lancet Neurol"},{"key":"5912_CR20","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.expneurol.2013.05.016","volume":"248","author":"K Gobel","year":"2013","unstructured":"Gobel K, Wedell JH, Herrmann AM, Wachsmuth L, Pankratz S (2013) 4-Aminopyridine ameliorates mobility but not disease course in an animal model of multiple sclerosis. Exp Neurol 248:62\u201371. https:\/\/doi.org\/10.1016\/j.expneurol.2013.05.016Epub 2013 Jun 5","journal-title":"Exp Neurol"},{"key":"5912_CR21","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1002\/cne.20323","volume":"478","author":"T Gonzalez-Hernandez","year":"2004","unstructured":"Gonzalez-Hernandez T, Barroso-Chinea P, De La Cruz MI, Del Mar P-DM, Rodriguez M (2004) Expression of dopamine and vesicular monoamine transporters and differential vulnerability of mesostriatal dopaminergic neurons. J Comp Neurol 478:198\u2013215. https:\/\/doi.org\/10.1002\/cne.20323","journal-title":"J Comp Neurol"},{"issue":"8","key":"5912_CR22","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1007\/s11064-016-1919-8","volume":"41","author":"Z Gul","year":"2016","unstructured":"Gul Z, Demircan C, Bagdas D, Buyukuysal RL (2016) Protective effects of chlorogenic acid and its metabolites on hydrogen peroxide-induced alterations in rat brain slices: a comparative study with resveratrol. Neurochem Res 41(8):2075\u20132085. https:\/\/doi.org\/10.1007\/s11064-016-1919-8","journal-title":"Neurochem Res"},{"issue":"3","key":"5912_CR23","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1080\/01616412.2020.1723299","volume":"42","author":"Z Gul","year":"2020","unstructured":"Gul Z, Buyukuysal MC, Buyukuysal RL (2020a) Brain slice viability determined under normoxic and oxidative stress conditions: involvement of slice quantity in the medium. Neurol Res 42(3):228\u2013238. https:\/\/doi.org\/10.1080\/01616412.2020.1723299","journal-title":"Neurol Res"},{"key":"5912_CR24","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2020.1730830","author":"Z Gul","year":"2020","unstructured":"Gul Z, Demircan C, Bagdas D, Buyukuysal RL (2020b) Aging protects rat cortical slices against to oxygen-glucose deprivation induced damage. Int J Neurosci. https:\/\/doi.org\/10.1080\/00207454.2020.1730830","journal-title":"Int J Neurosci"},{"issue":"9","key":"5912_CR25","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1007\/s11064-008-9645-5","volume":"33","author":"M Gursoy","year":"2008","unstructured":"Gursoy M, Buyukuysal RL (2008) Resveratrol protects rat striatal slices against anoxia-induced dopamine release. Neurochem Res 33(9):1838\u20131844. https:\/\/doi.org\/10.1007\/s11064-008-9645-5","journal-title":"Neurochem Res"},{"issue":"1","key":"5912_CR26","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.bbr.2011.04.021","volume":"223","author":"H Haghdoost-Yazdi","year":"2011","unstructured":"Haghdoost-Yazdi H, Faraji A, Fraidouni N, Movahedi M, Hadibeygi E, Vaezi F (2011) Significant effects of 4-aminopyridine and tetraethylammonium in the treatment of 6-hydroxydopamine-induced Parkinson\u2019s disease. Behav Brain Res 223(1):70\u201374. https:\/\/doi.org\/10.1016\/j.bbr.2011.04.021","journal-title":"Behav Brain Res"},{"key":"5912_CR27","doi-asserted-by":"publisher","first-page":"44","DOI":"10.17712\/nsj.2017.1.20160266","volume":"22","author":"H Haghdoost-Yazdi","year":"2017","unstructured":"Haghdoost-Yazdi H, Piri H, Najafipour R, Faraji A, Fraidouni N, Dargahi T (2017) Blockade of fast A-type and TEA-sensitive potassium channels provide an antiparkinsonian effect in a 6-OHDA animal model. Neurosciences (Riyadh) 22:44\u201350. https:\/\/doi.org\/10.17712\/nsj.2017.1.20160266","journal-title":"Neurosciences (Riyadh)"},{"issue":"4","key":"5912_CR28","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/j.1527-3458.2004.tb00029.x","volume":"10","author":"KC Hayes","year":"2004","unstructured":"Hayes KC (2004) The use of 4-aminopyridine (fampridine) in demyelinating disorders. CNS Drug Rev 10(4):295\u2013316. https:\/\/doi.org\/10.1111\/j.1527-3458.2004.tb00029.x","journal-title":"CNS Drug