{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T07:31:44Z","timestamp":1793604704521,"version":"4.5.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2019-ZD-0620"],"award-info":[{"award-number":["2019-ZD-0620"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Brain Res"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s00221-021-06129-1","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T06:27:20Z","timestamp":1623220040000},"page":"2435-2444","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Serotonin 2A receptor function and depression-like behavior in rats model of hypothyroidism"],"prefix":"10.1007","volume":"239","author":[{"given":"Zhicheng","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianer","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3208-0821","authenticated-orcid":false,"given":"Jing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengzi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"6129_CR1","first-page":"1","volume":"18","author":"H Abdi","year":"2019","unstructured":"Abdi H, Amouzegar A, Azizi F (2019) Antithyroid drugs. Iran J Pharm Res 18:1\u201312","journal-title":"Iran J Pharm Res"},{"key":"6129_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/397943","volume":"2015","author":"D Adongo","year":"2015","unstructured":"Adongo D, Kukuia K, Mante P, Ameyaw E, Woode E (2015) Antidepressant-like effect of the leaves of pseudospondias microcarpa in mice: evidence for the involvement of the serotoninergic system, NMDA receptor complex, and nitric oxide pathway. BioMed Res Int 2015:1\u201315","journal-title":"BioMed Res Int"},{"issue":"3","key":"6129_CR3","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/0892-0362(91)90077-A","volume":"13","author":"M Akaike","year":"1991","unstructured":"Akaike M, Kato N, Ohno H, Kobayashi T (1991) Hyperactivity and spatial maze learning impairment of adult rats with temporary neonatal hypothyroidism. Neurotoxicol Teratol 13(3):317\u2013322","journal-title":"Neurotoxicol Teratol"},{"issue":"1","key":"6129_CR4","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s00213-012-2795-9","volume":"225","author":"F Albert","year":"2013","unstructured":"Albert F, Santana N, Casta\u00f1\u00e9 A, Cort\u00e9s R, Mar\u00eda C (2013) Acute 5-ht1a autoreceptor knockdown increases antidepressant responses and serotonin release in stressful conditions. Psychopharmacology 225(1):61\u201374","journal-title":"Psychopharmacology"},{"issue":"12","key":"6129_CR5","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1007\/s11064-020-03153-5","volume":"45","author":"S Anton","year":"2020","unstructured":"Anton S, Tatiana V, Elena A, Dmitry V, Nina K, Vladimir S (2020) The chronic treatment with 5-HT2A\u00c2 receptor agonists affects the behavior and the BDNF system in mice. Neurochem Res 45(12):3059\u20133075","journal-title":"Neurochem Res"},{"key":"6129_CR6","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1192\/bjp.171.5.444","volume":"171","author":"F Biver","year":"1997","unstructured":"Biver F, Wikler D, Lotstra F, Damhaut P, Goldman S, Mendlewicz J (1997) Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex. Brit J Psychiatry 171:444\u2013448","journal-title":"Brit J Psychiatry"},{"key":"6129_CR7","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.ejphar.2018.01.017","volume":"822","author":"VC Bortolotto","year":"2018","unstructured":"Bortolotto VC, Pinheiro FC, Araujo SM, Poetini MR, Bertolazi BS, de Paula MT, Meichtry LB, de Almeida FP, de Freitas CS, Jesse CR, Prigol M (2018) Chrysin reverses the depressive-like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamine. Eur J Pharmacol 822:78\u201384","journal-title":"Eur J Pharmacol"},{"issue":"5","key":"6129_CR8","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/0031-9384(90)90200-N","volume":"48","author":"GM Brosvic","year":"1990","unstructured":"Brosvic GM, Hoey NE (1990) Taste detection and discrimination performance of rats following selective desalivation. Physiol Behav 48(5):617\u2013623","journal-title":"Physiol Behav"},{"issue":"1","key":"6129_CR9","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/0471142301.ns0810as55","volume":"55","author":"V