{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:52:58Z","timestamp":1783839178694,"version":"3.55.0"},"reference-count":88,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001849","name":"Defence Research and Development Organisation","doi-asserted-by":"publisher","award":["DIP-263"],"award-info":[{"award-number":["DIP-263"]}],"id":[{"id":"10.13039\/501100001849","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Brain Res"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s00221-021-06095-8","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T11:02:51Z","timestamp":1617015771000},"page":"1747-1763","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Elucidating the role of hypoxia\/reoxygenation in hippocampus-dependent memory impairment: do SK channels play role?"],"prefix":"10.1007","volume":"239","author":[{"given":"Manisha","family":"Kadam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Perveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neetu","family":"Kushwah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipti","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Panjwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhuvnesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0098-0072","authenticated-orcid":false,"given":"Nilofar","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"6095_CR1","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1146\/annurev-physiol-020911-153336","volume":"74","author":"JP Adelman","year":"2012","unstructured":"Adelman JP, Maylie J, Sah P (2012) Small-Conductance Ca 2+ -Activated K + channels: form and function. Annu Rev Physiol 74:245\u2013269. https:\/\/doi.org\/10.1146\/annurev-physiol-020911-153336","journal-title":"Annu Rev Physiol"},{"key":"6095_CR2","first-page":"22","volume":"32","author":"D Baeyens","year":"1978","unstructured":"Baeyens D, Meier M (1978) Effects of hyperbaric hypoxia on some enzyme systems in the mammalian liver. J Ark Acad Sci 32:22\u201324","journal-title":"J Ark Acad Sci"},{"key":"6095_CR3","doi-asserted-by":"publisher","first-page":"3201","DOI":"10.1242\/jeb.01106","volume":"207","author":"K Ballanyi","year":"2004","unstructured":"Ballanyi K (2004) Protective role of neuronal K ATP channels in brain hypoxia. J Exp Biol 207:3201\u20133212. https:\/\/doi.org\/10.1242\/jeb.01106","journal-title":"J Exp Biol"},{"key":"6095_CR4","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.ejphar.2007.05.063","volume":"570","author":"K Barhwal","year":"2007","unstructured":"Barhwal K, Singh SB, Hota SK et al (2007) Acetyl- L -Carnitine ameliorates hypobaric hypoxic impairment and spatial memory deficits in rats. Eur J Pharmacol 570:97\u2013107. https:\/\/doi.org\/10.1016\/j.ejphar.2007.05.063","journal-title":"Eur J Pharmacol"},{"key":"6095_CR5","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.nlm.2016.05.011","volume":"133","author":"S Biswal","year":"2016","unstructured":"Biswal S, Sharma D, Kumar K et al (2016) Global hypoxia induced impairment in learning and spatial memory is associated with precocious hippocampal aging. Neurobiol Learn Mem 133:157\u2013170. https:\/\/doi.org\/10.1016\/j.nlm.2016.05.011","journal-title":"Neurobiol Learn Mem"},{"key":"6095_CR6","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.neuron.2006.12.017","volume":"53","author":"BL Bloodgood","year":"2007","unstructured":"Bloodgood BL, Sabatini BL (2007) Nonlinear regulation of unitary synaptic by CaV2.3 voltage- sensitive calcium channels located in dendritic spines. Neuron 53:249\u2013260. https:\/\/doi.org\/10.1016\/j.neuron.2006.12.017","journal-title":"Neuron"},{"key":"6095_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fncel.2016.00206","volume":"10","author":"T Bock","year":"2016","unstructured":"Bock T, Stuart GJ, Martina M (2016) The impact of BK channels on cellular excitability depends on their subcellular location. Front Cell Neurosci 10:1\u20138. https:\/\/doi.org\/10.3389\/fncel.2016.00206","journal-title":"Front Cell Neurosci"},{"key":"6095_CR8","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1152\/jappl.1999.86.4.1211","volume":"86","author":"JA Boero","year":"1999","unstructured":"Boero JA, Ascher J, Arregui A et al (1999) Increased brain capillaries in chronic hypoxia. J Appl Physiol 86:1211\u20131219. https:\/\/doi.org\/10.1152\/jappl.1999.86.4.1211","journal-title":"J Appl Physiol"},{"key":"6095_CR9","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1111\/j.1749-6632.1999.tb11298.x","volume":"868","author":"CT Bond","year":"1999","unstructured":"Bond CT, Maylie J, Adelman JP (1999) Small-conductance calcium-activated potassium channels. Ann N Y Acad Sci 868:370\u2013378. https:\/\/doi.org\/10.1111\/j.1749-6632.1999.tb11298.x","journal-title":"Ann N Y Acad