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In many neurodegenerative disorders, SIFSs exhibit elevated amplitudes and frequencies. Elevated SIFS amplitudes have been shown to favour the occurrence of SWJs (\u201cSWJ coupling\u201d). We analysed SIFSs in different subject groups comprising both healthy controls (CTR) and patients with amyotrophic lateral sclerosis (ALS) and progressive supranuclear palsy (PSP), i.e. two neurodegenerative diseases with completely different neuropathological basis and different clinical phenotypes. We show that, across these groups, the relations between SIFS amplitude and the relative frequency of SWJ-like patterns and other SIFS characteristics follow a common law. As an explanation, we propose that physiological and technical noise comprises a small, amplitude-independent component that has little effect on large SIFSs, but causes considerable deviations from the intended amplitude and direction of small ones. Therefore, in contrast to large SIFSs, successive small SIFSs have a lower chance to meet the SWJ similarity criteria. In principle, every measurement of SIFSs is affected by an amplitude-independent noise background. Therefore, the dependence of SWJ coupling on SIFS amplitude will probably be encountered in almost any group of subjects. In addition, we find a positive correlation between SIFS amplitude and frequency in ALS, but none in PSP, suggesting that the elevated amplitudes might arise at different sites in the two disorders.<\/jats:p>","DOI":"10.1007\/s00221-023-06633-6","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T01:01:32Z","timestamp":1685322092000},"page":"1821-1833","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Patterns of small involuntary fixation saccades (SIFSs) in different neurodegenerative diseases: the role of noise"],"prefix":"10.1007","volume":"241","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5791-5987","authenticated-orcid":false,"given":"Wolfgang","family":"Becker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Behler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Vintonyak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7106-9270","authenticated-orcid":false,"given":"Jan","family":"Kassubek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,29]]},"reference":[{"key":"6633_CR1","doi-asserted-by":"publisher","first-page":"8.1","DOI":"10.16910\/jemr.12.6.8","volume":"12","author":"W Becker","year":"2019","unstructured":"Becker W, Gorges M, Lul\u00e9 D, Pinkhardt E, Ludolph AC, Kassubek J (2019) Saccadic intrusions in amyotrophic lateral sclerosis (ALS). 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Control subjects had given their written informed consent in accordance with the committee's regulations and with the Declaration of Helsinki. The above approvals also cover the retrospective use of data generated as part of patient's routine care.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}