{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:35:09Z","timestamp":1789508109977,"version":"build-2803163510"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Shanghai University of Medicine & Health Sciences Intelligent Neurorehabilitation Clinical Research Center","award":["22MC2022002"],"award-info":[{"award-number":["22MC2022002"]}]},{"name":"Key Discipline Project of Shanghai Pudong New Area","award":["PWZxk2022-10"],"award-info":[{"award-number":["PWZxk2022-10"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Brain Res"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1007\/s00221-024-06778-y","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T09:03:13Z","timestamp":1709197393000},"page":"869-878","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Preconditioning exercise reduces brain damage of ischemic stroke in rats via PI3K\u2013AKT pathway by bioinformatic analysis"],"prefix":"10.1007","volume":"242","author":[{"given":"Kai","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Kun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Sha","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Ya","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4834-6954","authenticated-orcid":false,"given":"Xia","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"6778_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.134607","volume":"714","author":"A Abdalmalak","year":"2020","unstructured":"Abdalmalak A et al (2020) Using fMRI to investigate the potential cause of inverse oxygenation reported in fNIRS studies of motor imagery. Neurosci Lett 714:134607","journal-title":"Neurosci Lett"},{"issue":"5","key":"6778_CR2","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1016\/j.cell.2019.03.032","volume":"177","author":"I Alim","year":"2019","unstructured":"Alim I et al (2019) Selenium drives a transcriptional adaptive program to block ferroptosis and treat stroke. Cell 177(5):1262-1279.e25","journal-title":"Cell"},{"issue":"11","key":"6778_CR3","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1177\/1535370217712691","volume":"242","author":"S Baillieul","year":"2017","unstructured":"Baillieul S et al (2017) Hypoxic conditioning and the central nervous system: A new therapeutic opportunity for brain and spinal cord injuries? Exp Biol Med (maywood) 242(11):1198\u20131206","journal-title":"Exp Biol Med (maywood)"},{"issue":"28","key":"6778_CR4","doi-asserted-by":"publisher","first-page":"6247","DOI":"10.1523\/JNEUROSCI.3017-17.2018","volume":"38","author":"C Bastian","year":"2018","unstructured":"Bastian C et al (2018) NOS3 inhibition confers post-ischemic protection to young and aging white matter integrity by conserving mitochondrial dynamics and Miro-2 levels. J Neurosci 38(28):6247\u20136266","journal-title":"J Neurosci"},{"key":"6778_CR5","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/436429","volume":"2014","author":"A Diaz-Ruiz","year":"2014","unstructured":"Diaz-Ruiz A et al (2014) Metallothionein-II inhibits lipid peroxidation and improves functional recovery after transient brain ischemia and reperfusion in rats. Oxid Med Cell Longev 2014:436429","journal-title":"Oxid Med Cell Longev"},{"issue":"2\u20133","key":"6778_CR6","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1007\/s12035-010-8142-4","volume":"41","author":"Y Dong","year":"2010","unstructured":"Dong Y et al (2010) 14-3-3gamma and neuroglobin are new intrinsic protective factors for cerebral ischemia. Mol Neurobiol 41(2\u20133):218\u2013231","journal-title":"Mol Neurobiol"},{"issue":"1","key":"6778_CR7","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/s12974-021-02181-4","volume":"18","author":"Y Feng","year":"2021","unstructured":"Feng Y et al (2021) miR-1224 contributes to ischemic stroke-mediated natural killer cell dysfunction by targeting Sp1 signaling. J Neuroinflammation 18(1):133","journal-title":"J Neuroinflammation"},{"key":"6778_CR8","first-page":"p. pdb.prt4986","volume":"2008","author":"AH Fischer","year":"2008","unstructured":"Fischer AH et al (2008) Hematoxylin and eosin staining of tissue and cell sections. CSH Protoc 2008:pdb.prt4986","journal-title":"CSH Protoc"},{"key":"6778_CR9","doi-asserted-by":"crossref","unstructured":"Fontenas, L. and S. Kucenas, Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia. Elife, 2021. 