Sci"},{"key":"6095_CR10","doi-asserted-by":"crossref","unstructured":"Bond CT, Sprengel R, Bissonnette JM, et al (2000) Respiration and Pafiurition Affected by Conditional Overexpression of the Ca2+- Activated K+ Channel Subunit, SK3","DOI":"10.1126\/science.289.5486.1942"},{"key":"6095_CR11","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.conb.2005.05.001","volume":"15","author":"CT Bond","year":"2005","unstructured":"Bond CT, Maylie J, Adelman JP (2005) SK channels in excitability, pacemaking and synaptic integration. Curr Opin Neurobiol 15:305\u2013311. https:\/\/doi.org\/10.1016\/j.conb.2005.05.001","journal-title":"Curr Opin Neurobiol"},{"key":"6095_CR12","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S0022-2828(03)00005-1","volume":"35","author":"V Borutaite","year":"2003","unstructured":"Borutaite V, Jekabsone A, Morkuniene R, Brown GC (2003) Inhibition of mitochondrial permeability transition prevents mitochondrial dysfunction, cytochrome c release and apoptosis induced by heart ischemia. J Mol Cell Cardiol 35:357\u2013366. https:\/\/doi.org\/10.1016\/S0022-2828(03)00005-1","journal-title":"J Mol Cell Cardiol"},{"key":"6095_CR13","first-page":"117","volume":"86","author":"LM Boyle","year":"2013","unstructured":"Boyle LM (2013) A neuroplasticity hypothesis of chronic stress in the basolateral amygdala. Yale J Biol Med 86:117\u2013125","journal-title":"Yale J Biol Med"},{"key":"6095_CR14","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3109\/00207458909002151","volume":"48","author":"R Brandies","year":"1989","unstructured":"Brandies R, Brandys Y, Yehuda S (1989) The use of the morris water maze in the study of memory and learning. Int J Neurosci 48:29\u201369. https:\/\/doi.org\/10.3109\/00207458909002151","journal-title":"Int J Neurosci"},{"key":"6095_CR15","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.neuron.2010.11.018","volume":"68","author":"KA Buchanan","year":"2010","unstructured":"Buchanan KA, Petrovic MM, Chamberlain SEL et al (2010) Facilitation of long-term potentiation by muscarinic M 1 receptors is mediated by inhibition of SK channels. Neuron 68:948\u2013963. https:\/\/doi.org\/10.1016\/j.neuron.2010.11.018","journal-title":"Neuron"},{"key":"6095_CR16","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S0005-2728(98)00109-1","volume":"1366","author":"J Cai","year":"1998","unstructured":"Cai J, Yang J, Jones DP (1998) Mitochondrial control of apoptosis: the role of cytochrome c. Biochim Biophys Acta Bioenerg 1366:139\u2013149. https:\/\/doi.org\/10.1016\/S0005-2728(98)00109-1","journal-title":"Biochim Biophys Acta Bioenerg"},{"key":"6095_CR17","doi-asserted-by":"crossref","unstructured":"Conforti L, Millhorn DE (2000) Regulation of Shaker- Type Potassium Channels by Hypoxia. In: Lahiri S, Prabhakar NR, Forster RE (eds) Oxygen Sensing. Advances in Experimental Medicine and Biology, 475th edn. Springer, Boston, MA, Boston, pp 265\u2013274","DOI":"10.1007\/0-306-46825-5_25"},{"key":"6095_CR18","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/01926230701320337","volume":"35","author":"S Elmore","year":"2007","unstructured":"Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35:495\u2013516. https:\/\/doi.org\/10.1080\/01926230701320337","journal-title":"Toxicol Pathol"},{"key":"6095_CR19","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1177\/1073858403252673","volume":"9","author":"ESL Faber","year":"2003","unstructured":"Faber ESL, Sah P (2003) Calcium-activated potassium channels: multiple contributions to neuronal function. Neuroscientist 9:181\u2013194. https:\/\/doi.org\/10.1177\/1073858403252673","journal-title":"Neuroscientist"},{"key":"6095_CR20","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1111\/j.1460-9568.2005.04357.x","volume":"22","author":"ESL Faber","year":"2005","unstructured":"Faber ESL, Sah P (2005) Independent roles of calcium and voltage-dependent potassium currents in controlling spike frequency adaptation in lateral amygdala pyramidal neurons. Eur J Neurosci 22:1627\u20131635. https:\/\/doi.org\/10.1111\/j.1460-9568.2005.04357.x","journal-title":"Eur J Neurosci"},{"key":"6095_CR21","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1111\/j.1440-1681.2007.04725.x","volume":"34","author":"ESL Faber","year":"2007","unstructured":"Faber ESL, Sah P (2007) Functions of SK channels in central neurons. Clin Exp Pharmacol Physiol 34:1077\u20131083. https:\/\/doi.org\/10.1111\/j.1440-1681.2007.04725.x","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"6095_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2020.555532","volume":"11","author":"Y Gao","year":"2020","unstructured":"Gao Y, Zhang Y, Dong Y et al (2020) Dexmedetomidine mediates neuroglobin up-regulation and alleviates the hypoxia \/ reoxygenation injury by inhibiting