{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:43:11Z","timestamp":1780580591629,"version":"3.54.1"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"11-12","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7202006"],"award-info":[{"award-number":["7202006"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Brain Res"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1007\/s00221-023-06717-3","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T18:02:56Z","timestamp":1697479376000},"page":"2735-2750","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The NR2B-targeted intervention alleviates the neuronal injuries at the sub-acute stage of cerebral ischemia: an exploration of stage-dependent strategy against ischemic insults"],"prefix":"10.1007","volume":"241","author":[{"given":"Bei","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimeng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiandai","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1904-900X","authenticated-orcid":false,"given":"Yanling","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"issue":"4","key":"6717_CR1","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/s00213-012-2793-y","volume":"226","author":"Y Alaghband","year":"2013","unstructured":"Alaghband Y, Marshall JF (2013) Common influences of non-competitive NMDA receptor antagonists on the consolidation and reconsolidation of cocaine-cue memory. Psychopharmacology 226(4):707\u2013719. https:\/\/doi.org\/10.1007\/s00213-012-2793-y","journal-title":"Psychopharmacology"},{"issue":"11","key":"6717_CR2","first-page":"1479","volume":"125","author":"JL Boulland","year":"2005","unstructured":"Boulland JL, Levy LM (2005) Glutamate, glutamine and ischaemia in the central nervous system. Tidsskr nor Laegeforen 125(11):1479\u20131481","journal-title":"Tidsskr nor Laegeforen"},{"issue":"15","key":"6717_CR3","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.1007\/s00018-013-1550-7","volume":"71","author":"M Brini","year":"2014","unstructured":"Brini M, Cal\u00ec T, Ottolini D, Carafoli E (2014) Neuronal calcium signaling: function and dysfunction. Cell Mol Life Sci 71(15):2787\u20132814. https:\/\/doi.org\/10.1007\/s00018-013-1550-7","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"6717_CR4","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/j.neuropharm.2012.07.012","volume":"63","author":"MK Brittain","year":"2012","unstructured":"Brittain MK, Brustovetsky T, Brittain JM, Khanna R, Cummins TR, Brustovetsky N (2012) Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+\/Ca2+ exchanger in neurons. Neuropharmacology 63(6):974\u2013982. https:\/\/doi.org\/10.1016\/j.neuropharm.2012.07.012","journal-title":"Neuropharmacology"},{"issue":"1","key":"6717_CR5","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1038\/s41467-020-16074-2","volume":"11","author":"M Calvo-Rodriguez","year":"2020","unstructured":"Calvo-Rodriguez M, Hou SS, Snyder AC, Kharitonova EK, Russ AN, Das S, Fan Z, Muzikansky A, Garcia-Alloza M, Serrano-Pozo A, Hudry E, Bacskai BJ (2020) Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer\u2019s disease. Nat Commun 11(1):2146. https:\/\/doi.org\/10.1038\/s41467-020-16074-2","journal-title":"Nat Commun"},{"key":"6717_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112933","volume":"397","author":"A Charousaei","year":"2021","unstructured":"Charousaei A, Nasehi M, Babapour V, Vaseghi S, Zarrindast MR (2021) The effect of 5-HT(4) serotonin receptors in the CA3 hippocampal region on D-AP5-induced anxiolytic-like effects: isobolographic analyses. Behav Brain Res 397:112933. https:\/\/doi.org\/10.1016\/j.bbr.2020.112933","journal-title":"Behav