{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T17:45:35Z","timestamp":1777225535363,"version":"3.51.4"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance code 001"],"award-info":[{"award-number":["Finance code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance code 001"],"award-info":[{"award-number":["Finance code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006740","name":"Funda\u00e7\u00e3o Coordena\u00e7\u00e3o de Projetos, Pesquisas e Estudos Tecnol\u00f3gicos","doi-asserted-by":"publisher","award":["Finance code 001"],"award-info":[{"award-number":["Finance code 001"]}],"id":[{"id":"10.13039\/501100006740","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004612","name":"Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"publisher","award":["PRONEX #116\/2018"],"award-info":[{"award-number":["PRONEX #116\/2018"]}],"id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["#306432\/2022-6"],"award-info":[{"award-number":["#306432\/2022-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Brain Res"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1007\/s00221-023-06605-w","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T12:19:23Z","timestamp":1680610763000},"page":"1289-1298","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Metabolic dysfunctions in the intranigral rotenone model of Parkinson\u2019s disease"],"prefix":"10.1007","volume":"241","author":[{"given":"Ana Paula","family":"Chuproski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evellyn Mayla","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica","family":"Ilkiw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica","family":"Miloch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9602-4880","authenticated-orcid":false,"given":"Marcelo M. S.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"key":"6605_CR1","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1111\/j.1471-4159.2008.05254.x","volume":"105","author":"P Bar-On","year":"2008","unstructured":"Bar-On P, Crews L, Koob AO et al (2008) Statins reduce neuronal \u03b1-synuclein aggregation in in vitro models of Parkinson\u2019s disease. J Neurochem 105:1656\u20131667. https:\/\/doi.org\/10.1111\/j.1471-4159.2008.05254.x","journal-title":"J Neurochem"},{"key":"6605_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2014.02.005","volume":"118","author":"F Bassil","year":"2014","unstructured":"Bassil F, Fernagut PO, Bezard E, Meissner WG (2014) Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification? Prog Neurobiol 118:1\u201318","journal-title":"Prog Neurobiol"},{"key":"6605_CR3","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.expneurol.2017.11.009","volume":"300","author":"JM Bonato","year":"2018","unstructured":"Bonato JM, Bassani TB, Milani H et al (2018) Pioglitazone reduces mortality, prevents depressive-like behavior, and impacts hippocampal neurogenesis in the 6-OHDA model of Parkinson\u2019s disease in rats. Exp Neurol 300:188\u2013200. https:\/\/doi.org\/10.1016\/j.expneurol.2017.11.009","journal-title":"Exp Neurol"},{"key":"6605_CR4","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1002\/pds.4079","volume":"26","author":"K Bykov","year":"2017","unstructured":"Bykov K, Yoshida K, Weisskopf MG, Gagne JJ (2017) Confounding of the association between statins and Parkinson disease: systematic review and meta-analysis. Pharmacoepidemiol Drug Saf 26:294\u2013300. https:\/\/doi.org\/10.1002\/pds.4079","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"6605_CR5","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/j.1471-4159.2010.06924.x","volume":"115","author":"D Cartelli","year":"2010","unstructured":"Cartelli D, Ronchi C, Maggioni MG et al (2010) Microtubule dysfunction precedes transport impairment and mitochondria damage in MPP+-induced neurodegeneration. J Neurochem 115:247\u2013258. https:\/\/doi.org\/10.1111\/j.1471-4159.2010.06924.x","journal-title":"J Neurochem"},{"key":"6605_CR6","doi-asserted-by":"crossref","unstructured":"Chia SJ, Tan EK, Chao YX (2020) Historical perspective: models of Parkinson\u2019s disease. Int J Mol Sci 