neuronal apoptosis in developing rats. Front Pharmacol 11:1\u20139. https:\/\/doi.org\/10.3389\/fphar.2020.555532","journal-title":"Front Pharmacol"},{"key":"6095_CR23","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3109\/03009738809178533","volume":"93","author":"U Haglund","year":"1988","unstructured":"Haglund U (1988) Hypoxia and reoxygenation\u2014two mechanisms for tissue injury in ischemia and shock. Ups J Med Sci 93:127\u2013129. https:\/\/doi.org\/10.3109\/03009738809178533","journal-title":"Ups J Med Sci"},{"key":"6095_CR24","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.ceb.2009.08.005","volume":"21","author":"RB Hamanaka","year":"2009","unstructured":"Hamanaka RB, Chandel NS (2009) Mitochondrial reactive oxygen species regulate hypoxic signaling. Curr Opin Cell Biol 21:894\u2013899. https:\/\/doi.org\/10.1016\/j.ceb.2009.08.005","journal-title":"Curr Opin Cell Biol"},{"key":"6095_CR25","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1523\/jneurosci.4106-05.2006","volume":"26","author":"RS Hammond","year":"2006","unstructured":"Hammond RS, Bond CT, Strassmaier T et al (2006) Small-Conductance Ca2+-Activated K+ channel type 2 (SK2) modulates hippocampal learning, memory, and synaptic plasticity. J Neurosci 26:1844\u20131853. https:\/\/doi.org\/10.1523\/jneurosci.4106-05.2006","journal-title":"J Neurosci"},{"key":"6095_CR26","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/S0165-0173(01)00067-4","volume":"36","author":"RD Hooge","year":"2001","unstructured":"Hooge RD, De DPP (2001) Applications of the Morris water maze in the study of learning and memory. Brain Res Rev 36:60\u201390","journal-title":"Brain Res Rev"},{"key":"6095_CR27","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.neuint.2007.04.003","volume":"51","author":"SK Hota","year":"2007","unstructured":"Hota SK, Barhwal K, Singh SB, Ilavazhagan G (2007) Differential temporal response of hippocampus, cortex and cerebellum to hypobaric hypoxia: a biochemical approach. Neurochem Int 51:384\u2013390. https:\/\/doi.org\/10.1016\/j.neuint.2007.04.003","journal-title":"Neurochem Int"},{"key":"6095_CR28","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.nlm.2008.01.003","volume":"89","author":"SK Hota","year":"2008","unstructured":"Hota SK, Barhwal K, Ray K et al (2008a) Ceftriaxone rescues hippocampal neurons from excitotoxicity and enhances memory retrieval in chronic hypobaric hypoxia. Neurobiol Learn Mem 89:522\u2013532. https:\/\/doi.org\/10.1016\/j.nlm.2008.01.003","journal-title":"Neurobiol Learn Mem"},{"key":"6095_CR29","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1002\/jnr.21554","volume":"86","author":"SK Hota","year":"2008","unstructured":"Hota SK, Barhwal K, Singh SB, Sairam M (2008b) NR1 and GluR2 expression mediates excitotoxicity in chronic hypobaric hypoxia. J Neurosci Res 86:1142\u20131152. https:\/\/doi.org\/10.1002\/jnr.21554","journal-title":"J Neurosci Res"},{"key":"6095_CR30","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.3892\/mmr.2019.9939","volume":"19","author":"Y Hou","year":"2019","unstructured":"Hou Y, Wang X, Chen X et al (2019) Establishment and evaluation of a simulated high-altitude hypoxic brain injury model in SD rats. Mol Med Rep 19:2758\u20132766. https:\/\/doi.org\/10.3892\/mmr.2019.9939","journal-title":"Mol Med Rep"},{"key":"6095_CR31","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1136\/thx.37.11.858","volume":"37","author":"FA Huppert","year":"1982","unstructured":"Huppert FA (1982) Memory impairment associated with chronic hypoxia. Thorax 37:858\u2013860. https:\/\/doi.org\/10.1136\/thx.37.11.858","journal-title":"Thorax"},{"key":"6095_CR32","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0014-2999(00)00736-6","volume":"407","author":"SY Inan","year":"2000","unstructured":"Inan SY, Aksu F, Baysal F (2000) The effects of some K+ channel blockers on scopolamine- or electroconvulsive shock-induced amnesia in mice. Eur J Pharmacol 407:159\u2013164","journal-title":"Eur J Pharmacol"},{"key":"6095_CR33","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s10571-012-9807-5","volume":"32","author":"V Jain","year":"2012","unstructured":"Jain V, Baitharu I, Barhwal K et al (2012) Enriched environment prevents hypobaric hypoxia induced neurodegeneration and is independent of antioxidant signaling. Cell Mol Neurobiol 32:599\u2013611. https:\/\/doi.org\/10.1007\/s10571-012-9807-5","journal-title":"Cell Mol Neurobiol"},{"key":"6095_CR34","doi-asserted-by":"publisher","first-page":"e62235","DOI":"10.1371\/journal.pone.0062235","volume":"8","author":"V Jain","year":"2013","unstructured":"Jain V, Baitharu I, Prasad D, Ilavazhagan G (2013) Enriched environment prevents hypobaric hypoxia induced memory impairment and neurodegeneration: role of BDNF \/ PI3K \/ GSK3 b pathway coupled with CREB activation. PLoS ONE 8:e62235. https:\/\/doi.org\/10.1371\/journal.pone.0062235","journal-title":"PLoS ONE"},{"key":"6095_CR35","doi-asserted-by":"publisher","first-page":"C848","DOI":"10.1152\/ajpcell.1998.275.3.C848","volume":"275","author":"BOS Jensen","year":"1998","unstructured":"Jensen BOS, Str\u00f8b\u00e6k D, Christophersen P et al (1998) Characterization of the cloned human intermediate-conductance Ca 2+ -activated K+ channel. Am J Physiol 275:C848\u2013C856. https:\/\/doi.org\/10.1152\/ajpcell.1998.275.3.C848","journal-title":"Am J Physiol"},{"key":"6095_CR36","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00275","author":"SH Jung","year":"2017","unstructured":"Jung SH, Brownlow ML, Pellegrini M, Jankord R (2017) Divergence in morris water maze-based cognitive performance under chronic stress is associated with the hippocampal whole transcriptomic modification in mice. Front Mol Neurosci. https:\/\/doi.org\/10.3389\/fnmol.2017.00275","journal-title":"Front Mol Neurosci"},{"key":"6095_CR37","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1113\/jphysiol.1986.sp016221","volume":"378","author":"IS Kass","year":"1986","unstructured":"Kass IS, Liptont P (1986) Calcium and long-term transmission damage following anoxia in dentate gyrus and CA1 regions of the rat hippocampal slice. J Physiol 378:313\u2013334. https:\/\/doi.org\/10.1113\/jphysiol.1986.sp016221","journal-title":"J Physiol"},{"key":"6095_CR38","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1152\/jn.1990.63.3.385","volume":"63","author":"K Kawasaki","year":"1990","unstructured":"Kawasaki K, Traynelis SF, Dingledine R (1990) Different responses of CA1 and CA3 regions to hypoxia in rat hippocampal slice. J Neurophysiol 63:385\u2013394. https:\/\/doi.org\/10.1152\/jn.1990.63.3.385","journal-title":"J Neurophysiol"},{"key":"6095_CR39","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/S0039-128X(01)00181-7","volume":"67","author":"MJ Kelly","year":"2002","unstructured":"Kelly MJ, R\u00f8nnekleiv OK, Ibrahim N et al (2002) Estrogen modulation of K +channel activity in hypothalamic neurons involved in the control of the reproductive axis. Steroids 67:447\u2013456. https:\/\/doi.org\/10.1016\/S0039-128X(01)00181-7","journal-title":"Steroids"},{"key":"6095_CR40","first-page":"375","volume":"40","author":"K Krnjevi\u0107","year":"1999","unstructured":"Krnjevi\u0107 K (1999) Early effects of hypoxia on brain cell function. Croat Med J 40:375\u2013380","journal-title":"Croat Med J"},{"key":"6095_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0149309","volume":"11","author":"N Kushwah","year":"2016","unstructured":"Kushwah N, Jain V, Deep S et al (2016) Neuroprotective role of intermittent hypobaric hypoxia in unpredictable chronic mild stress induced depression in rats. PLoS ONE 11:1\u201320. https:\/\/doi.org\/10.1371\/journal.pone.0149309","journal-title":"PLoS ONE"},{"key":"6095_CR42","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.neuroscience.2018.07.026","volume":"388","author":"N Kushwah","year":"2018","unstructured":"Kushwah N, Jain V, Dheer A et al (2018) Hypobaric Hypoxia induced learning and memory impairment: elucidating the role of small conductance Ca 2 + activated K + channels. Neuroscience 388:418\u2013429. https:\/\/doi.org\/10.1016\/j.neuroscience.2018.07.026","journal-title":"Neuroscience"},{"key":"6095_CR43","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.2174\/18715273156661609201239","volume":"15","author":"JV Lafuente","year":"2016","unstructured":"Lafuente JV, Bermudez G, Camargo- Arce L, Bulnes S (2016) Blood-brain barrier changes in high altitude. CNS Neurol Disord Drug Targets 15:1188\u20131197. https:\/\/doi.org\/10.2174\/18715273156661609201239","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"6095_CR44","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1152\/jappl.1992.72.6.2238","volume":"72","author":"JC LaManna","year":"1992","unstructured":"LaManna JC, Vendel LM, Farrell RM (1992) Brain adaptation to chronic hypobaric hypoxia in rats. J Appl Physiol 72:2238\u20132243. https:\/\/doi.org\/10.1152\/jappl.1992.72.6.2238","journal-title":"J Appl Physiol"},{"key":"6095_CR45","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/0041-008X(90)90278-3","volume":"104","author":"CP Lebel","year":"1990","unstructured":"Lebel CP, Ali SF, McKee M, Bondy SC (1990) Organometal-induced increases in oxygen reactive species: the potential of 2\u2019,7\u2019-dichlorofluorescin diacetate as an index of neurotoxic damage. Toxicol Appl Pharmacol 104:17\u201324. https:\/\/doi.org\/10.1016\/0041-008X(90)90278-3","journal-title":"Toxicol Appl Pharmacol"},{"key":"6095_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1756-8722-6-19","volume":"6","author":"X