{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:24:15Z","timestamp":1793154255849,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["C2020205011"],"award-info":[{"award-number":["C2020205011"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071171"],"award-info":[{"award-number":["32071171"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Brain Res"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s00221-022-06360-4","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T11:03:37Z","timestamp":1649243017000},"page":"1713-1725","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Aerobic exercise improves motor function and striatal MSNs-Erk\/MAPK signaling in mice with 6-OHDA-induced Parkinson\u2019s disease"],"prefix":"10.1007","volume":"240","author":[{"given":"Xiaodong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinhao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7979-7256","authenticated-orcid":false,"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"6360_CR1","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/0166-2236(89)90074-X","volume":"12","author":"RL Albin","year":"1989","unstructured":"Albin RL, Young AB, Penney JB (1989) The functional anatomy of basal ganglia disorders. Trends Neurosci 12:366\u2013375. https:\/\/doi.org\/10.1016\/0166-2236(89)90074-X","journal-title":"Trends Neurosci"},{"key":"6360_CR2","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.nlm.2010.04.008","volume":"94","author":"G Bureau","year":"2010","unstructured":"Bureau G, Carrier M, Lebel M, Cyr M (2010) Intrastriatal inhibition of extracellular signal-regulated kinases impaired the consolidation phase of motor skill learning. Neurobiol Learn Mem 94:107\u2013115. https:\/\/doi.org\/10.1016\/j.nlm.2010.04.008","journal-title":"Neurobiol Learn Mem"},{"key":"6360_CR3","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.nlm.2013.06.013","volume":"105","author":"M Cerovic","year":"2013","unstructured":"Cerovic M, D\u2019Isa R, Tonini R, Brambilla R (2013) Molecular and cellular mechanisms of dopamine-mediated behavioral plasticity in the striatum. Neurobiol Learn Mem 105:63\u201380. https:\/\/doi.org\/10.1016\/j.nlm.2013.06.013","journal-title":"Neurobiol Learn Mem"},{"key":"6360_CR4","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1677\/JOE-06-0168","volume":"193","author":"SJ Chang","year":"2007","unstructured":"Chang SJ, Wang TY, Lee YH, Tai CJ (2007) Extracellular ATP activates nuclear translocation of ERK1\/2 leading to the induction of matrix metalloproteinases expression in human endometrial stromal cells. J Endocrinol 193:393\u2013404. https:\/\/doi.org\/10.1677\/JOE-06-0168","journal-title":"J Endocrinol"},{"key":"6360_CR5","doi-asserted-by":"publisher","first-page":"228","DOI":"10.16038\/j.1000-6710.2015.03.002","volume":"34","author":"W Chen","year":"2015","unstructured":"Chen W, Shi KX, Liu XL (2015a) Exercise intervention improves behavioral function in PD rats through modulation of striatal MSNs structural plasticity. Chin J Sports Med 34:228\u2013234. https:\/\/doi.org\/10.16038\/j.1000-6710.2015.03.002","journal-title":"Chin J Sports Med"},{"key":"6360_CR6","doi-asserted-by":"publisher","first-page":"61","DOI":"10.19582\/j.cnki.11-3785\/g8.2015.02.011","volume":"38","author":"W Chen","year":"2015","unstructured":"Chen W, Wei X, Liu XL, Yan KL (2015b) Effect of exercise on cortex -striatum glutamatergic neurotransmission in PD model rats. J Beijing Sport Univ 38:61\u201366. https:\/\/doi.org\/10.19582\/j.cnki.11-3785\/g8.2015.02.011","journal-title":"J Beijing Sport Univ"},{"key":"6360_CR7","doi-asserted-by":"publisher","first-page":"2583910","DOI":"10.1155\/2017\/2583910","volume":"2017","author":"W Chen","year":"2017","unstructured":"Chen W, Qiao DC, Liu XL, Shi KX (2017) Treadmill exercise improves motor dysfunction and hyperactivity of the corticostriatal glutamatergic pathway in rats with 6-OHDA-induced Parkinson\u2019s disease. Neural Plast 2017:2583910. https:\/\/doi.org\/10.1155\/2017\/2583910","journal-title":"Neural Plast"},{"key":"6360_CR8","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/nrneurol.2012.126","volume":"8","author":"M Coelho","year":"2012","unstructured":"Coelho M, Ferreira JJ (2012) Late-stage Parkinson disease. Nat Rev Neurology 8:435\u2013442. https:\/\/doi.org\/10.1038\/nrneurol.2012.126","journal-title":"Nat