21","DOI":"10.3390\/ijms21072464"},{"key":"6605_CR7","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1002\/mds.28551","volume":"36","author":"H Chohan","year":"2021","unstructured":"Chohan H, Senkevich K, Patel RK et al (2021) Type 2 diabetes as a determinant of Parkinson\u2019s disease risk and progression. Mov Disord 36:1420\u20131429. https:\/\/doi.org\/10.1002\/mds.28551","journal-title":"Mov Disord"},{"key":"6605_CR8","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1037\/0003-066X.45.12.1304","volume":"45","author":"J Cohen","year":"1990","unstructured":"Cohen J (1990) Things I have learned (so far). Am Psychol 45:1304\u20131312","journal-title":"Am Psychol"},{"key":"6605_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094842","author":"M Colardo","year":"2022","unstructured":"Colardo M, Petraroia M, Lerza L et al (2022) NGF modulates cholesterol metabolism and stimulates ApoE secretion in glial cells conferring neuroprotection against oxidative stress. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms23094842","journal-title":"Int J Mol Sci"},{"key":"6605_CR10","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/s0896-6273(03)00568-3","volume":"39","author":"W Dauer","year":"2003","unstructured":"Dauer W, Przedborski S (2003) Parkinson\u2019s disease: mechanisms and models. Neuron 39:889\u2013909. https:\/\/doi.org\/10.1016\/s0896-6273(03)00568-3","journal-title":"Neuron"},{"key":"6605_CR11","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.neuint.2017.02.013","volume":"109","author":"C de la Fuente","year":"2017","unstructured":"de la Fuente C, Burke DG, Eaton S, Heales SJR (2017) Inhibition of neuronal mitochondrial complex I or lysosomal glucocerebrosidase is associated with increased dopamine and serotonin turnover. Neurochem Int 109:94\u2013100. https:\/\/doi.org\/10.1016\/j.neuint.2017.02.013","journal-title":"Neurochem Int"},{"key":"6605_CR12","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.freeradbiomed.2016.10.008","volume":"101","author":"M Doria","year":"2016","unstructured":"Doria M, Maugest L, Moreau T et al (2016) Contribution of cholesterol and oxysterols to the pathophysiology of Parkinson\u2019s disease. Free Radic Biol Med 101:393\u2013400","journal-title":"Free Radic Biol Med"},{"key":"6605_CR13","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1111\/j.1471-4159.2012.07836.x","volume":"122","author":"BP Dranka","year":"2012","unstructured":"Dranka BP, Zielonka J, Kanthasamy AG, Kalyanaraman B (2012) Alterations in bioenergetic function induced by Parkinson\u2019s disease mimetic compounds: lack of correlation with superoxide generation. J Neurochem 122:941\u2013951. https:\/\/doi.org\/10.1111\/j.1471-4159.2012.07836.x","journal-title":"J Neurochem"},{"key":"6605_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2016.00035","author":"AM Fathalla","year":"2016","unstructured":"Fathalla AM, Soliman AM, Ali MH, Moustafa AA (2016) Adenosine A2A receptor blockade prevents rotenone-induced motor impairment in a rat model of parkinsonism. Front Behav Neurosci. https:\/\/doi.org\/10.3389\/fnbeh.2016.00035","journal-title":"Front Behav Neurosci"},{"key":"6605_CR15","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1002\/mds.28396","volume":"36","author":"P Garc\u00eda-Sanz","year":"2021","unstructured":"Garc\u00eda-Sanz P, AertsMoratalla MFGR (2021) The role of cholesterol in \u03b1-synuclein and lewy body pathology in GBA1 Parkinson\u2019s disease. Mov Disord 36:1070\u20131085","journal-title":"Mov Disord"},{"key":"6605_CR16","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0197-0186(02)00225-5","volume":"43","author":"GE Gibson","year":"2003","unstructured":"Gibson GE, Kingsbury AE, Xu H et al (2003) Deficits in a tricarboxylic acid cycle enzyme in brains from patients with Parkinson\u2019s disease. Neurochem Int 43:129\u2013135. https:\/\/doi.org\/10.1016\/S0197-0186(02)00225-5","journal-title":"Neurochem Int"},{"key":"6605_CR17","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/nature09536","volume":"468","author":"JN Guzman","year":"2010","unstructured":"Guzman JN, Sanchez-Padilla J, Wokosin D et al (2010) Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature 468:696\u2013700. https:\/\/doi.org\/10.1038\/nature09536","journal-title":"Nature"},{"key":"6605_CR18","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1159\/000445751","volume":"46","author":"L Hirsch","year":"2016","unstructured":"Hirsch L, Jette N, Frolkis A et al (2016) The incidence of Parkinson\u2019s disease: a systematic review and meta-analysis. Neuroepidemiology 46:292\u2013300","journal-title":"Neuroepidemiology"},{"key":"6605_CR19","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3233\/JPD-181305","volume":"8","author":"E Hogg","year":"2018","unstructured":"Hogg E, Athreya K, Basile C et al (2018) High prevalence of undiagnosed insulin resistance in non-diabetic subjects with Parkinson\u2019s disease. J Parkinsons Dis 8:259\u2013265. https:\/\/doi.org\/10.3233\/JPD-181305","journal-title":"J Parkinsons Dis"},{"key":"6605_CR20","doi-asserted-by":"publisher","unstructured":"Hu G, Jousilahti P, Bidel S et al (2007) Type 2 diabetes and the risk of Parkinson\u2019s disease. https:\/\/doi.org\/10.2337\/dc06","DOI":"10.2337\/dc06"},{"key":"6605_CR21","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.nbd.2014.08.025","volume":"72","author":"Y Huang","year":"2014","unstructured":"Huang Y, Mahley RW (2014) Apolipoprotein E: Structure and function in lipid metabolism, neurobiology, and Alzheimer\u2019s diseases. Neurobiol Dis 72:3\u201312","journal-title":"Neurobiol Dis"},{"key":"6605_CR22","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1002\/mds.27609","volume":"34","author":"X Huang","year":"2019","unstructured":"Huang X, Sterling NW, Du G et al (2019) Brain cholesterol metabolism and Parkinson\u2019s disease. Mov Disord 34:386\u2013395. https:\/\/doi.org\/10.1002\/mds.27609","journal-title":"Mov Disord"},{"key":"6605_CR23","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1002\/mds.27681","volume":"34","author":"SM Jeong","year":"2019","unstructured":"Jeong SM, Jang W, Shin DW (2019) Association of statin use with Parkinson\u2019s disease: Dose\u2013response relationship. Mov Disord 34:1014\u20131021. https:\/\/doi.org\/10.1002\/mds.27681","journal-title":"Mov Disord"},{"key":"6605_CR24","doi-asserted-by":"publisher","first-page":"554","DOI":"10.5607\/en.2019.28.5.554","volume":"28","author":"U Jin","year":"2019","unstructured":"Jin U, Park SJ, Park SM (2019) Cholesterol metabolism in the brain and its association with Parkinson\u2019s disease. Exp Neurobiol 28:554\u2013567","journal-title":"Exp Neurobiol"},{"key":"6605_CR25","doi-asserted-by":"publisher","first-page":"5256","DOI":"10.1523\/JNEUROSCI.0984-06.2006","volume":"26","author":"PM Keeney","year":"2006","unstructured":"Keeney PM, Xie J, Capaldi RA, Bennett JP (2006) Parkinson\u2019s disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled. J Neurosci 26:5256\u20135264. https:\/\/doi.org\/10.1523\/JNEUROSCI.0984-06.2006","journal-title":"J Neurosci"},{"key":"6605_CR26","doi-asserted-by":"crossref","unstructured":"Kmita LC, Ilkiw JL, Rodrigues LS et al (2019) Absence of a synergic nigralproapoptotic effect triggered by REM sleep deprivation in the rotenone model of Parkinson\u2019s disease. In: Sleep science. Brazilian Association of Sleep and Latin American Federation of Sleep Societies, pp 196\u2013202","DOI":"10.5935\/1984-0063.20190078"},{"issue":"4","key":"6605_CR27","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.3233\/JPD-212725","volume":"1","author":"K Komici","year":"2021","unstructured":"Komici K, Femminella GD, Bencivenga L, Rengo G, Pagano G (2021) Diabetes mellitus and Parkinson\u2019s disease: a systematic review and meta-analyses. J Parkinsons Dis 1(4):1585\u20131596. https:\/\/doi.org\/10.3233\/JPD-212725","journal-title":"J Parkinsons Dis"},{"key":"6605_CR28","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1021\/cb400894a","volume":"9","author":"S Lei","year":"2014","unstructured":"Lei S, Zavala-Flores L, Garcia-Garcia A et al (2014) Alterations in energy\/redox metabolism induced by mitochondrial and environmental toxins: a specific role for glucose-6-phosphate-dehydrogenase and the pentose phosphate pathway in paraquat toxicity. ACS Chem Biol 9:2032\u20132048. https:\/\/doi.org\/10.1021\/cb400894a","journal-title":"ACS Chem