{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:11:05Z","timestamp":1759961465500,"version":"3.37.3"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["K2014-62X-12190-19-5","2019-01771-3"],"award-info":[{"award-number":["K2014-62X-12190-19-5","2019-01771-3"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004722","name":"Stiftelsen Lars Hiertas Minne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004722","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008316","name":"P. O. Zetterlings stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007051","name":"Uppsala Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007051","name":"Uppsala University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007051","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Brain Res"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Traumatic brain injury and stroke result in hemiplegia, hemiparesis, and asymmetry in posture. The effects are mostly contralateral; however, ipsilesional deficits may also develop. We here examined whether ablation brain injury and controlled cortical impact (CCI), a rat model of clinical focal traumatic brain injury, both centered over the left or right sensorimotor cortex, induced hindlimb postural asymmetry (HL-PA) with contralesional or ipsilesional limb flexion. The contralesional hindlimb was flexed after left or right side ablation injury. In contrast, both the left and right CCI unexpectedly produced HL-PA with flexion on left side. The flexion persisted after complete spinal cord transection suggesting that CCI triggered neuroplastic processes in lumbar neural circuits enabling asymmetric muscle contraction. Left limb flexion was exhibited under pentobarbital anesthesia. However, under ketamine anesthesia, the body of the left and right CCI rats bent laterally in the coronal plane to the ipsilesional side suggesting that the left and right injury engaged mirror-symmetrical motor pathways. Thus, the effects of the left and right CCI on HL-PA were not mirror-symmetrical in contrast to those of the ablation brain injury, and to the left and right CCI produced body bending. Ipsilateral effects of the left CCI on HL-PA may be mediated by a lateralized motor pathway that is not affected by the left ablation injury. Alternatively, the left-side-specific neurohormonal mechanism that signals from injured brain to spinal cord may be activated by both the left and right CCI but not by ablation injury.<\/jats:p>","DOI":"10.1007\/s00221-021-06118-4","type":"journal-article","created":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T08:02:47Z","timestamp":1621670567000},"page":"2221-2232","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Unilateral traumatic brain injury of the left and right hemisphere produces the left hindlimb response in rats"],"prefix":"10.1007","volume":"239","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8074-9833","authenticated-orcid":false,"given":"Georgy","family":"Bakalkin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1332-7067","authenticated-orcid":false,"given":"Olga","family":"Nosova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2451-4386","authenticated-orcid":false,"given":"Daniil","family":"Sarkisyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9835-870X","authenticated-orcid":false,"given":"Mathias","family":"Hallberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8366-0052","authenticated-orcid":false,"given":"Mengliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2815-6918","authenticated-orcid":false,"given":"Jens","family":"Schouenborg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9797-5626","authenticated-orcid":false,"given":"Niklas","family":"Marklund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1260-7139","authenticated-orcid":false,"given":"Hiroyuki","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,22]]},"reference":[{"key":"6118_CR1","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/0006-8993(89)90193-5","volume":"480","author":"G Bakalkin","year":"1989","unstructured":"Bakalkin G, Kobylyansky AG (1989) Opioids induce postural asymmetry in spinal rat: the side of the flexed limb depends upon the type of