Rev Neurology"},{"key":"6360_CR9","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/nan.12298","volume":"42","author":"K Del Tredici","year":"2016","unstructured":"Del Tredici K, Braak H (2016) Review: sporadic Parkinson\u2019s disease: development and distribution of alpha-synuclein pathology. Neuropathol Appl Neurobiol 42:33\u201350. https:\/\/doi.org\/10.1111\/nan.12298","journal-title":"Neuropathol Appl Neurobiol"},{"key":"6360_CR10","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.parkreldis.2009.04.009","volume":"15","author":"LE Dibble","year":"2009","unstructured":"Dibble LE, Hale TF, Marcus RL, Gerber JP, LaStayo PC (2009) High intensity eccentric resistance training decreases bradykinesia and improves quality of life in persons with Parkinson\u2019s disease: a preliminary study. Parkinsonism Relat Disord 15:752\u2013757. https:\/\/doi.org\/10.1016\/j.parkreldis.2009.04.009","journal-title":"Parkinsonism Relat Disord"},{"key":"6360_CR11","doi-asserted-by":"publisher","first-page":"41432","DOI":"10.1038\/srep41432","volume":"7","author":"D Gagnon","year":"2017","unstructured":"Gagnon D, Petryszyn S, Sanchez MG, Bories C, Beaulieu JM, De Koninck Y, Parent A, Parent M (2017) Striatal neurons expressing D1 and D2 receptors are morphologically distinct and differently affected by dopamine denervation in mice. Sci Rep 7:41432. https:\/\/doi.org\/10.1038\/srep41432","journal-title":"Sci Rep"},{"key":"6360_CR12","doi-asserted-by":"publisher","first-page":"5042","DOI":"10.1002\/neu.10053","volume":"22","author":"CR Gerfen","year":"2002","unstructured":"Gerfen CR, Miyachi S, Paletzki R, Brown P (2002) D1 dopamine receptor supersensitivity in the dopamine-depleted striatum results from a switch in the regulation of ERK1\/2\/MAP kinase. J Neurosci Off J Soc Neurosci 22:5042\u20135054. https:\/\/doi.org\/10.1002\/neu.10053","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"6360_CR13","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1097\/HJR.0b013e3281eacef1","volume":"14","author":"MA Hoydal","year":"2007","unstructured":"Hoydal MA, Wisloff U, Kemi OJ, Ellingsen O (2007) Running speed and maximal oxygen uptake in rats and mice: practical implications for exercise training. Eur J Cardiovasc Prev Rehabil 14:753\u2013760. https:\/\/doi.org\/10.1097\/HJR.0b013e3281eacef1","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"6360_CR14","doi-asserted-by":"publisher","first-page":"8102","DOI":"10.1523\/JNEUROSCI.0473-17.2017","volume":"37","author":"SR Hutton","year":"2017","unstructured":"Hutton SR, Otis JM, Kim EM, Lamsal Y, Stuber GD, Snider WD (2017) ERK\/MAPK signaling is required for pathway-specific striatal motor functions. J Neurosci Off J Soc Neurosci 37:8102\u20138115. https:\/\/doi.org\/10.1523\/JNEUROSCI.0473-17.2017","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"6360_CR15","doi-asserted-by":"publisher","first-page":"6999","DOI":"10.1523\/JNEUROSCI.5996-09.2010","volume":"30","author":"O Ibanez-Sandoval","year":"2010","unstructured":"Ibanez-Sandoval O, Tecuapetla F, Unal B, Shah F, Koos T, Tepper JM (2010) Electrophysiological and morphological characteristics and synaptic connectivity of tyrosine hydroxylase-expressing neurons in adult mouse striatum. J Neurosci 30:6999\u20137016. https:\/\/doi.org\/10.1523\/JNEUROSCI.5996-09.2010","journal-title":"J Neurosci"},{"key":"6360_CR16","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1007\/s12035-016-9822-5","volume":"54","author":"S Jamwal","year":"2017","unstructured":"Jamwal S, Kumar P (2017) L-theanine, a component of green tea prevents 3-nitropropionic acid (3-NP)-induced striatal toxicity by modulating nitric oxide pathway. Mol Neurobiol 54:2327\u20132337. https:\/\/doi.org\/10.1007\/s12035-016-9822-5","journal-title":"Mol Neurobiol"},{"key":"6360_CR17","doi-asserted-by":"publisher","first-page":"165","DOI":"10.2174\/1570159X16666180302115032","volume":"17","author":"S Jamwal","year":"2019","unstructured":"Jamwal S, Kumar P (2019) Insight into the emerging role of striatal neurotransmitters in the pathophysiology of Parkinson\u2019s disease and Huntington\u2019s disease: a review. Curr Neuropharmacol 17:165\u2013175. https:\/\/doi.org\/10.2174\/1570159X16666180302115032","journal-title":"Curr