{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T05:20:48Z","timestamp":1783660848191,"version":"3.55.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T00:00:00Z","timestamp":1666396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T00:00:00Z","timestamp":1666396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Brain Res"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s00221-022-06490-9","type":"journal-article","created":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T05:03:06Z","timestamp":1666414986000},"page":"3207-3216","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of overexpression of Hsp70 in neural stem cells on neurotoxicity and cognitive dysfunction in neonatal mice under sevoflurane exposure"],"prefix":"10.1007","volume":"240","author":[{"given":"Yijia","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxiang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghu","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,22]]},"reference":[{"key":"6490_CR2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000585","volume":"18","author":"P Bhattarai","year":"2020","unstructured":"Bhattarai P, Cosacak MI, Mashkaryan V et al (2020) Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer\u2019s model of adult zebrafish brain. PLoS Biol 18:e3000585. https:\/\/doi.org\/10.1371\/journal.pbio.3000585","journal-title":"PLoS Biol"},{"key":"6490_CR3","doi-asserted-by":"publisher","first-page":"16006","DOI":"10.1073\/pnas.1516131112","volume":"112","author":"NV Bobkova","year":"2015","unstructured":"Bobkova NV, Evgen\u2019ev M, Garbuz DG et al (2015) Exogenous Hsp70 delays senescence and improves cognitive function in aging mice. Proc Natl Acad Sci USA 112:16006\u201316011. https:\/\/doi.org\/10.1073\/pnas.1516131112","journal-title":"Proc Natl Acad Sci USA"},{"key":"6490_CR4","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/s13287-018-0913-2","volume":"9","author":"AC Boese","year":"2018","unstructured":"Boese AC, Le QE, Pham D, Hamblin MH, Lee JP (2018) Neural stem cell therapy for subacute and chronic ischemic stroke. Stem Cell Res Ther 9:154. https:\/\/doi.org\/10.1186\/s13287-018-0913-2","journal-title":"Stem Cell Res Ther"},{"issue":"831\u2013843","key":"6490_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.03.032","volume":"74","author":"M Boysen","year":"2019","unstructured":"Boysen M, Kityk R, Mayer MP (2019) Hsp70- and Hsp90-mediated regulation of the conformation of p53 DNA binding domain and p53 cancer variants. Mol Cell 74(831\u2013843):e834. https:\/\/doi.org\/10.1016\/j.molcel.2019.03.032","journal-title":"Mol Cell"},{"key":"6490_CR6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ijdevneu.2018.11.001","volume":"72","author":"D Chai","year":"2019","unstructured":"Chai D, Cheng Y, Jiang H (2019) Fundamentals of fetal toxicity relevant to sevoflurane exposures during pregnancy. Int J Dev Neurosci 72:31\u201335. https:\/\/doi.org\/10.1016\/j.ijdevneu.2018.11.001","journal-title":"Int J Dev Neurosci"},{"key":"6490_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109912","volume":"37","author":"W Chen","year":"2021","unstructured":"Chen W, Liu N, Shen S et al (2021) Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring. Cell Rep 37:109912. https:\/\/doi.org\/10.1016\/j.celrep.2021.109912","journal-title":"Cell Rep"},{"key":"6490_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093103","author":"R De Gioia","year":"2020","unstructured":"De Gioia R, Biella F, Citterio G et al (2020) Neural stem cell transplantation for neurodegenerative diseases. