{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:49:51Z","timestamp":1788922191851,"version":"build-2803163510"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020MH131"],"award-info":[{"award-number":["ZR2020MH131"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Project of Medical and Health Science and Technology Development Plan of Shandong Province","award":["2019WS316"],"award-info":[{"award-number":["2019WS316"]}]},{"name":"Project of Medical and Health Science and Technology Development Plan of Shandong Province","award":["202001020608"],"award-info":[{"award-number":["202001020608"]}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2023NSFSC1566"],"award-info":[{"award-number":["2023NSFSC1566"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Brain Res"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1007\/s00221-025-07066-z","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T08:31:16Z","timestamp":1746693076000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Supraspinal kappa-opioid receptors: new therapeutic strategies for pain, pruritus, and negative emotions"],"prefix":"10.1007","volume":"243","author":[{"given":"Li","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lujin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqi","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3264-0868","authenticated-orcid":false,"given":"Yi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"7066_CR1","doi-asserted-by":"publisher","first-page":"8031","DOI":"10.1523\/JNEUROSCI.0653-18.2018","volume":"38","author":"AD Abraham","year":"2018","unstructured":"Abraham AD, Schattauer SS, Reichard KL, Cohen JH, Fontaine HM, Song AJ, Johnson SD, Land BB, Chavkin C (2018) Estrogen regulation of GRK2 inactivates kappa opioid receptor signaling mediating analgesia, but not aversion. J Neurosci 38:8031\u20138043. https:\/\/doi.org\/10.1523\/JNEUROSCI.0653-18.2018","journal-title":"J Neurosci"},{"key":"7066_CR2","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/164_2021_519","volume-title":"The kappa opioid receptor","author":"JV Aldrich","year":"2021","unstructured":"Aldrich JV, McLaughlin JP (2021) Peptide kappa opioid receptor ligands and their potential for drug development. In: Liu-Chen L-Y, Inan S (eds) The kappa opioid receptor. Springer International Publishing, Cham, pp 197\u2013220. https:\/\/doi.org\/10.1007\/164_2021_519"},{"key":"7066_CR3","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1248\/bpb.b20-00097","volume":"43","author":"T Andoh","year":"2020","unstructured":"Andoh T, Suzuki K, Konno M, Tsuneyama K, Kuraishi Y (2020) Pharmacological characterization of a novel mouse model of cholestatic pruritus. Biol Pharm Bull 43:1111\u20131117. https:\/\/doi.org\/10.1248\/bpb.b20-00097","journal-title":"Biol Pharm Bull"},{"key":"7066_CR4","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1126\/scisignal.aai8441","volume":"9","author":"TF Brust","year":"2016","unstructured":"Brust TF, Morgenweck J, Kim SA, Rose JH, Locke JL, Schmid CL, Zhou L, Stahl EL, Cameron MD, Scarry SM, Aub\u00e9 J, Jones SR, Martin TJ, Bohn LM (2016) Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria. Sci Signal 9:117. https:\/\/doi.org\/10.1126\/scisignal.aai8441","journal-title":"Sci Signal"},{"key":"7066_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/164_2021_433","volume-title":"The kappa opioid receptor","author":"C Cahill","year":"2021","unstructured":"Cahill C, Tejeda HA, Spetea M, Chen C, Liu-Chen L-Y (2021) Fundamentals of the dynorphins\/kappa opioid receptor system: from distribution to signaling and function. In: Liu-Chen L-Y, Inan S (eds) The kappa opioid