{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T19:33:11Z","timestamp":1783711991441,"version":"3.55.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Brain Res"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1007\/s00221-022-06415-6","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T18:02:22Z","timestamp":1658340142000},"page":"2339-2348","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Modulation of the CB1 cannabinoid receptor has potential therapeutic utility in the 3-acetylpyridine cerebellar\u00a0ataxia rat model"],"prefix":"10.1007","volume":"240","author":[{"given":"Hoda","family":"Ranjbar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monavareh","family":"Soti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahyar","family":"Janahmadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi A.","family":"Kohlmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Sheibani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meysam","family":"Ahmadi-Zeidabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2082-5849","authenticated-orcid":false,"given":"Mohammad","family":"Shabani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,20]]},"reference":[{"issue":"1","key":"6415_CR1","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1109\/TVCG.2015.2467031","volume":"22","author":"A Abbasloo","year":"2015","unstructured":"Abbasloo A, Wiens V, Hermann M, Schultz T (2015) Visualizing tensor normal distributions at multiple levels of detail. IEEE Trans vis Comput Graph 22(1):975\u2013984","journal-title":"IEEE Trans vis Comput Graph"},{"issue":"Pt A","key":"6415_CR2","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.physbeh.2016.06.013","volume":"164","author":"H Abbassian","year":"2016","unstructured":"Abbassian H, Esmaeili P, Tahamtan M, Aghaei I, Vaziri Z, Sheibani V, Whalley BJ, Shabani M (2016a) Cannabinoid receptor agonism suppresses tremor, cognition disturbances and anxiety-like behaviors in a rat model of essential tremor. Physiol Behav 164(Pt A):314\u2013320","journal-title":"Physiol Behav"},{"issue":"22","key":"6415_CR3","doi-asserted-by":"publisher","first-page":"3196","DOI":"10.1111\/bph.13581","volume":"173","author":"H Abbassian","year":"2016","unstructured":"Abbassian H, Whalley BJ, Sheibani V, Shabani M (2016b) Cannabinoid type 1 receptor antagonism ameliorates harmaline-induced essential tremor in rat. Br J Pharmacol 173(22):3196\u20133207","journal-title":"Br J Pharmacol"},{"issue":"3","key":"6415_CR4","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S0168-0102(01)00234-6","volume":"40","author":"P Barenberg","year":"2001","unstructured":"Barenberg P, Strahlendorf H, Strahlendorf J (2001) Hypoxia induces an excitotoxic-type of dark cell degeneration in cerebellar Purkinje neurons. Neurosci Res 40(3):245\u2013254","journal-title":"Neurosci Res"},{"issue":"6","key":"6415_CR5","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.conb.2006.08.016","volume":"16","author":"AJ Bastian","year":"2006","unstructured":"Bastian AJ (2006) Learning to predict the future: the cerebellum adapts feedforward movement control. Curr Opin Neurobiol 16(6):645\u2013649","journal-title":"Curr Opin Neurobiol"},{"key":"6415_CR6","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.brainresbull.2019.01.016","volume":"146","author":"HS Baul","year":"2019","unstructured":"Baul HS, Manikandan C, Sen D (2019) Cannabinoid receptor as a potential therapeutic target for Parkinson\u2019s disease. Brain Res Bull 146:244\u2013252","journal-title":"Brain Res Bull"},{"issue":"1\u20132","key":"6415_CR7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1163\/156853990X00428","volume":"113","author":"KC Berridge","year":"1990","unstructured":"Berridge KC (1990) Comparative fine structure of action: rules of form and sequence in the grooming patterns of six rodent species. Behaviour 