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21093103","journal-title":"Int J Mol Sci"},{"key":"6490_CR9","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.15528.1","author":"MR Fernandez-Fernandez","year":"2018","unstructured":"Fernandez-Fernandez MR, Valpuesta JM (2018) Hsp70 chaperone: a master player in protein homeostasis. F1000Res. https:\/\/doi.org\/10.12688\/f1000research.15528.1","journal-title":"F1000Res"},{"key":"6490_CR10","doi-asserted-by":"publisher","first-page":"1068260","DOI":"10.1155\/2019\/1068260","volume":"2019","author":"Y Jiao","year":"2019","unstructured":"Jiao Y, Fan H, Wang K, Lu S (2019) Sevoflurane impairs short-term memory by affecting PSD-95 and AMPA receptor in the hippocampus of a mouse model. Behav Neurol 2019:1068260. https:\/\/doi.org\/10.1155\/2019\/1068260","journal-title":"Behav Neurol"},{"key":"6490_CR11","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1097\/ALN.0000000000002920","volume":"131","author":"LS Ju","year":"2019","unstructured":"Ju LS, Yang JJ, Xu N et al (2019) Intergenerational effects of sevoflurane in young adult rats. Anesthesiology 131:1092\u20131109. https:\/\/doi.org\/10.1097\/ALN.0000000000002920","journal-title":"Anesthesiology"},{"key":"6490_CR12","doi-asserted-by":"publisher","first-page":"94","DOI":"10.2174\/1872213X10666161213163301","volume":"10","author":"R Khandia","year":"2017","unstructured":"Khandia R, Munjal AK, Iqbal HMN, Dhama K (2017) Heat shock proteins: therapeutic perspectives in inflammatory disorders. Recent Pat Inflamm Allergy Drug Discov 10:94\u2013104. https:\/\/doi.org\/10.2174\/1872213X10666161213163301","journal-title":"Recent Pat Inflamm Allergy Drug Discov"},{"key":"6490_CR13","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1007\/s11626-016-0005-5","volume":"52","author":"F Kong","year":"2016","unstructured":"Kong F, Wang H, Guo J et al (2016) Hsp70 suppresses apoptosis of BRL cells by regulating the expression of Bcl-2, cytochrome C, and caspase 8\/3. In Vitro Cell Dev Biol Anim 52:568\u2013575. https:\/\/doi.org\/10.1007\/s11626-016-0005-5","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"6490_CR14","doi-asserted-by":"publisher","first-page":"12668","DOI":"10.1096\/fj.201901360R","volume":"33","author":"S Koutsogiannaki","year":"2019","unstructured":"Koutsogiannaki S, Hou L, Babazada H et al (2019) The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain-Fas-associated death domain interaction. FASEB J 33:12668\u201312679. https:\/\/doi.org\/10.1096\/fj.201901360R","journal-title":"FASEB J"},{"key":"6490_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.112118","volume":"374","author":"A Lazutkin","year":"2019","unstructured":"Lazutkin A, Podgorny O, Enikolopov G (2019) Modes of division and differentiation of neural stem cells. Behav Brain Res 374:112118. https:\/\/doi.org\/10.1016\/j.bbr.2019.112118","journal-title":"Behav Brain Res"},{"key":"6490_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116747","volume":"234","author":"H Li","year":"2019","unstructured":"Li H, Yang J, Wang Y, Liu Q, Cheng J, Wang F (2019) Neuroprotective effects of increasing levels of HSP70 against neuroinflammation in Parkinson\u2019s disease model by inhibition of NF-kappaB and STAT3. Life Sci 234:116747. https:\/\/doi.org\/10.1016\/j.lfs.2019.116747","journal-title":"Life Sci"},{"key":"6490_CR17","doi-asserted-by":"publisher","DOI":"10.37175\/stemedicine.v1i4.63","volume":"1","author":"H Li","year":"2020","unstructured":"Li H, Yu Z, Zhang W (2020) Misfolded protein aggregation and altered cellular pathways in neurodegenerative diseases. Stemedicine 1:e63. https:\/\/doi.org\/10.37175\/stemedicine.v1i4.63","journal-title":"Stemedicine"},{"key":"6490_CR18","doi-asserted-by":"publisher","first-page":"4097","DOI":"10.3892\/etm.2018.5950","volume":"15","author":"Z