10.","DOI":"10.7554\/eLife.64267"},{"issue":"6","key":"6778_CR10","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1093\/bib\/bby063","volume":"20","author":"J Gauthier","year":"2019","unstructured":"Gauthier J et al (2019) A brief history of bioinformatics. Brief Bioinform 20(6):1981\u20131996","journal-title":"Brief Bioinform"},{"issue":"5","key":"6778_CR11","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1007\/s12015-017-9755-z","volume":"13","author":"H Ghazavi","year":"2017","unstructured":"Ghazavi H et al (2017) Fibroblast growth factor type 1 (FGF1)-overexpressed adipose-derived mesenchaymal stem Cells (AD-MSC(FGF1)) induce neuroprotection and functional recovery in a rat stroke model. Stem Cell Rev Rep 13(5):670\u2013685","journal-title":"Stem Cell Rev Rep"},{"key":"6778_CR12","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/978-1-0716-1162-3_20","volume":"2255","author":"JL Guy","year":"2021","unstructured":"Guy JL, Mor GG (2021) Transcription Factor-Binding Site Identification and Enrichment Analysis. Methods Mol Biol 2255:241\u2013261","journal-title":"Methods Mol Biol"},{"issue":"1","key":"6778_CR13","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1158\/0008-5472.CAN-19-1904","volume":"81","author":"E Kapiainen","year":"2021","unstructured":"Kapiainen E et al (2021) The amino-terminal oligomerization domain of angiopoietin-2 affects vascular remodeling, mammary gland tumor growth, and lung metastasis in mice. Cancer Res 81(1):129\u2013143","journal-title":"Cancer Res"},{"issue":"5","key":"6778_CR14","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1161\/STROKEAHA.120.032201","volume":"52","author":"K Kinoshita","year":"2021","unstructured":"Kinoshita K et al (2021) Mature adult mice with exercise-preconditioning show better recovery after intracerebral hemorrhage. Stroke 52(5):1861\u20131865","journal-title":"Stroke"},{"issue":"9","key":"6778_CR15","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/s41419-021-04099-4","volume":"12","author":"X Lai","year":"2021","unstructured":"Lai X et al (2021) SOX10 ablation severely impairs the generation of postmigratory neural crest from human pluripotent stem cells. Cell Death Dis 12(9):814","journal-title":"Cell Death Dis"},{"key":"6778_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.134991","volume":"729","author":"H Lang","year":"2020","unstructured":"Lang H et al (2020) Linc-FOXD3 knockdown enhances hippocampal NSCs activation through upregulation of the Wnt\/\u03b2-catenin pathway. Neurosci Lett 729:134991","journal-title":"Neurosci Lett"},{"issue":"9778","key":"6778_CR17","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1016\/S0140-6736(11)60325-5","volume":"377","author":"P Langhorne","year":"2011","unstructured":"Langhorne P, Bernhardt J, Kwakkel G (2011) Stroke rehabilitation. Lancet 377(9778):1693\u20131702","journal-title":"Lancet"},{"issue":"3","key":"6778_CR18","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1002\/ame2.12179","volume":"4","author":"Y Li","year":"2021","unstructured":"Li Y, Zhang J (2021) Animal models of stroke. Animal Model Exp Med 4(3):204\u2013219","journal-title":"Animal Model Exp Med"},{"issue":"7","key":"6778_CR19","doi-asserted-by":"publisher","first-page":"5255","DOI":"10.1002\/jcp.26312","volume":"233","author":"XL Liu","year":"2018","unstructured":"Liu XL et al (2018) microRNA-137 promotes endothelial progenitor cell proliferation and angiogenesis in cerebral ischemic stroke mice by targeting NR4A2 through the Notch pathway. J Cell Physiol 233(7):5255\u20135266","journal-title":"J Cell