Neuropharmacol"},{"key":"6360_CR18","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/s1474-4422(04)00740-9","volume":"3","author":"AE Lang","year":"2004","unstructured":"Lang AE, Obeso JA (2004) Challenges in Parkinson\u2019s disease: restoration of the nigrostriatal dopamine system is not enough. Lancet Neurol 3:309\u2013316. https:\/\/doi.org\/10.1016\/s1474-4422(04)00740-9","journal-title":"Lancet Neurol"},{"key":"6360_CR19","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.neuron.2016.06.010","volume":"91","author":"HJ Lee","year":"2016","unstructured":"Lee HJ, Weitz AJ, Bernal-Casas D, Duffy BA, Choy M, Kravitz AV, Kreitzer AC, Lee JH (2016) Activation of direct and indirect pathway medium spiny neurons drives distinct brain-wide responses. Neuron 91:412\u2013424. https:\/\/doi.org\/10.1016\/j.neuron.2016.06.010","journal-title":"Neuron"},{"key":"6360_CR20","doi-asserted-by":"publisher","first-page":"62","DOI":"10.19582\/j.cnki.11-3785\/g8.2014.05.009","volume":"37","author":"XL Liu","year":"2014","unstructured":"Liu XL, Shi KX, Qiao DC (2014) Effects of exercise on striatum\u2019s neuronal activity in rats with Parkinson\u2019s disease. J Beijing Sport Univ 37:62\u201366. https:\/\/doi.org\/10.19582\/j.cnki.11-3785\/g8.2014.05.009","journal-title":"J Beijing Sport Univ"},{"key":"6360_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2019.104506","volume":"130","author":"LL Mariani","year":"2019","unstructured":"Mariani LL, Longueville S, Girault JA, Herve D, Gervasi N (2019) Differential enhancement of ERK, PKA and Ca(2+) signaling in direct and indirect striatal neurons of Parkinsonian mice. Neurobiol Dis 130:104506. https:\/\/doi.org\/10.1016\/j.nbd.2019.104506","journal-title":"Neurobiol Dis"},{"key":"6360_CR22","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1002\/mds.21346","volume":"22","author":"S Muhlack","year":"2007","unstructured":"Muhlack S, Welnic J, Woitalla D, Muller T (2007) Exercise improves efficacy of levodopa in patients with Parkinson\u2019s disease. Mov Disord 22:427\u2013430. https:\/\/doi.org\/10.1002\/mds.21346","journal-title":"Mov Disord"},{"key":"6360_CR23","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1212\/WNL.0b013e3181a1d44c","volume":"72","author":"CW Olanow","year":"2009","unstructured":"Olanow CW, Stern MB, Sethi K (2009) The scientific and clinical basis for the treatment of Parkinson disease (2009). Neurology 72:S1-136. https:\/\/doi.org\/10.1212\/WNL.0b013e3181a1d44c","journal-title":"Neurology"},{"key":"6360_CR24","doi-asserted-by":"publisher","first-page":"81","DOI":"10.18869\/acadpub.aassjournal.5.2.81","volume":"5","author":"F Rafie","year":"2017","unstructured":"Rafie F, Shabazi M, Sheikh M, Naghdi N, Sheibani V (2017) Effects of voluntary exercise on motor function in Parkinson\u2019s disease model of rats. Ann Appl Sport Sci 5:81\u201386. https:\/\/doi.org\/10.18869\/acadpub.aassjournal.5.2.81","journal-title":"Ann Appl Sport Sci"},{"key":"6360_CR25","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.neuroscience.2013.01.060","volume":"237","author":"CC Real","year":"2013","unstructured":"Real CC, Ferreira AFB, Chaves-Kirsten GP, Torro AS, Pires RS, Britto LRG (2013) BDNF receptor blockade hinders the beneficial effects of exercise in a rat model of Parkinson\u2019s disease. Neuroscience 237:118\u2013129. https:\/\/doi.org\/10.1016\/j.neuroscience.2013.01.060","journal-title":"Neuroscience"},{"key":"6360_CR26","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1111\/j.1471-4159.1988.tb02500.x","volume":"50","author":"JR Sanchez-Ramos","year":"1988","unstructured":"Sanchez-Ramos JR, Michel P, Weiner WJ, Hefti F (1988) Selective destruction of cultured dopaminergic neurons from fetal rat mesencephalon by 1-methyl-4-phenylpyridinium: cytochemical and morphological evidence. J Neurochem 50:1934\u20131944. https:\/\/doi.org\/10.1111\/j.1471-4159.1988.tb02500.x","journal-title":"J Neurochem"},{"key":"6360_CR27","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1001\/archneur.1992.00530280040020","volume":"49","author":"AJ Sasco","year":"1992","unstructured":"Sasco AJ, Paffenbarger RJ, Gendre I, Wing AL (1992) The role of physical exercise in the occurrence of Parkinson\u2019s disease. Arch Neurol 49:360\u2013365. https:\/\/doi.org\/10.1001\/archneur.1992.00530280040020","journal-title":"Arch