receptor. Springer International Publishing, Cham, pp 3\u201321. https:\/\/doi.org\/10.1007\/164_2021_433"},{"key":"7066_CR6","doi-asserted-by":"publisher","unstructured":"Can A, Dao DT, Terrillion CE, Piantadosi SC, Bhat S, Gould TD (2011) The tail suspension test. J Vis Exp 3769. https:\/\/doi.org\/10.3791\/3769","DOI":"10.3791\/3769"},{"key":"7066_CR7","doi-asserted-by":"publisher","unstructured":"Carlezon WA, Krystal AD (2016) Kappa-opioid antagonists for psychiatric disorders: from bench to clinical trials: 2015 ADAA scientific research symposium: KORs in psychiatric illness. Depress Anxiety 33:895\u2013906. https:\/\/doi.org\/10.1002\/da.22500","DOI":"10.1002\/da.22500"},{"key":"7066_CR8","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/ejp.1120","volume":"22","author":"U Coffeen","year":"2018","unstructured":"Coffeen U, Canseco-Alba A, Sim\u00f3n\u2010Arceo K, Almanza A, Mercado F, Le\u00f3n\u2010Olea M, Pellicer F (2018) Salvinorin A reduces neuropathic nociception in the insular cortex of the rat. Eur J Pain 22:311\u2013318. https:\/\/doi.org\/10.1002\/ejp.1120","journal-title":"Eur J Pain"},{"key":"7066_CR9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/0091-3057(94)90106-6","volume":"47","author":"R Dirksen","year":"1994","unstructured":"Dirksen R, Van Diejen D, Van Luijtelaar ELJM, Booij LHDJ (1994) Site- and test-dependent antinociceptive efficacy of amitriptyline in rats. Pharmacol Biochem Behav 47:21\u201326. https:\/\/doi.org\/10.1016\/0091-3057(94)90106-6","journal-title":"Pharmacol Biochem Behav"},{"key":"7066_CR10","doi-asserted-by":"publisher","first-page":"154359","DOI":"10.1016\/j.jcrc.2023.154359","volume":"78","author":"C Docherty","year":"2023","unstructured":"Docherty C, McPeake J, Quasim T, MacTavish P, Devine H, O\u2019Brien P, Strachan L, Lucie P, Hogg L, Sim M, Shaw M (2023) The relationship between pain, anxiety and depression in patients with post-intensive care syndrome. J Crit Care 78:154359. https:\/\/doi.org\/10.1016\/j.jcrc.2023.154359","journal-title":"J Crit Care"},{"key":"7066_CR11","doi-asserted-by":"publisher","first-page":"33401","DOI":"10.1038\/srep33401","volume":"6","author":"S Dogra","year":"2016","unstructured":"Dogra S, Kumar A, Umrao D, Sahasrabuddhe AA, Yadav PN (2016) Chronic kappa opioid receptor activation modulates NR2B: implication in treatment resistant depression. Sci Rep 6:33401. https:\/\/doi.org\/10.1038\/srep33401","journal-title":"Sci Rep"},{"key":"7066_CR12","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1002\/jps.3030460322","volume":"46","author":"NW Dunham","year":"1957","unstructured":"Dunham NW, Miya TS (1957) A note on a simple apparatus for detecting neurological deficit in rats and mice. J Am Pharm Assoc Sci Ed 46:208\u2013209. https:\/\/doi.org\/10.1002\/jps.3030460322","journal-title":"J Am Pharm Assoc Sci Ed"},{"key":"7066_CR13","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","volume":"32","author":"K Hargreaves","year":"1988","unstructured":"Hargreaves K, Dubner R, Brown F, Flores C, Joris J (1988) A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32:77\u201388. https:\/\/doi.org\/10.1016\/0304-3959(88)90026-7","journal-title":"Pain"},{"key":"7066_CR14","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/S0091-3057(96)00348-6","volume":"57","author":"NTT Huong","year":"1997","unstructured":"Huong NTT, Matsumoto K, Yamasaki K, Duc NM, Nham NT, Watanabe H (1997) Majonoside-R2, a major constituent of Vietnamese ginseng, attenuates opioid-induced antinociception. Pharmacol Biochem Behav 57:285\u2013291. https:\/\/doi.org\/10.1016\/S0091-3057(96)00348-6","journal-title":"Pharmacol Biochem