opioid agonist. Brain Res 480:277\u2013289. https:\/\/doi.org\/10.1016\/0006-8993(89)90193-5","journal-title":"Brain Res"},{"key":"6118_CR2","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/0196-9781(86)90025-2","volume":"7","author":"G Bakalkin","year":"1986","unstructured":"Bakalkin G, Kobylyansky AG, Nagornaya LV, Yarygin KN, Titov MI (1986) Met-enkephalin-induced release into the blood of a factor causing postural asymmetry. Peptides 7:551\u2013556. https:\/\/doi.org\/10.1016\/0196-9781(86)90025-2","journal-title":"Peptides"},{"key":"6118_CR3","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3109\/00207458908987436","volume":"47","author":"G Bakalkin","year":"1989","unstructured":"Bakalkin G, Pivovarov A, Kobylyansky AG, Yarygin KN, Akparov V (1989) Ipsilateral responses induced by factors present in left and right hemispheres. Int J Neurosci 47:217\u2013230","journal-title":"Int J Neurosci"},{"key":"6118_CR4","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1002\/bies.201100185","volume":"34","author":"CI Bargmann","year":"2012","unstructured":"Bargmann CI (2012) Beyond the connectome: how neuromodulators shape neural circuits. BioEssays 34:458\u2013465. https:\/\/doi.org\/10.1002\/bies.201100185","journal-title":"BioEssays"},{"key":"6118_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v080.i01","volume":"80","author":"PC Burkner","year":"2017","unstructured":"Burkner PC (2017) brms: an R package for Bayesian multilevel models using stan. Stat Softw 80:1\u201328. https:\/\/doi.org\/10.18637\/jss.v080.i01","journal-title":"Stat Softw"},{"key":"6118_CR6","doi-asserted-by":"publisher","first-page":"6174","DOI":"10.1038\/s41598-017-06351-4","volume":"7","author":"BL Carpenter","year":"2017","unstructured":"Carpenter BL, Liu J, Qi L, Wang C, O\u2019Connor KL (2017) Integrin alpha6beta4 upregulates amphiregulin and epiregulin through base excision repair-mediated DNA demethylation and promotes genome-wide DNA hypomethylation. Sci Rep 7:6174. https:\/\/doi.org\/10.1038\/s41598-017-06351-4","journal-title":"Sci Rep"},{"key":"6118_CR7","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/s0304-3959(00)00360-2","volume":"87","author":"RM Caudle","year":"2000","unstructured":"Caudle RM, Mannes AJ (2000) Dynorphin: friend or foe? Pain 87:235\u2013239. https:\/\/doi.org\/10.1016\/s0304-3959(00)00360-2","journal-title":"Pain"},{"key":"6118_CR8","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1152\/jn.1963.26.4.662","volume":"26","author":"TJ Chamberlain","year":"1963","unstructured":"Chamberlain TJ, Halick P, Gerard RW (1963) Fixation of experience in the rat spinal cord. J Neurophysiol 26:662\u2013673. https:\/\/doi.org\/10.1152\/jn.1963.26.4.662","journal-title":"J Neurophysiol"},{"key":"6118_CR9","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1007\/bf01985696","volume":"37","author":"EI Chazov","year":"1981","unstructured":"Chazov EI, Bakalkin G, Yarigin KN, Trushina ED, Titov MI, Smirnov VN (1981) Enkephalins induce asymmetrical effects on posture in the rat. Experientia 37:887\u2013889. https:\/\/doi.org\/10.1007\/bf01985696","journal-title":"Experientia"},{"key":"6118_CR10","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1111\/j.1460-9568.2011.07723.x","volume":"34","author":"F Clausen","year":"2011","unstructured":"Clausen F, Hanell A, Israelsson C et al (2011) Neutralization of interleukin-1beta reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice. Eur J Neurosci 34:110\u2013123. https:\/\/doi.org\/10.1111\/j.1460-9568.2011.07723.x","journal-title":"Eur J Neurosci"},{"key":"6118_CR11","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.12.021","volume":"28","author":"DB Coelho","year":"2019","unstructured":"Coelho DB, Fernandes CA, Martinelli AR, Teixeira LA (2019) Right in comparison to left cerebral hemisphere damage by stroke induces poorer muscular responses to stance perturbation regardless of visual information. J Stroke Cerebrovasc Dis 28:954\u2013962. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2018.12.021","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"6118_CR12","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/s41593-020-0633-7","volume":"23","author":"JM Cregg","year":"2020","unstructured":"Cregg JM, Leiras R, Montalant A, Wanken P, Wickersham IR, Kiehn O (2020) Brainstem neurons that command mammalian locomotor asymmetries. Nat Neurosci 23:730\u2013740. https:\/\/doi.org\/10.1038\/s41593-020-0633-7","journal-title":"Nat Neurosci"},{"key":"6118_CR13","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1080\/00222895.2017.1306479","volume":"50","author":"FP de Paiva Silva","year":"2018","unstructured":"de Paiva Silva FP, Freitas S, Banjai RM, Alouche SR (2018) Ipsilesional arm aiming movements after stroke: influence of the degree of contralesional impairment. J Mot Behav 50:104\u2013115. https:\/\/doi.org\/10.1080\/00222895.2017.1306479","journal-title":"J Mot Behav"},{"key":"6118_CR14","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1152\/jn.2000.84.3.1673","volume":"84","author":"TG Deliagina","year":"2000","unstructured":"Deliagina TG, Orlovsky GN, Selverston AI, Arshavsky YI (2000) Asymmetrical effect of GABA on the postural orientation in Clione. J Neurophysiol 84:1673\u20131676. https:\/\/doi.org\/10.1152\/jn.2000.84.3.1673","journal-title":"J Neurophysiol"},{"key":"6118_CR15","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1152\/jn.1990.64.3.767","volume":"64","author":"T Drew","year":"1990","unstructured":"Drew T, Rossignol S (1990) Functional organization within the medullary reticular formation of intact unanesthetized cat. I. movements evoked by microstimulation. J Neurophysiol 64:767\u2013781. https:\/\/doi.org\/10.1152\/jn.1990.64.3.767","journal-title":"J Neurophysiol"},{"key":"6118_CR16","doi-asserted-by":"publisher","first-page":"3096","DOI":"10.1152\/jn.01030.2011","volume":"108","author":"MD Ellis","year":"2012","unstructured":"Ellis MD, Drogos J, Carmona C, Keller T, Dewald JP (2012) Neck rotation modulates flexion synergy torques, indicating an ipsilateral reticulospinal source for impairment in stroke. J Neurophysiol 108:3096\u20133104. https:\/\/doi.org\/10.1152\/jn.01030.2011","journal-title":"J Neurophysiol"},{"key":"6118_CR17","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.humov.2017.09.015","volume":"57","author":"CA Fernandes","year":"2018","unstructured":"Fernandes CA, Coelho DB, Martinelli AR, Teixeira LA (2018) Right cerebral hemisphere specialization for quiet and perturbed body balance control: evidence from unilateral stroke. Hum Mov Sci 57:374\u2013387. https:\/\/doi.org\/10.1016\/j.humov.2017.09.015","journal-title":"Hum Mov Sci"},{"key":"6118_CR18","unstructured":"Stan Development Team (2019) Stan modeling language users guide and reference manual, 2.21. https:\/\/mc-stan.org ((Prior choice recommendations. Retrieved 2 May 2019 from https:\/\/github.com\/stan-dev\/stan\/wiki\/Prior-Choice-Recommendations)"},{"key":"6118_CR19","doi-asserted-by":"publisher","first-page":"3442","DOI":"10.1111\/j.1460-9568.2004.03751.x","volume":"20","author":"CL Gonzalez","year":"2004","unstructured":"Gonzalez CL, Gharbawie OA, Williams PT, Kleim JA, Kolb B, Whishaw IQ (2004) Evidence for bilateral control of skilled movements: ipsilateral skilled forelimb reaching deficits and functional recovery in rats follow motor cortex and lateral frontal cortex lesions. Eur J Neurosci 20:3442\u20133452. https:\/\/doi.org\/10.1111\/j.1460-9568.2004.03751.x","journal-title":"Eur J Neurosci"},{"key":"6118_CR20","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1002\/mus.20284","volume":"31","author":"JM Gracies","year":"2005","unstructured":"Gracies JM (2005) Pathophysiology of spastic paresis. I: paresis and soft tissue changes. Muscle Nerve 31:535\u2013551. https:\/\/doi.org\/10.1002\/mus.20284","journal-title":"Muscle Nerve"},{"key":"6118_CR21","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1089\/neu.2005.22.252","volume":"22","author":"ED Hall","year":"2005","unstructured":"Hall ED, Sullivan PG, Gibson TR, Pavel KM, Thompson BM, Scheff SW (2005) Spatial and temporal characteristics of neurodegeneration after controlled cortical impact in mice: more than a focal brain injury. J Neurotrauma 22:252\u2013265. https:\/\/doi.org\/10.1089\/neu.2005.22.252","journal-title":"J Neurotrauma"},{"key":"6118_CR22","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1089\/neu.2007.0383","volume":"25","author":"ED