{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:09:09Z","timestamp":1782947349315,"version":"3.54.5"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82401721"],"award-info":[{"award-number":["82401721"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Brain Res"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s00221-026-07332-8","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T09:03:40Z","timestamp":1781514220000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dexmedetomidine inhibits microglia ferroptosis to relieve postoperative cognitive dysfunction in elderly rats through JPX\/HIF-1\/DHODH pathway"],"prefix":"10.1007","volume":"244","author":[{"given":"Yunfei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"7332_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2021.106163","volume":"95","author":"S Bhushan","year":"2021","unstructured":"Bhushan S, Li Y, Huang X, Cheng H, Gao K, Xiao Z (2021) Progress of research in postoperative cognitive dysfunction in cardiac surgery patients: a review article. Int J Surg 95:106163","journal-title":"Int J Surg"},{"issue":"6","key":"7332_CR2","first-page":"7730","volume":"17","author":"Y Cao","year":"2018","unstructured":"Cao Y, Li Z, Ma L, Ni C, Li L, Yang N, Shi C, Guo X (2018) Isoflurane-induced postoperative cognitive dysfunction is mediated by hypoxia-inducible factor-1\u03b1-dependent neuroinflammation in aged rats. Mol Med Rep 17(6):7730\u20137736","journal-title":"Mol Med Rep"},{"key":"7332_CR3","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.2147\/DDDT.S405294","volume":"17","author":"Z Chen","year":"2023","unstructured":"Chen Z, Liu Z, Feng C, Jin Y, Zhao X (2023) Dexmedetomidine as an adjuvant in peripheral nerve block. Drug des Dev Ther 17:1463\u20131484","journal-title":"Drug des Dev Ther"},{"key":"7332_CR4","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.bbi.2021.01.003","volume":"93","author":"Y Cui","year":"2021","unstructured":"Cui Y, Zhang Y, Zhao X, Shao L, Liu G, Sun C, Xu R, Zhang Z (2021) ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation. Brain Behav Immun 93:312\u2013321","journal-title":"Brain Behav Immun"},{"issue":"3","key":"7332_CR5","doi-asserted-by":"publisher","first-page":"3766","DOI":"10.4081\/ejh.2023.3766","volume":"67","author":"G He","year":"2023","unstructured":"He G, He Y, Ni H, Wang K, Zhu Y, Bao Y (2023) Dexmedetomidine attenuates neuroinflammation and microglia activation in LPS-stimulated BV2 microglia cells through targeting circ-Shank3\/miR-140\u20133p\/TLR4 axis. Eur J Histochem 67(3):3766","journal-title":"Eur J Histochem"},{"issue":"2","key":"7332_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.70154","volume":"39","author":"YL He","year":"2025","unstructured":"He YL, Zhang Y, Liu Q (2025) Regulation of postoperative cognitive dysfunction by glutathione under various pathways: a narrative review. J Biochem Mol Toxicol 39(2):e70154","journal-title":"J Biochem Mol Toxicol"},{"key":"7332_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.965661","volume":"13","author":"Y Hu","year":"2022","unstructured":"Hu Y, Zhou H, Zhang H, Sui Y, Zhang Z, Zou Y, Li K, Zhao Y, Xie J, Zhang L (2022) The neuroprotective effect of dexmedetomidine and its mechanism. Front Pharmacol 13:965661","journal-title":"Front Pharmacol"},{"issue":"3","key":"7332_CR8","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s40140-021-00450-9","volume":"11","author":"I Kapoor","year":"2021","unstructured":"Kapoor I, Mahajan C, Prabhakar H (2021) Dexmedetomidine in modern neuroanesthesia practice. Curr Anesthesiol Rep 11(3):181\u2013188","journal-title":"Curr Anesthesiol Rep"},{"key":"7332_CR9","doi-asserted-by":"publisher","first-page":"113753","DOI":"10.1016\/j.biopha.2022.113753","volume":"155","author":"Y Kuang","year":"2022","unstructured":"Kuang Y, Shen W, Zhu H, Huang H, Zhou Q, Yin W, Zhou Y, Cao Y, Wang L, Li X et al (2022) The role of lncRNA just proximal to XIST (JPX) in human disease phenotypes and RNA methylation: the novel biomarker and therapeutic target potential. Biomed Pharmacother 155:113753","journal-title":"Biomed Pharmacother"},{"key":"7332_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.843069","volume":"16","author":"Z Li","year":"2022","unstructured":"Li Z, Zhu Y, Kang Y, Qin S, Chai J (2022) Neuroinflammation as the underlying mechanism of postoperative cognitive dysfunction and therapeutic