Lu","year":"2018","unstructured":"Lu Z, Sun J, Xin Y, Chen K, Ding W, Wang Y (2018) Sevoflurane-induced memory impairment in the postnatal developing mouse brain. Exp Ther Med 15:4097\u20134104. https:\/\/doi.org\/10.3892\/etm.2018.5950","journal-title":"Exp Ther Med"},{"key":"6490_CR19","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.tibs.2013.08.001","volume":"38","author":"MP Mayer","year":"2013","unstructured":"Mayer MP (2013) Hsp70 chaperone dynamics and molecular mechanism. Trends Biochem Sci 38:507\u2013514. https:\/\/doi.org\/10.1016\/j.tibs.2013.08.001","journal-title":"Trends Biochem Sci"},{"key":"6490_CR20","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1074\/jbc.REV118.002810","volume":"294","author":"MP Mayer","year":"2019","unstructured":"Mayer MP, Gierasch LM (2019) Recent advances in the structural and mechanistic aspects of Hsp70 molecular chaperones. J Biol Chem 294:2085\u20132097. https:\/\/doi.org\/10.1074\/jbc.REV118.002810","journal-title":"J Biol Chem"},{"key":"6490_CR21","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1074\/jbc.AAC119.012167","volume":"295","author":"MP Mayer","year":"2020","unstructured":"Mayer MP, Gierasch LM (2020) Correction: recent advances in the structural and mechanistic aspects of Hsp70 molecular chaperones. J Biol Chem 295:288. https:\/\/doi.org\/10.1074\/jbc.AAC119.012167","journal-title":"J Biol Chem"},{"key":"6490_CR22","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1134\/S000629791911004X","volume":"84","author":"LK Muranova","year":"2019","unstructured":"Muranova LK, Ryzhavskaya AS, Sudnitsyna MV, Shatov VM, Gusev NB (2019) Small heat shock proteins and human neurodegenerative diseases. Biochemistry (mosc) 84:1256\u20131267. https:\/\/doi.org\/10.1134\/S000629791911004X","journal-title":"Biochemistry (mosc)"},{"key":"6490_CR23","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1093\/bja\/aex244","volume":"119","author":"BJA Palanca","year":"2017","unstructured":"Palanca BJA, Avidan MS, Mashour GA (2017) Human neural correlates of sevoflurane-induced unconsciousness. Br J Anaesth 119:573\u2013582. https:\/\/doi.org\/10.1093\/bja\/aex244","journal-title":"Br J Anaesth"},{"key":"6490_CR24","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.neuroscience.2018.01.028","volume":"375","author":"RR Porto","year":"2018","unstructured":"Porto RR, Dutra FD, Crestani AP, Holsinger RMD, Quillfeldt JA, de Homem Bittencourt PI, de Oliveira Alvares L (2018) HSP70 facilitates memory consolidation of fear conditioning through MAPK pathway in the hippocampus. Neuroscience 375:108\u2013118. https:\/\/doi.org\/10.1016\/j.neuroscience.2018.01.028","journal-title":"Neuroscience"},{"key":"6490_CR25","doi-asserted-by":"publisher","first-page":"315","DOI":"10.2174\/1566524019666190326114720","volume":"19","author":"R Roufayel","year":"2019","unstructured":"Roufayel R, Kadry S (2019) Molecular chaperone HSP70 and key regulators of apoptosis\u2014a review. Curr Mol Med 19:315\u2013325. https:\/\/doi.org\/10.2174\/1566524019666190326114720","journal-title":"Curr Mol Med"},{"key":"6490_CR26","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.2174\/1389450118666170823121248","volume":"19","author":"J Saini","year":"2018","unstructured":"Saini J, Sharma PK (2018) Clinical, prognostic and therapeutic significance of heat shock proteins in cancer. Curr Drug Targets 19:1478\u20131490. https:\/\/doi.org\/10.2174\/1389450118666170823121248","journal-title":"Curr Drug Targets"},{"key":"6490_CR27","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1002\/jcp.27110","volume":"234","author":"YJ Song","year":"2019","unstructured":"Song YJ, Zhong CB, Wang XB (2019) Heat shock protein 70: a