{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:46:15Z","timestamp":1791999975170,"version":"4.4.0"},"reference-count":258,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T00:00:00Z","timestamp":1740873600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T00:00:00Z","timestamp":1740873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"ICMR-NIN","award":["No.ST\/1\/Intra-Proj-Allot(1)\/2023-24\/ 20-FS04\/21-FS04-dt 22-5-2023"],"award-info":[{"award-number":["No.ST\/1\/Intra-Proj-Allot(1)\/2023-24\/ 20-FS04\/21-FS04-dt 22-5-2023"]}]},{"name":"ICMR-NIN","award":["No.ST\/1\/Intra-Proj-Allot(1)\/2024-25 - dt 06-06-2024"],"award-info":[{"award-number":["No.ST\/1\/Intra-Proj-Allot(1)\/2024-25 - dt 06-06-2024"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Brain Res"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s00221-025-07016-9","type":"journal-article","created":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T17:01:41Z","timestamp":1740934901000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Fundamental origins of neural tube defects with a basis in genetics and nutrition"],"prefix":"10.1007","volume":"243","author":[{"given":"Anjusha","family":"Bhasker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9653-6939","authenticated-orcid":false,"given":"Shobi","family":"Veleri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,2]]},"reference":[{"issue":"11","key":"7016_CR1","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1056\/NEJMoa1014379","volume":"364","author":"NS Adzick","year":"2011","unstructured":"Adzick NS, Thom EA, Spong CY, Brock JW 3rd, Burrows PK, Johnson MP, Howell LJ, Farrell JA, Dabrowiak ME, Sutton LN, Gupta N, Tulipan NB, D\u2019Alton ME, Farmer DL (2011) A randomized trial of prenatal versus postnatal repair of myelomeningocele. N Engl J Med 364(11):993\u20131004","journal-title":"N Engl J Med"},{"issue":"2","key":"7016_CR2","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/0090-3019(95)80117-Y","volume":"43","author":"Z Akar","year":"1995","unstructured":"Akar Z (1995) Myelomeningocele. Surg Neurol 43(2):113\u2013118","journal-title":"Surg Neurol"},{"key":"7016_CR3","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.ejogrb.2021.01.008","volume":"258","author":"MS Alberry","year":"2021","unstructured":"Alberry MS, Aziz E, Ahmed SR, Abdel-Fattah S (2021) Non invasive prenatal testing (NIPT) for common aneuploidies and beyond. Eur J Obstet Gynecol Reprod Biol 258:424\u2013429","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"3","key":"7016_CR4","doi-asserted-by":"publisher","first-page":"e0118961","DOI":"10.1371\/journal.pone.0118961","volume":"10","author":"KP Allagh","year":"2015","unstructured":"Allagh KP, Shamanna BR, Murthy GV, Ness AR, Doyle P, Neogi SB, Pant HB (2015) Birth prevalence of neural tube defects and orofacial clefts in India: a systematic review and meta-analysis. PLoS ONE 10(3):e0118961","journal-title":"PLoS ONE"},{"issue":"6","key":"7016_CR5","doi-asserted-by":"publisher","first-page":"e5839","DOI":"10.1371\/journal.pone.0005839","volume":"4","author":"DD Anderson","year":"2009","unstructured":"Anderson DD, Stover PJ (2009) SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis. PLoS ONE 4(6):e5839","journal-title":"PLoS ONE"},{"issue":"1","key":"7016_CR6","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1021\/pr050361j","volume":"5","author":"C Andreini","year":"2006","unstructured":"Andreini C, Banci L, Bertini I, Rosato A (2006) Counting the zinc-proteins encoded in the human genome. J Proteome Res 5(1):196\u2013201","journal-title":"J Proteome Res"},{"issue":"2","key":"7016_CR7","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.ydbio.2010.12.013","volume":"350","author":"TC Archer","year":"2010","unstructured":"Archer TC, Jin J, Casey ES (2010) Interaction of Sox1, Sox2, Sox3 and Oct4 during primary neurogenesis. Dev Biol 350(2):429\u2013440","journal-title":"Dev Biol"},{"issue":"19","key":"7016_CR8","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1002\/bdr2.1380","volume":"111","author":"L Avagliano","year":"2018","unstructured":"Avagliano L, Massa V, George TM, Qureshy S, Bulfamante GP, Finnell RH (2018) Overview on neural tube defects: From development to physical characteristics. Birth Defects Res 111(19):1455\u20131467","journal-title":"Birth Defects Res"},{"issue":"1","key":"7016_CR9","first-page":"113","volume":"128","author":"G Avesani","year":"2022","unstructured":"Avesani G, Perazzolo A, Elia L, Anghelone AG, Gaudino S, Russo L, Genco E, Di Paola V, Massimi L, De Santis M, Tamburrini G, Manfredi R (2022) Fetal MRI prior to intrauterine surgery of open neural tube defects: What does the radiologist need to know. Radiol Med 128(1):113\u2013124","journal-title":"Radiol Med"},{"issue":"10","key":"7016_CR10","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1242\/dev.124.10.2075","volume":"124","author":"AG Bang","year":"1997","unstructured":"Bang AG, Papalopulu N, Kintner C, Goulding MD (1997) Expression of Pax-3 is initiated in the early neural plate by posteriorizing signals produced by the organizer and by posterior non-axial mesoderm. Development 124(10):2075\u20132085","journal-title":"Development"},{"key":"7016_CR11","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.ijdevneu.2018.04.005","volume":"68","author":"D Barry","year":"2018","unstructured":"Barry D, Ellul S, Watters L, Lee D, Haluska R Jr, White R (2018) The ketogenic diet in disease and development. Int J Dev Neurosci 68:53\u201358","journal-title":"Int J Dev Neurosci"},{"issue":"6","key":"7016_CR12","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.jpurol.2017.04.016","volume":"13","author":"M Bawa","year":"2017","unstructured":"Bawa M, Dash V, Kalavant A, Mahajan JK, Rao KLN (2017) Is urodynamic evaluation a must in all operated cases of open neural tube defects. J Pediatr Urol 13(6):614-e1","journal-title":"J Pediatr Urol"},{"issue":"12","key":"7016_CR13","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/nrn3820","volume":"15","author":"RP Bazinet","year":"2014","unstructured":"Bazinet RP, Laye S (2014) Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat Rev Neurosci 15(12):771\u2013785","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"7016_CR14","doi-asserted-by":"publisher","first-page":"789","DOI":"10.3945\/ajcn.110.002766","volume":"93","author":"AE Beaudin","year":"2011","unstructured":"Beaudin AE, Abarinov EV, Noden DM, Perry CA, Chu S, Stabler SP, Allen RH, Stover PJ (2011) Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice. Am J Clin Nutr 93(4):789\u2013798","journal-title":"Am J Clin Nutr"},{"issue":"2 Suppl","key":"7016_CR15","doi-asserted-by":"publisher","first-page":"S126","DOI":"10.1177\/15648265080292S117","volume":"29","author":"MM Black","year":"2008","unstructured":"Black MM (2008) Effects of vitamin B12 and folate deficiency on brain development in children. Food Nutr Bull 29(2 Suppl):S126-131","journal-title":"Food Nutr Bull"},{"issue":"1","key":"7016_CR16","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/nyas.13548","volume":"1414","author":"H Blencowe","year":"2018","unstructured":"Blencowe H, Kancherla V, Moorthie S, Darlison MW, Modell B (2018) Estimates of global and regional prevalence of neural tube defects for 2015: a systematic analysis. Ann N Y Acad Sci 1414(1):31\u201346","journal-title":"Ann N Y Acad Sci"},{"issue":"7","key":"7016_CR17","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1002\/dneu.22022","volume":"72","author":"AM Bond","year":"2012","unstructured":"Bond AM, Bhalala OG, Kessler JA (2012) The dynamic role of bone morphogenetic proteins in neural stem cell fate and maturation. Dev Neurobiol 72(7):1068\u20131084","journal-title":"Dev Neurobiol"},{"issue":"8","key":"7016_CR18","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1289\/ehp.1003185","volume":"119","author":"MF Bouchard","year":"2011","unstructured":"Bouchard MF, Chevrier J, Harley KG, Kogut K, Vedar M, Calderon N, Trujillo C, Johnson C, Bradman A, Barr DB, Eskenazi B (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children. Environ Health Perspect 119(8):1189\u20131195","journal-title":"Environ Health Perspect"},{"key":"7016_CR19","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.gene.2018.04.087","volume":"666","author":"S Boudjadi","year":"2018","unstructured":"Boudjadi S, Chatterjee B, Sun W, Vemu P, Barr FG (2018) The expression and function of PAX3 in development and disease. Gene 666:145\u2013157","journal-title":"Gene"},{"issue":"10","key":"7016_CR20","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1289\/ehp.9166","volume":"114","author":"AL Boyles","year":"2006","unstructured":"Boyles AL, Billups AV, Deak KL, Siegel DG, Mehltretter L, Slifer SH, Bassuk AG, Kessler JA, Reed MC, Nijhout HF, George TM, Enterline DS, Gilbert JR, Speer MC (2006) Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions. Environ Health Perspect 114(10):1547\u20131552","journal-title":"Environ Health Perspect"},{"key":"7016_CR21","unstructured":"Brea CM, Munakomi S (2023) Spina Bifida. [Updated 2023 Aug 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025:1\u201316. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559265\/.NCBIBookshelf."},{"issue":"2","key":"7016_CR22","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.ajhg.2011.01.007","volume":"88","author":"H Cario","year":"2011","unstructured":"Cario H, Smith DE, Blom H, Blau N, Bode H, Holzmann K, Pannicke U, Hopfner KP, Rump EM, Ayric Z, Kohne E, Debatin KM, Smulders Y, Schwarz K (2011) Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease. Am J Hum Genet 88(2):226\u2013231","journal-title":"Am J Hum Genet"},{"issue":"2","key":"7016_CR23","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.reprotox.2004.07.003","volume":"19","author":"L Carrillo-Ponce Mde","year":"2004","unstructured":"Carrillo-Ponce Mde L, Martinez-Ordaz VA, Velasco-Rodriguez VM, Hernandez-Garcia A, Hernandez-Serrano MC, Sanmiguel F (2004) Serum lead, cadmium, and zinc levels in newborns with neural tube defects from a polluted zone in Mexico. Reprod Toxicol 19(2):149\u2013154","journal-title":"Reprod Toxicol"},{"issue":"11","key":"7016_CR24","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1002\/bdra.23068","volume":"94","author":"AL Chandler","year":"2012","unstructured":"Chandler AL, Hobbs CA, Mosley BS, Berry RJ, Canfield MA, Qi YP, Siega-Riz AM, Shaw GM (2012) Neural tube defects and maternal intake of micronutrients related to one-carbon metabolism or antioxidant activity. Birth Defects Res A Clin Mol Teratol 94(11):864\u2013874","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"6599","key":"7016_CR25","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/383407a0","volume":"383","author":"C Chiang","year":"1996","unstructured":"Chiang C, Litingtung Y, Lee E, Young KE, Corden JL, Westphal H, Beachy PA (1996) Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383(6599):407\u2013413","journal-title":"Nature"},{"issue":"2","key":"7016_CR26","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1002\/(SICI)1096-8628(19990521)84:2<151::AID-AJMG12>3.0.CO;2-T","volume":"84","author":"B Christensen","year":"1999","unstructured":"Christensen B, Arbour L, Tran P, Leclerc D, Sabbaghian N, Platt R, Gilfix BM, Rosenblatt DS, Gravel RA, Forbes P, Rozen R (1999) Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects. Am J Med Genet 84(2):151\u2013157","journal-title":"Am J Med Genet"},{"key":"7016_CR27","doi-asserted-by":"publisher","first-page":"g4810","DOI":"10.1136\/bmj.g4810","volume":"349","author":"R Clarke","year":"2014","unstructured":"Clarke R, Bennett D (2014) Folate and prevention of neural tube defects. BMJ 349:g4810","journal-title":"BMJ"},{"issue":"3","key":"7016_CR28","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1159\/000364806","volume":"37","author":"BG Coleman","year":"2014","unstructured":"Coleman BG, Langer JE, Horii SC (2014) The diagnostic features of spina bifida: the role of ultrasound. Fetal Diagn Ther 37(3):179\u2013196","journal-title":"Fetal Diagn Ther"},{"issue":"19","key":"7016_CR29","doi-asserted-by":"publisher","first-page":"4407","DOI":"10.1242\/dev.02021","volume":"132","author":"AF Cooper","year":"2005","unstructured":"Cooper AF, Yu KP, Brueckner M, Brailey LL, Johnson L, McGrath JM, Bale AE (2005) Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused. Development 