Hall","year":"2008","unstructured":"Hall ED, Bryant YD, Cho W, Sullivan PG (2008) Evolution of post-traumatic neurodegeneration after controlled cortical impact traumatic brain injury in mice and rats as assessed by the de Olmos silver and fluorojade staining methods. J Neurotrauma 25:235\u2013247. https:\/\/doi.org\/10.1089\/neu.2007.0383","journal-title":"J Neurotrauma"},{"key":"6118_CR23","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3389\/fneur.2012.00029","volume":"3","author":"A Hanell","year":"2012","unstructured":"Hanell A, Hedin J, Clausen F, Marklund N (2012) Facilitated assessment of tissue loss following traumatic brain injury. Front Neurol 3:29. https:\/\/doi.org\/10.3389\/fneur.2012.00029","journal-title":"Front Neurol"},{"key":"6118_CR24","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1136\/jnnp.73.5.574","volume":"73","author":"B Hanna-Pladdy","year":"2002","unstructured":"Hanna-Pladdy B, Mendoza JE, Apostolos GT, Heilman KM (2002) Lateralised motor control: hemispheric damage and the loss of deftness. J Neurol Neurosurg Psychiatry 73:574\u2013577. https:\/\/doi.org\/10.1136\/jnnp.73.5.574","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"6118_CR25","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1177\/1545968305284528","volume":"20","author":"JE Harris","year":"2006","unstructured":"Harris JE, Eng JJ (2006) Individuals with the dominant hand affected following stroke demonstrate less impairment than those with the nondominant hand affected. Neurorehabil Neural Repair 20:380\u2013389. https:\/\/doi.org\/10.1177\/1545968305284528","journal-title":"Neurorehabil Neural Repair"},{"key":"6118_CR26","doi-asserted-by":"publisher","first-page":"216","DOI":"10.2741\/1522","volume":"10","author":"KF Hauser","year":"2005","unstructured":"Hauser KF, Aldrich JV, Anderson KJ et al (2005) Pathobiology of dynorphins in trauma and disease. Front Biosci 10:216\u2013235. https:\/\/doi.org\/10.2741\/1522","journal-title":"Front Biosci"},{"key":"6118_CR27","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/0091-3057(85)90291-6","volume":"22","author":"BE Hetzler","year":"1985","unstructured":"Hetzler BE, Wautlet BS (1985) Ketamine-induced locomotion in rats in an open-field. Pharmacol Biochem Behav 22:653\u2013655. https:\/\/doi.org\/10.1016\/0091-3057(85)90291-6","journal-title":"Pharmacol Biochem Behav"},{"key":"6118_CR28","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1111\/j.1748-1716.1983.tb07358.x","volume":"119","author":"H Hultborn","year":"1983","unstructured":"Hultborn H, Malmsten J (1983) Changes in segmental reflexes following chronic spinal cord hemisection in the cat. II. Conditioned monosynaptic test reflexes. Acta Physiol Scand 119:423\u2013433. https:\/\/doi.org\/10.1111\/j.1748-1716.1983.tb07358.x","journal-title":"Acta Physiol Scand"},{"key":"6118_CR29","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1089\/neu.2011.2286","volume":"29","author":"ZM Hussain","year":"2012","unstructured":"Hussain ZM, Fitting S, Watanabe H et al (2012) Lateralized response of dynorphin a peptide levels after traumatic brain injury. J Neurotrauma 29:1785\u20131793. https:\/\/doi.org\/10.1089\/neu.2011.2286","journal-title":"J Neurotrauma"},{"key":"6118_CR30","doi-asserted-by":"publisher","first-page":"R1290","DOI":"10.1016\/j.cub.2018.09.063","volume":"28","author":"D Knebel","year":"2018","unstructured":"Knebel D, Rillich J, Ayali A, Pfluger HJ, Rigosi E (2018) Ex vivo recordings reveal desert locust forelimb control is asymmetric. Curr Biol 28:R1290\u2013R1291. https:\/\/doi.org\/10.1016\/j.cub.2018.09.063","journal-title":"Curr Biol"},{"key":"6118_CR31","doi-asserted-by":"publisher","first-page":"594304","DOI":"10.3389\/fncel.2020.594304","volume":"14","author":"M Lacalle-Aurioles","year":"2020","unstructured":"Lacalle-Aurioles M, Cassel de Camps C, Zorca CE, Beitel LK, Durcan TM (2020) Applying hiPSCs and biomaterials towards an understanding and treatment of traumatic brain injury. Front Cell Neurosci 14:594304. https:\/\/doi.org\/10.3389\/fncel.2020.594304","journal-title":"Front Cell Neurosci"},{"key":"6118_CR32","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.clinph.2017.10.023","volume":"129","author":"J