Rev"},{"issue":"4","key":"5912_CR29","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.neuropharm.2006.05.013","volume":"51","author":"CL Hu","year":"2006","unstructured":"Hu CL, Liu Z, Zeng XM, Liu ZQ, Chen XH, Zhang ZH, Mei YA (2006) 4-aminopyridine, a Kv channel antagonist, prevents apoptosis of rat cerebellar granule neurons. Neuropharmacol 51(4):737\u2013746. https:\/\/doi.org\/10.1016\/j.neuropharm.2006.05.013","journal-title":"Neuropharmacol"},{"issue":"2","key":"5912_CR30","doi-asserted-by":"publisher","first-page":"131e44","DOI":"10.1002\/mds.25273","volume":"28","author":"LV Kalia","year":"2013","unstructured":"Kalia LV, Brotchie JM, Fox SH (2013) Novel nondopaminergic targets for motor features of Parkinson\u2019s disease: review of recent trials. Mov Disord 28(2):131e44. https:\/\/doi.org\/10.1002\/mds.25273Epub 2012 Dec 5","journal-title":"Mov Disord"},{"key":"5912_CR31","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/s0928-4680(00)00053-5","volume":"7","author":"K Kannan","year":"2000","unstructured":"Kannan K, Jain SK (2000) Oxidative stress and apoptosis. Pathophysiology 7:153\u2013163. https:\/\/doi.org\/10.1016\/s0928-4680(00)00053-5","journal-title":"Pathophysiology"},{"key":"5912_CR32","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/bs.irn.2017.01.006","volume":"132","author":"HJ Kim","year":"2017","unstructured":"Kim HJ, Jeon BS, Jenner P (2017) Hallmarks of treatment aspects: Parkinson\u2019s disease throughout centuries including l-Dopa. Int Rev Neurobiol 132:295\u2013343. https:\/\/doi.org\/10.1016\/bs.irn.2017.01.006","journal-title":"Int Rev Neurobiol"},{"issue":"2","key":"5912_CR33","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1006\/exnr.1998.6848","volume":"152","author":"D Kirik","year":"1998","unstructured":"Kirik D, Rosenblad C, Bj\u00f6rklund A (1998) Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat. Exp Neurol 152(2):259\u2013277. https:\/\/doi.org\/10.1006\/exnr.1998.6848","journal-title":"Exp Neurol"},{"issue":"5","key":"5912_CR34","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1212\/01.WNL.0000152880.77812.5B","volume":"64","author":"R Kurlan","year":"2005","unstructured":"Kurlan R (2005) \u201cLevodopa phobia\u201d: a new iatrogenic cause of disability in Parkinson disease. Neurology 64(5):923\u2013924. https:\/\/doi.org\/10.1212\/01.WNL.0000152880.77812.5B","journal-title":"Neurology"},{"issue":"1","key":"5912_CR35","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.expneurol.2010.11.004","volume":"227","author":"G Leung","year":"2011","unstructured":"Leung G, Sun W, Brookes S, Smith D, Shi R (2011) Potassium channel blocker, 4-aminopyridine-3-methanol, restores axonal conduction in spinal cord of an animal model of multiple sclerosis. Exp Neurol 227(1):232\u2013235. https:\/\/doi.org\/10.1016\/j.expneurol.2010.11.004Epub 2010 Nov 17","journal-title":"Exp Neurol"},{"key":"5912_CR36","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.bioorg.2017.05.010","volume":"73","author":"S Li","year":"2017","unstructured":"Li S, Wei D, Mao Z, Chen L, Yan X, Li Y (2017) Design, synthesis, immunocytochemistry evaluation, and molecular docking investigation of several 4-aminopyridine derivatives as potential neuroprotective agents for treating Parkinson\u2019s disease. Bioorg Chem 73:63\u201375. https:\/\/doi.org\/10.1016\/j.bioorg.2017.05.010Epub 2017 May 31","journal-title":"Bioorg Chem"},{"key":"5912_CR37","doi-asserted-by":"publisher","first-page":"5715","DOI":"10.1093\/emboj\/20.20.5715","volume":"20","author":"B Liss","year":"2001","unstructured":"Liss B, Franz O, Sewing S, Bruns R, Neuhoff H, Roeper J (2001) Tuning pacemaker frequency of individual dopaminergic neurons by Kv4. 3L and KChip3. 