Brain Res"},{"issue":"5","key":"6717_CR7","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1007\/s00429-016-1341-7","volume":"222","author":"YW Chen","year":"2017","unstructured":"Chen YW, Actor-Engel H, Sherpa AD, Klingensmith L, Chowdhury TG, Aoki C (2017) NR2A- and NR2B-NMDA receptors and drebrin within postsynaptic spines of the hippocampus correlate with hunger-evoked exercise. Brain Struct Funct 222(5):2271\u20132294. https:\/\/doi.org\/10.1007\/s00429-016-1341-7","journal-title":"Brain Struct Funct"},{"issue":"4","key":"6717_CR8","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1007\/s11064-020-02966-8","volume":"45","author":"G Chen","year":"2020","unstructured":"Chen G, Li T, Xiao J, Wang J, Shang Q, Qian H, Qiao C, Zhang P, Chen T, Liu X (2020) Ifenprodil attenuates methamphetamine-induced behavioral sensitization through the GluN2B-PP2A-AKT cascade in the dorsal striatum of mice. Neurochem Res 45(4):891\u2013901. https:\/\/doi.org\/10.1007\/s11064-020-02966-8","journal-title":"Neurochem Res"},{"issue":"Pt C","key":"6717_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.127624","volume":"424","author":"S Chen","year":"2022","unstructured":"Chen S, Chen L, Ye L, Jiang Y, Li Q, Zhang H, Zhang R, Li H, Yu D, Zhang R, Niu Y, Zhao Q, Liu J, Ouyang G, Aschner M, Zheng Y, Zhang L, Chen W, Li D (2022) PP2A-mTOR-p70S6K\/4E-BP1 axis regulates M1 polarization of pulmonary macrophages and promotes ambient particulate matter induced mouse lung injury. J Hazard Mater 424(Pt C):127624. https:\/\/doi.org\/10.1016\/j.jhazmat.2021.127624","journal-title":"J Hazard Mater"},{"issue":"6","key":"6717_CR10","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.1042\/bst20210460","volume":"49","author":"S Cogliati","year":"2021","unstructured":"Cogliati S, Cabrera-Alarc\u00f3n JL, Enriquez JA (2021) Regulation and functional role of the electron transport chain supercomplexes. Biochem Soc Trans 49(6):2655\u20132668. https:\/\/doi.org\/10.1042\/bst20210460","journal-title":"Biochem Soc Trans"},{"issue":"7","key":"6717_CR11","doi-asserted-by":"publisher","first-page":"4865","DOI":"10.1007\/s12035-015-9391-z","volume":"53","author":"HB Dai","year":"2016","unstructured":"Dai HB, Xu MM, Lv J, Ji XJ, Zhu SH, Ma RM, Miao XL, Duan ML (2016) Mild hypothermia combined with hydrogen sulfide treatment during resuscitation reduces hippocampal neuron apoptosis via NR2A, NR2B, and PI3K-Akt signaling in a rat model of cerebral ischemia-reperfusion injury. Mol Neurobiol 53(7):4865\u20134873. https:\/\/doi.org\/10.1007\/s12035-015-9391-z","journal-title":"Mol Neurobiol"},{"issue":"4","key":"6717_CR12","doi-asserted-by":"publisher","first-page":"552","DOI":"10.15252\/embr.201541439","volume":"17","author":"JM Decker","year":"2016","unstructured":"Decker JM, Kr\u00fcger L, Sydow A, Dennissen FJ, Siskova Z, Mandelkow E, Mandelkow EM (2016) The Tau\/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity. EMBO Rep 17(4):552\u2013569. https:\/\/doi.org\/10.15252\/embr.201541439","journal-title":"EMBO Rep"},{"issue":"5","key":"6717_CR13","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1089\/ars.2010.3375","volume":"14","author":"F Di Lisa","year":"2011","unstructured":"Di Lisa F, Canton M, Carpi A, Kaludercic N, Menab\u00f2 R, Menazza S, Semenzato M (2011) Mitochondrial injury and protection in ischemic pre- and postconditioning. Antioxid Redox Signal 14(5):881\u2013891. https:\/\/doi.org\/10.1089\/ars.2010.3375","journal-title":"Antioxid Redox Signal"},{"issue":"3","key":"6717_CR14","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","volume":"22","author":"EF