Lorentzen","year":"2018","unstructured":"Lorentzen J, Pradines M, Gracies JM, Bo Nielsen J (2018) On Denny-Brown\u2019s \u2018spastic dystonia\u2019\u2014what is it and what causes it? Clin Neurophysiol 129:89\u201394. https:\/\/doi.org\/10.1016\/j.clinph.2017.10.023","journal-title":"Clin Neurophysiol"},{"key":"6118_CR33","doi-asserted-by":"publisher","DOI":"10.1101\/2020.04.23.056937","author":"N Lukoyanov","year":"2020","unstructured":"Lukoyanov N, Watanabe H, Carvalho LS et al (2020) Endocrine signaling mediates asymmetric motor deficits after unilateral brain injury. BioRxiv. https:\/\/doi.org\/10.1101\/2020.04.23.056937","journal-title":"BioRxiv"},{"key":"6118_CR34","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1177\/1545968319875951","volume":"34","author":"C Maenza","year":"2020","unstructured":"Maenza C, Good DC, Winstein CJ, Wagstaff DA, Sainburg RL (2020) Functional deficits in the less-impaired arm of stroke survivors depend on hemisphere of damage and extent of paretic arm impairment. Neurorehabil Neural Repair 34:39\u201350. https:\/\/doi.org\/10.1177\/1545968319875951","journal-title":"Neurorehabil Neural Repair"},{"key":"6118_CR35","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1093\/brain\/aws283","volume":"136","author":"S Mani","year":"2013","unstructured":"Mani S, Mutha PK, Przybyla A, Haaland KY, Good DC, Sainburg RL (2013) Contralesional motor deficits after unilateral stroke reflect hemisphere-specific control mechanisms. Brain 136:1288\u20131303. https:\/\/doi.org\/10.1093\/brain\/aws283","journal-title":"Brain"},{"key":"6118_CR36","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nature14402","volume":"520","author":"BJ Marlin","year":"2015","unstructured":"Marlin BJ, Mitre M, D\u2019Amour JA, Chao MV, Froemke RC (2015) Oxytocin enables maternal behaviour by balancing cortical inhibition. Nature 520:499\u2013504. https:\/\/doi.org\/10.1038\/nature14402","journal-title":"Nature"},{"key":"6118_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.39","author":"O Maximyuk","year":"2015","unstructured":"Maximyuk O, Khmyz V, Lindskog CJ et al (2015) Plasma membrane poration by opioid neuropeptides: a possible mechanism of pathological signal transduction. Cell Death Dis. https:\/\/doi.org\/10.1038\/cddis.2015.39","journal-title":"Cell Death Dis"},{"key":"6118_CR38","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3389\/fneur.2017.00112","volume":"8","author":"AA McCall","year":"2017","unstructured":"McCall AA, Miller DM, Yates BJ (2017) Descending influences on vestibulospinal and vestibulosympathetic reflexes. Front Neurol 8:112. https:\/\/doi.org\/10.3389\/fneur.2017.00112","journal-title":"Front Neurol"},{"key":"6118_CR39","volume-title":"Statistical rethinking. A Bayesian course with examples in R and Stan","author":"R McElreath","year":"2019","unstructured":"McElreath R (2019) Statistical rethinking. A Bayesian course with examples in R and Stan. Chapman and Hall\/CRC"},{"key":"6118_CR40","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1113\/JP274968","volume":"596","author":"JG McPherson","year":"2018","unstructured":"McPherson JG, Chen A, Ellis MD, Yao J, Heckman CJ, Dewald JPA (2018) Progressive recruitment of contralesional cortico-reticulospinal pathways drives motor impairment post stroke. J Physiol 596:1211\u20131225. https:\/\/doi.org\/10.1113\/JP274968","journal-title":"J Physiol"},{"key":"6118_CR41","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1097\/j.pain.0000000000001167","volume":"159","author":"KM Nation","year":"2018","unstructured":"Nation KM, De Felice M, Hernandez PI, Dodick DW, Neugebauer V, Navratilova E, Porreca F (2018) Lateralized kappa opioid receptor signaling from the amygdala central nucleus promotes stress-induced functional pain. Pain 159:919\u2013928. https:\/\/doi.org\/10.1097\/j.pain.0000000000001167","journal-title":"Pain"},{"key":"6118_CR42","doi-asserted-by":"publisher","first-page":"528","DOI":"10.3389\/fncel.2019.00528","volume":"13","author":"SY Ng","year":"2019","unstructured":"Ng SY, Lee AYW (2019) Traumatic brain injuries: pathophysiology and potential therapeutic targets. Front Cell Neurosci 13:528. https:\/\/doi.org\/10.3389\/fncel.2019.00528","journal-title":"Front