Castagn\u00e9","year":"2011","unstructured":"Castagn\u00e9 V, Moser P, Roux S, Porsolt RD (2011) Rodent models of depression: forced swim and tail suspension behavioral despair tests in rats and mice. Curr Protoc Neurosci 55(1):8\u201310 (A (1\u20134))","journal-title":"Curr Protoc Neurosci"},{"issue":"3","key":"6129_CR10","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1159\/000353777","volume":"2","author":"CM Dayan","year":"2013","unstructured":"Dayan CM, Panicker V (2013) Hypothyroidism and depression. Eur Thyroid J 2(3):168\u2013179","journal-title":"Eur Thyroid J"},{"issue":"8","key":"6129_CR11","doi-asserted-by":"publisher","first-page":"3864","DOI":"10.1210\/jcem.86.8.7749","volume":"86","author":"EL Constant","year":"2001","unstructured":"Constant EL, de Volder AG, Ivanoiu A, Bol A, Labar D, Seghers A, Cosnard G, Melin J, Daumerie C (2001) Cerebral blood flow and glucose metabolism in hypothyroidism: a positron emission tomography study. J Clin Endocrinol Metab 86(8):3864\u20133870","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"6129_CR12","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/1475-2891-13-117","volume":"13","author":"J Correia","year":"2014","unstructured":"Correia J, Ravasco P (2014) Weight changes in Portuguese patients with depression: which factors are involved? Nutr J 13(1):117","journal-title":"Nutr J"},{"issue":"2","key":"6129_CR13","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S0166-4328(03)00041-X","volume":"143","author":"S Darbra","year":"2003","unstructured":"Darbra S, Garau A, Balada F, Sala J, Mart\u00ed-Carbonell MA (2003) Perinatal hypothyroidism effects on neuromotor competence, novelty-directed exploratory and anxiety-related behaviour and learning in rats. Behav Brain Res 143(2):209\u2013215","journal-title":"Behav Brain Res"},{"issue":"9\u201311","key":"6129_CR14","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.lfs.2013.07.024","volume":"93","author":"F Donato","year":"2013","unstructured":"Donato F, de Gomes MG, Goes AT, Seus N, Alves D, Jesse CR, Savegnago L (2013) Involvement of the dopaminergic and serotonergic systems in the antidepressant-like effect caused by 4-phenyl-1-(phenylselanylmethyl)-1,2,3-triazole. Life Sci 93(9\u201311):393\u2013400","journal-title":"Life Sci"},{"issue":"1","key":"6129_CR15","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1002\/da.22692","volume":"35","author":"S Fischer","year":"2018","unstructured":"Fischer S, Ehlert U (2018) Hypothalamic-pituitary-thyroid (HPT) axis functioning in anxiety disorders. A systematic review. Depress Anxiety 35(1):98\u2013110","journal-title":"Depress Anxiety"},{"issue":"3","key":"6129_CR16","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1007\/s12020-013-0001-4","volume":"45","author":"JF Ge","year":"2014","unstructured":"Ge JF, Peng YY, Qi CC, Chen FH, Zhou JN (2014) Depression-like behavior in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization. Endocrine 45(3):430\u2013438","journal-title":"Endocrine"},{"issue":"8","key":"6129_CR17","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/j.1365-2826.2010.02002.x","volume":"22","author":"N Ghenimi","year":"2010","unstructured":"Ghenimi N, Alfos S, Redonnet A, Higueret P, Pallet V, Enderlin V (2010) Adult-onset hypothyroidism induces the amyloidogenic pathway of amyloid precursor protein processing in the rat hippocampus. J Neuroendocrinol 22(8):951\u2013959","journal-title":"J Neuroendocrinol"},{"issue":"3","key":"6129_CR18","first-page":"186","volume":"29","author":"E G\u00f3mez","year":"2001","unstructured":"G\u00f3mez E, Catal\u00e1n R, Navin\u00e9s R, Gast\u00f3 C (2001) Serotonin receptor changes in depression: evidences and limitations. Actas Espanolas de Psiquiatria 29(3):186\u2013194","journal-title":"Actas Espanolas de Psiquiatria"},{"issue":"4","key":"6129_CR20","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1023\/A:1010401015064","volume":"31","author":"AV Kulikov","year":"2001","unstructured":"Kulikov AV, Jeanningro R (2001) The effects of hypothyroidism on 5-HT1A and 5-HT2A receptors and the serotonin transporter protein in the rat brain. Neurosci Behav Physiol 31(4):445\u2013449","journal-title":"Neurosci