Behav"},{"key":"7066_CR15","doi-asserted-by":"publisher","first-page":"173394","DOI":"10.1016\/j.pbb.2022.173394","volume":"217","author":"SL Huskinson","year":"2022","unstructured":"Huskinson SL, Platt DM, Zamarripa CA, Dunaway K, Brasfield M, Prisinzano TE, Blough BE, Freeman KB (2022) The G-protein biased kappa opioid agonists, Triazole 1.1 and Nalfurafine, produce non-uniform behavioral effects in male rhesus monkeys. Pharmacol Biochem Behav 217:173394. https:\/\/doi.org\/10.1016\/j.pbb.2022.173394","journal-title":"Pharmacol Biochem Behav"},{"key":"7066_CR16","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/164_2020_420","volume-title":"The kappa opioid receptor","author":"S Inan","year":"2020","unstructured":"Inan S, Cowan A (2020) Antipruritic effects of kappa opioid receptor agonists: evidence from rodents to humans. In: Liu-Chen L-Y, Inan S (eds) The kappa opioid receptor. Springer International Publishing, Cham, pp 275\u2013292"},{"key":"7066_CR17","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/s0014-2999(01)00941-4","volume":"418","author":"J Kamei","year":"2001","unstructured":"Kamei J, Nagase H (2001) Norbinaltorphimine, a selective k-opioid receptor antagonist, induces an itch-associated response in mice. Eur J Pharmacol 418:141\u2013145. https:\/\/doi.org\/10.1016\/s0014-2999(01)00941-4","journal-title":"Eur J Pharmacol"},{"key":"7066_CR18","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.neuron.2014.02.046","volume":"82","author":"AP Kardon","year":"2014","unstructured":"Kardon AP, Polg\u00e1r E, Hachisuka J, Snyder LM, Cameron D, Savage S, Cai X, Karnup S, Fan CR, Hemenway GM, Bernard CS, Schwartz ES, Nagase H, Schwarzer C, Watanabe M, Furuta T, Kaneko T, Koerber HR, Todd AJ, Ross SE (2014) Dynorphin acts as a neuromodulator to inhibit itch in the dorsal Horn of the spinal cord. Neuron 82:573\u2013586. https:\/\/doi.org\/10.1016\/j.neuron.2014.02.046","journal-title":"Neuron"},{"key":"7066_CR19","doi-asserted-by":"publisher","first-page":"114785","DOI":"10.1016\/j.ejmech.2022.114785","volume":"243","author":"MIH Khan","year":"2022","unstructured":"Khan MIH, Sawyer BJ, Akins NS, Le HV (2022) A systematic review on the kappa opioid receptor and its ligands: new directions for the treatment of pain, anxiety, depression, and drug abuse. Eur J Med Chem 243:114785. https:\/\/doi.org\/10.1016\/j.ejmech.2022.114785","journal-title":"Eur J Med Chem"},{"key":"7066_CR20","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1124\/jpet.102.044909","volume":"305","author":"MCH Ko","year":"2003","unstructured":"Ko MCH, Lee H, Song MS, Sobczyk-Kojiro K, Mosberg HI, Kishioka S, Woods JH, Naughton NN (2003) Activation of \u03ba-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys. J Pharmacol Exp Ther 305:173\u2013179. https:\/\/doi.org\/10.1124\/jpet.102.044909","journal-title":"J Pharmacol Exp Ther"},{"key":"7066_CR21","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1111\/ejn.14686","volume":"53","author":"M Kremer","year":"2021","unstructured":"Kremer M, Becker LJ, Barrot M, Yalcin I (2021) How to study anxiety and depression in rodent models of chronic pain? Eur J Neurosci 53:236\u2013270. https:\/\/doi.org\/10.1111\/ejn.14686","journal-title":"Eur J Neurosci"},{"key":"7066_CR22","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.jaad.2016.11.021","volume":"76","author":"H Kuhn","year":"2017","unstructured":"Kuhn H, Mennella C, Magid M, Stamu-O\u2019Brien C, Kroumpouzos G (2017) Psychocutaneous disease. J Am Acad Dermatol 76:795\u2013808. https:\/\/doi.org\/10.1016\/j.jaad.2016.11.021","journal-title":"J Am Acad