Physiol"},{"issue":"18","key":"6778_CR20","doi-asserted-by":"publisher","first-page":"6454","DOI":"10.3390\/ijms21186454","volume":"21","author":"CD Maida","year":"2020","unstructured":"Maida CD et al (2020) Neuroinflammatory mechanisms in ischemic stroke: focus on cardioembolic stroke, background, and therapeutic approaches. Int J Mol Sci 21(18):6454","journal-title":"Int J Mol Sci"},{"key":"6778_CR21","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.bbr.2016.01.049","volume":"303","author":"S Otsuka","year":"2016","unstructured":"Otsuka S et al (2016) The neuroprotective effects of preconditioning exercise on brain damage and neurotrophic factors after focal brain ischemia in rats. Behav Brain Res 303:9\u201318","journal-title":"Behav Brain Res"},{"issue":"2","key":"6778_CR22","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1007\/s00429-018-1800-4","volume":"224","author":"S Otsuka","year":"2019","unstructured":"Otsuka S et al (2019) Preconditioning exercise reduces brain damage and neuronal apoptosis through enhanced endogenous 14-3-3\u03b3 after focal brain ischemia in rats. Brain Struct Funct 224(2):727\u2013738","journal-title":"Brain Struct Funct"},{"issue":"11","key":"6778_CR23","doi-asserted-by":"publisher","first-page":"5602","DOI":"10.1007\/s12035-021-02506-7","volume":"58","author":"S Otsuka","year":"2021","unstructured":"Otsuka S et al (2021a) Preconditioning exercise in rats attenuates early brain injury resulting from subarachnoid hemorrhage by reducing oxidative stress, inflammation, and neuronal apoptosis. Mol Neurobiol 58(11):5602\u20135617","journal-title":"Mol Neurobiol"},{"issue":"7","key":"6778_CR24","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1007\/s00429-021-02317-5","volume":"226","author":"S Otsuka","year":"2021","unstructured":"Otsuka S et al (2021b) Effects of detraining on preconditioning exercise-induced neuroprotective potential after ischemic stroke in rats. Brain Struct Funct 226(7):2169\u20132180","journal-title":"Brain Struct Funct"},{"issue":"2","key":"6778_CR25","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s00401-018-1954-4","volume":"137","author":"A Otxoa-de-Amezaga","year":"2019","unstructured":"Otxoa-de-Amezaga A et al (2019) Microglial cell loss after ischemic stroke favors brain neutrophil accumulation. Acta Neuropathol 137(2):321\u2013341","journal-title":"Acta Neuropathol"},{"issue":"10154","key":"6778_CR26","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1016\/S0140-6736(18)31269-8","volume":"392","author":"JD Pandian","year":"2018","unstructured":"Pandian JD et al (2018) Prevention of stroke: a global perspective. Lancet 392(10154):1269\u20131278","journal-title":"Lancet"},{"key":"6778_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113518","volume":"335","author":"S Paul","year":"2021","unstructured":"Paul S, Candelario-Jalil E (2021) Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies. Exp Neurol 335:113518","journal-title":"Exp Neurol"},{"issue":"3","key":"6778_CR900","doi-asserted-by":"publisher","first-page":"BSR20180226","DOI":"10.1042\/BSR20180226","volume":"39","author":"L Ren","year":"2019","unstructured":"Ren L, Wei C, Li K, Lu Z (2019) LncRNA MALAT1 up-regulates VEGF-A and ANGPT2 to promote angiogenesis in brain microvascular endothelial cells against oxygen-glucose deprivation via targetting miR-145. Biosci Rep 39(3):BSR20180226","journal-title":"Biosci Rep"},{"issue":"1","key":"6778_CR29","first-page":"77","volume":"8","author":"N Shamsaei","year":"2017","unstructured":"Shamsaei N et al (2017) Neuroprotective effects of exercise on brain edema and neurological movement disorders following the cerebral ischemia and reperfusion in Rats. Basic Clin Neurosci 8(1):77\u201384","journal-title":"Basic Clin Neurosci"},{"issue":"6","key":"6778_CR30","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1623","volume":"10","author":"Y Shao","year":"2020","unstructured":"Shao Y et al (2020) Effect of Sox10 on