Fang","year":"2019","unstructured":"Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan-Olive MM, Caponio D, Dan X, Rockt\u00e4schel P, Croteau DL, Akbari M, Greig NH, Fladby T, Nilsen H, Cader MZ, Mattson MP, Tavernarakis N, Bohr VA (2019) Mitophagy inhibits amyloid-\u03b2 and tau pathology and reverses cognitive deficits in models of alzheimer\u2019s disease. Nat Neurosci 22(3):401\u2013412. https:\/\/doi.org\/10.1038\/s41593-018-0332-9","journal-title":"Nat Neurosci"},{"issue":"5","key":"6717_CR15","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.nrl.2011.10.014","volume":"27","author":"ME Flores-Soto","year":"2012","unstructured":"Flores-Soto ME, Chaparro-Huerta V, Escoto-Delgadillo M, Vazquez-Valls E, Gonz\u00e1lez-Casta\u00f1eda RE, Beas-Zarate C (2012) Structure and function of NMDA-type glutamate receptor subunits. Neurologia 27(5):301\u2013310. https:\/\/doi.org\/10.1016\/j.nrl.2011.10.014","journal-title":"Neurologia"},{"issue":"4","key":"6717_CR16","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.neuint.2012.03.019","volume":"61","author":"R Fukumori","year":"2012","unstructured":"Fukumori R, Takarada T, Kambe Y, Nakazato R, Fujikawa K, Yoneda Y (2012) Possible involvement of mitochondrial uncoupling protein-2 in cytotoxicity mediated by acquired N-methyl-D-aspartate receptor channels. Neurochem Int 61(4):498\u2013505. https:\/\/doi.org\/10.1016\/j.neuint.2012.03.019","journal-title":"Neurochem Int"},{"issue":"41","key":"6717_CR17","doi-asserted-by":"publisher","first-page":"35018","DOI":"10.1074\/jbc.M504108200","volume":"280","author":"S Gasc\u00f3n","year":"2005","unstructured":"Gasc\u00f3n S, Deogracias R, Sobrado M, Roda JM, Renart J, Rodr\u00edguez-Pe\u00f1a A, D\u00edaz-Guerra M (2005) Transcription of the NR1 subunit of the N-methyl-D-aspartate receptor is down-regulated by excitotoxic stimulation and cerebral ischemia. J Biol Chem 280(41):35018\u201335027. https:\/\/doi.org\/10.1074\/jbc.M504108200","journal-title":"J Biol Chem"},{"issue":"1","key":"6717_CR18","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/sj.mp.4002017","volume":"13","author":"S Gasc\u00f3n","year":"2008","unstructured":"Gasc\u00f3n S, Sobrado M, Roda JM, Rodr\u00edguez-Pe\u00f1a A, D\u00edaz-Guerra M (2008) Excitotoxicity and focal cerebral ischemia induce truncation of the NR2A and NR2B subunits of the NMDA receptor and cleavage of the scaffolding protein PSD-95. Mol Psychiatry 13(1):99\u2013114. https:\/\/doi.org\/10.1038\/sj.mp.4002017","journal-title":"Mol Psychiatry"},{"issue":"46","key":"6717_CR19","doi-asserted-by":"publisher","first-page":"34859","DOI":"10.1074\/jbc.M602568200","volume":"281","author":"MS Hammond","year":"2006","unstructured":"Hammond MS, Sims C, Parameshwaran K, Suppiramaniam V, Schachner M, Dityatev A (2006) Neural cell adhesion molecule-associated polysialic acid inhibits NR2B-containing N-methyl-D-aspartate receptors and prevents glutamate-induced cell death. J Biol Chem 281(46):34859\u201334869. https:\/\/doi.org\/10.1074\/jbc.M602568200","journal-title":"J Biol Chem"},{"key":"6717_CR20","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.freeradbiomed.2019.11.005","volume":"146","author":"Z He","year":"2020","unstructured":"He Z, Ning N, Zhou Q, Khoshnam SE, Farzaneh M (2020) Mitochondria as a therapeutic target for ischemic stroke. Free Radic Biol Med 146:45\u201358. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2019.11.005","journal-title":"Free Radic Biol Med"},{"issue":"12","key":"6717_CR21","doi-asserted-by":"publisher","first-page":"3204","DOI":"10.1002\/jnr.24937","volume":"99","author":"Y Huo","year":"2021","unstructured":"Huo Y, Feng X, Niu M, Wang L, Xie Y, Wang L, Ha J, Cheng X, Gao Z, Sun Y (2021) Therapeutic time windows of compounds against NMDA receptors signaling pathways for ischemic stroke. J Neurosci Res 99(12):3204\u20133221. https:\/\/doi.org\/10.1002\/jnr.24937","journal-title":"J Neurosci Res"},{"issue":"7","key":"6717_CR22","doi-asserted-by":"publisher","first-page":"C570","DOI":"10.1152\/ajpcell.00353.2014","volume":"308","author":"JH Lee","year":"2015","unstructured":"Lee JH, Wei ZZ, Chen D, Gu X, Wei L, Yu SP (2015) A neuroprotective role of the NMDA receptor subunit GluN3A (NR3A) in ischemic stroke of the adult mouse. Am J Physiol Cell Physiol 308(7):C570-577. https:\/\/doi.org\/10.1152\/ajpcell.00353.2014","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"6717_CR23","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s12031-016-0786-8","volume":"60","author":"S Liraz-Zaltsman","year":"2016","unstructured":"Liraz-Zaltsman S, Yaka R, Shabashov D, Shohami E, Biegon A (2016) Neuroinflammation-induced memory deficits are amenable to treatment with D-Cycloserine. J Mol Neurosci 60(1):46\u201362. https:\/\/doi.org\/10.1007\/s12031-016-0786-8","journal-title":"J Mol Neurosci"},{"issue":"5","key":"6717_CR24","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.neuint.2012.07.005","volume":"61","author":"Y Lu","year":"2012","unstructured":"Lu Y, Zhang J, Ma B, Li K, Li X, Bai H, Yang Q, Zhu X, Ben J, Chen Q (2012) Glycine attenuates cerebral ischemia\/reperfusion injury by inhibiting neuronal apoptosis in mice. Neurochem Int 61(5):649\u2013658. https:\/\/doi.org\/10.1016\/j.neuint.2012.07.005","journal-title":"Neurochem Int"},{"issue":"1","key":"6717_CR25","doi-asserted-by":"publisher","first-page":"52","DOI":"10.2174\/1871527320666210212141232","volume":"21","author":"A Ludhiadch","year":"2022","unstructured":"Ludhiadch A, Sharma R, Muriki A, Munshi A (2022) Role of calcium homeostasis in ischemic stroke: a review. CNS Neurol Disord Drug Targets 21(1):52\u201361. https:\/\/doi.org\/10.2174\/1871527320666210212141232","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"10","key":"6717_CR26","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.1161\/strokeaha.118.022330","volume":"49","author":"Y Luo","year":"2018","unstructured":"Luo Y, Ma H, Zhou JJ, Li L, Chen SR, Zhang J, Chen L, Pan HL (2018) Focal cerebral ischemia and reperfusion induce brain injury through \u03b12\u03b4-1-bound NMDA receptors. Stroke 49(10):2464\u20132472. https:\/\/doi.org\/10.1161\/strokeaha.118.022330","journal-title":"Stroke"},{"issue":"1","key":"6717_CR27","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.neuroscience.2008.01.080","volume":"158","author":"MA Martel","year":"2009","unstructured":"Martel MA, Wyllie DJ, Hardingham GE (2009) In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death. Neuroscience 158(1):334\u2013343. https:\/\/doi.org\/10.1016\/j.neuroscience.2008.01.080","journal-title":"Neuroscience"},{"issue":"2","key":"6717_CR28","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.cell.2010.01.014","volume":"140","author":"HG Martin","year":"2010","unstructured":"Martin HG, Wang YT (2010) Blocking the deadly effects of the NMDA receptor in stroke. Cell 140(2):174\u2013176. https:\/\/doi.org\/10.1016\/j.cell.2010.01.014","journal-title":"Cell"},{"issue":"3","key":"6717_CR29","doi-asserted-by":"publisher","first-page":"433","DOI":"10.4103\/1673-5374.293129","volume":"16","author":"H MartInez-Coria","year":"2021","unstructured":"MartInez-Coria H, Arrieta-Cruz I, Cruz ME, L\u00f3pez-Vald\u00e9s HE (2021) Physiopathology of ischemic stroke and its modulation using memantine: evidence from