132(19):4407\u20134417","journal-title":"Development"},{"issue":"2","key":"7016_CR30","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/wdev.71","volume":"2","author":"AJ Copp","year":"2013","unstructured":"Copp AJ, Greene ND (2013) Neural tube defects\u2013disorders of neurulation and related embryonic processes. Wiley Interdiscip Rev Dev Biol 2(2):213\u2013227","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"issue":"9","key":"7016_CR31","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1002\/dvdy.21256","volume":"236","author":"AC Correia","year":"2007","unstructured":"Correia AC, Costa M, Moraes F, Bom J, Novoa A, Mallo M (2007) Bmp2 is required for migration but not for induction of neural crest cells in the mouse. Dev Dyn 236(9):2493\u20132501","journal-title":"Dev Dyn"},{"issue":"1","key":"7016_CR32","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.ydbio.2008.10.020","volume":"325","author":"S Cortellino","year":"2009","unstructured":"Cortellino S, Wang C, Wang B, Bassi MR, Caretti E, Champeval D, Calmont A, Jarnik M, Burch J, Zaret KS, Larue L, Bellacosa A (2009) Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122\/Wdr10, partially overlapping with the DNA repair gene Med1\/Mbd4. Dev Biol 325(1):225\u2013237","journal-title":"Dev Biol"},{"key":"7016_CR33","doi-asserted-by":"crossref","unstructured":"Cortes-Albornoz MC, Garcia-Guaqueta DP, Velez-van-Meerbeke A, Talero-Gutierrez C (2021) Maternal nutrition and neurodevelopment: a scoping Review. Nutri 13(10):1-18","DOI":"10.3390\/nu13103530"},{"issue":"4","key":"7016_CR34","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1002\/pd.1970150407","volume":"15","author":"BF Crandall","year":"1995","unstructured":"Crandall BF, Chua C (1995) Detecting neural tube defects by amniocentesis between 11 and 15 weeks\u2019 gestation. Prenat Diagn 15(4):339\u2013343","journal-title":"Prenat Diagn"},{"issue":"13","key":"7016_CR35","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/S0960-9822(03)00374-9","volume":"13","author":"JA Curtin","year":"2003","unstructured":"Curtin JA, Quint E, Tsipouri V, Arkell RM, Cattanach B, Copp AJ, Henderson DJ, Spurr N, Stanier P, Fisher EM, Nolan PM, Steel KP, Brown SD, Gray IC, Murdoch JN (2003) Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. Curr Biol 13(13):1129\u20131133","journal-title":"Curr Biol"},{"issue":"11","key":"7016_CR36","doi-asserted-by":"publisher","first-page":"9235","DOI":"10.1007\/s11033-020-05921-6","volume":"47","author":"A Cuschieri","year":"2020","unstructured":"Cuschieri A, Calleja-Agius J (2020) Wnt\/PCP signalling cascade disruption by JNK inhibition as a potential mechanism underlying the teratogenic effects of potato glycoalkaloids. Mol Biol Rep 47(11):9235\u20139238","journal-title":"Mol Biol Rep"},{"issue":"1\u20132","key":"7016_CR37","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1385\/JMN:13:1-2:127","volume":"13","author":"B Dabrowska-Bouta","year":"1999","unstructured":"Dabrowska-Bouta B, Sulkowski G, Bartosz G, Walski M, Rafalowska U (1999) Chronic lead intoxication affects the myelin membrane status in the central nervous system of adult rats. J Mol Neurosci 13(1\u20132):127\u2013139","journal-title":"J Mol Neurosci"},{"issue":"4668","key":"7016_CR38","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1136\/bmj.1.4668.1447","volume":"1","author":"JV Dacie","year":"1950","unstructured":"Dacie JV, Dresner E, Mollin DL, White JC (1950) Aminopterin in the treatment of acute leukaemia. Br Med J 1(4668):1447\u20131457","journal-title":"Br Med J"},{"issue":"39","key":"7016_CR39","doi-asserted-by":"publisher","first-page":"13208","DOI":"10.1523\/JNEUROSCI.1850-14.2014","volume":"34","author":"A Dady","year":"2014","unstructured":"Dady A, Havis E, Escriou V, Catala M, Duband JL (2014) Junctional neurulation: a unique developmental program shaping a discrete region of the spinal cord highly susceptible to neural tube defects. J Neurosci 34(39):13208\u201313221","journal-title":"J Neurosci"},{"issue":"5","key":"7016_CR40","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.gep.2009.04.002","volume":"9","author":"SM Danesh","year":"2009","unstructured":"Danesh SM, Villasenor A, Chong D, Soukup C, Cleaver O (2009) BMP and BMP receptor expression during murine organogenesis. Gene Expr Patterns 9(5):255\u2013265","journal-title":"Gene Expr Patterns"},{"issue":"20","key":"7016_CR41","doi-asserted-by":"publisher","first-page":"e2117075119","DOI":"10.1073\/pnas.2117075119","volume":"119","author":"V de Goederen","year":"2022","unstructured":"de Goederen V, Vetter R, McDole K, Iber D (2022) Hinge point emergence in mammalian spinal neurulation. Proc Natl Acad Sci U S A 119(20):e2117075119","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"7016_CR42","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/biof.170","volume":"37","author":"P De Marco","year":"2011","unstructured":"De Marco P, Merello E, Cama A, Kibar Z, Capra V (2011) Human neural tube defects: genetic causes and prevention. BioFactors 37(4):261\u2013268","journal-title":"BioFactors"},{"issue":"3","key":"7016_CR43","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1007\/s12031-012-9871-9","volume":"49","author":"P De Marco","year":"2012","unstructured":"De Marco P, Merello E, Consales A, Piatelli G, Cama A, Kibar Z, Capra V (2012) Genetic analysis of disheveled 2 and disheveled 3 in human neural tube defects. J Mol Neurosci 49(3):582\u2013588","journal-title":"J Mol Neurosci"},{"issue":"2","key":"7016_CR44","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.biopsych.2018.08.006","volume":"85","author":"M DeCapo","year":"2018","unstructured":"DeCapo M, Thompson JR, Dunn G, Sullivan EL (2018) Perinatal nutrition and programmed risk for neuropsychiatric disorders: a focus on animal models. Biol Psychiatry 85(2):122\u2013134","journal-title":"Biol Psychiatry"},{"issue":"3","key":"7016_CR45","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1006\/taap.2001.9219","volume":"174","author":"W Deng","year":"2001","unstructured":"Deng W, McKinnon RD, Poretz RD (2001) Lead exposure delays the differentiation of oligodendroglial progenitors in vitro. Toxicol Appl Pharmacol 174(3):235\u2013244","journal-title":"Toxicol Appl Pharmacol"},{"issue":"3","key":"7016_CR46","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.ntt.2004.12.007","volume":"27","author":"ER Detrait","year":"2005","unstructured":"Detrait ER, George TM, Etchevers HC, Gilbert JR, Vekemans M, Speer MC (2005) Human neural tube defects: developmental biology, epidemiology, and genetics. Neurotoxicol Teratol 27(3):515\u2013524","journal-title":"Neurotoxicol Teratol"},{"issue":"4","key":"7016_CR47","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/0896-6273(90)90108-R","volume":"4","author":"RJ Detrick","year":"1990","unstructured":"Detrick RJ, Dickey D, Kintner CR (1990) The effects of N-cadherin misexpression on morphogenesis in Xenopus embryos. Neuron 4(4):493\u2013506","journal-title":"Neuron"},{"issue":"8","key":"7016_CR48","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1194\/jlr.R400004-JLR200","volume":"45","author":"JM Dietschy","year":"2004","unstructured":"Dietschy JM, Turley SD (2004) Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J Lipid Res 45(8):1375\u20131397","journal-title":"J Lipid Res"},{"issue":"1","key":"7016_CR49","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cmet.2016.08.009","volume":"25","author":"GS Ducker","year":"2016","unstructured":"Ducker GS, Rabinowitz JD (2016) One-carbon metabolism in health and disease. Cell Metab 25(1):27\u201342","journal-title":"Cell Metab"},{"issue":"5","key":"7016_CR50","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1002\/dvg.20211","volume":"44","author":"J Dufner-Beattie","year":"2006","unstructured":"Dufner-Beattie J, Huang ZL, Geiser J, Xu W, Andrews GK (2006) Mouse ZIP1 and ZIP3 genes together are essential for adaptation to dietary zinc deficiency during pregnancy. Genesis 44(5):239\u2013251","journal-title":"Genesis"},{"issue":"11","key":"7016_CR51","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1016\/j.febslet.2006.04.020","volume":"580","author":"LP Dunlevy","year":"2006","unstructured":"Dunlevy LP, Burren KA, Chitty LS, Copp AJ, Greene ND (2006a) Excess methionine suppresses the methylation cycle and inhibits neural tube closure in mouse embryos. FEBS Lett 580(11):2803\u20132807","journal-title":"FEBS Lett"},{"issue":"7","key":"7016_CR52","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1002\/bdra.20286","volume":"76","author":"LP Dunlevy","year":"2006","unstructured":"Dunlevy LP, Burren KA, Mills K, Chitty LS, Copp AJ, Greene ND (2006b) Integrity of the methylation cycle is essential for mammalian neural tube closure. Birth Defects Res A Clin Mol Teratol 76(7):544\u2013552","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"6","key":"7016_CR53","doi-asserted-by":"publisher","first-page":"690","DOI":"10.3171\/2016.12.PEDS1668","volume":"19","author":"EB Dupepe","year":"2017","unstructured":"Dupepe EB, Patel DM, Rocque BG, Hopson B, Arynchyna AA, Bishop ER, Blount JP (2017) Surveillance survey of family history in children with neural tube defects. J Neurosurg Pediatr 19(6):690\u2013695","journal-title":"J Neurosurg Pediatr"},{"issue":"3","key":"7016_CR54","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1258\/0007142991902646","volume":"55","author":"SJ Duthie","year":"1999","unstructured":"Duthie SJ (1999) Folic acid deficiency and cancer: mechanisms of DNA instability. Br Med Bull 55(3):578\u2013592","journal-title":"Br Med Bull"},{"issue":"8","key":"7016_CR55","doi-asserted-by":"publisher","first-page":"86002","DOI":"10.1289\/EHP11872","volume":"131","author":"LA Eaves","year":"2023","unstructured":"Eaves LA, Choi G, Hall E, Sille FCM, Fry RC, Buckley JP, Keil AP (2023) Prenatal exposure to toxic metals and neural tube defects: a systematic review of the epidemiologic evidence. Environ Health Perspect 131(8):86002","journal-title":"Environ Health Perspect"},{"issue":"6843","key":"7016_CR56","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/35084089","volume":"412","author":"JT Eggenschwiler","year":"2001","unstructured":"Eggenschwiler JT, Espinoza E, Anderson KV (2001) Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Nature 412(6843):194\u2013198","journal-title":"Nature"},{"issue":"3","key":"7016_CR57","doi-asserted-by":"publisher","first-page":"327","DOI":"10.3340\/jkns.2020.0018","volume":"63","author":"S Eibach","year":"2020","unstructured":"Eibach S, Pang D (2020) Junctional Neural Tube Defect. J Korean Neurosurg Soc 63(3):327\u2013337","journal-title":"J Korean Neurosurg Soc"},{"issue":"9","key":"7016_CR58","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1016\/S0969-2126(02)00796-7","volume":"10","author":"JC Evans","year":"2002","unstructured":"Evans JC, Huddler DP, Jiracek J, Castro C, Millian NS, Garrow TA, Ludwig ML (2002) Betaine-homocysteine methyltransferase: zinc in a distorted barrel. Structure 10(9):1159\u20131171","journal-title":"Structure"},{"issue":"23","key":"7016_CR59","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1056\/NEJM194806032382301","volume":"238","author":"S Farber","year":"1948","unstructured":"Farber S, Diamond LK (1948) Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid. N Engl J Med 238(23):787\u2013793","journal-title":"N Engl J Med"},{"issue":"2764","key":"7016_CR60","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1126\/science.106.2764.619","volume":"106","author":"S Farber","year":"1947","unstructured":"Farber S, Cutler EC, Hawkins JW, Harrison JH, Peirce EC 2nd, Lenz GG (1947) The action of pteroylglutamic conjugates on man. Science 106(2764):619\u2013621","journal-title":"Science"},{"key":"7016_CR61","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/978-1-60761-580-4_7","volume":"620","author":"MJ Fazzari","year":"2010","unstructured":"Fazzari MJ, Greally JM (2010) Introduction to epigenomics and epigenome-wide analysis. Methods Mol Biol 620:243\u2013265","journal-title":"Methods Mol Biol"},{"issue":"4","key":"7016_CR62","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1002\/bdra.20111","volume":"73","author":"SA Ferguson","year":"2005","unstructured":"Ferguson SA, Berry KJ, Hansen DK, Wall KS, White G, Antony AC (2005) Behavioral effects of prenatal folate deficiency in mice. Birth Defects Res A Clin Mol Teratol 