Behav Physiol"},{"issue":"6","key":"6129_CR19","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1159\/000054449","volume":"69","author":"A Kulikov","year":"1999","unstructured":"Kulikov A, Moreau X, Jeanningros R (1999) Effects of experimental hypothyroidism on 5-HT1A, 5-HT2A receptors, 5-HT uptake sites and tryptophan hydroxylase activity in mature rat brain. Neuroendocrinology 69(6):453\u2013459","journal-title":"Neuroendocrinology"},{"issue":"4","key":"6129_CR21","first-page":"209","volume":"16","author":"F Lafaille","year":"1991","unstructured":"Lafaille F, Welner SA, Suranyi-Cadotte BE (1991) Regulation of serotonin type 2 (5-HT2) and beta-adrenergic receptors in rat cerebral cortex following novel and classical antidepressant treatment. J Psychiatry Neurosci 16(4):209\u2013214","journal-title":"J Psychiatry Neurosci"},{"key":"6129_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2020.11.013","author":"VL\u00c2 Lene","year":"2020","unstructured":"Lene VL\u00c2, N\u00eddiaea FJ (2020) Effects of a single dose of psilocybin on behaviour, brain 5-HT2A\u00c2 receptor occupancy and gene expression in the pig. Eur Neuropsychopharmacol. https:\/\/doi.org\/10.1016\/j.euroneuro.2020.11.013","journal-title":"Eur Neuropsychopharmacol"},{"key":"6129_CR23","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.jep.2016.06.044","volume":"191","author":"Y Liang","year":"2016","unstructured":"Liang Y, Yang X, Zhang X, Duan H, Jin M, Sun Y, Yuan H, Li J, Qi Y, Qiao W (2016) Antidepressant-like effect of the saponins part of ethanol extract from SHF. J Ethnopharmacol 191:307\u2013314","journal-title":"J Ethnopharmacol"},{"key":"6129_CR24","doi-asserted-by":"publisher","unstructured":"Odagaki Y, Kinoshita M, Meana J, Callado L, Garc\u00eda-Sevilla J (2020) 5-HT2A receptor-mediated G$$\\alpha$$ activation in psychiatric disorders: a postmortem study. World J Biol Psychiatry. https:\/\/doi.org\/10.1080\/15622975.2020.1839967","DOI":"10.1080\/15622975.2020.1839967"},{"issue":"2","key":"6129_CR25","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0169-328X(96)00126-X","volume":"42","author":"PA Piosik","year":"1996","unstructured":"Piosik PA, Groenigen MV, Baas F (1996) Effect of thyroid hormone deficiency on RC3\/neurogranin mRNA expression in the prenatal and adult caprine brain. Brain Res Mol Brain Res 42(2):227\u2013235","journal-title":"Brain Res Mol Brain Res"},{"issue":"5604","key":"6129_CR26","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/266730a0","volume":"266","author":"RD Porsolt","year":"1977","unstructured":"Porsolt RD, Le Pichon M, Jalfre M (1977) Depression: a new animal model sensitive to antidepressant treatments. Nature 266(5604):730\u2013732","journal-title":"Nature"},{"issue":"3","key":"6129_CR27","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1097\/YIC.0b013e3283311acd","volume":"25","author":"G Racagni","year":"2010","unstructured":"Racagni G, Popoli M (2010) The pharmacological properties of antidepressants. Int Clin Psychopharmacol 25(3):117","journal-title":"Int Clin Psychopharmacol"},{"issue":"1","key":"6129_CR28","first-page":"80","volume":"232","author":"RS Rivlin","year":"1977","unstructured":"Rivlin RS, Osnos M, Rosenthal S, Henkin RI (1977) Abnormalities in taste preference in hypothyroid rats. Am J Physiol 232(1):80\u201384","journal-title":"Am J Physiol"},{"issue":"1","key":"6129_CR29","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/0006-8993(80)90674-5","volume":"185","author":"A Ruiz-Marcos","year":"1980","unstructured":"Ruiz-Marcos A, S\u00e1nchez-Toscano F, Escobar F, Rey D, Escobar GMD (1980) Reversible morphological alterations of cortical neurons in juvenile and adult hypothyroidism in the rat. Brain Res 185(1):91\u2013102","journal-title":"Brain Res"},{"key":"6129_CR30","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.bbadis.2017.01.002","volume":"4","author":"P Salazar","year":"2017","unstructured":"Salazar P, Cisternas P, Codocedo JF, Inestrosa NC (2017) Induction of hypothyroidism during early postnatal stages triggers a decrease in cognitive performance by decreasing hippocampal synaptic plasticity. Biochimica et Biophysica Acta 