preclinical stroke. Neural Regen Res 16(3):433\u2013439. https:\/\/doi.org\/10.4103\/1673-5374.293129","journal-title":"Neural Regen Res"},{"issue":"8","key":"6717_CR30","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14164","volume":"33","author":"K Michel","year":"2021","unstructured":"Michel K, Kr\u00fcger D, Sch\u00e4uffele S, Zeller F, Demir IE, Theisen J, Schemann M (2021) Fast synaptic excitatory neurotransmission in the human submucosal plexus. Neurogastroenterol Motil 33(8):e14164. https:\/\/doi.org\/10.1111\/nmo.14164","journal-title":"Neurogastroenterol Motil"},{"key":"6717_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2019.107628","volume":"205","author":"RG Mira","year":"2019","unstructured":"Mira RG, Tapia-Rojas C, P\u00e9rez MJ, Jara C, Vergara EH, Quintanilla RA, Cerpa W (2019) Alcohol impairs hippocampal function: from NMDA receptor synaptic transmission to mitochondrial function. Drug Alcohol Depend 205:107628. https:\/\/doi.org\/10.1016\/j.drugalcdep.2019.107628","journal-title":"Drug Alcohol Depend"},{"issue":"4","key":"6717_CR32","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.neuint.2012.01.004","volume":"61","author":"DT Monaghan","year":"2012","unstructured":"Monaghan DT, Irvine MW, Costa BM, Fang G, Jane DE (2012) Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators. Neurochem Int 61(4):581\u2013592. https:\/\/doi.org\/10.1016\/j.neuint.2012.01.004","journal-title":"Neurochem Int"},{"issue":"5","key":"6717_CR33","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1111\/ejn.12086","volume":"37","author":"RG Morris","year":"2013","unstructured":"Morris RG, Steele RJ, Bell JE, Martin SJ (2013) N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci 37(5):700\u2013717. https:\/\/doi.org\/10.1111\/ejn.12086","journal-title":"Eur J Neurosci"},{"issue":"1","key":"6717_CR34","first-page":"27","volume":"59","author":"I Nakahara","year":"1990","unstructured":"Nakahara I (1990) Experimental studies on the changes of mitochondrial membrane phospholipids during cerebral ischemia and recirculation. Nihon Geka Hokan 59(1):27\u201338","journal-title":"Nihon Geka Hokan"},{"key":"6717_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113518","volume":"335","author":"S Paul","year":"2021","unstructured":"Paul S, Candelario-Jalil E (2021) Emerging neuroprotective strategies for the treatment of ischemic stroke: an overview of clinical and preclinical studies. Exp Neurol 335:113518. https:\/\/doi.org\/10.1016\/j.expneurol.2020.113518","journal-title":"Exp Neurol"},{"issue":"32","key":"6717_CR36","doi-asserted-by":"publisher","first-page":"6121","DOI":"10.1523\/jneurosci.0880-20.2020","volume":"40","author":"A Phensy","year":"2020","unstructured":"Phensy A, Lindquist KL, Lindquist KA, Bairuty D, Gauba E, Guo L, Tian J, Du H, Kroener S (2020) Deletion of the mitochondrial matrix protein cyclophilind prevents parvalbumin interneuron dysfunctionand cognitive deficits in a mouse model of NMDA hypofunction. J Neurosci 40(32):6121\u20136132. https:\/\/doi.org\/10.1523\/jneurosci.0880-20.2020","journal-title":"J Neurosci"},{"key":"6717_CR37","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/964518","volume":"2015","author":"H Prentice","year":"2015","unstructured":"Prentice H, Modi JP, Wu JY (2015) Mechanisms of neuronal protection against excitotoxicity, endoplasmic reticulum stress, and mitochondrial dysfunction in stroke and neurodegenerative diseases. Oxid Med Cell Longev 2015:964518. https:\/\/doi.org\/10.1155\/2015\/964518","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"6717_CR38","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1212\/con.0000000000000840","volume":"26","author":"AA