73(4):249\u2013252","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"21","key":"7016_CR63","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.1242\/dev.004325","volume":"134","author":"M Fernandes","year":"2007","unstructured":"Fernandes M, Gutin G, Alcorn H, McConnell SK, Hebert JM (2007) Mutations in the BMP pathway in mice support the existence of two molecular classes of holoprosencephaly. Development 134(21):3789\u20133794","journal-title":"Development"},{"key":"7016_CR64","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.ejogrb.2020.06.012","volume":"253","author":"E Ferrazzi","year":"2020","unstructured":"Ferrazzi E, Tiso G, Di Martino D (2020) Folic acid versus 5- methyl tetrahydrofolate supplementation in pregnancy. Eur J Obstet Gynecol Reprod Biol 253:312\u2013319","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"2","key":"7016_CR65","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1002\/tera.1053","volume":"64","author":"MC Fisher","year":"2001","unstructured":"Fisher MC, Zeisel SH, Mar MH, Sadler TW (2001) Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos. Teratology 64(2):114\u2013122","journal-title":"Teratology"},{"key":"7016_CR66","doi-asserted-by":"publisher","first-page":"105190","DOI":"10.1016\/j.earlhumdev.2020.105190","volume":"150","author":"E Fitzgerald","year":"2020","unstructured":"Fitzgerald E, Hor K, Drake AJ (2020) Maternal influences on fetal brain development: The role of nutrition, infection and stress, and the potential for intergenerational consequences. Early Hum Dev 150:105190","journal-title":"Early Hum Dev"},{"issue":"2","key":"7016_CR67","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.ajog.2014.02.005","volume":"211","author":"A Flick","year":"2014","unstructured":"Flick A, Krakow D, Martirosian A, Silverman N, Platt LD (2014) Routine measurement of amniotic fluid alpha-fetoprotein and acetylcholinesterase: the need for a reevaluation. Am J Obstet Gynecol 211(2):139","journal-title":"Am J Obstet Gynecol"},{"issue":"Suppl 1","key":"7016_CR68","first-page":"3","volume":"26","author":"AL Flores","year":"2015","unstructured":"Flores AL, Vellozzi C, Valencia D, Sniezek J (2015) Global burden of neural tube defects, risk factors, and prevention. Ind J Commun Health 26(Suppl 1):3\u20135","journal-title":"Ind J Commun Health"},{"issue":"3","key":"7016_CR69","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1002\/bdra.20556","volume":"85","author":"B Franke","year":"2009","unstructured":"Franke B, Vermeulen SH, Steegers-Theunissen RP, Coenen MJ, Schijvenaars MM, Scheffer H, den Heijer M, Blom HJ (2009) An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). Birth Defects Res A Clin Mol Teratol 85(3):216\u2013226","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"7016_CR70","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.neubiorev.2020.01.031","volume":"117","author":"K Franke","year":"2020","unstructured":"Franke K, Van den Bergh BRH, de Rooij SR, Kroegel N, Nathanielsz PW, Rakers F, Roseboom TJ, Witte OW, Schwab M (2020) Effects of maternal stress and nutrient restriction during gestation on offspring neuroanatomy in humans. Neurosci Biobehav Rev 117:5\u201325","journal-title":"Neurosci Biobehav Rev"},{"issue":"4","key":"7016_CR71","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1002\/jimd.12009","volume":"42","author":"DS Froese","year":"2019","unstructured":"Froese DS, Fowler B, Baumgartner MR (2019) Vitamin B(12), folate, and the methionine remethylation cycle-biochemistry, pathways, and regulation. J Inherit Metab Dis 42(4):673\u2013685","journal-title":"J Inherit Metab Dis"},{"issue":"12","key":"7016_CR72","doi-asserted-by":"publisher","first-page":"2853","DOI":"10.1242\/dev.01156","volume":"131","author":"M Furthauer","year":"2004","unstructured":"Furthauer M, Van Celst J, Thisse C, Thisse B (2004) Fgf signalling controls the dorsoventral patterning of the zebrafish embryo. Development 131(12):2853\u20132864","journal-title":"Development"},{"key":"7016_CR73","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S1043-4526(08)00605-0","volume":"56","author":"J Gelineau-van Waes","year":"2009","unstructured":"Gelineau-van Waes J, Voss KA, Stevens VL, Speer MC, Riley RT (2009) Maternal fumonisin exposure as a risk factor for neural tube defects. Adv Food Nutr Res 56:145\u2013181","journal-title":"Adv Food Nutr Res"},{"issue":"8","key":"7016_CR74","doi-asserted-by":"publisher","first-page":"3671","DOI":"10.1021\/acschemneuro.9b00248","volume":"10","author":"TC Genaro-Mattos","year":"2019","unstructured":"Genaro-Mattos TC, Anderson A, Allen LB, Korade Z, Mirnics K (2019) Cholesterol biosynthesis and uptake in developing neurons. ACS Chem Neurosci 10(8):3671\u20133681","journal-title":"ACS Chem Neurosci"},{"issue":"4","key":"7016_CR75","doi-asserted-by":"publisher","first-page":"109","DOI":"10.5758\/vsi.2015.31.4.109","volume":"31","author":"H Ghaznavi","year":"2016","unstructured":"Ghaznavi H, Soheili Z, Samiei S, Soltanpour MS (2016) Association of methylenetetrahydrofolate reductase C677T polymorphism with hyperhomocysteinemia and deep vein thrombosis in the iranian population. Vasc Specialist Int 31(4):109\u2013114","journal-title":"Vasc Specialist Int"},{"issue":"1","key":"7016_CR76","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/uog.12504","volume":"42","author":"MM Gil","year":"2013","unstructured":"Gil MM, Quezada MS, Bregant B, Ferraro M, Nicolaides KH (2013) Implementation of maternal blood cell-free DNA testing in early screening for aneuploidies. Ultrasound Obstet Gynecol 42(1):34\u201340","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"5","key":"7016_CR77","doi-asserted-by":"publisher","first-page":"529","DOI":"10.4103\/jiaps.jiaps_64_24","volume":"29","author":"P Goel","year":"2024","unstructured":"Goel P, Sharma M, Kaushik H, Kumar S, Singh H, Jain V, Dhua AK, Yadav DK, Kumar N, Agarwala S (2024) Genetic markers of spina bifida in an Indian cohort. J Indian Assoc Pediatr Surg 29(5):529\u2013535","journal-title":"J Indian Assoc Pediatr Surg"},{"key":"7016_CR78","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.semcdb.2017.07.014","volume":"69","author":"AM Goffinet","year":"2017","unstructured":"Goffinet AM, Tissir F (2017) Seven pass Cadherins CELSR1-3. Semin Cell Dev Biol 69:102\u2013110","journal-title":"Semin Cell Dev Biol"},{"issue":"5","key":"7016_CR79","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1002\/j.1460-2075.1991.tb08054.x","volume":"10","author":"MD Goulding","year":"1991","unstructured":"Goulding MD, Chalepakis G, Deutsch U, Erselius JR, Gruss P (1991) Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J 10(5):1135\u20131147","journal-title":"EMBO J"},{"issue":"8","key":"7016_CR80","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1002\/dvdy.22028","volume":"238","author":"RS Gray","year":"2009","unstructured":"Gray RS, Bayly RD, Green SA, Agarwala S, Lowe CJ, Wallingford JB (2009) Diversification of the expression patterns and developmental functions of the dishevelled gene family during chordate evolution. Dev Dyn 238(8):2044\u20132057","journal-title":"Dev Dyn"},{"issue":"1","key":"7016_CR81","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0925-4773(98)00029-X","volume":"73","author":"ND Greene","year":"1998","unstructured":"Greene ND, Gerrelli D, Van Straaten HW, Copp AJ (1998) Abnormalities of floor plate, notochord and somite differentiation in the loop-tail (Lp) mouse: a model of severe neural tube defects. Mech Dev 73(1):59\u201372","journal-title":"Mech Dev"},{"issue":"3","key":"7016_CR82","doi-asserted-by":"publisher","first-page":"e545","DOI":"10.1002\/mgg3.545","volume":"7","author":"C Guy","year":"2019","unstructured":"Guy C, Haji-Sheikhi F, Rowland CM, Anderson B, Owen R, Lacbawan FL, Alagia DP (2019) Prenatal cell-free DNA screening for fetal aneuploidy in pregnant women at average or high risk: Results from a large US clinical laboratory. Mol Genet Genomic Med 7(3):e545","journal-title":"Mol Genet Genomic Med"},{"issue":"24","key":"7016_CR83","doi-asserted-by":"publisher","first-page":"5827","DOI":"10.1242\/dev.00164","volume":"129","author":"NS Hamblet","year":"2002","unstructured":"Hamblet NS, Lijam N, Ruiz-Lozano P, Wang J, Yang Y, Luo Z, Mei L, Chien KR, Sussman DJ, Wynshaw-Boris A (2002) Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development 129(24):5827\u20135838","journal-title":"Development"},{"issue":"7","key":"7016_CR84","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.ijdevneu.2011.06.006","volume":"29","author":"ZJ Han","year":"2011","unstructured":"Han ZJ, Song G, Cui Y, Xia HF, Ma X (2011) Oxidative stress is implicated in arsenic-induced neural tube defects in chick embryos. Int J Dev Neurosci 29(7):673\u2013680","journal-title":"Int J Dev Neurosci"},{"issue":"10","key":"7016_CR85","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1002\/mrd.21085","volume":"76","author":"MJ Harrington","year":"2009","unstructured":"Harrington MJ, Hong E, Brewster R (2009) Comparative analysis of neurulation: first impressions do not count. Mol Reprod Dev 76(10):954\u2013965","journal-title":"Mol Reprod Dev"},{"issue":"4","key":"7016_CR86","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1111\/cga.12516","volume":"63","author":"M Hasler","year":"2023","unstructured":"Hasler M, Fideli US, Susi A, Hisle-Gorman E (2023) Examining the relationship between autism spectrum disorder and neural tube defects. Congenit Anom (Kyoto) 63(4):100\u2013108","journal-title":"Congenit Anom (Kyoto)"},{"issue":"2","key":"7016_CR87","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1006\/mgme.2001.3175","volume":"73","author":"SG Heil","year":"2001","unstructured":"Heil SG, Van der Put NM, Waas ET, den Heijer M, Trijbels FJ, Blom HJ (2001) Is mutated serine hydroxymethyltransferase (SHMT) involved in the etiology of neural tube defects? Mol Genet Metab 73(2):164\u2013172","journal-title":"Mol Genet Metab"},{"issue":"4173","key":"7016_CR88","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1126\/science.187.4173.226","volume":"187","author":"R Holliday","year":"1975","unstructured":"Holliday R, Pugh JE (1975) DNA modification mechanisms and gene activity during development. Science 187(4173):226\u2013232","journal-title":"Science"},{"issue":"24","key":"7016_CR89","doi-asserted-by":"publisher","first-page":"4049","DOI":"10.1242\/dev.029835","volume":"135","author":"AN Hoover","year":"2008","unstructured":"Hoover AN, Wynkoop A, Zeng H, Jia J, Niswander LA, Liu A (2008) C2cd3 is required for cilia formation and Hedgehog signaling in mouse. Development 135(24):4049\u20134058","journal-title":"Development"},{"issue":"3","key":"7016_CR90","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/ng0393-241","volume":"3","author":"CC Hui","year":"1993","unstructured":"Hui CC, Joyner AL (1993) A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nat Genet 3(3):241\u2013246","journal-title":"Nat Genet"},{"key":"7016_CR91","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S0021-9258(17)34960-8","volume":"170","author":"BL Hutchings","year":"1947","unstructured":"Hutchings BL, Mowat JH, Oleson J, Stokstad ELR, Boothe JH, Waller CW, Angier RB, Semb J, Subbabow Y (1947) Pteroylaspartic acid, an antagonist for pteroylglutamic acid. J Biol Chem 170:323\u2013328","journal-title":"J Biol Chem"},{"issue":"1","key":"7016_CR92","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/71114","volume":"3","author":"M Hynes","year":"2000","unstructured":"Hynes M, Ye W, Wang K, Stone D, Murone M, Sauvage F, Rosenthal A (2000) The seven-transmembrane receptor smoothened cell-autonomously induces multiple ventral cell types. Nat Neurosci 3(1):41\u201346","journal-title":"Nat Neurosci"},{"issue":"9","key":"7016_CR93","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1111\/j.0953-816X.2004.03345.x","volume":"19","author":"A Ichinohe","year":"2004","unstructured":"Ichinohe A, Kure S, Mikawa S, Ueki T, Kojima K, Fujiwara K, Iinuma K, Matsubara Y, Sato K (2004) Glycine cleavage system in neurogenic regions. Eur J Neurosci 19(9):2365\u20132370","journal-title":"Eur J Neurosci"},{"issue":"12","key":"7016_CR94","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1007\/PL00000653","volume":"57","author":"JP Incardona","year":"2000","unstructured":"Incardona JP, Roelink H (2000) The role of cholesterol in Shh signaling and teratogen-induced holoprosencephaly. Cell Mol Life Sci 57(12):1709\u20131719","journal-title":"Cell Mol Life Sci"},{"key":"7016_CR95","doi-asserted-by":"crossref","unstructured":"Isakovic