Biol"},{"key":"6605_CR29","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1002\/mds.28474","volume":"36","author":"CH Lin","year":"2021","unstructured":"Lin CH, Chang CH, Tai CH et al (2021) A double-blind, randomized, controlled trial of lovastatin in early-stage Parkinson\u2019s disease. Mov Disord 36:1229\u20131237. https:\/\/doi.org\/10.1002\/mds.28474","journal-title":"Mov Disord"},{"key":"6605_CR30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0258928","author":"S Madiha","year":"2021","unstructured":"Madiha S, Batool Z, Tabassum S et al (2021) Quercetin exhibits potent antioxidant activity, restores motor and non-motor deficits induced by rotenone toxicity. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0258928","journal-title":"PLoS ONE"},{"key":"6605_CR31","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1161\/ATVBAHA.116.307023","volume":"36","author":"RW Mahley","year":"2016","unstructured":"Mahley RW (2016) Central nervous system lipoproteins: ApoE and regulation of cholesterol metabolism. Arterioscler Thromb Vasc Biol 36:1305\u20131315. https:\/\/doi.org\/10.1161\/ATVBAHA.116.307023","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"6605_CR32","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.parkreldis.2018.05.026","volume":"55","author":"A Marques","year":"2018","unstructured":"Marques A, Dutheil F, Durand E et al (2018) Glucose dysregulation in Parkinson\u2019s disease: too much glucose or not enough insulin? Parkinsonism Relat Disord 55:122\u2013127. https:\/\/doi.org\/10.1016\/j.parkreldis.2018.05.026","journal-title":"Parkinsonism Relat Disord"},{"key":"6605_CR33","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1089\/ars.2011.4033","volume":"16","author":"TN Martinez","year":"2012","unstructured":"Martinez TN, Greenamyre JT (2012) Toxin models of mitochondrial dysfunction in Parkinson\u2019s disease. Antioxid Redox Signal 16:920\u2013934","journal-title":"Antioxid Redox Signal"},{"key":"6605_CR34","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.phrs.2009.03.010","volume":"60","author":"E Mutez","year":"2009","unstructured":"Mutez E, Duhamel A, Defebvre L et al (2009) Lipid-lowering drugs are associated with delayed onset and slower course of Parkinson\u2019s disease. Pharmacol Res 60:41\u201345. https:\/\/doi.org\/10.1016\/j.phrs.2009.03.010","journal-title":"Pharmacol Res"},{"key":"6605_CR35","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1111\/neup.12204","volume":"35","author":"K Nakamura","year":"2015","unstructured":"Nakamura K, Mori F, Tanji K et al (2015) Isopentenyl diphosphate isomerase, a cholesterol synthesizing enzyme, is localized in Lewy bodies. Neuropathology 35:432\u2013440. https:\/\/doi.org\/10.1111\/neup.12204","journal-title":"Neuropathology"},{"key":"6605_CR36","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.bbr.2014.09.007","volume":"275","author":"ACD Noseda","year":"2014","unstructured":"Noseda ACD, Rodrigues LS, Targa ADS et al (2014) Putative role of monoamines in the antidepressant-like mechanism induced by striatal MT2 blockade. Behav Brain Res 275:136\u2013145. https:\/\/doi.org\/10.1016\/j.bbr.2014.09.007","journal-title":"Behav Brain Res"},{"key":"6605_CR37","doi-asserted-by":"publisher","first-page":"E1654","DOI":"10.1212\/WNL.0000000000005475","volume":"90","author":"G Pagano","year":"2018","unstructured":"Pagano G, Polychronis S, Wilson H et al (2018) Diabetes mellitus and Parkinson disease. Neurology 90:E1654\u2013E1662. https:\/\/doi.org\/10.1212\/WNL.0000000000005475","journal-title":"Neurology"},{"key":"6605_CR38","doi-asserted-by":"publisher","first-page":"42026","DOI":"10.1074\/jbc.M508628200","volume":"280","author":"A Panov","year":"2005","unstructured":"Panov A, Dikalov S, Shalbuyeva N et al (2005) Rotenone model of Parkinson disease: multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication. J Biol Chem 280:42026\u201342035. https:\/\/doi.org\/10.1074\/jbc.M508628200","journal-title":"J Biol Chem"},{"key":"6605_CR39","volume-title":"The rat brain in stereotaxic coordinates","author":"WC PaxinosG","year":"1997","unstructured":"PaxinosG WC (1997) The rat brain in stereotaxic coordinates. Academic