Rabinstein","year":"2020","unstructured":"Rabinstein AA (2020) Update on treatment of acute ischemic stroke. Continuum (minneap Minn) 26(2):268\u2013286. https:\/\/doi.org\/10.1212\/con.0000000000000840","journal-title":"Continuum (minneap Minn)"},{"key":"6717_CR39","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3389\/fphar.2019.00297","volume":"10","author":"FA Shah","year":"2019","unstructured":"Shah FA, Liu G, Al Kury LT, Zeb A, Abbas M, Li T, Yang X, Liu F, Jiang Y, Li S, Koh PO (2019) Melatonin protects MCAO-induced neuronal loss via NR2A mediated prosurvival pathways. Front Pharmacol 10:297. https:\/\/doi.org\/10.3389\/fphar.2019.00297","journal-title":"Front Pharmacol"},{"issue":"2","key":"6717_CR40","doi-asserted-by":"publisher","first-page":"158","DOI":"10.13459\/j.cnki.cjap.2016.02.016","volume":"32","author":"Y Shang","year":"2016","unstructured":"Shang Y, Xue Q, Gu PF, Li Y, Gao GJ (2016) Effect of dexmedetomidine on the changes of EAA and the expression of NMDA NR1 protein in hippocampus in global cerebral ischemia\/reperfusion rats. Zhongguo Ying Yong Sheng Li Xue Za Zhi 32(2):158\u2013162. https:\/\/doi.org\/10.13459\/j.cnki.cjap.2016.02.016","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"issue":"5","key":"6717_CR41","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.brainresbull.2008.08.002","volume":"77","author":"H Shen","year":"2008","unstructured":"Shen H, Yuan Y, Ding F, Liu J, Gu X (2008) The protective effects of Achyranthes bidentata polypeptides against NMDA-induced cell apoptosis in cultured hippocampal neurons through differential modulation of NR2A- and NR2B-containing NMDA receptors. Brain Res Bull 77(5):274\u2013281. https:\/\/doi.org\/10.1016\/j.brainresbull.2008.08.002","journal-title":"Brain Res Bull"},{"issue":"15","key":"6717_CR42","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1097\/WNR.0b013e32834ae32e","volume":"22","author":"M Shi","year":"2011","unstructured":"Shi M, Wu X, Wei C, Yang M, Liu Z, Ren W (2011) Effects of NR2A and NR2B-containing N-methyl-D-aspartate receptors on neuronal-firing properties. NeuroReport 22(15):762\u2013766. https:\/\/doi.org\/10.1097\/WNR.0b013e32834ae32e","journal-title":"NeuroReport"},{"key":"6717_CR43","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/978-981-10-7757-9_7","volume":"87","author":"JS Sousa","year":"2018","unstructured":"Sousa JS, D\u2019Imprima E, Vonck J (2018) Mitochondrial respiratory chain complexes. Subcell Biochem 87:167\u2013227. https:\/\/doi.org\/10.1007\/978-981-10-7757-9_7","journal-title":"Subcell Biochem"},{"issue":"1\u20132","key":"6717_CR44","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.brainres.2005.09.060","volume":"1064","author":"N Sun","year":"2005","unstructured":"Sun N, Zou X, Shi J, Liu X, Li L, Zhao L (2005) Electroacupuncture regulates NMDA receptor NR1 subunit expression via PI3-K pathway in a rat model of cerebral ischemia-reperfusion. Brain Res 1064(1\u20132):98\u2013107. https:\/\/doi.org\/10.1016\/j.brainres.2005.09.060","journal-title":"Brain Res"},{"issue":"2","key":"6717_CR45","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1007\/s12035-017-0395-8","volume":"55","author":"Y Sun","year":"2018","unstructured":"Sun Y, Cheng X, Hu J, Gao Z (2018) The role of GluN2A in Cerebral ischemia: promoting neuron death and survival in the early stage and thereafter. Mol Neurobiol 55(2):1208\u20131216. https:\/\/doi.org\/10.1007\/s12035-017-0395-8","journal-title":"Mol Neurobiol"},{"issue":"1\u20133","key":"6717_CR46","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ejphar.2010.07.026","volume":"644","author":"N