J, Simunic I, Jagecic D, Hribljan V, Mitrecic D (2022)Overview of neural tube defects: gene-environment interactions, preventative approaches and future perspectives. Biomedi 10(5):1\u201325","DOI":"10.3390\/biomedicines10050965"},{"issue":"1","key":"7016_CR96","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1177\/08465371211015657","volume":"73","author":"P Jabehdar Maralani","year":"2021","unstructured":"Jabehdar Maralani P, Kapadia A, Liu G, Moretti F, Ghandehari H, Clarke SE, Wiebe S, Garel J, Ertl-Wagner B, Hurrell C, Schieda N (2021) Canadian association of radiologists recommendations for the safe use of MRI during pregnancy. Can Assoc Radiol J 73(1):56\u201367","journal-title":"Can Assoc Radiol J"},{"issue":"11","key":"7016_CR97","first-page":"e48538","volume":"15","author":"A Jaiswal","year":"2023","unstructured":"Jaiswal A, Dewani D, Reddy LS, Patel A (2023) Choline supplementation in pregnancy: current evidence and implications. Cureus 15(11):e48538","journal-title":"Cureus"},{"issue":"10","key":"7016_CR98","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/s41580-019-0151-1","volume":"20","author":"A Jambhekar","year":"2019","unstructured":"Jambhekar A, Dhall A, Shi Y (2019) Roles and regulation of histone methylation in animal development. Nat Rev Mol Cell Biol 20(10):625\u2013641","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"7016_CR99","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s11154-012-9215-7","volume":"13","author":"SC Kalhan","year":"2012","unstructured":"Kalhan SC, Marczewski SE (2012) Methionine, homocysteine, one carbon metabolism and fetal growth. Rev Endocr Metab Disord 13(2):109\u2013119","journal-title":"Rev Endocr Metab Disord"},{"key":"7016_CR100","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.reprotox.2016.09.005","volume":"66","author":"S Kalra","year":"2016","unstructured":"Kalra S, Dewan P, Batra P, Sharma T, Tyagi V, Banerjee BD (2016) Organochlorine pesticide exposure in mothers and neural tube defects in offsprings. Reprod Toxicol 66:56\u201360","journal-title":"Reprod Toxicol"},{"issue":"7","key":"7016_CR101","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.1007\/s00044-015-1360-6","volume":"24","author":"K Kaminski","year":"2015","unstructured":"Kaminski K, Wiklik B, Obniska J (2015) Synthesis and anticonvulsant activity of new N-phenyl-2-(4-phenylpiperazin-1-yl)acetamide derivatives. Med Chem Res 24(7):3047\u20133061","journal-title":"Med Chem Res"},{"issue":"3","key":"7016_CR102","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/bdra.23578","volume":"109","author":"S Kant","year":"2016","unstructured":"Kant S, Malhotra S, Singh AK, Haldar P, Kaur R, Misra P, Gupta N (2016) Prevalence of neural tube defects in a rural area of north india from 2001 to 2014: a population-based survey. Birth Defects Res 109(3):203\u2013210","journal-title":"Birth Defects Res"},{"issue":"5","key":"7016_CR103","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s00381-018-3734-9","volume":"34","author":"E Kantarcioglu","year":"2018","unstructured":"Kantarcioglu E, Kahilogullari G, Zaimoglu M, Atmis EO, Peker E, Yigman Z, Billur D, Aydin S, Erden IM, Unlu A (2018) The effect of magnetic resonance imaging on neural tube development in an early chicken embryo model. Childs Nerv Syst 34(5):933\u2013938","journal-title":"Childs Nerv Syst"},{"issue":"4","key":"7016_CR104","doi-asserted-by":"publisher","first-page":"106277","DOI":"10.1016\/j.isci.2023.106277","volume":"26","author":"S Khan","year":"2023","unstructured":"Khan S, Takeuchi A, Nabeka H, Khan F, Shimokawa T, Takanezawa S, Saitou T, Imamura T, Tachibana T, Nishizono A, Hamada F, Matsuda S (2023) Administration of prosaposin-derived neurotrophic factor to neural tube defects facilitates regeneration and restores neurological functions. IScience 26(4):106277","journal-title":"IScience"},{"issue":"3","key":"7016_CR105","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/90081","volume":"28","author":"Z Kibar","year":"2001","unstructured":"Kibar Z, Vogan KJ, Groulx N, Justice MJ, Underhill DA, Gros P (2001) Ltap, a mammalian homolog of Drosophila Strabismus\/Van Gogh, is altered in the mouse neural tube mutant Loop-tail. Nat Genet 28(3):251\u2013255","journal-title":"Nat Genet"},{"issue":"14","key":"7016_CR106","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1056\/NEJMoa060651","volume":"356","author":"Z Kibar","year":"2007","unstructured":"Kibar Z, Torban E, McDearmid JR, Reynolds A, Berghout J, Mathieu M, Kirillova I, De Marco P, Merello E, Hayes JM, Wallingford JB, Drapeau P, Capra V, Gros P (2007) Mutations in VANGL1 associated with neural-tube defects. N Engl J Med 356(14):1432\u20131437","journal-title":"N Engl J Med"},{"issue":"2","key":"7016_CR107","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/BF01659328","volume":"1","author":"G Kikuchi","year":"1973","unstructured":"Kikuchi G (1973) The glycine cleavage system: composition, reaction mechanism, and physiological significance. Mol Cell Biochem 1(2):169\u2013187","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"7016_CR108","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0022-510X(96)00256-0","volume":"145","author":"T Kishi","year":"1997","unstructured":"Kishi T, Fujita N, Eguchi T, Ueda K (1997) Mechanism for reduction of serum folate by antiepileptic drugs during prolonged therapy. J Neurol Sci 145(1):109\u2013112","journal-title":"J Neurol Sci"},{"key":"7016_CR109","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1146\/annurev.cellbio.21.012704.132806","volume":"21","author":"TJ Klein","year":"2005","unstructured":"Klein TJ, Mlodzik M (2005) Planar cell polarization: an emerging model points in the right direction. Annu Rev Cell Dev Biol 21:155\u2013176","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"12","key":"7016_CR110","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.ebiom.2015.11.002","volume":"2","author":"LP Klosinski","year":"2016","unstructured":"Klosinski LP, Yao J, Yin F, Fonteh AN, Harrington MG, Christensen TA, Trushina E, Brinton RD (2016) White matter lipids as a ketogenic fuel supply in aging female brain: implications for alzheimer\u2019s disease. EBioMedicine 2(12):1888\u20131904","journal-title":"EBioMedicine"},{"issue":"1","key":"7016_CR111","first-page":"35","volume":"58","author":"LA Kluijtmans","year":"1996","unstructured":"Kluijtmans LA, van den Heuvel LP, Boers GH, Frosst P, Stevens EM, van Oost BA, den Heijer M, Trijbels FJ, Rozen R, Blom HJ (1996) Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease. Am J Hum Genet 58(1):35\u201341","journal-title":"Am J Hum Genet"},{"issue":"22","key":"7016_CR112","doi-asserted-by":"publisher","first-page":"5829","DOI":"10.1182\/bloodadvances.2022007233","volume":"6","author":"TW Kuijpers","year":"2022","unstructured":"Kuijpers TW, de Vries ACH, van Leeuwen EM, Ermens A, de Pont S, Smith DEC, Wamelink MMC, Mensenkamp AR, Nelen MR, Lango Allen H, Pals ST, Beverloo BHB, Huidekoper HH, Wagner A (2022) Megalobastic anemia, infantile leukemia, and immunodeficiency caused by a novel homozygous mutation in the DHFR gene. Blood Adv 6(22):5829\u20135834","journal-title":"Blood Adv"},{"issue":"5","key":"7016_CR113","doi-asserted-by":"publisher","first-page":"E92","DOI":"10.1371\/journal.pbio.0020092","volume":"2","author":"H Kuroda","year":"2004","unstructured":"Kuroda H, Wessely O, De Robertis EM (2004) Neural induction in Xenopus: requirement for ectodermal and endomesodermal signals via Chordin, Noggin, beta-Catenin, and Cerberus. PLoS Biol 2(5):E92","journal-title":"PLoS Biol"},{"issue":"5134","key":"7016_CR114","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1126\/science.8235591","volume":"262","author":"TM Lamb","year":"1993","unstructured":"Lamb TM, Knecht AK, Smith WC, Stachel SE, Economides AN, Stahl N, Yancopolous GD, Harland RM (1993) Neural induction by the secreted polypeptide noggin. Science 262(5134):713\u2013718","journal-title":"Science"},{"issue":"2","key":"7016_CR115","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1057\/biosoc.2011.1","volume":"6","author":"H Landecker","year":"2011","unstructured":"Landecker H (2011) Food as exposure: Nutritional epigenetics and the new metabolism. BioSocieties 6(2):167\u2013194","journal-title":"BioSocieties"},{"issue":"8","key":"7016_CR116","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1093\/hmg\/ddg107","volume":"12","author":"D Lang","year":"2003","unstructured":"Lang D, Epstein JA (2003) Sox10 and Pax3 physically interact to mediate activation of a conserved c-RET enhancer. Hum Mol Genet 12(8):937\u2013945","journal-title":"Hum Mol Genet"},{"key":"7016_CR117","doi-asserted-by":"publisher","DOI":"10.3390\/nu8010006","author":"L Lauritzen","year":"2016","unstructured":"Lauritzen L, Brambilla P, Mazzocchi A, Harslof LB, Ciappolino V, Agostoni C (2016) DHA Effects in Brain Development and Function. Nutrients. https:\/\/doi.org\/10.3390\/nu8010006","journal-title":"Nutrients"},{"issue":"1","key":"7016_CR118","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.neuron.2016.02.033","volume":"90","author":"E Lauwers","year":"2016","unstructured":"Lauwers E, Goodchild R, Verstreken P (2016) Membrane Lipids in Presynaptic Function and Disease. Neuron 90(1):11\u201325","journal-title":"Neuron"},{"issue":"4","key":"7016_CR119","first-page":"170","volume":"1","author":"MA Leddy","year":"2008","unstructured":"Leddy MA, Power ML, Schulkin J (2008) The impact of maternal obesity on maternal and fetal health. Rev Obstet Gynecol 1(4):170\u2013178","journal-title":"Rev Obstet Gynecol"},{"issue":"7","key":"7016_CR120","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.tins.2020.04.009","volume":"43","author":"S Lee","year":"2020","unstructured":"Lee S, Gleeson JG (2020) Closing in on mechanisms of open neural tube defects. Trends Neurosci 43(7):519\u2013532","journal-title":"Trends Neurosci"},{"issue":"21","key":"7016_CR121","doi-asserted-by":"publisher","first-page":"3394","DOI":"10.1101\/gad.12.21.3394","volume":"12","author":"KJ Lee","year":"1998","unstructured":"Lee KJ, Mendelsohn M, Jessell TM (1998) Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord. Genes Dev 12(21):3394\u20133407","journal-title":"Genes Dev"},{"issue":"4","key":"7016_CR122","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/s41551-022-00868-4","volume":"6","author":"JH Lee","year":"2022","unstructured":"Lee JH, Shin H, Shaker MR, Kim HJ, Park SH, Kim JH, Lee N, Kang M, Cho S, Kwak TH, Kim JW, Song MR, Kwon SH, Han DW, Lee S, Choi SY, Rhyu IJ, Kim H, Geum D, Cho IJ, Sun W (2022) Production of human spinal-cord organoids recapitulating neural-tube morphogenesis. Nat Biomed Eng 6(4):435\u2013448","journal-title":"Nat Biomed Eng"},{"issue":"3","key":"7016_CR123","doi-asserted-by":"publisher","first-page":"e92207","DOI":"10.1371\/journal.pone.0092207","volume":"9","author":"Y Lei","year":"2014","unstructured":"Lei Y, Zhu H, Yang W, Ross ME, Shaw GM, Finnell RH (2014) Identification of novel CELSR1 mutations in spina bifida. PLoS ONE 9(3):e92207","journal-title":"PLoS ONE"},{"key":"7016_CR124","unstructured":"Lei Y, Finnell RH (2016) New Techniques for the Study of Neural Tube Defects. Adv Tech Biol Med 4(1):1-4"},{"key":"7016_CR125","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.ydbio.2021.05.013","volume":"478","author":"AC Lesko","year":"2021","unstructured":"Lesko AC, Keller R, Chen P, Sutherland A (2021) Scribble mutation disrupts convergent extension and apical constriction during mammalian neural tube closure. Dev Biol 478:59\u201375","journal-title":"Dev Biol"},{"issue":"7","key":"7016_CR126","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1016\/j.celrep.2017.10.072","volume":"21","author":"KY Leung","year":"2017","unstructured":"Leung KY, Pai YJ, Chen Q, Santos C, Calvani E, Sudiwala S, Savery D, Ralser M, Gross SS, Copp AJ, Greene NDE (2017) Partitioning of one-carbon units in folate and methionine metabolism is essential for neural tube closure. Cell Rep 21(7):1795\u20131808","journal-title":"Cell Rep"},{"issue":"2","key":"7016_CR127","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3945\/an.110.000174","volume":"2","author":"CW Levenson","year":"2011","unstructured":"Levenson CW, Morris D (2011) Zinc and neurogenesis: making new neurons from development to adulthood. Adv Nutr 2(2):96\u2013100","journal-title":"Adv