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Advancing age and neurological disease compromise force generation; the impact of age and pathology on the dynamic control of grip force release is unclear. The aim of this project was to determine the impact of age and Parkinson\u2019s disease (PD) on grip force generation and release. Young adults (YA, n\u2009=\u200910, 18\u201328\u00a0years), older adults (OA, n\u2009=\u200910, 57\u201377\u00a0years), and people with PD (PwPD, n\u2009=\u200910, 56\u201375\u00a0years) completed a sinusoidal force tracking task using a precision grip with their dominant hand. Maximum grip force was not different between groups, however, OA relative to YA exhibited deficits in force generation, release and amplitude scaling. Although PwPD had global declines in force control, force release was disproportionately affected compared to force generation. The ability to scale force during its generation and release was compromised by PD. Two-point discrimination of the thumb and index fingers was impaired in PwPD and was moderately correlated with force tracking accuracy and force amplitude. While aging impacts grip force generation and release similarly during a task requiring continuous grip force modulation, PD disproportionately affects grip force release compared to generation. Force amplitude progressively decreases in older adults and PwPD. Potential sources of PD deficits include neural circuitry changes between the prefrontal cortex and striatum, impaired sensorimotor integration, and altered motor unit structure and function. Additional work is focused on identifying the neural mechanism(s) underlying impaired control and regulation of grip forces in PwPD.<\/jats:p>","DOI":"10.1007\/s00221-026-07241-w","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T13:17:24Z","timestamp":1771420644000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Parkinson\u2019s disease impairs grip force release during a sinusoidal force tracking task"],"prefix":"10.1007","volume":"244","author":[{"given":"Sara","family":"Davidson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Learman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anson B.","family":"Rosenfeldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay L.","family":"Alberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"issue":"4","key":"7241_CR1","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.neuron.2013.07.051","volume":"79","author":"VE Abraira","year":"2013","unstructured":"Abraira VE, Ginty DD (2013) The sensory neurons of touch. 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Fox Foundation, the Parkinson\u2019s Foundation, and Department of Defense. SD has received funding from the Foundation for Physical Therapy Research. KL has received royalties for a Medbridge Course on research methods and statistics. JLA also a member of the scientific advisory board for Qr8 Health and Ceraxis Health. He has authored intellectual property that has been licensed to both entities. ABR and JLA have authored intellectual property associated with virtual and augmented reality applications licensed to Elm Park Labs and Strolll Ltd.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Approval was obtained from the institutional review board of the Cleveland Clinic. This study adhered to the tenets of the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all study participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"46"}}