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These behavioural changes are side effects of treatment with dopaminergic drugs in Parkinson disease, but their likelihood of occurrence is difficult to predict and may be influenced by the individual\u2019s baseline endogenous dopamine state, and indeed correlate with sensation-seeking personality traits. We here collected data on a standard gambling task in healthy volunteers given either placebo, 2.5\u00a0mg of the dopamine antagonist haloperidol or 100\/25\u00a0mg of the dopamine precursor levodopa in a within-subject design. We found an increase in risky choices on levodopa. Choices were, however, made faster on haloperidol with no effect of levodopa on deliberation time. Shortened deliberation times on haloperidol occurred in low sensation-seekers only, suggesting a correlation between sensation-seeking personality trait and baseline dopamine levels. We hypothesise that levodopa increases risk-taking behaviour via overstimulation at both D1 and D2 receptor level, while a single low dose of haloperidol, as previously reported (Frank and O\u2019Reilly 2006), may block D2 receptors pre- and post-synaptically and may paradoxically lead to higher striatal dopamine acting on remaining striatal D1 receptors, causing speedier decision without influencing risk tolerance. These effects could also fit with a recently proposed computational model of the basal ganglia (Moeller and Bogacz 2019; Moeller et al. 2021). Furthermore, our data suggest that the actual dopaminergic drug effect may be dependent on the individual\u2019s baseline dopamine state, which may influence our therapeutic decision as clinicians in the future.<\/jats:p>","DOI":"10.1007\/s00221-022-06501-9","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T10:03:24Z","timestamp":1667988204000},"page":"3351-3360","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dopamine increases risky choice while D2 blockade shortens decision time"],"prefix":"10.1007","volume":"240","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9554-4275","authenticated-orcid":false,"given":"Stephanie T.","family":"Hirschbichler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Rothwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay G.","family":"Manohar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"issue":"2","key":"6501_CR1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1037\/1064-1297.16.2.113","volume":"16","author":"A Acheson","year":"2008","unstructured":"Acheson A, de Wit H (2008) bupropion improves attention but does not affect impulsive behavior in healthy young adults. 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