Nutr"},{"issue":"3","key":"7016_CR128","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.ymgme.2008.03.013","volume":"94","author":"F Li","year":"2008","unstructured":"Li F, Feng Q, Lee C, Wang S, Pelleymounter LL, Moon I, Eckloff BW, Wieben ED, Schaid DJ, Yee V, Weinshilboum RM (2008) Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: common gene sequence variation and functional characterization. Mol Genet Metab 94(3):326\u2013335","journal-title":"Mol Genet Metab"},{"key":"7016_CR129","doi-asserted-by":"publisher","DOI":"10.1242\/dev.169797","author":"H Li","year":"2018","unstructured":"Li H, Zhang J, Niswander L (2018) Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation. Development. https:\/\/doi.org\/10.1242\/dev.169797","journal-title":"Development"},{"key":"7016_CR130","doi-asserted-by":"crossref","unstructured":"Li K, Wahlqvist ML, Li D (2016) Nutrition, one-carbon metabolism and neural tube defects: a review. Nutrients 8(11)","DOI":"10.3390\/nu8110741"},{"key":"7016_CR131","doi-asserted-by":"crossref","unstructured":"Li M, Francis E, Hinkle SN, Ajjarapu AS, Zhang C (2019) Preconception and prenatal nutrition and neurodevelopmental disorders: a systematic review and meta-analysis. Nutrients 11(7):1-34","DOI":"10.3390\/nu11071628"},{"key":"7016_CR132","doi-asserted-by":"crossref","unstructured":"Libby ARG, Joy DA, Elder NH, Bulger EA, Krakora MZ, Gaylord EA, Mendoza-Camacho F, Butts JC, McDevitt TC 2021 Axial elongation of caudalized human organoids mimics aspects of neural tube development. Development 148(12):1-16","DOI":"10.1242\/dev.198275"},{"issue":"32","key":"7016_CR133","doi-asserted-by":"publisher","first-page":"13377","DOI":"10.1073\/pnas.0906944106","volume":"106","author":"KF Liem Jr","year":"2009","unstructured":"Liem KF Jr, He M, Ocbina PJ, Anderson KV (2009) Mouse Kif7\/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling. Proc Natl Acad Sci U S A 106(32):13377\u201313382","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"7016_CR134","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1002\/ana.22229","volume":"69","author":"M Linnebank","year":"2011","unstructured":"Linnebank M, Moskau S, Semmler A, Widman G, Stoffel-Wagner B, Weller M, Elger CE (2011) Antiepileptic drugs interact with folate and vitamin B12 serum levels. Ann Neurol 69(2):352\u2013359","journal-title":"Ann Neurol"},{"issue":"12","key":"7016_CR135","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1038\/nrn1805","volume":"6","author":"A Liu","year":"2005","unstructured":"Liu A, Niswander LA (2005) Bone morphogenetic protein signalling and vertebrate nervous system development. Nat Rev Neurosci 6(12):945\u2013954","journal-title":"Nat Rev Neurosci"},{"key":"7016_CR136","doi-asserted-by":"publisher","unstructured":"MacGowan J, Cardenas M, Williams MK (2023) Vangl2 deficient zebrafish exhibit hallmarks of neural tube closure defects. https:\/\/doi.org\/10.1101\/2023.11.09.566412 (preprint)","DOI":"10.1101\/2023.11.09.566412"},{"issue":"4","key":"7016_CR137","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1002\/bdrb.21018","volume":"95","author":"M Mallela","year":"2012","unstructured":"Mallela M, Hrubec T (2012) Reduction in valproic acid-induced neural tube defects by maternal immune stimulation: role of apoptosis. Birth Defects Res B Dev Reprod Toxicol 95(4):296\u2013303","journal-title":"Birth Defects Res B Dev Reprod Toxicol"},{"issue":"4 Suppl 10","key":"7016_CR138","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/S0093-7754(03)00283-5","volume":"30","author":"C Manegold","year":"2003","unstructured":"Manegold C (2003) Pemetrexed (Alimta, MTA, multitargeted antifolate, LY231514) for malignant pleural mesothelioma. Semin Oncol 30(4 Suppl 10):32\u201336","journal-title":"Semin Oncol"},{"issue":"4","key":"7016_CR139","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1093\/jn\/134.4.711","volume":"134","author":"WF Marasas","year":"2004","unstructured":"Marasas WF, Riley RT, Hendricks KA, Stevens VL, Sadler TW, Gelineau-van Waes J, Missmer SA, Cabrera J, Torres O, Gelderblom WC, Allegood J, Martinez C, Maddox J, Miller JD, Starr L, Sullards MC, Roman AV, Voss KA, Wang E, Merrill AH Jr (2004) Fumonisins disrupt sphingolipid metabolism, folate transport, and neural tube development in embryo culture and in vivo: a potential risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize. J Nutr 134(4):711\u2013716","journal-title":"J Nutr"},{"issue":"2","key":"7016_CR140","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0012-1606(98)80008-0","volume":"198","author":"L Marchant","year":"1998","unstructured":"Marchant L, Linker C, Ruiz P, Guerrero N, Mayor R (1998) The inductive properties of mesoderm suggest that the neural crest cells are specified by a BMP gradient. Dev Biol 198(2):319\u2013329","journal-title":"Dev Biol"},{"issue":"11","key":"7016_CR141","doi-asserted-by":"publisher","first-page":"e28408","DOI":"10.1371\/journal.pone.0028408","volume":"6","author":"NJ Marini","year":"2011","unstructured":"Marini NJ, Hoffmann TJ, Lammer EJ, Hardin J, Lazaruk K, Stein JB, Gilbert DA, Wright C, Lipzen A, Pennacchio LA, Carmichael SL, Witte JS, Shaw GM, Rine J (2011) A genetic signature of spina bifida risk from pathway-informed comprehensive gene-variant analysis. PLoS ONE 6(11):e28408","journal-title":"PLoS ONE"},{"issue":"8","key":"7016_CR142","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.1242\/dev.121.8.2537","volume":"121","author":"E Marti","year":"1995","unstructured":"Marti E, Takada R, Bumcrot DA, Sasaki H, McMahon AP (1995) Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo. Development 121(8):2537\u20132547","journal-title":"Development"},{"issue":"6","key":"7016_CR143","first-page":"549","volume":"10","author":"S Masihi","year":"2012","unstructured":"Masihi S, Barati M, Marfu J, Eskandari Z (2012) Detection of neural tube defect in the first and second trimester of pregnancy by ultrasound in Imam Hospital, Ahwaz between December 2008\u20132010. Iran J Reprod Med 10(6):549\u2013554","journal-title":"Iran J Reprod Med"},{"issue":"2","key":"7016_CR144","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1002\/bdra.23577","volume":"109","author":"M Mazumdar","year":"2017","unstructured":"Mazumdar M (2017) Does arsenic increase the risk of neural tube defects among a highly exposed population? A new case-control study in Bangladesh. Birth Defects Res 109(2):92\u201398","journal-title":"Birth Defects Res"},{"issue":"2","key":"7016_CR145","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1093\/toxsci\/kfm114","volume":"98","author":"KL McDaniel","year":"2007","unstructured":"McDaniel KL, Padilla S, Marshall RS, Phillips PM, Podhorniak L, Qian Y, Moser VC (2007) Comparison of acute neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat. Toxicol Sci 98(2):552\u2013560","journal-title":"Toxicol Sci"},{"issue":"37","key":"7016_CR146","doi-asserted-by":"publisher","first-page":"15157","DOI":"10.1073\/pnas.1103605108","volume":"108","author":"G McEntee","year":"2011","unstructured":"McEntee G, Minguzzi S, O\u2019Brien K, Ben Larbi N, Loscher C, O\u2019Fagain C, Parle-McDermott A (2011) The former annotated human pseudogene dihydrofolate reductase-like 1 (DHFRL1) is expressed and functional. Proc Natl Acad Sci U S A 108(37):15157\u201315162","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"7016_CR147","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.ydbio.2015.06.003","volume":"404","author":"SG McShane","year":"2015","unstructured":"McShane SG, Mole MA, Savery D, Greene ND, Tam PP, Copp AJ (2015) Cellular basis of neuroepithelial bending during mouse spinal neural tube closure. Dev Biol 404(2):113\u2013124","journal-title":"Dev Biol"},{"issue":"3","key":"7016_CR148","doi-asserted-by":"publisher","first-page":"e9469","DOI":"10.15252\/emmm.201809469","volume":"12","author":"X Mei","year":"2020","unstructured":"Mei X, Qi D, Zhang T, Zhao Y, Jin L, Hou J, Wang J, Lin Y, Xue Y, Zhu P, Liu Z, Huang L, Nie J, Si W, Ma J, Ye J, Finnell RH, Saiyin H, Wang H, Zhao J, Zhao S, Xu W (2020) Inhibiting MARSs reduces hyperhomocysteinemia-associated neural tube and congenital heart defects. EMBO Mol Med 12(3):e9469","journal-title":"EMBO Mol Med"},{"issue":"6","key":"7016_CR149","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.stemcr.2014.09.020","volume":"3","author":"A Meinhardt","year":"2014","unstructured":"Meinhardt A, Eberle D, Tazaki A, Ranga A, Niesche M, Wilsch-Brauninger M, Stec A, Schackert G, Lutolf M, Tanaka EM (2014) 3D reconstitution of the patterned neural tube from embryonic stem cells. Stem Cell Reports 3(6):987\u2013999","journal-title":"Stem Cell Reports"},{"issue":"3","key":"7016_CR150","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1159\/000203749","volume":"4","author":"LM Meyer","year":"1950","unstructured":"Meyer LM, Miller FR, Rowen MJ, Bock G, Rutzky J (1950) Treatment of acute leukemia with amethopterin (4-amino, 10-methyl pteroyl glutamic acid). Acta Haematol 4(3):157\u2013167","journal-title":"Acta Haematol"},{"issue":"2","key":"7016_CR151","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/0029-7844(95)00141-D","volume":"86","author":"G Millicovsky","year":"1995","unstructured":"Millicovsky G, Lazar ML (1995) Spina bifida: role of neural tissue damage during pregnancy in producing spinal paralysis. Obstet Gynecol 86(2):300\u2013301","journal-title":"Obstet Gynecol"},{"issue":"3","key":"7016_CR152","doi-asserted-by":"publisher","first-page":"756S","DOI":"10.1093\/jn\/126.suppl_3.756S","volume":"126","author":"JL Mills","year":"1996","unstructured":"Mills JL, Scott JM, Kirke PN, McPartlin JM, Conley MR, Weir DG, Molloy AM, Lee YJ (1996) Homocysteine and neural tube defects. J Nutr 126(3):756S-760S","journal-title":"J Nutr"},{"issue":"30","key":"7016_CR153","first-page":"1307","volume":"31","author":"B Mirakowski","year":"1976","unstructured":"Mirakowski B, Niedbal M (1976) Case of developmental anomaly of the appendix (double appendix). Pol Tyg Lek 31(30):1307","journal-title":"Pol Tyg Lek"},{"issue":"2","key":"7016_CR154","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/s003940200010","volume":"41","author":"A Misra","year":"2002","unstructured":"Misra A, Vikram NK, Pandey RM, Dwivedi M, Ahmad FU, Luthra K, Jain K, Khanna N, Devi JR, Sharma R, Guleria R (2002) Hyperhomocysteinemia, and low intakes of folic acid and vitamin B12 in urban North India. Eur J Nutr 41(2):68\u201377","journal-title":"Eur J Nutr"},{"issue":"3","key":"7016_CR155","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1542\/peds.2008-1173","volume":"123","author":"AM Molloy","year":"2009","unstructured":"Molloy AM, Kirke PN, Troendle JF, Burke H, Sutton M, Brody LC, Scott JM, Mills JL (2009) Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortification. Pediatrics 123(3):917\u2013923","journal-title":"Pediatrics"},{"key":"7016_CR156","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1146\/annurev-nutr-071714-034235","volume":"37","author":"AM Molloy","year":"2017","unstructured":"Molloy AM, Pangilinan F, Brody LC (2017) Genetic risk factors for folate-responsive neural tube defects. Annu Rev Nutr 37:269\u2013291","journal-title":"Annu Rev Nutr"},{"issue":"9","key":"7016_CR157","doi-asserted-by":"publisher","first-page":"870","DOI":"10.2176\/nmc.50.870","volume":"50","author":"T Morioka","year":"2010","unstructured":"Morioka T, Hashiguchi K, Mukae N, Sayama T, Sasaki T (2010) Neurosurgical management of patients with lumbosacral myeloschisis. Neurol Med Chir (Tokyo) 50(9):870\u2013876","journal-title":"Neurol Med Chir (Tokyo)"},{"issue":"1","key":"7016_CR158","first-page":"17","volume":"58","author":"AG Motulsky","year":"1996","unstructured":"Motulsky AG (1996) Nutritional ecogenetics: homocysteine-related arteriosclerotic vascular disease, neural tube defects, and folic acid. Am J Hum Genet 58(1):17\u201320","journal-title":"Am J Hum Genet"},{"issue":"8760","key":"7016_CR159","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0140-6736(91)90133-A","volume":"338","author":"MRC Vitamin Study Research Group","year":"1991","unstructured":"MRC Vitamin Study Research Group (1991) Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group. Lancet 338(8760):131\u2013137","journal-title":"Lancet"},{"issue":"8","key":"7016_CR160","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1002\/bdra.20686","volume":"88","author":"JN Murdoch","year":"2010","unstructured":"Murdoch JN, Copp AJ (2010) The relationship between sonic Hedgehog