remyelination of the hippocampus in cuprizone-induced demyelinated mice. Brain Behav 10(6):e01623","journal-title":"Brain Behav"},{"key":"6778_CR31","doi-asserted-by":"publisher","first-page":"16106","DOI":"10.1038\/ncomms16106","volume":"8","author":"M Teichert","year":"2017","unstructured":"Teichert M et al (2017) Pericyte-expressed Tie2 controls angiogenesis and vessel maturation. Nat Commun 8:16106","journal-title":"Nat Commun"},{"key":"6778_CR32","doi-asserted-by":"publisher","first-page":"2464269","DOI":"10.1155\/2021\/2464269","volume":"2021","author":"W Wei","year":"2021","unstructured":"Wei W et al (2021) Disorder genes regulate the progression of ischemic stroke through the NF-\u03baB signaling pathway. Biomed Res Int 2021:2464269","journal-title":"Biomed Res Int"},{"issue":"2","key":"6778_CR33","doi-asserted-by":"publisher","first-page":"91","DOI":"10.2165\/00007256-200838020-00001","volume":"38","author":"LJ White","year":"2008","unstructured":"White LJ, Castellano V (2008) Exercise and brain health\u2013implications for multiple sclerosis: Part 1\u2013neuronal growth factors. Sports Med 38(2):91\u2013100","journal-title":"Sports Med"},{"key":"6778_CR34","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/978-1-4939-7717-8_2","volume":"1754","author":"H Zhang","year":"2018","unstructured":"Zhang H, He L, Cai L (2018) Transcriptome Sequencing: RNA-Seq. Methods Mol Biol 1754:15\u201327","journal-title":"Methods Mol Biol"},{"issue":"6","key":"6778_CR35","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1111\/asj.13208","volume":"90","author":"W Zhu","year":"2019","unstructured":"Zhu W et al (2019) MiR-222 inhibits apoptosis in porcine follicular granulosa cells by targeting the THBS1 gene. Anim Sci J 90(6):719\u2013727","journal-title":"Anim Sci J"},{"key":"6778_CR36","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.866360","volume":"13","author":"Y Zhu","year":"2022","unstructured":"Zhu Y et al (2022) Insight into the mechanism of exercise preconditioning in ischemic stroke. Front Pharmacol 13:866360","journal-title":"Front Pharmacol"},{"key":"6778_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.577623","volume":"12","author":"A Zito","year":"2021","unstructured":"Zito A et al (2021) Gene set enrichment analysis of interaction networks weighted by node centrality. Front Genet 12:577623","journal-title":"Front Genet"},{"key":"6778_CR38","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3389\/fphar.2020.00059","volume":"11","author":"Y Zou","year":"2020","unstructured":"Zou Y et al (2020) Non-mitogenic fibroblast growth factor 1 enhanced angiogenesis following ischemic stroke by regulating the sphingosine-1-phosphate 1 pathway. Front Pharmacol 11:59","journal-title":"Front Pharmacol"}],"container-title":["Experimental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-024-06778-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00221-024-06778-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-024-06778-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T02:06:08Z","timestamp":1711591568000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00221-024-06778-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,29]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["6778"],"URL":"https:\/\/doi.org\/10.1007\/s00221-024-06778-y","relation":{},"ISSN":["0014-4819","1432-1106"],"issn-type":[{"value":"0014-4819","type":"print"},{"value":"1432-1106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,29]]},"assertion":[{"value":"31 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors of this manuscript have no conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants but animals. All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed. Approval was granted by Laboratory Animal Welfare and Ethics Committee, Shanghai University of Traditional Chinese Medicine. The review ethics number is: PZSHUTCM210305004.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}