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Towards addressing this problem, here we aimed to characterise post-stroke alterations in upper-limb control from a novel perspective to the muscle synergy by applying, for the first time, a computational approach that quantifies diverse types of functional muscle interactions (i.e. functionally-similar (redundant), -complementary (synergistic) and -independent (unique)). From single-trials of a simple forward pointing movement, we extracted networks of functionally diverse muscle interactions from chronic stroke survivors and unimpaired controls, identifying shared and group-specific modules across each interaction type (i.e. redundant, synergistic and unique). Reconciling previous studies, we found evidence for both the concurrent preservation of healthy functional modules post-stroke and muscle network structure alterations underpinned by systemic muscle interaction re-weighting and functional reorganisation across all interaction types. Cluster analysis of stroke survivors revealed two distinct patient subgroups from each interaction type that all distinguished less impaired individuals who were able to adopt novel motor patterns different to unimpaired controls from more severely impaired individuals who did not. Our work here provides a nuanced account of post-stroke functional impairment and, in doing so, paves new avenues towards progressing the clinical use case of muscle synergy analysis.<\/jats:p>","DOI":"10.1007\/s00221-024-06973-x","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:14:24Z","timestamp":1734912864000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Alterations of upper-extremity functional muscle networks in chronic stroke survivors"],"prefix":"10.1007","volume":"243","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8471-9447","authenticated-orcid":false,"given":"David","family":"O\u2019Reilly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Delis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"issue":"7307","key":"6973_CR1","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nature09182","volume":"466","author":"YY Ahn","year":"2010","unstructured":"Ahn YY, Bagrow JP, Lehmann S (2010) Link communities reveal multiscale complexity in networks. 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