signaling, cilia, and neural tube defects. Birth Defects Res A Clin Mol Teratol 88(8):633\u2013652","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"22","key":"7016_CR161","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1093\/hmg\/10.22.2593","volume":"10","author":"JN Murdoch","year":"2001","unstructured":"Murdoch JN, Doudney K, Paternotte C, Copp AJ, Stanier P (2001) Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification. Hum Mol Genet 10(22):2593\u20132601","journal-title":"Hum Mol Genet"},{"key":"7016_CR162","doi-asserted-by":"crossref","unstructured":"Murphy MM, Higgins KA, Bi X, Barraj LM (2021) Adequacy and sources of protein intake among pregnant women in the United States, NHANES 2003\u20132012. Nutri 13(3):1\u201311","DOI":"10.3390\/nu13030795"},{"issue":"1","key":"7016_CR163","doi-asserted-by":"publisher","first-page":"5","DOI":"10.4103\/jpn.JPN_126_21","volume":"16","author":"D Muzumdar","year":"2021","unstructured":"Muzumdar D, Hawaldar A, bhambhere s, singh m, lunawat a, nanavati r (2021) Open neural tube defects in COVID-19 pandemic: an analysis of 26 neonatal patients in a tertiary care center. J Pediatr Neurosci 16(1):5\u201310","journal-title":"J Pediatr Neurosci"},{"issue":"7","key":"7016_CR164","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1093\/hmg\/ddr585","volume":"21","author":"A Narisawa","year":"2012","unstructured":"Narisawa A, Komatsuzaki S, Kikuchi A, Niihori T, Aoki Y, Fujiwara K, Tanemura M, Hata A, Suzuki Y, Relton CL, Grinham J, Leung KY, Partridge D, Robinson A, Stone V, Gustavsson P, Stanier P, Copp AJ, Greene ND, Tominaga T, Matsubara Y, Kure S (2012) Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans. Hum Mol Genet 21(7):1496\u20131503","journal-title":"Hum Mol Genet"},{"key":"7016_CR165","first-page":"144","volume":"181","author":"H Nau","year":"1994","unstructured":"Nau H (1994) Valproic acid-induced neural tube defects. Ciba Found Symp 181:144\u2013152","journal-title":"Ciba Found Symp"},{"key":"7016_CR166","volume-title":"Beyond Our Genes","author":"IC Nettore","year":"2020","unstructured":"Nettore IC, Ungaro P, Macchia PE (2020) Food and Nutrition as Prime Environmental Factors. In: Teperino R (ed) Beyond Our Genes. Springer, Cham"},{"issue":"12","key":"7016_CR167","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1038\/bjc.2017.118","volume":"116","author":"AC Newman","year":"2017","unstructured":"Newman AC, Maddocks ODK (2017) One-carbon metabolism in cancer. Br J Cancer 116(12):1499\u20131504","journal-title":"Br J Cancer"},{"issue":"4","key":"7016_CR168","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1242\/dev.145904","volume":"144","author":"E Nikolopoulou","year":"2017","unstructured":"Nikolopoulou E, Galea GL, Rolo A, Greene ND, Copp AJ (2017) Neural tube closure: cellular, molecular and biomechanical mechanisms. Development 144(4):552\u2013566","journal-title":"Development"},{"issue":"2","key":"7016_CR169","first-page":"48","volume":"6","author":"ER Norwitz","year":"2014","unstructured":"Norwitz ER, Levy B (2014) Noninvasive prenatal testing: the future is now. Rev Obstet Gynecol 6(2):48\u201362","journal-title":"Rev Obstet Gynecol"},{"issue":"11","key":"7016_CR170","doi-asserted-by":"publisher","first-page":"4167","DOI":"10.1096\/fj.10-165084","volume":"24","author":"SG Obican","year":"2010","unstructured":"Obican SG, Finnell RH, Mills JL, Shaw GM, Scialli AR (2010) Folic acid in early pregnancy: a public health success story. FASEB J 24(11):4167\u20134174","journal-title":"FASEB J"},{"key":"7016_CR171","doi-asserted-by":"publisher","first-page":"37697","DOI":"10.1038\/srep37697","volume":"6","author":"Y Okamoto-Uchida","year":"2016","unstructured":"Okamoto-Uchida Y, Yu R, Miyamura N, Arima N, Ishigami-Yuasa M, Kagechika H, Yoshida S, Hosoya T, Nawa M, Kasama T, Asaoka Y, Alois RW, Elling U, Penninger JM, Nishina S, Azuma N, Nishina H (2016) The mevalonate pathway regulates primitive streak formation via protein farnesylation. Sci Rep 6:37697","journal-title":"Sci Rep"},{"issue":"1","key":"7016_CR172","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.reprotox.2009.02.014","volume":"28","author":"A Ornoy","year":"2009","unstructured":"Ornoy A (2009) Valproic acid in pregnancy: how much are we endangering the embryo and fetus? Reprod Toxicol 28(1):1\u201310","journal-title":"Reprod Toxicol"},{"issue":"2","key":"7016_CR173","doi-asserted-by":"publisher","first-page":"429","DOI":"10.3181\/00379727-97-23764","volume":"97","author":"MJ Osborn","year":"1958","unstructured":"Osborn MJ, Freeman M, Huennekens FM (1958) Inhibition of dihydrofolic reductase by aminopterin and amethopterin. Proc Soc Exp Biol Med 97(2):429\u2013431","journal-title":"Proc Soc Exp Biol Med"},{"key":"7016_CR174","doi-asserted-by":"publisher","first-page":"6388","DOI":"10.1038\/ncomms7388","volume":"6","author":"YJ Pai","year":"2015","unstructured":"Pai YJ, Leung KY, Savery D, Hutchin T, Prunty H, Heales S, Brosnan ME, Brosnan JT, Copp AJ, Greene ND (2015) Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice. Nat Commun 6:6388","journal-title":"Nat Commun"},{"issue":"11","key":"7016_CR175","doi-asserted-by":"publisher","first-page":"e23445","DOI":"10.1002\/dvg.23445","volume":"59","author":"AJ Palmer","year":"2021","unstructured":"Palmer AJ, Savery D, Massa V, Copp AJ, Greene NDE (2021) Genetic interaction of Pax3 mutation and canonical Wnt signaling modulates neural tube defects and neural crest abnormalities. Genesis 59(11):e23445","journal-title":"Genesis"},{"issue":"1","key":"7016_CR176","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.ydbio.2008.11.009","volume":"326","author":"Y Pan","year":"2009","unstructured":"Pan Y, Wang C, Wang B (2009) Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development. Dev Biol 326(1):177\u2013189","journal-title":"Dev Biol"},{"issue":"6","key":"7016_CR177","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1101\/gad.969302","volume":"16","author":"L Pani","year":"2002","unstructured":"Pani L, Horal M, Loeken MR (2002) Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3- dependent development and tumorigenesis. Genes Dev 16(6):676\u2013680","journal-title":"Genes Dev"},{"issue":"10","key":"7016_CR178","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1093\/hmg\/ddp075","volume":"18","author":"VL Patterson","year":"2009","unstructured":"Patterson VL, Damrau C, Paudyal A, Reeve B, Grimes DT, Stewart ME, Williams DJ, Siggers P, Greenfield A, Murdoch JN (2009) Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway. Hum Mol Genet 18(10):1719\u20131739","journal-title":"Hum Mol Genet"},{"key":"7016_CR179","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/1471-213X-10-87","volume":"10","author":"A Paudyal","year":"2010","unstructured":"Paudyal A, Damrau C, Patterson VL, Ermakov A, Formstone C, Lalanne Z, Wells S, Lu X, Norris DP, Dean CH, Henderson DJ, Murdoch JN (2010) The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear. BMC Dev Biol 10:87","journal-title":"BMC Dev Biol"},{"issue":"14","key":"7016_CR180","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1002\/bdr2.1365","volume":"110","author":"S Paul","year":"2018","unstructured":"Paul S, Sadhukhan S, Munian D, Bankura B, Das M (2018) Association of FOLH1, DHFR, and MTHFR gene polymorphisms with susceptibility of neural tube defects: a case control study from Eastern India. Birth Defects Res 110(14):1129\u20131138","journal-title":"Birth Defects Res"},{"issue":"2 Pt 1","key":"7016_CR181","first-page":"325","volume":"104","author":"AAO Pediatrics","year":"1999","unstructured":"Pediatrics AAO (1999) Folic acid for the prevention of neural tube defects. American Academy of Pediatrics. Committee on Genetics. Pediatrics 104(2 Pt 1):325\u2013327","journal-title":"Pediatrics"},{"issue":"4","key":"7016_CR182","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/S0092-8674(00)80132-4","volume":"86","author":"S Piccolo","year":"1996","unstructured":"Piccolo S, Sasai Y, Lu B, De Robertis EM (1996) Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4. Cell 86(4):589\u2013598","journal-title":"Cell"},{"issue":"4","key":"7016_CR183","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1007\/s00246-011-9913-z","volume":"32","author":"KD Piggott","year":"2011","unstructured":"Piggott KD, Sorbello A, Riddle E, DeCampli W (2011) Congenital cardiac defects: a possible association of aminopterin syndrome and in utero methotrexate exposure? Pediatr Cardiol 32(4):518\u2013520","journal-title":"Pediatr Cardiol"},{"issue":"2","key":"7016_CR184","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1002\/jcp.10008","volume":"189","author":"P Pla","year":"2001","unstructured":"Pla P, Moore R, Morali OG, Grille S, Martinozzi S, Delmas V, Larue L (2001) Cadherins in neural crest cell development and transformation. J Cell Physiol 189(2):121\u2013132","journal-title":"J Cell Physiol"},{"key":"7016_CR185","doi-asserted-by":"crossref","unstructured":"Poitelon Y, Kopec AM, Belin S (2020) Myelin fat facts: an overview of lipids and fatty acid metabolism. Cells 9(4):1\u201317","DOI":"10.3390\/cells9040812"},{"issue":"4","key":"7016_CR186","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/nure.12102","volume":"72","author":"EL Prado","year":"2014","unstructured":"Prado EL, Dewey KG (2014) Nutrition and brain development in early life. Nutr Rev 72(4):267\u2013284","journal-title":"Nutr Rev"},{"issue":"7","key":"7016_CR187","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1080\/1354750X.2018.1471619","volume":"23","author":"KR Prasoona","year":"2018","unstructured":"Prasoona KR, Sunitha T, Srinadh B, Muni Kumari T, Jyothy A (2018) Maternal association and influence of DHFR 19 bp deletion variant predisposes foetus to anencephaly susceptibility: a family-based triad study. Biomarkers 23(7):640\u2013646","journal-title":"Biomarkers"},{"key":"7016_CR188","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/978-1-61779-510-7_11","volume":"839","author":"SE Pryor","year":"2012","unstructured":"Pryor SE, Massa V, Savery D, Greene ND, Copp AJ (2012) Convergent extension analysis in mouse whole embryo culture. Methods Mol Biol 839:133\u2013146","journal-title":"Methods Mol Biol"},{"issue":"10","key":"7016_CR189","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.tcb.2013.05.002","volume":"23","author":"D Puchkov","year":"2013","unstructured":"Puchkov D, Haucke V (2013) Greasing the synaptic vesicle cycle by membrane lipids. Trends Cell Biol 23(10):493\u2013503","journal-title":"Trends Cell Biol"},{"issue":"3","key":"7016_CR190","doi-asserted-by":"publisher","first-page":"134","DOI":"10.4103\/0974-8237.161596","volume":"5","author":"RV Ramdasi","year":"2014","unstructured":"Ramdasi RV, Nadkarni TD, Goel AH (2014) Congenital meningocoele presenting in an adult. J Craniovertebr Junction Spine 5(3):134\u2013136","journal-title":"J Craniovertebr Junction Spine"},{"key":"7016_CR191","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ijdevneu.2015.04.006","volume":"43","author":"RS Rathod","year":"2015","unstructured":"Rathod RS, Khaire AA, Kale AA, Joshi SR (2015) Maternal omega-3 fatty acid supplementation to a vitamin B12 deficient diet normalizes angiogenic markers in the pup brain at birth. Int J Dev Neurosci 43:43\u201349","journal-title":"Int J Dev Neurosci"},{"issue":"12","key":"7016_CR192","doi-asserted-by":"publisher","first-page":"4383","DOI":"10.4103\/jfmpc.jfmpc_904_21","volume":"10","author":"KS Ravi","year":"2022","unstructured":"Ravi KS, Divasha SB, Hassan R, Pasi SM, Kumar R (2022) Neural tube defects: different types and brief review of neurulation process and its clinical implication. J Family Med Prim Care 10(12):4383\u20134390","journal-title":"J Family Med Prim Care"},{"issue":"Suppl 2","key":"7016_CR193","doi-asserted-by":"publisher","first-page":"S109","DOI":"10.1079\/BJN2000302","volume":"85","author":"H Refsum","year":"2001","unstructured":"Refsum H (2001) Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome. Br J Nutr 85(Suppl 2):S109-113","journal-title":"Br J Nutr"},{"issue":"1","key":"7016_CR194","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1101\/gad.1363606","volume":"20","author":"JF Reiter","year":"2006","unstructured":"Reiter JF, Skarnes WC (2006) Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition. Genes Dev 20(1):22\u201327","journal-title":"Genes Dev"},{"issue":"6","key":"7016_CR195","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1002\/tera.1420420605","volume":"42","author":"M