Li","year":"2013","unstructured":"Li X, Fang P, Mai J et al (2013) Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers. J Hematol Oncol 6:1\u201319. https:\/\/doi.org\/10.1186\/1756-8722-6-19","journal-title":"J Hematol Oncol"},{"key":"6095_CR47","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1159\/000015415","volume":"86","author":"M Litt","year":"1999","unstructured":"Litt M, Lamorticella D, Bond CT, Adelman JP (1999) Gene structure and chromosome mapping of the human small-conductance calcium- activated potassium channel SK1 gene. Cytogenet Cell Genet 86:70\u201373. https:\/\/doi.org\/10.1159\/000015415","journal-title":"Cytogenet Cell Genet"},{"key":"6095_CR48","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1038\/jcbfm.2010.29","volume":"30","author":"JJ Lochhead","year":"2010","unstructured":"Lochhead JJ, Mccaffrey G, Quigley CE et al (2010) Oxidative stress increases blood \u2013 brain barrier permeability and induces alterations in occludin during hypoxia \u2013 reoxygenation. J Cereb Blood Flow Metab 30:1625\u20131636. https:\/\/doi.org\/10.1038\/jcbfm.2010.29","journal-title":"J Cereb Blood Flow Metab"},{"key":"6095_CR49","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.neuint.2006.06.002","volume":"49","author":"P Maiti","year":"2006","unstructured":"Maiti P, Singh SB, Sharma AK et al (2006) Hypobaric hypoxia induces oxidative stress in rat brain. Neurochem Int 49:709\u2013716. https:\/\/doi.org\/10.1016\/j.neuint.2006.06.002","journal-title":"Neurochem Int"},{"key":"6095_CR50","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.bbr.2008.01.007","volume":"189","author":"P Maiti","year":"2008","unstructured":"Maiti P, Muthuraju S, Ilavazhagan G, Singh SB (2008a) Hypobaric hypoxia induces dendritic plasticity in cortical and hippocampal pyramidal neurons in rat brain. Behav Brain Res 189:233\u2013243. https:\/\/doi.org\/10.1016\/j.bbr.2008.01.007","journal-title":"Behav Brain Res"},{"key":"6095_CR51","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.jchemneu.2008.07.003","volume":"36","author":"P Maiti","year":"2008","unstructured":"Maiti P, Singh SB, Mallick B et al (2008b) High altitude memory impairment is due to neuronal apoptosis in hippocampus, cortex and striatum. J Chem Neuroanat 36:227\u2013238. https:\/\/doi.org\/10.1016\/j.jchemneu.2008.07.003","journal-title":"J Chem Neuroanat"},{"key":"6095_CR52","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.acthis.2008.10.005","volume":"112","author":"P Maiti","year":"2010","unstructured":"Maiti P, Singh SB, Ilavazhagan G (2010) Nitric oxide system is involved in hypobaric hypoxia-induced oxidative stress in rat brain. Acta Histochem 112:222\u2013232. https:\/\/doi.org\/10.1016\/j.acthis.2008.10.005","journal-title":"Acta Histochem"},{"key":"6095_CR53","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1056\/NEJM198501173120305","volume":"312","author":"JM McCord","year":"1985","unstructured":"McCord JM (1985) Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 312:159\u2013163. https:\/\/doi.org\/10.1056\/NEJM198501173120305","journal-title":"N Engl J Med"},{"key":"6095_CR54","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0165-3806(89)90014-X","volume":"45","author":"OP Mishra","year":"1989","unstructured":"Mishra OP, Delivoria-papadopoulos M (1989) Lipid peroxidation in developing fetal guinea pig brain during normoxia and hypoxia. Dev Brain Res 45:129\u2013135. https:\/\/doi.org\/10.1016\/0165-3806(89)90014-X","journal-title":"Dev Brain Res"},{"key":"6095_CR55","first-page":"41","volume":"21","author":"S Muthuraju","year":"2014","unstructured":"Muthuraju S, Pati S (2014) Effect of hypobaric hypoxia on cognitive functions and potential therapeutic agents. Malaysian J Med Sci 21:41\u201345","journal-title":"Malaysian J Med Sci"},{"key":"6095_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbr.2009.03.026","volume":"203","author":"S Muthuraju","year":"2009","unstructured":"Muthuraju S, Maiti P, Solanki P et al (2009) Acetylcholinesterase inhibitors enhance cognitive functions in rats following hypobaric hypoxia. Behav Brain Res 203:1\u201314. https:\/\/doi.org\/10.1016\/j.bbr.2009.03.026","journal-title":"Behav Brain Res"},{"key":"6095_CR57","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ejphar.2011.08.023","volume":"672","author":"S Muthuraju","year":"2011","unstructured":"Muthuraju S, Maiti P, Pati S et al (2011) Role of cholinergic markers on memory function of rats exposed to hypobaric hypoxia. Eur J Pharmacol 672:96\u2013105. https:\/\/doi.org\/10.1016\/j.ejphar.2011.08.023","journal-title":"Eur J Pharmacol"},{"key":"6095_CR58","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0166-4328(02)00060-8","volume":"139","author":"N Naghdi","year":"2003","unstructured":"Naghdi