113(1\u20132):21\u201356","journal-title":"Behaviour"},{"issue":"6","key":"6415_CR8","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1002\/ana.410130616","volume":"13","author":"DB Clifford","year":"1983","unstructured":"Clifford DB (1983) Tetrahydrocannabinol for tremor in multiple sclerosis. Ann Neurol 13(6):669\u2013671","journal-title":"Ann Neurol"},{"issue":"1","key":"6415_CR9","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/0006-8993(80)90491-6","volume":"187","author":"F Colin","year":"1980","unstructured":"Colin F, Manil J, Desclin J (1980) The olivocerebellar system. I. Delayed and slow inhibitory effects: an overlooked salient feature of cerebellar climbing fibers. Brain Res 187(1):3\u201327","journal-title":"Brain Res"},{"issue":"1","key":"6415_CR10","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1159\/000112901","volume":"38","author":"P Consroe","year":"1997","unstructured":"Consroe P, Musty R, Rein J, Tillery W, Pertwee R (1997) The perceived effects of smoked cannabis on patients with multiple sclerosis. Eur Neurol 38(1):44\u201348","journal-title":"Eur Neurol"},{"issue":"1\u20132","key":"6415_CR11","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0091-3057(01)00539-1","volume":"69","author":"KP DeSanty","year":"2001","unstructured":"DeSanty KP, Dar MS (2001) Cannabinoid-induced motor incoordination through the cerebellar CB(1) receptor in mice. Pharmacol Biochem Behav 69(1\u20132):251\u2013259","journal-title":"Pharmacol Biochem Behav"},{"issue":"3","key":"6415_CR12","doi-asserted-by":"publisher","first-page":"309","DOI":"10.4161\/pri.20026","volume":"6","author":"A Didonna","year":"2012","unstructured":"Didonna A, Sussman J, Benetti F, Legname G (2012) The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells. Prion 6(3):309\u2013316","journal-title":"Prion"},{"issue":"7","key":"6415_CR13","doi-asserted-by":"publisher","first-page":"a028035","DOI":"10.1101\/cshperspect.a028035","volume":"9","author":"BN Dugger","year":"2017","unstructured":"Dugger BN, Dickson DW (2017) Pathology of neurodegenerative diseases. Cold Spring Harb Perspect Biol 9(7):a028035","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"4","key":"6415_CR14","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s13311-015-0381-7","volume":"12","author":"J Fern\u00e1ndez-Ruiz","year":"2015","unstructured":"Fern\u00e1ndez-Ruiz J, Moro MA, Mart\u00ednez-Orgado J (2015) Cannabinoids in neurodegenerative disorders and stroke\/brain trauma: from preclinical models to clinical applications. Neurotherapeutics 12(4):793\u2013806","journal-title":"Neurotherapeutics"},{"issue":"9\u201310","key":"6415_CR15","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1016\/j.bbabio.2006.06.014","volume":"1757","author":"N Festjens","year":"2006","unstructured":"Festjens N, Vanden Berghe T, Vandenabeele P (2006) Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. Biochim Biophys Acta 1757(9\u201310):1371\u20131387","journal-title":"Biochim Biophys Acta"},{"issue":"18","key":"6415_CR16","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.1038\/onc.2012.248","volume":"32","author":"I Garcia","year":"2013","unstructured":"Garcia I, Crowther AJ, Gama V, Miller CR, Deshmukh M, Gershon TR (2013) Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation. Oncogene 32(18):2304\u20132314","journal-title":"Oncogene"},{"issue":"1","key":"6415_CR17","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1177\/0192623310389621","volume":"39","author":"RH Garman","year":"2011","unstructured":"Garman RH (2011) Histology of the central nervous system. Toxicol Pathol 39(1):22\u201335","journal-title":"Toxicol Pathol"},{"issue":"16","key":"6415_CR18","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1093\/hmg\/ddi239","volume":"14","author":"D Glynn","year":"2005","unstructured":"Glynn D, Drew CJ, Reim K, Brose N, Morton AJ (2005) Profound ataxia in complexin I knockout mice masks a complex phenotype that includes