Press, Orlando"},{"key":"6605_CR40","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jneumeth.2009.12.002","volume":"187","author":"CC Pegg","year":"2010","unstructured":"Pegg CC, He C, Stroink AR et al (2010) Technique for collection of cerebrospinal fluid from the cisterna magna in rat. J Neurosci Methods 187:8\u201312. https:\/\/doi.org\/10.1016\/j.jneumeth.2009.12.002","journal-title":"J Neurosci Methods"},{"key":"6605_CR41","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1002\/mds.28124","volume":"35","author":"I P\u00e9rez-Taboada","year":"2020","unstructured":"P\u00e9rez-Taboada I, Alberquilla S, Mart\u00edn ED et al (2020) Diabetes causes dysfunctional dopamine neurotransmission favoring nigrostriatal degeneration in mice. Mov Disord 35:1636\u20131648. https:\/\/doi.org\/10.1002\/mds.28124","journal-title":"Mov Disord"},{"key":"6605_CR42","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009332","author":"C Perier","year":"2012","unstructured":"Perier C, Vila M (2012) Mitochondrial biology and Parkinson\u2019s disease. Cold Spring Harb Perspect Med. https:\/\/doi.org\/10.1101\/cshperspect.a009332","journal-title":"Cold Spring Harb Perspect Med"},{"key":"6605_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105502","author":"I Piatkowska-Chmiel","year":"2022","unstructured":"Piatkowska-Chmiel I, Herbet M, Gawro\u0144ska-Grzywacz M, Dudka J (2022) Regulation of neuroinflammatory signaling by PPAR\u03b3 agonist in mouse model of diabetes. Int J MolSci. https:\/\/doi.org\/10.3390\/ijms23105502","journal-title":"Int J MolSci"},{"key":"6605_CR44","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-016-0090-7","author":"M Pinto","year":"2016","unstructured":"Pinto M, Nissanka N, Peralta S et al (2016) Pioglitazone ameliorates the phenotype of a novel Parkinson\u2019s disease mouse model by reducing neuroinflammation. Mol Neurodegener. https:\/\/doi.org\/10.1186\/s13024-016-0090-7","journal-title":"Mol Neurodegener"},{"key":"6605_CR45","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1159\/000481551","volume":"24","author":"A Raju","year":"2018","unstructured":"Raju A, Jaisankar P, Borah A, Mohanakumar KP (2018) 1-Methyl-4-phenylpyridinium-induced death of differentiated SH-SY5Y neurons is potentiated by cholesterol. Ann Neurosci 24:243\u2013251. https:\/\/doi.org\/10.1159\/000481551","journal-title":"Ann Neurosci"},{"key":"6605_CR46","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00383","author":"LS Rodrigues","year":"2014","unstructured":"Rodrigues LS, Targa ADS, Noseda ACD et al (2014) Olfactory impairment in the rotenone model of parkinson\u2019s disease is associated with bulbar dopaminergic D2 activity after REM sleep deprivation. Front Cell Neurosci. https:\/\/doi.org\/10.3389\/fncel.2014.00383","journal-title":"Front Cell Neurosci"},{"key":"6605_CR47","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.parkreldis.2021.06.002","volume":"89","author":"A S\u00e1nchez-G\u00f3mez","year":"2021","unstructured":"S\u00e1nchez-G\u00f3mez A, D\u00edaz Y, Duarte-Salles T et al (2021) Prediabetes, type 2 diabetes mellitus and risk of Parkinson\u2019s disease: a population-based cohort study. Parkinsonism Relat Disord 89:22\u201327. https:\/\/doi.org\/10.1016\/j.parkreldis.2021.06.002","journal-title":"Parkinsonism Relat Disord"},{"key":"6605_CR48","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1016\/j.pnpbp.2010.06.004","volume":"34","author":"RM Santiago","year":"2010","unstructured":"Santiago RM, Barbieiro J, Lima MMS et al (2010) Depressive-like behaviors alterations induced by intranigral MPTP, 6-OHDA, LPS and rotenone models of Parkinson\u2019s disease are predominantly associated with serotonin and dopamine. Prog Neuropsychopharmacol Biol Psychiatry 34:1104\u20131114. https:\/\/doi.org\/10.1016\/j.pnpbp.2010.06.004","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"6605_CR49","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.brainres.2005.04.051","volume":"1049","author":"KS Saravanan","year":"2005","unstructured":"Saravanan KS, Sindhu KM, Mohanakumar KP (2005) Acute intranigral infusion of rotenone in rats causes progressive biochemical lesions in the striatum similar to Parkinson\u2019s