N, Majlessi N, Bozorgmehr T (2003) The effects of anisomycin (a protein synthesis inhibitor ) on spatial learning and memory in CA1 region of rats hippocampus. Behav Brain Res 139:69\u201373. https:\/\/doi.org\/10.1016\/S0166-4328(02)00060-8","journal-title":"Behav Brain Res"},{"key":"6095_CR59","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/nn1449","volume":"8","author":"TJ Ngo-anh","year":"2005","unstructured":"Ngo-anh TJ, Bloodgood BL, Lin M et al (2005) SK channels and NMDA receptors form a Ca 2 + -mediated feedback loop in dendritic spines. Nat Neurosci 8:642\u2013649. https:\/\/doi.org\/10.1038\/nn1449","journal-title":"Nat Neurosci"},{"key":"6095_CR60","doi-asserted-by":"publisher","first-page":"3196","DOI":"10.1007\/s00018-008-8216-x","volume":"65","author":"P Pedarzani","year":"2008","unstructured":"Pedarzani P, Stocker M (2008) Molecular and cellular basis of small- and intermediate-conductance, calcium-activated potassium channel function in the brain. Cell Mol Life Sci 65:3196\u20133217. https:\/\/doi.org\/10.1007\/s00018-008-8216-x","journal-title":"Cell Mol Life Sci"},{"key":"6095_CR61","doi-asserted-by":"publisher","first-page":"41404","DOI":"10.1074\/jbc.M509610200","volume":"280","author":"P Pedarzani","year":"2005","unstructured":"Pedarzani P, Mccutcheon JE, Rogge G et al (2005) Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I AHP and modulates the firing properties of hippocampal pyramidal neurons*. J Biol Chem 280:41404\u201341411. https:\/\/doi.org\/10.1074\/jbc.M509610200","journal-title":"J Biol Chem"},{"key":"6095_CR62","doi-asserted-by":"publisher","DOI":"10.1159\/000356579","author":"D Peng","year":"2013","unstructured":"Peng D, Pan X, Cui J et al (2013) Hyperphosphorylation of tau protein in hippocampus of central insulin- resistant rats is associated with cognitive impairment. Cell Physiol Biochem. https:\/\/doi.org\/10.1159\/000356579","journal-title":"Cell Physiol Biochem"},{"key":"6095_CR63","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/BF00240043","volume":"160\u2013161","author":"A Pinson","year":"1996","unstructured":"Pinson A, Tirosh R (1996) Reversible and irreversible damage in reoxygenated \u201cischemic\u201d ventricular myocytes in culture. Mol Cell Biochem 160\u2013161:137\u2013141. https:\/\/doi.org\/10.1007\/BF00240043","journal-title":"Mol Cell Biochem"},{"key":"6095_CR64","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1161\/01.CIR.83.2.566","volume":"83","author":"RA Quaife","year":"1991","unstructured":"Quaife RA, Kohmoto O, Barry WH (1991) Mechanisms of reoxygenation injury in cultured ventricular myocytes. Circulation 83:566\u2013577. https:\/\/doi.org\/10.1161\/01.CIR.83.2.566","journal-title":"Circulation"},{"key":"6095_CR65","doi-asserted-by":"publisher","first-page":"9698","DOI":"10.1523\/jneurosci.22-22-09698.2002","volume":"22","author":"CA Sailer","year":"2002","unstructured":"Sailer CA, Hu H, Kaufmann WA et al (2002) Regional differences in distribution and functional expression of small-conductance Ca 2+ -Activated K + channels in rat brain. J Neurosci 22:9698\u20139707. https:\/\/doi.org\/10.1523\/jneurosci.22-22-09698.2002","journal-title":"J Neurosci"},{"key":"6095_CR66","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1093\/brain\/awf257","volume":"125","author":"HJ Schoch","year":"2002","unstructured":"Schoch HJ, Fischer S, Marti HH (2002) Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brain. Brain 125:2549\u20132557. https:\/\/doi.org\/10.1093\/brain\/awf257","journal-title":"Brain"},{"key":"6095_CR67","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/0165-0270(89)90004-6","volume":"28","author":"A Schurr","year":"1989","unstructured":"Schurr A, West CA, Rigor BM (1989) Electrophysiology of energy metabolism and neuronal function in the hippocampal slice preparation. J Neurosci Methods 28:7\u201313. https:\/\/doi.org\/10.1016\/0165-0270(89)90004-6","journal-title":"J Neurosci Methods"},{"key":"6095_CR68","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.3892\/mmr.2020.11442","volume":"22","author":"X Shi","year":"2020","unstructured":"Shi X, Liu Z, Li J (2020) Protective effects of dexmedetomidine on hypoxia\/reoxygenation injury in cardiomyocytes by regulating the CHOP signaling pathway. Mol Med Rep 22:3307\u20133315. https:\/\/doi.org\/10.3892\/mmr.2020.11442","journal-title":"Mol Med Rep"},{"key":"6095_CR69","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1207\/s15327108ijap0804_1","volume":"8","author":"B Shukitt-hale","year":"1998","unstructured":"Shukitt-hale B, Banderet LE, Lieberman HR (1998) Elevation-dependent symptom, mood, and performance changes produced by exposure to hypobaric hypoxia. Int J Aviat Psychol 8:319\u2013334. https:\/\/doi.org\/10.1207\/s15327108ijap0804_1","journal-title":"Int