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In previous work, we have demonstrated that dyslexic carriers of a mutation of the <jats:italic>DCDC2<\/jats:italic> gene have a very strong impairment in motion perception. In the present study, we investigated structural white matter alterations associated with the poor motion perception in a cohort of twenty dyslexics with a subgroup carrying the DCDC2 gene deletion (DCDC2d+) and a subgroup without the risk variant (DCDC2d\u2013). We observed significant deficits in motion contrast sensitivity and in motion direction discrimination accuracy at high contrast, stronger in the DCDC2d+\u2009group. Both motion perception impairments correlated significantly with the fractional anisotropy in posterior ventral and dorsal tracts, including early visual pathways both along the optic radiation and in proximity of occipital cortex, MT and VWFA. However, the DCDC2d+\u2009group showed stronger correlations between FA and motion perception impairments than the DCDC2d\u2013 group in early visual white matter bundles, including the optic radiations, and in ventral pathways located in the left inferior temporal cortex. Our results suggest that the DCDC2d+\u2009group experiences higher vulnerability in visual motion processing even at early stages of visual analysis, which might represent a specific feature associated with the genotype and provide further neurobiological support to the visual-motion deficit account of dyslexia in a specific subpopulation.<\/jats:p>","DOI":"10.1007\/s00221-021-06137-1","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T15:04:29Z","timestamp":1625583869000},"page":"2725-2740","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["White matter deficits correlate with visual motion perception impairments in dyslexic carriers of the DCDC2 genetic risk variant"],"prefix":"10.1007","volume":"239","author":[{"given":"Daniela","family":"Perani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Scifo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3303-0420","authenticated-orcid":false,"given":"Guido M.","family":"Cicchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale Della","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Banfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mascheretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Falini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Concetta","family":"Morrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,6]]},"reference":[{"key":"6137_CR1","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/s00234-010-0716-3","volume":"52","author":"O Abe","year":"2010","unstructured":"Abe O, Takao H, Gonoi W, Sasaki H, Murakami M, Kabasawa H et al (2010) Voxel-based analysis of the diffusion tensor. 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