Cell Neurosci"},{"key":"6118_CR43","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nrn.2017.56","volume":"18","author":"MP Nusbaum","year":"2017","unstructured":"Nusbaum MP, Blitz DM, Marder E (2017) Functional consequences of neuropeptide and small-molecule co-transmission. Nat Rev Neurosci 18:389\u2013403. https:\/\/doi.org\/10.1038\/nrn.2017.56","journal-title":"Nat Rev Neurosci"},{"key":"6118_CR44","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1097\/j.pain.0000000000001553","volume":"160","author":"CE Phelps","year":"2019","unstructured":"Phelps CE, Navratilova E, Dickenson AH, Porreca F, Bannister K (2019) Kappa opioid signaling in the right central amygdala causes hind paw specific loss of diffuse noxious inhibitory controls in experimental neuropathic pain. Pain 160:1614\u20131621. https:\/\/doi.org\/10.1097\/j.pain.0000000000001553","journal-title":"Pain"},{"key":"6118_CR45","volume-title":"Neuroscience","author":"D Purves","year":"2012","unstructured":"Purves D, Augustine GJ, Fitzpatrick D, Hall WC, LaMantia AS, White LE (2012) Neuroscience. Sinauer Associates"},{"key":"6118_CR46","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1007\/s00221-003-1787-8","volume":"156","author":"S Quessy","year":"2004","unstructured":"Quessy S, Freedman EG (2004) Electrical stimulation of rhesus monkey nucleus reticularis gigantocellularis. I. Characteristics of evoked head movements. Exp Brain Res 156:342\u2013356. https:\/\/doi.org\/10.1007\/s00221-003-1787-8","journal-title":"Exp Brain Res"},{"key":"6118_CR47","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1126\/science.462179","volume":"205","author":"RG Robinson","year":"1979","unstructured":"Robinson RG (1979) Differential behavioral and biochemical effects of right and left hemispheric cerebral infarction in the rat. Science 205:707\u2013710. https:\/\/doi.org\/10.1126\/science.462179","journal-title":"Science"},{"key":"6118_CR48","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1146\/annurev-neuro-061010-113746","volume":"34","author":"S Rossignol","year":"2011","unstructured":"Rossignol S, Frigon A (2011) Recovery of locomotion after spinal cord injury: some facts and mechanisms. Annu Rev Neurosci 34:413\u2013440. https:\/\/doi.org\/10.1146\/annurev-neuro-061010-113746","journal-title":"Annu Rev Neurosci"},{"key":"6118_CR49","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.3389\/fpsyg.2014.01092","volume":"5","author":"RL Sainburg","year":"2014","unstructured":"Sainburg RL (2014) Convergent models of handedness and brain lateralization. Front Psychol 5:1092. https:\/\/doi.org\/10.3389\/fpsyg.2014.01092","journal-title":"Front Psychol"},{"key":"6118_CR50","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1080\/00031305.1980.10483031","volume":"34","author":"SR Searle","year":"1980","unstructured":"Searle SR, Speed FM, Milliken GA (1980) Population marginal means in the linear model: an alternative to least squares means. Am Stat 34:216\u2013221. https:\/\/doi.org\/10.1080\/00031305.1980.10483031","journal-title":"Am Stat"},{"key":"6118_CR51","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.pmrj.2009.08.002","volume":"1","author":"G Sheean","year":"2009","unstructured":"Sheean G, McGuire JR (2009) Spastic hypertonia and movement disorders: pathophysiology, clinical presentation, and quantification. PM R 1:827\u2013833. https:\/\/doi.org\/10.1016\/j.pmrj.2009.08.002","journal-title":"PM R"},{"key":"6118_CR52","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1212\/01.wnl.0000343961.35429.09","volume":"72","author":"M Shevell","year":"2009","unstructured":"Shevell M (2009) The tripartite origins of the tonic neck reflex: gesell, gerstmann, and magnus. Neurology 72:850\u2013853. https:\/\/doi.org\/10.1212\/01.wnl.0000343961.35429.09","journal-title":"Neurology"},{"key":"6118_CR53","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.1093\/brain\/awv195","volume":"138","author":"CJ Smeets","year":"2015","unstructured":"Smeets CJ, Jezierska J, Watanabe H et al (2015) Elevated mutant dynorphin a causes Purkinje cell loss and motor dysfunction in spinocerebellar ataxia type 23. Brain 