J Aviat Psychol"},{"key":"6095_CR70","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S0166-4328(02)00366-2","volume":"141","author":"Z \u0160imonov\u00e1","year":"2003","unstructured":"\u0160imonov\u00e1 Z, \u0160t\u02c7 K, Bro\u017eek G, Sykov\u00e1 E (2003) Postnatal hypobaric hypoxia in rats impairs water maze learning and the morphology of neurones and macroglia in cortex and hippocampus. Behav Brain Res 141:195\u2013205","journal-title":"Behav Brain Res"},{"key":"6095_CR71","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.ijdevneu.2014.09.003","volume":"38","author":"A Souza","year":"2014","unstructured":"Souza A, Dussan-Sarria JA, Medeiros LF et al (2014) Neonatal hypoxic-ischemic encephalopathy reduces c-Fos activation in the rat hippocampus: evidence of a long-lasting effect. Int J Dev Neurosci 38:213\u2013222. https:\/\/doi.org\/10.1016\/j.ijdevneu.2014.09.003","journal-title":"Int J Dev Neurosci"},{"key":"6095_CR72","doi-asserted-by":"publisher","first-page":"10163","DOI":"10.1523\/jneurosci.22-23-10163.2002","volume":"22","author":"RW Stackman","year":"2002","unstructured":"Stackman RW, Hammond RS, Linardatos E et al (2002) Small conductance Ca2+-activated K+ channels modulate synaptic plasticity and memory encoding. J Neurosci 22:10163\u201310171. https:\/\/doi.org\/10.1523\/jneurosci.22-23-10163.2002","journal-title":"J Neurosci"},{"key":"6095_CR73","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1101\/lm.906808.These","volume":"4","author":"RW Stackman Jr","year":"2008","unstructured":"Stackman RW Jr, Bond CT, Adelman JP (2008) Contextual memory deficits observed in mice overexpressing small conductance Ca 2 + -activated K + type 2 (K Ca 2. 2, SK2) channels are caused by an encoding deficit. Learn Mem 4:208\u2013213. https:\/\/doi.org\/10.1101\/lm.906808.These","journal-title":"Learn Mem"},{"key":"6095_CR74","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0165-3806(00)00135-8","volume":"126","author":"RC Vannucci","year":"2001","unstructured":"Vannucci RC, Brucklacher RM, Vannucci SJ (2001) Intracellular calcium accumulation during the evolution of hypoxic \u2013 ischemic brain damage in the immature rat. Dev Brain Res 126:117\u2013120. https:\/\/doi.org\/10.1016\/S0165-3806(00)00135-8","journal-title":"Dev Brain Res"},{"key":"6095_CR75","doi-asserted-by":"publisher","first-page":"3537","DOI":"10.1523\/JNEUROSCI.0380-04.2004","volume":"24","author":"C Villalobos","year":"2004","unstructured":"Villalobos C, Shakkottai VG, Chandy KG et al (2004) SK Ca Channels mediate the medium but not the slow calcium-activated afterhyperpolarization in cortical neurons. J Neurosci 24:3537\u20133542. https:\/\/doi.org\/10.1523\/JNEUROSCI.0380-04.2004","journal-title":"J Neurosci"},{"key":"6095_CR76","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1038\/nprot.2006.116","volume":"1","author":"CV Vorhees","year":"2006","unstructured":"Vorhees CV, Williams MT (2006) Forms of learning and memory. Nat Protoc 1:848\u2013858. https:\/\/doi.org\/10.1038\/nprot.2006.116","journal-title":"Nat Protoc"},{"key":"6095_CR77","first-page":"21","volume":"299","author":"EJ Wagner","year":"2001","unstructured":"Wagner EJ, R\u00f8nnekleiv OK, Kelly MJ (2001) The noradrenergic inhibition of an apamin-sensitive, small-conductance Ca2+-activated K+ channel in hypothalamic y-aminobutyric acid neurons\u202f: pharmacology, estrogen sensitivity, and relevance to the control of the reproductive axis. J Pharmacol Exp Ther 299:21\u201330","journal-title":"J Pharmacol Exp Ther"},{"key":"6095_CR78","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.neulet.2010.12.065","volume":"491","author":"L Wang","year":"2011","unstructured":"Wang L, Zhu Q, Wang G et al (2011) The protective roles of mitochondrial ATP-sensitive potassium channels during hypoxia \u2013 ischemia \u2013 reperfusion in brain. Neurosci Lett 491:63\u201367. https:\/\/doi.org\/10.1016\/j.neulet.2010.12.065","journal-title":"Neurosci Lett"},{"key":"6095_CR79","first-page":"69","volume-title":"Progress in Brain Research","author":"BD Watson","year":"1993","unstructured":"Watson BD (1993) Evaluation of the concomitance of lipid peroxidation in experimental models of cerebral ischemia and stroke. In: Kogure K, Hossmann K-A, Siesj\u00f6 BK (eds) Progress in Brain Research, 1st edn. Elsevier, Amsterdam, pp 69\u201395","edition":"1"},{"key":"6095_CR80","doi-asserted-by":"publisher","first-page":"4821","DOI":"10.3892\/mmr.2019.10742","volume":"20","author":"W Wei","year":"2019","unstructured":"Wei W, Peng J, Li J (2019) Curcumin attenuates hypoxia\/reoxygenation-induced myocardial injury. Mol Med Rep 20:4821\u20134830. https:\/\/doi.org\/10.3892\/mmr.2019.10742","journal-title":"Mol Med