Dermatol"},{"key":"7066_CR23","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/S0166-4328(97)00198-8","volume":"94","author":"G Liebsch","year":"1998","unstructured":"Liebsch G, Montkowski A, Holsboer F, Landgraf R (1998) Behavioural profiles of two Wistar rat lines selectively bred for high or low anxiety-related behaviour. Behav Brain Res 94:301\u2013310. https:\/\/doi.org\/10.1016\/S0166-4328(97)00198-8","journal-title":"Behav Brain Res"},{"key":"7066_CR24","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.3389\/fphar.2018.01388","volume":"9","author":"H Machelska","year":"2018","unstructured":"Machelska H, Celik M\u00d6 (2018) Advances in achieving opioid analgesia without side effects. Front Pharmacol 9:1388. https:\/\/doi.org\/10.3389\/fphar.2018.01388","journal-title":"Front Pharmacol"},{"key":"7066_CR25","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1002\/ejp.1003","volume":"21","author":"A Malfliet","year":"2017","unstructured":"Malfliet A, Coppieters I, Van Wilgen P, Kregel J, De Pauw R, Dolphens M, Ickmans K (2017) Brain changes associated with cognitive and emotional factors in chronic pain: A systematic review. Eur J Pain 21:769\u2013786. https:\/\/doi.org\/10.1002\/ejp.1003","journal-title":"Eur J Pain"},{"key":"7066_CR26","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1097\/00000542-200404000-00022","volume":"100","author":"H Mansikka","year":"2004","unstructured":"Mansikka H, Uhl G (2004) Nerve injury induces a tonic bilateral \u00b5-opioid receptor\u2013 mediated inhibitory effect on mechanical allodynia in mice. Srinivasa N Raja Anesthesiology 100:912\u2013921. https:\/\/doi.org\/10.1097\/00000542-200404000-00022","journal-title":"Srinivasa N Raja Anesthesiology"},{"key":"7066_CR27","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1080\/00325481.2019.1663705","volume":"131","author":"A Michaelides","year":"2019","unstructured":"Michaelides A, Zis P (2019) Depression, anxiety and acute pain: links and management challenges. Postgrad Med 131:438\u2013444. https:\/\/doi.org\/10.1080\/00325481.2019.1663705","journal-title":"Postgrad Med"},{"key":"7066_CR28","doi-asserted-by":"publisher","first-page":"e104420","DOI":"10.1371\/journal.pone.0104420","volume":"9","author":"J Mika","year":"2014","unstructured":"Mika J, Popiolek-Barczyk K, Rojewska E, Makuch W, Starowicz K, Przewlocka B (2014) Delta-opioid receptor analgesia is independent of microglial activation in a rat model of neuropathic pain. PLoS ONE 9:e104420. https:\/\/doi.org\/10.1371\/journal.pone.0104420","journal-title":"PLoS ONE"},{"issue":"1","key":"7066_CR29","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/S0022-3565(25)24719-X","volume":"257","author":"CW Murray","year":"1991","unstructured":"Murray CW, Cowan A (1991) Tonic pain perception in the mouse: differential modulation by three receptor-selective opioid agonists. J Pharmacol Exp Ther 257(1):335\u2013341","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"7066_CR30","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1254\/jjp.62.15","volume":"62","author":"M Narita","year":"1993","unstructured":"Narita M, Takahashi Y, Takamori K, Funada M, Suzuki T, Misawa M, Nagase H (1993) Effects of kappa-agonist on the antinociception and locomotor enhancing action induced by morphine in mice. Jpn J Pharmacol 62(1):15\u201324. https:\/\/doi.org\/10.1254\/jjp.62.15","journal-title":"Jpn J Pharmacol"},{"key":"7066_CR31","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.1093\/brain\/awac189","volume":"145","author":"E Nguyen","year":"2022","unstructured":"Nguyen E, Smith KM, Cramer N, Holland RA, Bleimeister IH, Flores-Felix K, Silberberg H, Keller A, Pichon CEL, Ross SE (2022) Medullary