1 transcription. EMBO J 20:5715\u20135724. https:\/\/doi.org\/10.1093\/emboj\/20.20.5715","journal-title":"EMBO J"},{"key":"5912_CR38","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265\u2013275","journal-title":"J Biol Chem"},{"issue":"10","key":"5912_CR39","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.1007\/s00415-013-7090-0","volume":"260","author":"CC Luca","year":"2013","unstructured":"Luca CC, Singer C (2013) 4-Aminopyridine improves freezing of gait in Parkinson\u2019s disease. J Neurol 260(10):2662\u20132664. https:\/\/doi.org\/10.1007\/s00415-013-7090-0","journal-title":"J Neurol"},{"key":"5912_CR40","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jns.2017.05.011","volume":"379","author":"CC Luca","year":"2017","unstructured":"Luca CC, Nadayil G, Dong C, Nahab FB, Field-Fote E, Singer C (2017) Dalfampridine in Parkinson\u2019s disease related gait dysfunction: a randomized double-blind trial. J Neurol Sci 379:7\u201311. https:\/\/doi.org\/10.1016\/j.jns.2017.05.011","journal-title":"J Neurol Sci"},{"key":"5912_CR41","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S0166-4328(89)80121-4","volume":"33","author":"J Luthman","year":"1989","unstructured":"Luthman J, Fredriksson A, Sundstrom E, Jonsson G, Archer T (1989) Selective lesion of central dopamine or noradrenaline neuron systems in the neonatal rat: motor behavior and monoamine alterations at adult stage. Behav Brain Res 33:267\u2013277. https:\/\/doi.org\/10.1016\/S0166-4328(89)80121-4","journal-title":"Behav Brain Res"},{"key":"5912_CR42","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1113\/jphysiol.2012.248831","volume":"591","author":"JK Maffie","year":"2013","unstructured":"Maffie JK, Dvoretskova E, Bougis PE, Martin-Eauclaire MF, Rudy B (2013) Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to Kv4-mediated A-type K channels. J Physiol 591:2419\u20132427. https:\/\/doi.org\/10.1113\/jphysiol.2012.248831","journal-title":"J Physiol"},{"issue":"11","key":"5912_CR43","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1212\/01.wnl.0000129263.14219.a8","volume":"62","author":"C Mainero","year":"2004","unstructured":"Mainero C, Inghilleri M, Pantano P, Conte A, Lenzi D, Frasca V, Bozzao L, Pozzilli C (2004) Enhanced brain motor activity in patients with MS after a single dose of 3,4-diaminopyridine. Neurology 62(11):2044\u20132050. https:\/\/doi.org\/10.1212\/01.wnl.0000129263.14219.a8","journal-title":"Neurology"},{"key":"5912_CR44","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1006\/exnr.1994.1034","volume":"125","author":"JL McDermott","year":"1994","unstructured":"McDermott JL, Liu B, Dluzen DE (1994) Sex differences and effects of estrogen on dopamine and DOPAC release from the striatum of male and female CD-1 mice. Exp Neurol 125:306\u2013311. https:\/\/doi.org\/10.1006\/exnr.1994.1034","journal-title":"Exp Neurol"},{"issue":"2","key":"5912_CR45","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/0003-2697(80)90101-3","volume":"104","author":"IN Mefford","year":"1980","unstructured":"Mefford IN, Gilberg M, Barchas JD (1980) Simultaneous determination of catecholamines and unconjugated 3, 4-dihydroxyphenylacetic acid in brain tissue by ion-pairing reverse-phase high-performance liquid chromatography with electrochemical detection. Anal Biochem 104(2):469\u2013472. https:\/\/doi.org\/10.1016\/0003-2697(80)90101-3","journal-title":"Anal Biochem"},{"issue":"6","key":"5912_CR46","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1002\/mds.23588","volume":"26","author":"JG Nutt","year":"2011","unstructured":"Nutt JG, Horak FB, Bloem BR (2011) Milestones in gait, balance, and falling. Mov Disord 26(6):1166\u20131174. https:\/\/doi.org\/10.1002\/mds.23588","journal-title":"Mov Disord"},{"issue":"6","key":"5912_CR47","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.neuropharm.2004.12.018","volume":"48","author":"K Ogita","year":"2005","unstructured":"Ogita K, Okuda H, Watanabe M, Nagashima R, Sugiyama C, Yoneda Y (2005) In vivo treatment with the K+ channel blocker 4-aminopyridine protects against kainate-induced neuronal cell death through activation of NMDA receptors in murine hippocampus. Neuropharmacol 48(6):810\u2013821. https:\/\/doi.org\/10.1016\/j.neuropharm.2004.12.018","journal-title":"Neuropharmacol"},{"key":"5912_CR48","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0006-8993(96)01102-X","volume":"743","author":"V Ries","year":"1996","unstructured":"Ries V, Hertting G, Jackisch R (1996) Properties of 3,4-diaminopyridine-evoked dopamine and acetylcholine