138:2537\u20132552. https:\/\/doi.org\/10.1093\/brain\/awv195","journal-title":"Brain"},{"key":"6118_CR54","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/bs.pbr.2018.06.002","volume":"238","author":"G Stancher","year":"2018","unstructured":"Stancher G, Sovrano VA, Vallortigara G (2018) Motor asymmetries in fishes, amphibians, and reptiles. Prog Brain Res 238:33\u201356. https:\/\/doi.org\/10.1016\/bs.pbr.2018.06.002","journal-title":"Prog Brain Res"},{"key":"6118_CR55","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1111\/j.1460-9568.2007.05997.x","volume":"27","author":"S Tandon","year":"2008","unstructured":"Tandon S, Kambi N, Jain N (2008) Overlapping representations of the neck and whiskers in the rat motor cortex revealed by mapping at different anaesthetic depths. Eur J Neurosci 27:228\u2013237. https:\/\/doi.org\/10.1111\/j.1460-9568.2007.05997.x","journal-title":"Eur J Neurosci"},{"key":"6118_CR56","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.3389\/fneur.2019.01340","volume":"10","author":"R Varghese","year":"2019","unstructured":"Varghese R, Winstein CJ (2019) Relationship between motor capacity of the contralesional and ipsilesional hand depends on the side of stroke in chronic stroke survivors with mild-to-moderate impairment. Front Neurol 10:1340. https:\/\/doi.org\/10.3389\/fneur.2019.01340","journal-title":"Front Neurol"},{"key":"6118_CR57","first-page":"281","volume":"98","author":"EI Varlinskaia","year":"1984","unstructured":"Varlinskaia EI, Rogachii MG, Klement\u2019ev BI, Vartanian GA (1984) Dynamics of the activity of the postural asymmetry factor after unilateral damage to the motor area of the cortex. Biull Eksp Biol Med 98:281\u2013283","journal-title":"Biull Eksp Biol Med"},{"key":"6118_CR59","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa208","author":"H Watanabe","year":"2020","unstructured":"Watanabe H, Nosova O, Sarkisyan D et al (2020) Ipsilesional versus contralesional postural deficits induced by unilateral brain trauma: a side reversal by opioid mechanism. Brain Commun. https:\/\/doi.org\/10.1093\/braincomms\/fcaa208","journal-title":"Brain Commun"},{"key":"6118_CR58","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0548-20.2021","author":"H Watanabe","year":"2021","unstructured":"Watanabe H, Nosova O, Sarkisyan D et al (2021) Left-right side-specific neuropeptide mechanism mediates contralateral responses to a unilateral brain injury. eNeuro. https:\/\/doi.org\/10.1523\/ENEURO.0548-20.2021","journal-title":"eneuro"},{"key":"6118_CR60","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/0028-3908(86)90156-5","volume":"25","author":"WD Winters","year":"1986","unstructured":"Winters WD, Hance AJ, Cadd GC, Lakin ML (1986) Seasonal and sex influences on ketamine-induced analgesia and catalepsy in the rat; a possible role for melatonin. Neuropharmacology 25:1095\u20131101. https:\/\/doi.org\/10.1016\/0028-3908(86)90156-5","journal-title":"Neuropharmacology"},{"key":"6118_CR61","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa055","author":"M Zhang","year":"2020","unstructured":"Zhang M, Watanabe H, Sarkisyan D et al (2020) Hindlimb motor responses to unilateral brain injury: spinal cord encoding and left-right asymmetry. Brain Commun. https:\/\/doi.org\/10.1093\/braincomms\/fcaa055","journal-title":"Brain Commun"}],"container-title":["Experimental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-021-06118-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00221-021-06118-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-021-06118-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T05:05:54Z","timestamp":1626325554000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00221-021-06118-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,22]]},"references-count":61,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["6118"],"URL":"https:\/\/doi.org\/10.1007\/s00221-021-06118-4","relation":{},"ISSN":["0014-4819","1432-1106"],"issn-type":[{"type":"print","value":"0014-4819"},{"type":"electronic","value":"1432-1106"}],"subject":[],"published":{"date-parts":[[2021,5,22]]},"assertion":[{"value":"9 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Authors report no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}