Repetto","year":"1990","unstructured":"Repetto M, Maziere JC, Citadelle D, Dupuis R, Meier M, Biade S, Quiec D, Roux C (1990) Teratogenic effect of the cholesterol synthesis inhibitor AY 9944 on rat embryos in vitro. Teratology 42(6):611\u2013618","journal-title":"Teratology"},{"issue":"11","key":"7016_CR196","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1101\/gad.559910","volume":"24","author":"V Ribes","year":"2010","unstructured":"Ribes V, Balaskas N, Sasai N, Cruz C, Dessaud E, Cayuso J, Tozer S, Yang LL, Novitch B, Marti E, Briscoe J (2010) Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube. Genes Dev 24(11):1186\u20131200","journal-title":"Genes Dev"},{"issue":"11","key":"7016_CR197","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1038\/s41587-020-0525-0","volume":"38","author":"P Rifes","year":"2020","unstructured":"Rifes P, Isaksson M, Rathore GS, Aldrin-Kirk P, Moller OK, Barzaghi G, Lee J, Egerod KL, Rausch DM, Parmar M, Pers TH, Laurell T, Kirkeby A (2020) Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic WNT gradient. Nat Biotechnol 38(11):1265\u20131273","journal-title":"Nat Biotechnol"},{"issue":"2","key":"7016_CR198","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.reprotox.2010.05.009","volume":"30","author":"JF Robinson","year":"2010","unstructured":"Robinson JF, Griffith WC, Yu X, Hong S, Kim E, Faustman EM (2010) Methylmercury induced toxicogenomic response in C57 and SWV mouse embryos undergoing neural tube closure. Reprod Toxicol 30(2):284\u2013291","journal-title":"Reprod Toxicol"},{"key":"7016_CR199","doi-asserted-by":"crossref","unstructured":"Roll L, Lessmann K, Brustle O, Faissner A (2022) Cerebral organoids maintain the expression of neural stem cell-associated glycoepitopes and extracellular matrix. Cells  11(5):1\u201327","DOI":"10.3390\/cells11050760"},{"issue":"8","key":"7016_CR200","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.earlhumdev.2006.07.001","volume":"82","author":"T Roseboom","year":"2006","unstructured":"Roseboom T, de Rooij S, Painter R (2006) The Dutch famine and its long-term consequences for adult health. Early Hum Dev 82(8):485\u2013491","journal-title":"Early Hum Dev"},{"issue":"2","key":"7016_CR201","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1056\/NEJMoa031145","volume":"350","author":"SP Rothenberg","year":"2004","unstructured":"Rothenberg SP, da Costa MP, Sequeira JM, Cracco J, Roberts JL, Weedon J, Quadros EV (2004) Autoantibodies against folate receptors in women with a pregnancy complicated by a neural-tube defect. N Engl J Med 350(2):134\u2013142","journal-title":"N Engl J Med"},{"issue":"8","key":"7016_CR202","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1093\/aje\/kwj101","volume":"163","author":"RP Rull","year":"2006","unstructured":"Rull RP, Ritz B, Shaw GM (2006) Neural tube defects and maternal residential proximity to agricultural pesticide applications. Am J Epidemiol 163(8):743\u2013753","journal-title":"Am J Epidemiol"},{"issue":"1\u20132","key":"7016_CR203","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0925-4773(99)00213-0","volume":"89","author":"K Sabapathy","year":"1999","unstructured":"Sabapathy K, Jochum W, Hochedlinger K, Chang L, Karin M, Wagner EF (1999) Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech Dev 89(1\u20132):115\u2013124","journal-title":"Mech Dev"},{"key":"7016_CR204","doi-asserted-by":"crossref","unstructured":"Saha S, Jungas TT, Ohayon D, Audouard C, Ye T, Fawal MA, Davy A (2023) Dihydrofolate reductase activity controls neurogenic transitions in the developing neocortex. Develop 150(20):1\u201313","DOI":"10.1242\/dev.201696"},{"key":"7016_CR205","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2020.102075","volume":"83","author":"A Sahay","year":"2020","unstructured":"Sahay A, Kale A, Joshi S (2020) Role of neurotrophins in pregnancy and offspring brain development. Neuropeptides 83:102075","journal-title":"Neuropeptides"},{"issue":"5","key":"7016_CR206","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1289\/ehp.8552","volume":"114","author":"L Schnaas","year":"2006","unstructured":"Schnaas L, Rothenberg SJ, Flores MF, Martinez S, Hernandez C, Osorio E, Velasco SR, Perroni E (2006) Reduced intellectual development in children with prenatal lead exposure. Environ Health Perspect 114(5):791\u2013797","journal-title":"Environ Health Perspect"},{"issue":"2","key":"7016_CR207","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1002\/bdr2.1620","volume":"112","author":"K Schoner","year":"2019","unstructured":"Schoner K, Witsch-Baumgartner M, Behunova J, Petrovic R, Bald R, Kircher SG, Ramaswamy A, Kluge B, Meyer-Wittkopf M, Schmitz R, Fritz B, Zschocke J, Laccone F, Rehder H (2019) Smith-Lemli-Opitz syndrome\u2014Fetal phenotypes with special reference to the syndrome-specific internal malformation pattern. Birth Defects Res 112(2):175\u2013185","journal-title":"Birth Defects Res"},{"issue":"10","key":"7016_CR208","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1111\/jog.13751","volume":"44","author":"SM Senousy","year":"2018","unstructured":"Senousy SM, Farag MK, Gouda AS, El Noury MA, Dabbous OA, Gaber KR (2018) Association between biomarkers of vitamin B12 status and the risk of neural tube defects. J Obstet Gynaecol Res 44(10):1902\u20131908","journal-title":"J Obstet Gynaecol Res"},{"issue":"11","key":"7016_CR209","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1038\/nrn2734","volume":"10","author":"SL Sensi","year":"2009","unstructured":"Sensi SL, Paoletti P, Bush AI, Sekler I (2009) Zinc in the physiology and pathology of the CNS. Nat Rev Neurosci 10(11):780\u2013791","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"7016_CR210","doi-asserted-by":"publisher","first-page":"125","DOI":"10.4103\/0971-6866.116101","volume":"19","author":"R Sharma","year":"2013","unstructured":"Sharma R (2013) Birth defects in India: Hidden truth, need for urgent attention. Indian J Hum Genet 19(2):125\u2013129","journal-title":"Indian J Hum Genet"},{"issue":"5","key":"7016_CR211","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1093\/aje\/kwh066","volume":"159","author":"L Sharp","year":"2004","unstructured":"Sharp L, Little J (2004) Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review. Am J Epidemiol 159(5):423\u2013443","journal-title":"Am J Epidemiol"},{"issue":"8","key":"7016_CR212","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1093\/carcin\/4.8.1051","volume":"4","author":"N Shivapurkar","year":"1983","unstructured":"Shivapurkar N, Poirier LA (1983) Tissue levels of S-adenosylmethionine and S-adenosylhomocysteine in rats fed methyl-deficient, amino acid-defined diets for one to five weeks. Carcinogenesis 4(8):1051\u20131057","journal-title":"Carcinogenesis"},{"issue":"5","key":"7016_CR213","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/0092-8674(92)90316-5","volume":"70","author":"WC Smith","year":"1992","unstructured":"Smith WC, Harland RM (1992) Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. Cell 70(5):829\u2013840","journal-title":"Cell"},{"issue":"8332","key":"7016_CR214","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/S0140-6736(83)92654-5","volume":"1","author":"RW Smithells","year":"1983","unstructured":"Smithells RW, Nevin NC, Seller MJ, Sheppard S, Harris R, Read AP, Fielding DW, Walker S, Schorah CJ, Wild J (1983) Further experience of vitamin supplementation for prevention of neural tube defect recurrences. Lancet 1(8332):1027\u20131031","journal-title":"Lancet"},{"issue":"8","key":"7016_CR215","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1242\/dev.126.8.1753","volume":"126","author":"MJ Solloway","year":"1999","unstructured":"Solloway MJ, Robertson EJ (1999) Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup. Development 126(8):1753\u20131768","journal-title":"Development"},{"key":"7016_CR216","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ab.2018.10.026","volume":"566","author":"ML Sowers","year":"2018","unstructured":"Sowers ML, Herring J, Zhang W, Tang H, Ou Y, Gu W, Zhang K (2018) Analysis of glucose-derived amino acids involved in one-carbon and cancer metabolism by stable-isotope tracing gas chromatography mass spectrometry. Anal Biochem 566:1\u20139","journal-title":"Anal Biochem"},{"issue":"1","key":"7016_CR217","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1002\/dvdy.20107","volume":"231","author":"O Spiegelstein","year":"2004","unstructured":"Spiegelstein O, Mitchell LE, Merriweather MY, Wicker NJ, Zhang Q, Lammer EJ, Finnell RH (2004) Embryonic development of folate binding protein-1 (Folbp1) knockout mice: Effects of the chemical form, dose, and timing of maternal folate supplementation. Dev Dyn 231(1):221\u2013231","journal-title":"Dev Dyn"},{"issue":"2","key":"7016_CR218","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1002\/tera.1420050208","volume":"5","author":"JM Spyker","year":"1972","unstructured":"Spyker JM, Smithberg M (1972) Effects of methylmercury on prenatal development in mice. Teratology 5(2):181\u2013190","journal-title":"Teratology"},{"issue":"9","key":"7016_CR219","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1242\/dev.01794","volume":"132","author":"CD Stern","year":"2005","unstructured":"Stern CD (2005) Neural induction: old problem, new findings, yet more questions. Development 132(9):2007\u20132021","journal-title":"Development"},{"issue":"22","key":"7016_CR220","doi-asserted-by":"publisher","first-page":"3715","DOI":"10.1007\/s00018-012-0991-8","volume":"69","author":"TJ Stuhlmiller","year":"2012","unstructured":"Stuhlmiller TJ, Garcia-Castro MI (2012) Current perspectives of the signaling pathways directing neural crest induction. Cell Mol Life Sci 69(22):3715\u20133737","journal-title":"Cell Mol Life Sci"},{"key":"7016_CR221","doi-asserted-by":"crossref","unstructured":"Sudiwala S, Palmer A, Massa V, Burns AJ, Dunlevy LPE,. de Castro SCP, Savery D, Leung KY, Copp AJ, Greene NDE (2019) Cellular mechanisms underlying Pax3-related neural tube defects and their prevention by folic acid. Dis Model Mech 12(11):1\u201310","DOI":"10.1242\/dmm.042234"},{"issue":"1","key":"7016_CR222","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1093\/clinids\/5.1.137","volume":"5","author":"B Sugarman","year":"1983","unstructured":"Sugarman B (1983) Zinc and infection. Rev Infect Dis 5(1):137\u2013147","journal-title":"Rev Infect Dis"},{"issue":"3","key":"7016_CR223","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1080\/15287399409531921","volume":"43","author":"LG Sultatos","year":"1994","unstructured":"Sultatos LG (1994) Mammalian toxicology of organophosphorus pesticides. J Toxicol Environ Health 43(3):271\u2013289","journal-title":"J Toxicol Environ Health"},{"issue":"3","key":"7016_CR224","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1093\/oxfordjournals.aje.a009439","volume":"147","author":"E Susser","year":"1998","unstructured":"Susser E, Hoek HW, Brown A (1998) Neurodevelopmental disorders after prenatal famine: the story of the dutch famine study. Am J Epidemiol 147(3):213\u2013216","journal-title":"Am J Epidemiol"},{"key":"7016_CR225","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/1471-2393-13-198","volume":"13","author":"D Sussman","year":"2013","unstructured":"Sussman D, Ellegood J, Henkelman M (2013) A gestational ketogenic diet alters maternal metabolic status as well as offspring physiological growth and brain structure in the neonatal mouse. BMC Pregnancy Childbirth 13:198","journal-title":"BMC Pregnancy Childbirth"},{"issue":"6","key":"7016_CR226","first-page":"435","volume":"8","author":"JH Sweiry","year":"1986","unstructured":"Sweiry JH, Page KR, Dacke CG, Abramovich DR, Yudilevich DL (1986) Evidence of saturable uptake mechanisms at maternal and fetal sides of the perfused human placenta by rapid paired-tracer dilution: studies with calcium and choline. J Dev Physiol 8(6):435\u2013445","journal-title":"J Dev Physiol"},{"issue":"22","key":"7016_CR227","doi-asserted-by":"publisher","first-page":"4095","DOI":"10.1242\/dev.010272","volume":"134","author":"E Tahinci","year":"2007","unstructured":"Tahinci E, Thorne CA, Franklin JL, Salic A, Christian KM, Lee LA, Coffey RJ, Lee E (2007) Lrp6 is required for convergent extension during Xenopus gastrulation. Development 134(22):4095\u20134106","journal-title":"Development"},{"issue":"4","key":"7016_CR228","doi-asserted-by":"publisher","first-page":"223","DOI":"10.4161\/cam.2.4.6835","volume":"2","author":"LA