promising therapeutic target for myocardial ischemia-reperfusion injury. J Cell Physiol 234:1190\u20131207. https:\/\/doi.org\/10.1002\/jcp.27110","journal-title":"J Cell Physiol"},{"key":"6490_CR28","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/pan.12785","volume":"26","author":"T Suehara","year":"2016","unstructured":"Suehara T, Morishita J, Ueki M, Ueno M, Maekawa N, Mizobuchi S (2016) Effects of sevoflurane exposure during late pregnancy on brain development of offspring mice. Paediatr Anaesth 26:52\u201359. https:\/\/doi.org\/10.1111\/pan.12785","journal-title":"Paediatr Anaesth"},{"key":"6490_CR29","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s11010-020-03786-8","volume":"472","author":"R Tian","year":"2020","unstructured":"Tian R, Guo K, Wu B, Wang H (2020a) Correction to: overexpression of Shrm4 promotes proliferation and differentiation of neural stem cells through activation of GABA signaling pathway. Mol Cell Biochem 472:255\u2013257. https:\/\/doi.org\/10.1007\/s11010-020-03786-8","journal-title":"Mol Cell Biochem"},{"key":"6490_CR30","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s11010-019-03634-4","volume":"463","author":"R Tian","year":"2020","unstructured":"Tian R, Guo K, Wu B, Wang H (2020b) Overexpression of Shrm4 promotes proliferation and differentiation of neural stem cells through activation of GABA signaling pathway. Mol Cell Biochem 463:115\u2013126. https:\/\/doi.org\/10.1007\/s11010-019-03634-4","journal-title":"Mol Cell Biochem"},{"key":"6490_CR31","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1007\/s12015-012-9372-9","volume":"8","author":"H Ulrich","year":"2012","unstructured":"Ulrich H, Abbracchio MP, Burnstock G (2012) Extrinsic purinergic regulation of neural stem\/progenitor cells: implications for CNS development and repair. Stem Cell Rev Rep 8:755\u2013767. https:\/\/doi.org\/10.1007\/s12015-012-9372-9","journal-title":"Stem Cell Rev Rep"},{"key":"6490_CR32","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.brainresbull.2015.11.016","volume":"121","author":"S Umukoro","year":"2016","unstructured":"Umukoro S, Aluko OM, Eduviere AT, Owoeye O (2016) Evaluation of adaptogenic-like property of methyl jasmonate in mice exposed to unpredictable chronic mild stress. Brain Res Bull 121:105\u2013114. https:\/\/doi.org\/10.1016\/j.brainresbull.2015.11.016","journal-title":"Brain Res Bull"},{"key":"6490_CR33","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.neuron.2019.09.026","volume":"104","author":"N Urban","year":"2019","unstructured":"Urban N, Blomfield IM, Guillemot F (2019) Quiescence of adult mammalian neural stem cells: a highly regulated rest. Neuron 104:834\u2013848. https:\/\/doi.org\/10.1016\/j.neuron.2019.09.026","journal-title":"Neuron"},{"key":"6490_CR34","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1038\/s41591-021-01404-8","volume":"27","author":"NA Vitanza","year":"2021","unstructured":"Vitanza NA, Johnson AJ, Wilson AL et al (2021) Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis. Nat Med 27:1544\u20131552. https:\/\/doi.org\/10.1038\/s41591-021-01404-8","journal-title":"Nat Med"},{"key":"6490_CR35","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.ydbio.2018.01.022","volume":"435","author":"Y Wang","year":"2018","unstructured":"Wang Y, Yin S, Xue H, Yang Y, Zhang N, Zhao P (2018) Mid-gestational sevoflurane exposure inhibits fetal neural stem cell proliferation and impairs postnatal learning and memory function in a dose-dependent manner. Dev Biol 435:185\u2013197. https:\/\/doi.org\/10.1016\/j.ydbio.2018.01.022","journal-title":"Dev Biol"},{"key":"6490_CR36","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1691\/ph.2019.8935","volume":"74","author":"C