exploratory and habituation deficits. Hum Mol Genet 14(16):2369\u20132385","journal-title":"Hum Mol Genet"},{"key":"6415_CR19","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3389\/fnmol.2019.00094","volume":"12","author":"M G\u00f3mez-Ruiz","year":"2019","unstructured":"G\u00f3mez-Ruiz M, Rodr\u00edguez-Cueto C, Luna-Pi\u00f1el E, Hern\u00e1ndez-G\u00e1lvez M, Fern\u00e1ndez-Ruiz J (2019) Endocannabinoid system in spinocerebellar ataxia type-3 and other autosomal-dominant cerebellar ataxias: potential role in pathogenesis and expected relevance as neuroprotective targets. Front Mol Neurosci 12:94","journal-title":"Front Mol Neurosci"},{"key":"6415_CR20","volume-title":"Necrosis StatPearls Treasure Island (FL), StatPearls Publishing Copyright \u00a9 2022","author":"N Khalid","year":"2022","unstructured":"Khalid N, Azimpouran M (2022) Necrosis StatPearls Treasure Island (FL), StatPearls Publishing Copyright \u00a9 2022. StatPearls Publishing LLC, New York"},{"key":"6415_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2020.172950","volume":"194","author":"M Leija-Salazar","year":"2020","unstructured":"Leija-Salazar M, de Le\u00f3n MB, Gonz\u00e1lez-Horta A, Gonz\u00e1lez-Hern\u00e1ndez B (2020) Arachidonyl-2\u2032-chloroethylamide (ACEA), a synthetic agonist of cannabinoid receptor, increases CB1R gene expression and reduces dyskinesias in a rat model of Parkinson\u2019s disease. Pharmacol Biochem Behav 194:172950","journal-title":"Pharmacol Biochem Behav"},{"key":"6415_CR22","doi-asserted-by":"publisher","first-page":"406","DOI":"10.3389\/fnins.2016.00406","volume":"10","author":"G Navarro","year":"2016","unstructured":"Navarro G, Morales P, Rodr\u00edguez-Cueto C, Fern\u00e1ndez-Ruiz J, Jagerovic N, Franco R (2016) Targeting cannabinoid CB2 receptors in the central nervous system. Medicinal chemistry approaches with focus on neurodegenerative disorders. Front Neurosci 10:406","journal-title":"Front Neurosci"},{"issue":"2","key":"6415_CR23","first-page":"629","volume":"297","author":"S Patel","year":"2001","unstructured":"Patel S, Hillard CJ (2001) Cannabinoid CB(1) receptor agonists produce cerebellar dysfunction in mice. J Pharmacol Exp Ther 297(2):629\u2013637","journal-title":"J Pharmacol Exp Ther"},{"key":"6415_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112481","volume":"382","author":"S Rauf","year":"2020","unstructured":"Rauf S, Soesatyo MH, Agustiningsih D, Partadiredja G (2020) Moderate intensity intermittent exercise upregulates neurotrophic and neuroprotective genes expression and inhibits Purkinje cell loss in the cerebellum of ovariectomized rats. Behav Brain Res 382:112481","journal-title":"Behav Brain Res"},{"key":"6415_CR25","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.neuroscience.2016.09.046","volume":"339","author":"C Rodriguez-Cueto","year":"2016","unstructured":"Rodriguez-Cueto C, Hernandez-Galvez M, Hillard CJ, Maciel P, Garcia-Garcia L, Valdeolivas S, Pozo MA, Ramos JA, Gomez-Ruiz M, Fernandez-Ruiz J (2016) Dysregulation of the endocannabinoid signaling system in the cerebellum and brainstem in a transgenic mouse model of spinocerebellar ataxia type-3. Neuroscience 339:191\u2013209","journal-title":"Neuroscience"},{"key":"6415_CR26","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.neuroscience.2010.10.031","volume":"172","author":"M Shabani","year":"2011","unstructured":"Shabani M, Hosseinmardi N, Haghani M, Shaibani V, Janahmadi M (2011) Maternal exposure to the CB1 cannabinoid agonist WIN 55212\u20132 produces robust changes in motor function and intrinsic electrophysiological properties of cerebellar Purkinje neurons in rat offspring. Neuroscience 172:139\u2013152","journal-title":"Neuroscience"},{"issue":"4","key":"6415_CR27","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1139\/y11-132","volume":"90","author":"M Shabani","year":"2012","unstructured":"Shabani M, Larizadeh MH, Parsania S, Asadi