Neurol"},{"key":"6360_CR28","doi-asserted-by":"publisher","first-page":"11038","DOI":"10.1073\/pnas.1901712116","volume":"116","author":"MJ Sheng","year":"2019","unstructured":"Sheng MJ, Lu D, Shen ZM, Poo MM (2019) Emergence of stable striatal D1R and D2R neuronal ensembles with distinct firing sequence during motor learning. Proc Natl Acad Sci 116:11038\u201311047. https:\/\/doi.org\/10.1073\/pnas.1901712116","journal-title":"Proc Natl Acad Sci"},{"key":"6360_CR29","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.bbr.2010.12.010","volume":"218","author":"MW Shiflett","year":"2011","unstructured":"Shiflett MW, Balleine BW (2011) Contributions of ERK signaling in the striatum to instrumental learning and performance. Behav Brain Res 218:240\u2013247. https:\/\/doi.org\/10.1016\/j.bbr.2010.12.010","journal-title":"Behav Brain Res"},{"key":"6360_CR30","doi-asserted-by":"publisher","first-page":"2951","DOI":"10.1523\/JNEUROSCI.1778-09.2010","volume":"30","author":"MW Shiflett","year":"2010","unstructured":"Shiflett MW, Brown RA, Balleine BW (2010) Acquisition and performance of goal-directed instrumental actions depends on ERK signaling in distinct regions of dorsal striatum in rats. J Neurosci Off J SocNeurosci 30:2951\u20132959. https:\/\/doi.org\/10.1523\/JNEUROSCI.1778-09.2010","journal-title":"J Neurosci Off J SocNeurosci"},{"key":"6360_CR31","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1001\/jama.2019.18983","volume":"322","author":"A Slomski","year":"2019","unstructured":"Slomski A (2019) Intense exercise improved motor function in Parkinson disease. JAMA 322:1948. https:\/\/doi.org\/10.1001\/jama.2019.18983","journal-title":"JAMA"},{"key":"6360_CR32","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.parkreldis.2020.09.034","volume":"80","author":"J Song","year":"2020","unstructured":"Song J, Ahn JH, Choi I, Mun JK, Cho JW, Youn J (2020) The changes of exercise pattern and clinical symptoms in patients with Parkinson\u2019s disease in the era of COVID-19 pandemic. Parkinsonism Relat Disord 80:148\u2013151. https:\/\/doi.org\/10.1016\/j.parkreldis.2020.09.034","journal-title":"Parkinsonism Relat Disord"},{"key":"6360_CR33","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1046\/j.1460-9568.2003.02800.x","volume":"18","author":"D Stanic","year":"2003","unstructured":"Stanic D, Finkelstein DI, Bourke DW, Drago J, Horne MK (2003) Timecourse of striatal re-innervation following lesions of dopaminergic SNpc neurons of the rat. Eur J Neurosci 18:1175\u20131188. https:\/\/doi.org\/10.1046\/j.1460-9568.2003.02800.x","journal-title":"Eur J Neurosci"},{"key":"6360_CR34","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.biopsych.2013.05.006","volume":"75","author":"LM Suarez","year":"2014","unstructured":"Suarez LM, Solis O, Carames JM, Taravini IR, Solis JM, Murer MG, Moratalla R (2014) L-DOPA treatment selectively restores spine density in dopamine receptor D2-expressing projection neurons in dyskinetic mice. Biol Psychiat 75:711\u2013722. https:\/\/doi.org\/10.1016\/j.biopsych.2013.05.006","journal-title":"Biol Psychiat"},{"key":"6360_CR35","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1212\/WNL.0b013e3181ea1597","volume":"75","author":"Q Xu","year":"2010","unstructured":"Xu Q, Park Y, Huang X (2010) Physical activities and future risk of Parkinson disease. Neurology 75:341\u2013348. https:\/\/doi.org\/10.1212\/WNL.0b013e3181ea1597","journal-title":"Neurology"}],"container-title":["Experimental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-022-06360-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00221-022-06360-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-022-06360-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T19:35:40Z","timestamp":1744140940000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00221-022-06360-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,6]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["6360"],"URL":"https:\/\/doi.org\/10.1007\/s00221-022-06360-4","relation":{},"ISSN":["0014-4819","1432-1106"],"issn-type":[{"value":"0014-4819","type":"print"},{"value":"1432-1106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,6]]},"assertion":[{"value":"17 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no conflict of interest regarding the publication of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}