4:870\u2013883","journal-title":"Biochimica et Biophysica Acta"},{"issue":"3","key":"6129_CR31","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1023\/A:1015050021293","volume":"32","author":"N Sapronov","year":"2002","unstructured":"Sapronov N, Fedotova Y (2002) The effect of l-tryptophan on conditioned reflflex learning and behavior in rats with experimental pathology ofthe thyroid gland. Neurosci Behav Physiol 32(3):237\u2013241","journal-title":"Neurosci Behav Physiol"},{"issue":"6","key":"6129_CR32","doi-asserted-by":"publisher","first-page":"886","DOI":"10.4103\/ijem.IJEM_265_17","volume":"21","author":"P Tayde","year":"2017","unstructured":"Tayde P, Bhagwat N, Sharma P, Sharma B, Dalwadi P, Sonawane A, Subramanyam A, Chadha M, Varthakavi P (2017) Hypothyroidism and depression: are cytokines the link? Indian J Endocrinol Metab 21(6):886\u2013892","journal-title":"Indian J Endocrinol Metab"},{"issue":"1","key":"6129_CR33","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/s41398-018-0309-1","volume":"8","author":"MD Underwood","year":"2018","unstructured":"Underwood MD, Kassir SA, Bakalian MJ, Galfalvy H, Dwork AJ, Mann JJ, Arango V (2018) Serotonin receptors and suicide, major depression, alcohol use disorder and reported early life adversity. Transl Psychiatry 8(1):279","journal-title":"Transl Psychiatry"},{"issue":"1","key":"6129_CR34","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1007\/s12011-011-9089-7","volume":"144","author":"Y Wang","year":"2011","unstructured":"Wang Y, Zhong J, Wei W, Gong J, Dong J, Yu F, Wang Y, Chen J (2011) Developmental iodine deficiency and hypothyroidism impair neural development, upregulate caveolin-1, and downregulate synaptotagmin-1 in the rat cerebellum. Biol Trace Element Res 144(1):1039\u20131049","journal-title":"Biol Trace Element Res"},{"issue":"1","key":"6129_CR35","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.bbr.2006.10.030","volume":"177","author":"J Wilcoxon","year":"2006","unstructured":"Wilcoxon J, Nadolski G, Samarut J, Chassande O, Redei E (2006) Behavioral inhibition and impaired spatial learning and memory in hypothyroid mice lacking thyroid hormone receptor alpha. Behav Brain Res 177(1):109\u2013116","journal-title":"Behav Brain Res"},{"issue":"1","key":"6129_CR36","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1002\/(SICI)1098-2396(199709)27:1<79::AID-SYN8>3.0.CO;2-A","volume":"27","author":"DL Willins","year":"1997","unstructured":"Willins DL, Deutch AY, Roth BL (1997) Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex. Synapse 27(1):79\u201382","journal-title":"Synapse"},{"key":"6129_CR37","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.bbr.2014.06.019","volume":"271","author":"J Yu","year":"2014","unstructured":"Yu J, Tang YY, Feng HB, Cheng XX (2014) A behavioral and micro positron emission tomography imaging study in a rat model of hypothyroidism. Behav Brain Res 271:228\u2013233","journal-title":"Behav Brain Res"},{"key":"6129_CR38","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.brainresbull.2016.05.007","volume":"124","author":"Q Zhang","year":"2016","unstructured":"Zhang Q, Feng JJ, Yang S, Liu XF, Li JC, Zhao H (2016) Lateral habenula as a link between thyroid and serotoninergic system modiates depressive symptoms in hypothyroidism rats. Brain Res Bull 124:198\u2013205","journal-title":"Brain Res Bull"}],"container-title":["Experimental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-021-06129-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00221-021-06129-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-021-06129-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T17:52:06Z","timestamp":1699120326000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00221-021-06129-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,9]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["6129"],"URL":"https:\/\/doi.org\/10.1007\/s00221-021-06129-1","relation":{},"ISSN":["0014-4819","1432-1106"],"issn-type":[{"value":"0014-4819","type":"print"},{"value":"1432-1106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,9]]},"assertion":[{"value":"28 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}