Takagi","year":"2010","unstructured":"Takagi N, Besshoh S, Morita H, Terao M, Takeo S, Tanonaka K (2010) Metabotropic glutamate mGlu5 receptor-mediated serine phosphorylation of NMDA receptor subunit NR1 in hippocampal CA1 region after transient global ischemia in rats. Eur J Pharmacol 644(1\u20133):96\u2013100. https:\/\/doi.org\/10.1016\/j.ejphar.2010.07.026","journal-title":"Eur J Pharmacol"},{"issue":"11","key":"6717_CR47","doi-asserted-by":"publisher","first-page":"3066","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.06.041","volume":"27","author":"AA Tameh","year":"2018","unstructured":"Tameh AA, Karimian M, Zare-Dehghanani Z, Aftabi Y, Beyer C (2018) Role of steroid therapy after ischemic stroke by n-methyl-d-aspartate receptor gene regulation. J Stroke Cerebrovasc Dis 27(11):3066\u20133075. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2018.06.041","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"6717_CR49","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2867","author":"X Tang","year":"2022","unstructured":"Tang X, Xie S, Wang H, Li Y, Lai Z, Sun S, Pan R, Huang Y, Cai J (2022) The combination of astragalus membranaceus and ligustrazine mitigates cerebral ischemia-reperfusion injury via regulating NR2B-ERK\/CREB signaling. Brain Behav. https:\/\/doi.org\/10.1002\/brb3.2867","journal-title":"Brain Behav"},{"issue":"2","key":"6717_CR50","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2867","volume":"13","author":"X Tang","year":"2023","unstructured":"Tang X, Xie S, Wang H, Li Y, Lai Z, Sun S, Pan R, Huang Y, Cai J (2023) The combination of astragalus membranaceus and ligustrazine mitigates cerebral ischemia-reperfusion injury via regulating NR2B-ERK\/CREB signaling. Brain Behav 13(2):e2867. https:\/\/doi.org\/10.1002\/brb3.2867","journal-title":"Brain Behav"},{"key":"6717_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2022.105381","volume":"158","author":"JS Tauskela","year":"2022","unstructured":"Tauskela JS, Brunette E, Aylsworth A, Zhao X (2022) Neuroprotection against supra-lethal \u2018stroke in a dish\u2019 insults by an anti-excitotoxic receptor antagonist cocktail. Neurochem Int 158:105381. https:\/\/doi.org\/10.1016\/j.neuint.2022.105381","journal-title":"Neurochem Int"},{"issue":"2","key":"6717_CR52","doi-asserted-by":"publisher","first-page":"3786","DOI":"10.1111\/ejn.15669","volume":"56","author":"J Tian","year":"2022","unstructured":"Tian J, Yao H, Liu Y, Wang X, Wu J, Wang J, Yu D, Xie Y, Gao J, Zhu Y, Yang C (2022) Extracellular vesicles from bone marrow stromal cells reduce the impact of stroke on glial cell activation and blood brain-barrier permeability via a putative miR-124\/PRX1 signalling pathway. Eur J Neurosci 56(2):3786\u20133805. https:\/\/doi.org\/10.1111\/ejn.15669","journal-title":"Eur J Neurosci"},{"key":"6717_CR53","doi-asserted-by":"publisher","DOI":"10.3390\/biom10071051","author":"JM Valdivielso","year":"2020","unstructured":"Valdivielso JM, Eritja \u00c0, Caus M, Bozic M (2020) Glutamate-gated NMDA receptors: insights into the function and signaling in the kidney. Biomolecules. https:\/\/doi.org\/10.3390\/biom10071051","journal-title":"Biomolecules"},{"issue":"2","key":"6717_CR54","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/s41580-021-00415-0","volume":"23","author":"I Vercellino","year":"2022","unstructured":"Vercellino I, Sazanov LA (2022) The assembly, regulation and function of the mitochondrial respiratory chain. Nat Rev Mol Cell Biol 23(2):141\u2013161. https:\/\/doi.org\/10.1038\/s41580-021-00415-0","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"11","key":"6717_CR55","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1002\/jcp.24607","volume":"229","author":"Y