release in rabbit caudate nucleus slices: involvement of facilitatory adenosine A2 receptors or nitric oxide? Brain Res 743:303\u2013314. https:\/\/doi.org\/10.1016\/S0006-8993(96)01102-X","journal-title":"Brain Res"},{"issue":"1","key":"5912_CR49","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0306-3623(91)90329-5","volume":"22","author":"HW Scheer","year":"1991","unstructured":"Scheer HW, Lavoie PA (1991) Mechanism of aminopyridine-induced release of [3H]dopamine from rat brain synaptosomes. Gen Pharmacol 22(1):169\u2013172. https:\/\/doi.org\/10.1016\/0306-3623(91)90329-5","journal-title":"Gen Pharmacol"},{"key":"5912_CR50","unstructured":"Shieh CC, Coghlan M, Sullivan JP, Gopalakrishnan M (2000) Potassium channels: molecular defects, diseases, and therapeutic opportunities. Pharmacol Rev 52(4):557\u2013594. Doi: 10.1.1.322.385&rep=rep1&type=pdf."},{"issue":"1","key":"5912_CR51","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/s1550-8579(07)80003-9","volume":"4","author":"LM Shulman","year":"2007","unstructured":"Shulman LM (2007) Gender differences in Parkinson\u2019s disease. Gend Med 4(1):8\u201318. https:\/\/doi.org\/10.1016\/s1550-8579(07)80003-9","journal-title":"Gend Med"},{"key":"5912_CR52","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1152\/jn.00154.2009","volume":"103","author":"W Sun","year":"2010","unstructured":"Sun W, Smith D, Fu Y, Cheng JX, Bryn S, Borgens R (2010) Novel potassium channel blocker, 4-AP-3-MeOH, inhibits fast potassium channels and restores axonal conduction in injured guinea pig spinal cord white matter. J Neurophysiol 103:469\u2013478. https:\/\/doi.org\/10.1152\/jn.00154.2009","journal-title":"J Neurophysiol"},{"key":"5912_CR53","first-page":"142","volume":"2","author":"R Taherian","year":"2016","unstructured":"Taherian R, Ahmadi MA (2016) 4-aminopyridine decreases MPTP induced behavioral disturbances in animal model of Parkinson\u2019s disease. Int Clin Neurosci J 2:142\u2013146","journal-title":"Int Clin Neurosci J"},{"key":"5912_CR54","doi-asserted-by":"publisher","first-page":"6037","DOI":"10.1046\/j.1432-1033.2002.03294.x","volume":"269","author":"H Vacher","year":"2002","unstructured":"Vacher H, Alami M, Crest M, Possani LD, Bougis PE, MartinEauclaire MF (2002) Expanding the scorpion toxin a-KTX 15 family with AmmTX3 from Androctonus mauretanicus. FEBS J 269:6037\u20136041. https:\/\/doi.org\/10.1046\/j.1432-1033.2002.03294.x","journal-title":"FEBS J"},{"issue":"52","key":"5912_CR55","doi-asserted-by":"publisher","first-page":"36453","DOI":"10.1074\/jbc.M109.075523","volume":"284","author":"ZZ Wu","year":"2009","unstructured":"Wu ZZ, Li DP, Chen SR, Pan HL (2009) Aminopyridines potentiate synaptic and neuromuscular transmission by targeting the voltage-activated calcium channel beta subunit. J Biol Chem 284(52):36453\u201336461. https:\/\/doi.org\/10.1074\/jbc.M109.075523","journal-title":"J Biol Chem"},{"issue":"4","key":"5912_CR56","first-page":"315","volume":"32","author":"RJ Wurtman","year":"1980","unstructured":"Wurtman RJ, Hefti F, Melamed E (1980) Precursor control of neurotransmitter synthesis. Pharmacol Rev 32(4):315\u2013335","journal-title":"Pharmacol Rev"}],"container-title":["Experimental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-020-05912-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00221-020-05912-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-020-05912-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T01:33:36Z","timestamp":1630460016000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00221-020-05912-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,1]]},"references-count":56,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["5912"],"URL":"https:\/\/doi.org\/10.1007\/s00221-020-05912-w","relation":{},"ISSN":["0014-4819","1432-1106"],"issn-type":[{"type":"print","value":"0014-4819"},{"type":"electronic","value":"1432-1106"}],"subject":[],"published":{"date-parts":[[2020,9,1]]},"assertion":[{"value":"1 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors report no conflict or interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}