kappa-opioid receptor neurons inhibit pain and itch through a descending circuit. Brain 145:2586\u20132601. https:\/\/doi.org\/10.1093\/brain\/awac189","journal-title":"Brain"},{"key":"7066_CR32","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyz054","author":"S Page","year":"2019","unstructured":"Page S, Mavrikaki MM, Lintz T, Puttick D, Roberts E, Rosen H, Carroll FI, Carlezon WA, Chartoff EH (2019) Behavioral Pharmacology of novel kappa opioid receptor antagonists in rats. Int J Neuropsychopharmacol. https:\/\/doi.org\/10.1093\/ijnp\/pyz054. pyz054","journal-title":"Int J Neuropsychopharmacol"},{"key":"7066_CR33","doi-asserted-by":"publisher","first-page":"3611","DOI":"10.1016\/j.neuroimage.2011.10.099","volume":"59","author":"ADP Papoiu","year":"2012","unstructured":"Papoiu ADP, Coghill RC, Kraft RA, Wang H, Yosipovitch G (2012) A Tale of two itches. Common features and notable differences in brain activation evoked by cowhage and Histamine induced itch. NeuroImage 59:3611\u20133623. https:\/\/doi.org\/10.1016\/j.neuroimage.2011.10.099","journal-title":"NeuroImage"},{"key":"7066_CR34","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.drugalcdep.2012.01.013","volume":"124","author":"J Peng","year":"2012","unstructured":"Peng J, Sarkar S, Chang SL (2012) Opioid receptor expression in human brain and peripheral tissues using absolute quantitative real-time RT-PCR. Drug Alcohol Depend 124:223\u2013228. https:\/\/doi.org\/10.1016\/j.drugalcdep.2012.01.013","journal-title":"Drug Alcohol Depend"},{"key":"7066_CR35","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1111\/j.1476-5381.1994.tb17155.x","volume":"113","author":"S Pieretti","year":"1994","unstructured":"Pieretti S, Giannuario AD, Domenici MR, Loizzo A (1994) Dexamethasone-induced selective Inhibition of the central \u039c opioid receptor: functional in vivo and in vitro evidence in rodents. Br J Pharmacol 113:1416\u20131422. https:\/\/doi.org\/10.1111\/j.1476-5381.1994.tb17155.x","journal-title":"Br J Pharmacol"},{"key":"7066_CR36","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1007\/BF02245945","volume":"118","author":"TH Privette","year":"1995","unstructured":"Privette TH, Terrian DM (1995) Kappa opioid agonists produce anxiolytic-like behavior on the elevated plus-maze. Psychopharmacology 118:444\u2013450. https:\/\/doi.org\/10.1007\/BF02245945","journal-title":"Psychopharmacology"},{"key":"7066_CR37","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/S0022-3565(25)23495-4","volume":"249","author":"C Roerig","year":"1989","unstructured":"Roerig C (1989) Multiplicative interaction between intrathecally and intracerebroventricularly administered mu opioid agonists but limited interactions between delta and kappa agonists for antinociception in mice. J Pharmacol Exp Ther 249:762\u2013768","journal-title":"J Pharmacol Exp Ther"},{"key":"7066_CR38","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.ejphar.2018.03.008","volume":"827","author":"K Rutten","year":"2018","unstructured":"Rutten K, Schr\u00f6der W, Christoph T, Koch T, Tzschentke TM (2018) Selectivity profiling of NOP, MOP, DOP and KOP receptor antagonists in the rat spinal nerve ligation model of mononeuropathic pain. Eur J Pharmacol 827:41\u201348. https:\/\/doi.org\/10.1016\/j.ejphar.2018.03.008","journal-title":"Eur J Pharmacol"},{"key":"7066_CR39","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.anai.2019.04.020","volume":"123","author":"JI Silverberg","year":"2019","unstructured":"Silverberg JI (2019) Comorbidities and the impact of atopic dermatitis. Ann Allergy Asthma Immunol 123:144\u2013151. https:\/\/doi.org\/10.1016\/j.anai.2019.04.020","journal-title":"Ann