Taneyhill","year":"2008","unstructured":"Taneyhill LA (2008) To adhere or not to adhere: the role of Cadherins in neural crest development. Cell Adh Migr 2(4):223\u2013230","journal-title":"Cell Adh Migr"},{"issue":"Suppl 1","key":"7016_CR229","first-page":"S81","volume":"18","author":"Z Tolou-Ghamari","year":"2013","unstructured":"Tolou-Ghamari Z, Zare M, Habibabadi JM, Najafi MR (2013) A quick review of carbamazepine pharmacokinetics in epilepsy from 1953 to 2012. J Res Med Sci 18(Suppl 1):S81-85","journal-title":"J Res Med Sci"},{"key":"7016_CR230","doi-asserted-by":"publisher","first-page":"106425","DOI":"10.1016\/j.envint.2021.106425","volume":"150","author":"M Tong","year":"2021","unstructured":"Tong M, Yu J, Liu M, Li Z, Wang L, Yin C, Ren A, Chen L, Jin L (2021) Total mercury concentration in placental tissue, a good biomarker of prenatal mercury exposure, is associated with risk for neural tube defects in offspring. Environ Int 150:106425","journal-title":"Environ Int"},{"key":"7016_CR231","doi-asserted-by":"publisher","DOI":"10.1242\/dev.199961","author":"WB Tu","year":"2023","unstructured":"Tu WB, Christofk HR, Plath K (2023) Nutrient regulation of development and cell fate decisions. Development. https:\/\/doi.org\/10.1242\/dev.199961","journal-title":"Development"},{"issue":"22","key":"7016_CR232","doi-asserted-by":"publisher","first-page":"4921","DOI":"10.1242\/dev.070805","volume":"138","author":"M Tuson","year":"2011","unstructured":"Tuson M, He M, Anderson KV (2011) Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube. Development 138(22):4921\u20134930","journal-title":"Development"},{"issue":"1","key":"7016_CR233","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/j.1528-1167.2012.03625.x","volume":"54","author":"FJ Vajda","year":"2012","unstructured":"Vajda FJ, O\u2019Brien TJ, Lander CM, Graham J, Roten A, Eadie MJ (2012) Teratogenesis in repeated pregnancies in antiepileptic drug-treated women. Epilepsia 54(1):181\u2013186","journal-title":"Epilepsia"},{"issue":"12","key":"7016_CR234","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/0962-8924(96)84934-8","volume":"6","author":"M van den Heuvel","year":"1996","unstructured":"van den Heuvel M, Ingham PW (1996) \u201cSmoothening\u201d the path for hedgehogs. Trends Cell Biol 6(12):451\u2013453","journal-title":"Trends Cell Biol"},{"issue":"1","key":"7016_CR235","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.ymgme.2007.01.009","volume":"91","author":"IJ van der Linden","year":"2007","unstructured":"van der Linden IJ, Nguyen U, Heil SG, Franke B, Vloet S, Gellekink H, den Heijer M, Blom HJ (2007) Variation and expression of dihydrofolate reductase (DHFR) in relation to spina bifida. Mol Genet Metab 91(1):98\u2013103","journal-title":"Mol Genet Metab"},{"issue":"8982","key":"7016_CR236","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/S0140-6736(95)91743-8","volume":"346","author":"NM van der Put","year":"1995","unstructured":"van der Put NM, Steegers-Theunissen RP, Frosst P, Trijbels FJ, Eskes TK, van den Heuvel LP, Mariman EC, den Heyer M, Rozen R, Blom HJ (1995) Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet 346(8982):1070\u20131071","journal-title":"Lancet"},{"key":"7016_CR237","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.reprotox.2018.05.004","volume":"80","author":"JD van Gool","year":"2018","unstructured":"van Gool JD, Hirche H, Lax H, De Schaepdrijver L (2018) Folic acid and primary prevention of neural tube defects: a review. Reprod Toxicol 80:73\u201384","journal-title":"Reprod Toxicol"},{"key":"7016_CR238","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/B978-0-323-85652-2.00015-4","volume-title":"Epigenetics and Metabolomics","author":"S Veleri","year":"2021","unstructured":"Veleri S (2021) Nutrients seminal role in the development and epigenetic reprogramming during the first 1000 days of life. Epigenetics and Metabolomics. Academic Press, pp 265\u2013277"},{"key":"7016_CR239","doi-asserted-by":"publisher","first-page":"4207","DOI":"10.1038\/ncomms5207","volume":"5","author":"S Veleri","year":"2014","unstructured":"Veleri S, Manjunath SH, Fariss RN, May-Simera H, Brooks M, Foskett TA, Gao C, Longo TA, Liu P, Nagashima K, Rachel RA, Li T, Dong L, Swaroop A (2014) Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal appendages on the mother centriole during cilia biogenesis. Nat Commun 5:4207","journal-title":"Nat Commun"},{"issue":"3","key":"7016_CR240","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.hoc.2012.02.002","volume":"26","author":"M Visentin","year":"2012","unstructured":"Visentin M, Zhao R, Goldman ID (2012) The antifolates. Hematol Oncol Clin North Am 26(3):629\u2013648","journal-title":"Hematol Oncol Clin North Am"},{"issue":"9298","key":"7016_CR241","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1016\/S0140-6736(01)07104-5","volume":"358","author":"NJ Wald","year":"2001","unstructured":"Wald NJ, Law MR, Morris JK, Wald DS (2001) Quantifying the effect of folic acid. Lancet 358(9298):2069\u20132073","journal-title":"Lancet"},{"issue":"20","key":"7016_CR242","doi-asserted-by":"publisher","first-page":"4421","DOI":"10.1242\/dev.02068","volume":"132","author":"JB Wallingford","year":"2005","unstructured":"Wallingford JB, Habas R (2005) The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity. Development 132(20):4421\u20134436","journal-title":"Development"},{"issue":"23","key":"7016_CR243","doi-asserted-by":"publisher","first-page":"5442","DOI":"10.1016\/j.febslet.2006.07.027","volume":"580","author":"HR Waterham","year":"2006","unstructured":"Waterham HR (2006) Defects of cholesterol biosynthesis. FEBS Lett 580(23):5442\u20135449","journal-title":"FEBS Lett"},{"issue":"5","key":"7016_CR244","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1083\/jcb.200307181","volume":"162","author":"G Weidinger","year":"2003","unstructured":"Weidinger G, Moon RT (2003) When Wnts antagonize Wnts. J Cell Biol 162(5):753\u2013755","journal-title":"J Cell Biol"},{"issue":"2","key":"7016_CR245","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0021-9150(03)00010-8","volume":"167","author":"IS Weisberg","year":"2003","unstructured":"Weisberg IS, Park E, Ballman KV, Berger P, Nunn M, Suh DS, Breksa AP 3rd, Garrow TA, Rozen R (2003) Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease. Atherosclerosis 167(2):205\u2013214","journal-title":"Atherosclerosis"},{"issue":"21","key":"7016_CR246","doi-asserted-by":"publisher","first-page":"5393","DOI":"10.1242\/dev.01379","volume":"131","author":"L Wine-Lee","year":"2004","unstructured":"Wine-Lee L, Ahn KJ, Richardson RD, Mishina Y, Lyons KM, Crenshaw EB 3rd (2004) Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord. Development 131(21):5393\u20135403","journal-title":"Development"},{"key":"7016_CR247","doi-asserted-by":"publisher","first-page":"2630","DOI":"10.12659\/MSM.895155","volume":"21","author":"J Wu","year":"2015","unstructured":"Wu J, Bao Y, Lu X, Wu L, Zhang T, Guo J, Yang J (2015) Polymorphisms in MTHFD1 gene and susceptibility to neural tube defects: a case-control study in a chinese han population with relatively low folate levels. Med Sci Monit 21:2630\u20132637","journal-title":"Med Sci Monit"},{"issue":"1","key":"7016_CR248","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s12986-016-0114-x","volume":"13","author":"L Xu","year":"2016","unstructured":"Xu L, Wang L, Wang J, Zhu Z, Chang G, Guo Y, Tian X, Niu B (2016) The effect of inhibiting glycinamide ribonucleotide formyl transferase on the development of neural tube in mice. Nutr Metab (Lond) 13(1):56","journal-title":"Nutr Metab (Lond)"},{"key":"7016_CR249","doi-asserted-by":"publisher","first-page":"e803","DOI":"10.1016\/j.wneu.2021.01.096","volume":"149","author":"A Yacob","year":"2021","unstructured":"Yacob A, Carr CJ, Foote J, Scullen T, Werner C, Mathkour M, Bui CJ, Dumont AS (2021) The global burden of neural tube defects and disparities in neurosurgical care. World Neurosurg 149:e803\u2013e820","journal-title":"World Neurosurg"},{"issue":"5","key":"7016_CR250","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1096\/fj.201700783RR","volume":"32","author":"M Yamazaki","year":"2018","unstructured":"Yamazaki M, Yamada H, Munetsuna E, Ishikawa H, Mizuno G, Mukuda T, Mouri A, Nabeshima T, Saito K, Suzuki K, Hashimoto S, Ohashi K (2018) Excess maternal fructose consumption impairs hippocampal function in offspring via epigenetic modification of BDNF promoter. FASEB J 32(5):2549\u20132562","journal-title":"FASEB J"},{"issue":"3","key":"7016_CR251","doi-asserted-by":"publisher","first-page":"386","DOI":"10.3340\/jkns.2021.0023","volume":"64","author":"J Yang","year":"2021","unstructured":"Yang J, Lee JY, Kim KH, Wang KC (2021) Disorders of secondary neurulation\u202f: mainly focused on pathoembryogenesis. J Korean Neurosurg Soc 64(3):386\u2013405","journal-title":"J Korean Neurosurg Soc"},{"key":"7016_CR252","doi-asserted-by":"publisher","first-page":"135146","DOI":"10.1016\/j.scitotenv.2019.135146","volume":"708","author":"S Yin","year":"2019","unstructured":"Yin S, Wei J, Wei Y, Jin L, Wang L, Zhang X, Jia X, Ren A (2019) Organochlorine pesticides exposure may disturb homocysteine metabolism in pregnant women. Sci Total Environ 708:135146","journal-title":"Sci Total Environ"},{"issue":"11","key":"7016_CR253","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1038\/s10038-020-0793-z","volume":"65","author":"H Yin","year":"2020","unstructured":"Yin H, Peng R, Chen Z, Wang H, Zhang T, Zheng Y (2020) WDR34 mutation from anencephaly patients impaired both SHH and PCP signaling pathways. J Hum Genet 65(11):985\u2013993","journal-title":"J Hum Genet"},{"issue":"5","key":"7016_CR254","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/dneu.20765","volume":"70","author":"A Yoshii","year":"2010","unstructured":"Yoshii A, Constantine-Paton M (2010) Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease. Dev Neurobiol 70(5):304\u2013322","journal-title":"Dev Neurobiol"},{"issue":"3","key":"7016_CR255","first-page":"201","volume":"98","author":"HY Yu","year":"1999","unstructured":"Yu HY, Shen YZ (1999) Displacement effect of valproate on bilirubin-albumin binding in human plasma. J Formos Med Assoc 98(3):201\u2013204","journal-title":"J Formos Med Assoc"},{"issue":"9","key":"7016_CR256","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1002\/jat.2769","volume":"33","author":"J Zhao","year":"2012","unstructured":"Zhao J, Guan T, Wang J, Xiang Q, Wang M, Wang X, Guan Z, Xie Q, Niu B, Zhang T (2012) Influence of the antifolate drug Methotrexate on the development of murine neural tube defects and genomic instability. J Appl Toxicol 33(9):915\u2013923","journal-title":"J Appl Toxicol"},{"key":"7016_CR257","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.jes.2023.03.036","volume":"138","author":"S Zhu","year":"2024","unstructured":"Zhu S, Li X, Dai X, Li J (2024) Prenatal cadmium exposure impairs neural tube closure via inducing excessive apoptosis in neuroepithelium. J Environ Sci (China) 138:572\u2013584","journal-title":"J Environ Sci (China)"},{"issue":"4","key":"7016_CR258","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/S0092-8674(00)80133-6","volume":"86","author":"LB Zimmerman","year":"1996","unstructured":"Zimmerman LB, De Jesus-Escobar JM, Harland RM (1996) The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 86(4):599\u2013606","journal-title":"Cell"}],"container-title":["Experimental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-025-07016-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00221-025-07016-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-025-07016-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T09:01:52Z","timestamp":1745053312000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00221-025-07016-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,2]]},"references-count":258,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["7016"],"URL":"https:\/\/doi.org\/10.1007\/s00221-025-07016-9","relation":{},"ISSN":["0014-4819","1432-1106"],"issn-type":[{"value":"0014-4819","type":"print"},{"value":"1432-1106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,2]]},"assertion":[{"value":"7 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no competing interests to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"79"}}