disease. Brain Res 1049:147\u2013155. https:\/\/doi.org\/10.1016\/j.brainres.2005.04.051","journal-title":"Brain Res"},{"key":"6605_CR50","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/nrn.2017.62","volume":"18","author":"AHV Schapira","year":"2017","unstructured":"Schapira AHV, Chaudhuri KR, Jenner P (2017) Non-motor features of Parkinson disease. Nat Rev Neurosci 18:435\u2013450","journal-title":"Nat Rev Neurosci"},{"key":"6605_CR51","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.2337\/dc10-1333","volume":"34","author":"E Schernhammer","year":"2011","unstructured":"Schernhammer E, Hansen J, Rugbjerg K et al (2011) Diabetes and the risk of developing Parkinson\u2019s disease in Denmark. Diabetes Care 34:1102\u20131108. https:\/\/doi.org\/10.2337\/dc10-1333","journal-title":"Diabetes Care"},{"key":"6605_CR52","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1002\/mds.24051","volume":"27","author":"MB Stern","year":"2012","unstructured":"Stern MB, Lang A, Poewe W (2012) Toward a redefinition of Parkinson\u2019s disease. Mov Disord 27:54\u201360","journal-title":"Mov Disord"},{"key":"6605_CR53","doi-asserted-by":"publisher","first-page":"279","DOI":"10.4300\/jgme-d-12-00156.1","volume":"4","author":"GM Sullivan","year":"2012","unstructured":"Sullivan GM, Feinn R (2012) Using effect size\u2014or why the p value is not enough. J Grad Med Educ 4:279\u2013282. https:\/\/doi.org\/10.4300\/jgme-d-12-00156.1","journal-title":"J Grad Med Educ"},{"key":"6605_CR54","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.tox.2010.03.019","volume":"272","author":"S Swarnkar","year":"2010","unstructured":"Swarnkar S, Singh S, Mathur R et al (2010) A study to correlate rotenone induced biochemical changes and cerebral damage in brain areas with neuromuscular coordination in rats. Toxicology 272:17\u201322. https:\/\/doi.org\/10.1016\/j.tox.2010.03.019","journal-title":"Toxicology"},{"key":"6605_CR55","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.molbrainres.2004.11.007","volume":"134","author":"CM Testa","year":"2005","unstructured":"Testa CM, Sherer TB, Greenamyre JT (2005) Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures. Mol Brain Res 134:109\u2013118. https:\/\/doi.org\/10.1016\/j.molbrainres.2004.11.007","journal-title":"Mol Brain Res"},{"key":"6605_CR56","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1007\/s00702-017-1686-y","volume":"124","author":"OB Tysnes","year":"2017","unstructured":"Tysnes OB, Storstein A (2017) Epidemiology of Parkinson\u2019s disease. J Neural Transm 124:901\u2013905","journal-title":"J Neural Transm"},{"key":"6605_CR57","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/S1474-4422(15)00186-6","volume":"14","author":"M Volta","year":"2015","unstructured":"Volta M, Milnerwood AJ, Farrer MJ (2015) Insights from late-onset familial parkinsonism on the pathogenesis of idiopathic Parkinson\u2019s disease. Lancet Neurol 14:1054\u20131064","journal-title":"Lancet Neurol"},{"key":"6605_CR58","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3389\/fgene.2015.00078","volume":"6","author":"MC Zanellati","year":"2015","unstructured":"Zanellati MC, Monti V, Barzaghi C et al (2015) Mitochondrial dysfunction in Parkinson disease: evidence in mutant PARK2 fibroblasts. Front Genet 6:78. https:\/\/doi.org\/10.3389\/fgene.2015.00078","journal-title":"Front Genet"}],"container-title":["Experimental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-023-06605-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00221-023-06605-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-023-06605-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T16:07:31Z","timestamp":1682438851000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00221-023-06605-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,31]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["6605"],"URL":"https:\/\/doi.org\/10.1007\/s00221-023-06605-w","relation":{},"ISSN":["0014-4819","1432-1106"],"issn-type":[{"value":"0014-4819","type":"print"},{"value":"1432-1106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,31]]},"assertion":[{"value":"6 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}