Shekaari M, Shahrokhi N (2012a) Profound destructive effects of adolescent exposure to vincristine accompanied with some sex differences in motor and memory performance. Can J Physiol Pharmacol 90(4):379\u2013386","journal-title":"Can J Physiol Pharmacol"},{"issue":"8","key":"6415_CR28","doi-asserted-by":"publisher","first-page":"439","DOI":"10.3109\/00207454.2012.673515","volume":"122","author":"M Shabani","year":"2012","unstructured":"Shabani M, Larizadeh MH, Parsania S, Hajali V, Shojaei A (2012b) Evaluation of destructive effects of exposure to cisplatin during developmental stage: no profound evidence for sex differences in impaired motor and memory performance. Int J Neurosci 122(8):439\u2013448","journal-title":"Int J Neurosci"},{"key":"6415_CR29","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.nbd.2016.01.009","volume":"88","author":"CJ Smeets","year":"2016","unstructured":"Smeets CJ, Verbeek D (2016) Climbing fibers in spinocerebellar ataxia: a mechanism for the loss of motor control. Neurobiol Dis 88:96\u2013106","journal-title":"Neurobiol Dis"},{"issue":"16","key":"6415_CR30","doi-asserted-by":"publisher","first-page":"4631","DOI":"10.1113\/JP271106","volume":"594","author":"G Stephens","year":"2016","unstructured":"Stephens G (2016) Does modulation of the endocannabinoid system have potential therapeutic utility in cerebellar ataxia? J Physiol 594(16):4631\u20134641","journal-title":"J Physiol"},{"issue":"16","key":"6415_CR31","doi-asserted-by":"publisher","first-page":"3919","DOI":"10.1113\/jphysiol.2012.244947","volume":"591","author":"X Wang","year":"2013","unstructured":"Wang X, Whalley BJ, Stephens GJ (2013) The du2J mouse model of ataxia and absence epilepsy has deficient cannabinoid CB1 receptor-mediated signalling. J Physiol 591(16):3919\u20133933","journal-title":"J Physiol"},{"issue":"5","key":"6415_CR32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002063","volume":"7","author":"L Zhao","year":"2011","unstructured":"Zhao L, Spassieva SD, Jucius TJ, Shultz LD, Shick HE, Macklin WB, Hannun YA, Obeid LM, Ackerman SL (2011) A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. PLoS Genet 7(5):e1002063","journal-title":"PLoS Genet"},{"issue":"3","key":"6415_CR33","doi-asserted-by":"publisher","first-page":"833","DOI":"10.3390\/ijms19030833","volume":"19","author":"S Zou","year":"2018","unstructured":"Zou S, Kumar U (2018) Cannabinoid receptors and the endocannabinoid system: signaling and function in the central nervous system. Int J Mol Sci 19(3):833","journal-title":"Int J Mol Sci"}],"container-title":["Experimental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-022-06415-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00221-022-06415-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-022-06415-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T19:40:44Z","timestamp":1662666044000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00221-022-06415-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,20]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["6415"],"URL":"https:\/\/doi.org\/10.1007\/s00221-022-06415-6","relation":{},"ISSN":["0014-4819","1432-1106"],"issn-type":[{"value":"0014-4819","type":"print"},{"value":"1432-1106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,20]]},"assertion":[{"value":"27 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest and declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies were in accordance with the ethical standards of the ethical committee of Kerman University of Medical Sciences (Ethical approval number: IR.KMU.REC.1398.012, Reg. No. 97000860).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The protocol was established, according to the ethical guidelines of the Helsinki Declaration, and was approved by the Institutional Ethics Committee of Kerman University of Medical Sciences.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}