Allergy Asthma Immunol"},{"key":"7066_CR40","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1254\/jphs.94.305","volume":"94","author":"S Sounvoravong","year":"2004","unstructured":"Sounvoravong S, Takahashi M, Nakashima MN, Nakashima K (2004) Disability of development of tolerance to morphine and U-50,488H, a selective -opioid receptor agonist, in neuropathic pain model mice. J Pharmacol Sci 94:305\u2013312. https:\/\/doi.org\/10.1254\/jphs.94.305","journal-title":"J Pharmacol Sci"},{"key":"7066_CR41","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.1111\/bph.13854","volume":"174","author":"M Spetea","year":"2017","unstructured":"Spetea M, Eans SO, Ganno ML, Lantero A, Mairegger M, Toll L, Schmidhammer H, McLaughlin JP (2017) Selective \u039a receptor partial agonist HS666 produces potent antinociception without inducing aversion after I.c.v. Administration in mice. Br J Pharmacol 174:2444\u20132456. https:\/\/doi.org\/10.1111\/bph.13854","journal-title":"Br J Pharmacol"},{"key":"7066_CR42","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.pain.2006.01.003","volume":"122","author":"T Sprenger","year":"2006","unstructured":"Sprenger T, Valet M, Boecker H, Henriksen G, Spilker ME, Willoch F, Wagner KJ, Wester HJ, T\u00f6lle TR (2006) Opioidergic activation in the medial pain system after heat pain. Pain 122:63\u201367. https:\/\/doi.org\/10.1016\/j.pain.2006.01.003","journal-title":"Pain"},{"issue":"1","key":"7066_CR43","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0022-3565(25)21011-4","volume":"246","author":"AE Takemori","year":"1988","unstructured":"Takemori AE, Ho BY, Naeseth JS, Portoghese PS (1988) Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays. J Pharmacol Exp Ther 246(1):255\u2013258","journal-title":"J Pharmacol Exp Ther"},{"key":"7066_CR44","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.1016\/j.lfs.2004.05.033","volume":"75","author":"Y Wakasa","year":"2004","unstructured":"Wakasa Y, Fujiwara A, Umeuchi H, Endoh T, Okano K, Tanaka T, Nagase H (2004) Inhibitory effects of TRK-820 on systemic skin scratching induced by morphine in rhesus monkeys. Life Sci 75:2947\u20132957. https:\/\/doi.org\/10.1016\/j.lfs.2004.05.033","journal-title":"Life Sci"},{"key":"7066_CR45","doi-asserted-by":"publisher","first-page":"e00964","DOI":"10.1002\/brb3.964","volume":"8","author":"X Wang","year":"2018","unstructured":"Wang X, Yang G, Bai Y, Feng Y, Li H (2018) The behavioral study on the interactive aggravation between pruritus and depression. Brain Behav 8:e00964. https:\/\/doi.org\/10.1002\/brb3.964","journal-title":"Brain Behav"},{"key":"7066_CR46","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1038\/npp.2008.188","volume":"34","author":"MD Wiley","year":"2009","unstructured":"Wiley MD, Poveromo LB, Antapasis J, Herrera CM (2009) \u03ba-opioid system regulates the long-lasting behavioral adaptations induced by early-life exposure to methylphenidate. Neuropsychopharmacology 34:1339\u20131350. https:\/\/doi.org\/10.1038\/npp.2008.188","journal-title":"Neuropsychopharmacology"},{"key":"7066_CR47","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1006\/bbrc.1996.0156","volume":"218","author":"G Wittert","year":"1996","unstructured":"Wittert G, Hope P, Pyle D (1996) Tissue distribution of opioid receptor gene expression in the rat. Biochem Biophys Res Commun 218:877\u2013881. https:\/\/doi.org\/10.1006\/bbrc.1996.0156","journal-title":"Biochem Biophys Res Commun"},{"key":"7066_CR48","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/npp.2008.142","volume":"34","author":"W Wittmann","year":"2009","unstructured":"Wittmann W, Schunk E, Rosskothen