Rep"},{"key":"6095_CR81","doi-asserted-by":"publisher","first-page":"3404","DOI":"10.1523\/JNEUROSCI.22-09-03404.2002","volume":"22","author":"J Wolfart","year":"2002","unstructured":"Wolfart J, Roeper J (2002) Selective coupling of T-type calcium channels to SK potassium channels prevents intrinsic bursting in dopaminergic midbrain neurons. J Neurosci 22:3404\u20133413. https:\/\/doi.org\/10.1523\/JNEUROSCI.22-09-03404.2002","journal-title":"J Neurosci"},{"key":"6095_CR82","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.1523\/JNEUROSCI.23-07-02600.2003","volume":"23","author":"MD Womack","year":"2003","unstructured":"Womack MD, Khodakhah K (2003) Cerebellar Purkinje neurons. J Neurosci 23:2600\u20132607. https:\/\/doi.org\/10.1523\/JNEUROSCI.23-07-02600.2003","journal-title":"J Neurosci"},{"key":"6095_CR83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2174\/092986708783330665","volume":"15","author":"CHY Wong","year":"2008","unstructured":"Wong CHY, Crack PJ (2008) Modulation of neuro-inflammation and vascular response by oxidative stress following cerebral ischemia-reperfusion injury. Curr Med Chem 15:1\u201314. https:\/\/doi.org\/10.2174\/092986708783330665","journal-title":"Curr Med Chem"},{"key":"6095_CR84","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1097\/00006123-199809000-00102","volume":"43","author":"S Wu","year":"1998","unstructured":"Wu S, Tamaki N, Nagashima T, Yamaguchi M (1998) Reactive oxygen species in reoxygenation injury of rat brain capillary endothelial cells: commentaries. Neurosurgery 43:584. https:\/\/doi.org\/10.1097\/00006123-199809000-00102","journal-title":"Neurosurgery"},{"key":"6095_CR85","doi-asserted-by":"publisher","first-page":"108563","DOI":"10.1016\/j.cbpc.2019.108563","volume":"225","author":"J Xie","year":"2019","unstructured":"Xie J, Cheng C, Jie Y et al (2019) Expression of lactate dehydrogenase is induced during hypoxia via HIF-1 in the mud crab Scylla paramamosain. Comp Biochem Physiol Part C 225:108563. https:\/\/doi.org\/10.1016\/j.cbpc.2019.108563","journal-title":"Comp Biochem Physiol Part C"},{"key":"6095_CR86","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1152\/jn.01058.2004","volume":"93","author":"S Ying","year":"2005","unstructured":"Ying S, Goldstein PA (2005) Propofol-block of SK channels in reticular thalamic neurons enhances GABaergic inhibition in relay neurons. J Neurophysiol 93:1935\u20131948. https:\/\/doi.org\/10.1152\/jn.01058.2004","journal-title":"J Neurophysiol"},{"key":"6095_CR87","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3892\/ijmm.2019.4188","volume":"44","author":"RZ Zhao","year":"2019","unstructured":"Zhao RZ, Jiang S, Zhang L, Bin YuZ (2019) Mitochondrial electron transport chain, ROS generation and uncoupling (Review). Int J Mol Med 44:3\u201315. https:\/\/doi.org\/10.3892\/ijmm.2019.4188","journal-title":"Int J Mol Med"},{"key":"6095_CR88","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.3892\/mmr.2019.10371","volume":"20","author":"P Zhu","year":"2019","unstructured":"Zhu P, Yang M, He H et al (2019) Curcumin attenuates hypoxia\/reoxygenation-induced cardiomyocyte injury by downregulating Notch signaling. Mol Med Rep 20:1541\u20131550. https:\/\/doi.org\/10.3892\/mmr.2019.10371","journal-title":"Mol Med Rep"}],"container-title":["Experimental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-021-06095-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00221-021-06095-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-021-06095-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T18:22:44Z","timestamp":1626200564000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00221-021-06095-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,29]]},"references-count":88,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["6095"],"URL":"https:\/\/doi.org\/10.1007\/s00221-021-06095-8","relation":{},"ISSN":["0014-4819","1432-1106"],"issn-type":[{"value":"0014-4819","type":"print"},{"value":"1432-1106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,29]]},"assertion":[{"value":"30 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal experiments were conducted in accordance with the guidelines of \u201cCommittee for the Purpose of Control and Supervision of Experiments on Animals\u201d of the government of India. Protocols for experiments and animal care were approved by the Institutional Animal Ethical Committee for Animal Care and Use (ICACU). (27\/40\/RBi\/SL\/99\/CPCSEA).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Na.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Na.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The datasets used and\/or analyzed during the current study are available from the corresponding author on reasonable request.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}}]}}