Wang","year":"2014","unstructured":"Wang Y, Wang W, Li D, Li M, Wang P, Wen J, Liang M, Su B, Yin Y (2014) IGF-1 alleviates NMDA-induced excitotoxicity in cultured hippocampal neurons against autophagy via the NR2B\/PI3K-AKT-mTOR pathway. J Cell Physiol 229(11):1618\u20131629. https:\/\/doi.org\/10.1002\/jcp.24607","journal-title":"J Cell Physiol"},{"issue":"2","key":"6717_CR56","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1046\/j.1471-4159.1997.68020469.x","volume":"68","author":"A Wenzel","year":"1997","unstructured":"Wenzel A, Fritschy JM, Mohler H, Benke D (1997) NMDA receptor heterogeneity during postnatal development of the rat brain: differential expression of the NR2A, NR2B, and NR2C subunit proteins. J Neurochem 68(2):469\u2013478. https:\/\/doi.org\/10.1046\/j.1471-4159.1997.68020469.x","journal-title":"J Neurochem"},{"issue":"2","key":"6717_CR57","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/s0304-3940(01)01625-1","volume":"301","author":"MH Won","year":"2001","unstructured":"Won MH, Kang T, Park S, Jeon G, Kim Y, Seo JH, Choi E, Chung M, Cho SS (2001) The alterations of N-Methyl-D-aspartate receptor expressions and oxidative DNA damage in the CA1 area at the early time after ischemia-reperfusion insult. Neurosci Lett 301(2):139\u2013142. https:\/\/doi.org\/10.1016\/s0304-3940(01)01625-1","journal-title":"Neurosci Lett"},{"issue":"10","key":"6717_CR58","doi-asserted-by":"publisher","first-page":"5253","DOI":"10.1007\/s12035-021-02494-8","volume":"58","author":"M Wu","year":"2021","unstructured":"Wu M, Gu X, Ma Z (2021) Mitochondrial quality control in cerebral ischemia-reperfusion injury. Mol Neurobiol 58(10):5253\u20135271. https:\/\/doi.org\/10.1007\/s12035-021-02494-8","journal-title":"Mol Neurobiol"},{"issue":"6","key":"6717_CR59","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1080\/15548627.2021.1975914","volume":"18","author":"T Zhang","year":"2022","unstructured":"Zhang T, Liu Q, Gao W, Sehgal SA, Wu H (2022) The multifaceted regulation of mitophagy by endogenous metabolites. Autophagy 18(6):1216\u20131239. https:\/\/doi.org\/10.1080\/15548627.2021.1975914","journal-title":"Autophagy"},{"key":"6717_CR60","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.neuroscience.2022.05.016","volume":"496","author":"Y Zhong","year":"2022","unstructured":"Zhong Y, Gu L, Ye Y, Zhu H, Pu B, Wang J, Li Y, Qiu S, Xiong X, Jian Z (2022) JAK2\/STAT3 axis intermediates microglia\/macrophage polarization during cerebral ischemia\/reperfusion injury. Neuroscience 496:119\u2013128. https:\/\/doi.org\/10.1016\/j.neuroscience.2022.05.016","journal-title":"Neuroscience"}],"container-title":["Experimental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-023-06717-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00221-023-06717-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-023-06717-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T08:25:45Z","timestamp":1699518345000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00221-023-06717-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,16]]},"references-count":59,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["6717"],"URL":"https:\/\/doi.org\/10.1007\/s00221-023-06717-3","relation":{},"ISSN":["0014-4819","1432-1106"],"issn-type":[{"value":"0014-4819","type":"print"},{"value":"1432-1106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,16]]},"assertion":[{"value":"28 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing financial interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}