I, Gaburro S, Singewald N, Herzog H, Schwarzer C (2009) Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone. Neuropsychopharmacology 34:775\u2013785. https:\/\/doi.org\/10.1038\/npp.2008.142","journal-title":"Neuropsychopharmacology"},{"key":"7066_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/7328437","volume":"2021","author":"T Wu","year":"2021","unstructured":"Wu T, Yao H, Zhang B, Zhou S, Hou P, Chen K (2021) \u03ba opioid receptor agonist inhibits myocardial injury in heart failure rats through activating Nrf2\/HO-1 pathway and regulating Ca2+-SERCA2a. Oxid Med Cell Longev 2021:1\u201313. https:\/\/doi.org\/10.1155\/2021\/7328437","journal-title":"Oxid Med Cell Longev"},{"key":"7066_CR50","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.ejphar.2010.07.039","volume":"649","author":"A Yamamoto","year":"2010","unstructured":"Yamamoto A, Sugimoto Y (2010) Involvement of peripheral mu opioid receptors in scratching behavior in mice. Eur J Pharmacol 649:336\u2013341. https:\/\/doi.org\/10.1016\/j.ejphar.2010.07.039","journal-title":"Eur J Pharmacol"},{"key":"7066_CR51","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.3390\/nu12072036","volume":"12","author":"K Yoshizaki","year":"2020","unstructured":"Yoshizaki K, Asai M, Hara T (2020) High-fat diet enhances working memory in the Y-maze test in male C57BL\/6J mice with less anxiety in the elevated plus maze test. Nutrients 12:2036. https:\/\/doi.org\/10.3390\/nu12072036","journal-title":"Nutrients"},{"key":"7066_CR53","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.2147\/JIR.S327234","volume":"15","author":"X-M Zhang","year":"2022","unstructured":"Zhang X-M, Lun M-H, Du W, Ma F, Huang Z-Q (2022a) The \u03ba-opioid receptor agonist U50488H ameliorates neuropathic pain through the Ca2+\/CaMKII\/CREB pathway in rats. J Inflamm Res 15:3039\u20133051. https:\/\/doi.org\/10.2147\/JIR.S327234","journal-title":"J Inflamm Res"},{"key":"7066_CR52","doi-asserted-by":"publisher","first-page":"7862","DOI":"10.1523\/JNEUROSCI.1182-22.2022","volume":"42","author":"J Zhang","year":"2022","unstructured":"Zhang J, Junigan JM, Trinh R, Kavelaars A, Heijnen CJ, Grace PM (2022b) HDAC6 Inhibition reverses cisplatin-induced mechanical hypersensitivity via tonic delta opioid receptor signaling. J Neurosci 42:7862\u20137874. https:\/\/doi.org\/10.1523\/JNEUROSCI.1182-22.2022","journal-title":"J Neurosci"},{"key":"7066_CR54","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12902-015-0004-7","volume":"15","author":"X Zhou","year":"2015","unstructured":"Zhou X, Wang D, Zhang Y, Zhang J, Xiang D, Wang H (2015) Activation of \u03ba-opioid receptor by U50,488H improves vascular dysfunction in streptozotocin-induced diabetic rats. BMC Endocr Disord 15:7. https:\/\/doi.org\/10.1186\/s12902-015-0004-7","journal-title":"BMC Endocr Disord"}],"container-title":["Experimental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-025-07066-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00221-025-07066-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-025-07066-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T08:22:05Z","timestamp":1748247725000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00221-025-07066-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,15]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["7066"],"URL":"https:\/\/doi.org\/10.1007\/s00221-025-07066-z","relation":{},"ISSN":["0014-4819","1432-1106"],"issn-type":[{"value":"0014-4819","type":"print"},{"value":"1432-1106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,15]]},"assertion":[{"value":"9 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"116"}}