Wang","year":"2019","unstructured":"Wang C, Li L, Xu H, Lv H, Zhang H (2019) Effect of desflurane-remifentanil or sevoflurane-remifentanil on early recovery in elderly patients: a meta-analysis of randomized controlled trials. Pharmazie 74:201\u2013205. https:\/\/doi.org\/10.1691\/ph.2019.8935","journal-title":"Pharmazie"},{"key":"6490_CR37","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3389\/fncel.2018.00122","volume":"12","author":"Z Wu","year":"2018","unstructured":"Wu Z, Li X, Zhang Y, Tong D, Wang L, Zhao P (2018) Effects of sevoflurane exposure during mid-pregnancy on learning and memory in offspring rats: beneficial effects of maternal exercise. Front Cell Neurosci 12:122. https:\/\/doi.org\/10.3389\/fncel.2018.00122","journal-title":"Front Cell Neurosci"},{"key":"6490_CR38","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.brainresbull.2018.05.020","volume":"140","author":"L Xu","year":"2018","unstructured":"Xu L, Shen J, Yu L, Sun J, McQuillan PM, Hu Z, Yan M (2018) Role of autophagy in sevoflurane-induced neurotoxicity in neonatal rat hippocampal cells. Brain Res Bull 140:291\u2013298. https:\/\/doi.org\/10.1016\/j.brainresbull.2018.05.020","journal-title":"Brain Res Bull"},{"key":"6490_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116916","volume":"239","author":"X Yang","year":"2019","unstructured":"Yang X, Zheng YT, Rong W (2019) Sevoflurane induces apoptosis and inhibits the growth and motility of colon cancer in vitro and in vivo via inactivating Ras\/Raf\/MEK\/ERK signaling. Life Sci 239:116916. https:\/\/doi.org\/10.1016\/j.lfs.2019.116916","journal-title":"Life Sci"},{"key":"6490_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/cells9010060","author":"CW Yun","year":"2019","unstructured":"Yun CW, Kim HJ, Lim JH, Lee SH (2019) Heat shock proteins: agents of cancer development and therapeutic targets in anti-cancer therapy. Cells. https:\/\/doi.org\/10.3390\/cells9010060","journal-title":"Cells"},{"key":"6490_CR42","doi-asserted-by":"publisher","first-page":"102067","DOI":"10.18632\/oncotarget.22155","volume":"8","author":"JJ Zhang","year":"2017","unstructured":"Zhang JJ, Zhu JJ, Hu YB et al (2017) Transplantation of bFGF-expressing neural stem cells promotes cell migration and functional recovery in rat brain after transient ischemic stroke. Oncotarget 8:102067\u2013102077. https:\/\/doi.org\/10.18632\/oncotarget.22155","journal-title":"Oncotarget"},{"key":"6490_CR43","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1097\/ALN.0b013e3182834d5d","volume":"118","author":"H Zheng","year":"2013","unstructured":"Zheng H, Dong Y, Xu Z, Crosby G, Culley DJ, Zhang Y, Xie Z (2013) Sevoflurane anesthesia in pregnant mice induces neurotoxicity in fetal and offspring mice. Anesthesiology 118:516\u2013526. https:\/\/doi.org\/10.1097\/ALN.0b013e3182834d5d","journal-title":"Anesthesiology"}],"container-title":["Experimental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-022-06490-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00221-022-06490-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-022-06490-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T13:48:19Z","timestamp":1669038499000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00221-022-06490-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,22]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["6490"],"URL":"https:\/\/doi.org\/10.1007\/s00221-022-06490-9","relation":{},"ISSN":["0014-4819","1432-1106"],"issn-type":[{"value":"0014-4819","type":"print"},{"value":"1432-1106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,22]]},"assertion":[{"value":"9 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}