strategies. Front Cell Neurosci 16:843069","journal-title":"Front Cell Neurosci"},{"key":"7332_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2024.114862","volume":"379","author":"Y Li","year":"2024","unstructured":"Li Y, Ruan X, Sun M, Yuan M, Song J, Zhou Z, Li H, Ma Y, Mi W, Zhang X (2024) Iron deposition participates in LPS-induced cognitive impairment by promoting neuroinflammation and ferroptosis in mice. Exp Neurol 379:114862","journal-title":"Exp Neurol"},{"key":"7332_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2025.115235","volume":"389","author":"J Li","year":"2025","unstructured":"Li J, Jia B, Xu Y, Zhao Y, Wang S, Yang R, Su L, Zeng X, Li Q, Luo C (2025) Inhibition of mitoNEET ameliorates traumatic brain injury-induced ferroptosis and cognitive dysfunction by stabilizing dihydroorotate dehydrogenase. Exp Neurol 389:115235","journal-title":"Exp Neurol"},{"issue":"7","key":"7332_CR13","doi-asserted-by":"publisher","first-page":"846","DOI":"10.3390\/brainsci11070846","volume":"11","author":"Z Liaquat","year":"2021","unstructured":"Liaquat Z, Xu X, Zilundu PLM, Fu R, Zhou L (2021) The current role of dexmedetomidine as neuroprotective agent: an updated review. Brain Sci 11(7):846","journal-title":"Brain Sci"},{"key":"7332_CR14","doi-asserted-by":"publisher","first-page":"175909142211332","DOI":"10.1177\/17590914221133236","volume":"14","author":"S Liu","year":"2022","unstructured":"Liu S, Gao X, Zhou S (2022) New target for prevention and treatment of neuroinflammation: microglia iron accumulation and ferroptosis. ASN Neuro 14:17590914221133236","journal-title":"ASN Neuro"},{"key":"7332_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118306","volume":"331","author":"Y Ningning","year":"2024","unstructured":"Ningning Y, Ying X, Xiang L, Yue S, Zhongda W, Ruoyu J, Hanwen S, Weiwei T, Yafeng Z, Junjie M et al (2024) Danggui-Shaoyao San alleviates cognitive impairment via enhancing HIF-1\u03b1\/EPO axis in vascular dementia rats. J Ethnopharmacol 331:118306","journal-title":"J Ethnopharmacol"},{"issue":"8","key":"7332_CR16","doi-asserted-by":"publisher","first-page":"511","DOI":"10.5498\/wjp.v13.i8.511","volume":"13","author":"L Qiao","year":"2023","unstructured":"Qiao L, Li G, Yuan HX (2023) Dexmedetomidine mediates the mechanism of action of ferroptosis in mice with Alzheimer\u2019s disease by regulating the mTOR-TFR1 pathway. World J Psychiatry 13(8):511\u2013523","journal-title":"World J Psychiatry"},{"issue":"4","key":"7332_CR17","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.jatmed.2025.11.001","volume":"4","author":"Z Shang","year":"2025","unstructured":"Shang Z, Wu Y, Gu C, Gao J, Wang C (2025) Neuroprotective mechanisms of dexmedetomidine in perioperative neurocognitive disorders: from molecular pathways to clinical translation. J Anesthesia Transl Med 4(4):220\u2013230","journal-title":"J Anesthesia Transl Med"},{"issue":"11","key":"7332_CR18","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23190","volume":"36","author":"H Shen","year":"2022","unstructured":"Shen H, Zhai L, Wang G (2022) Hepcidin regulates neuronal ferroptosis: a mechanism for postoperative cognitive dysfunction. J Biochem Mol Toxicol 36(11):e23190","journal-title":"J Biochem Mol Toxicol"},{"issue":"3","key":"7332_CR19","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.3892\/etm.2021.10470","volume":"22","author":"L Suo","year":"2021","unstructured":"Suo L, Wang M (2021) Dexmedetomidine facilitates the expression of nNOS in the hippocampus to alleviate surgery-induced neuroinflammation and cognitive dysfunction in aged rats. Exp Ther Med 22(3):1038","journal-title":"Exp Ther Med"},{"key":"7332_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2025.151770","volume":"763","author":"J Tang","year":"2025","unstructured":"Tang J, Huang Z, Yu P (2025) The role of JPX in regulating FUS\/SLC7A11 signaling pathway mediated ferroptosis in keloid fibroblasts and its potential in scar repair. Biochem Biophys Res Commun 763:151770","journal-title":"Biochem Biophys Res Commun"},{"key":"7332_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122949","volume":"354","author":"L Tian","year":"2024","unstructured":"Tian L, Liu Q, Wang X, Chen S, Li Y (2024) Fighting ferroptosis: protective effects of dexmedetomidine on vital organ injuries. Life Sci 354:122949","journal-title":"Life Sci"},{"key":"7332_CR22","doi-asserted-by":"publisher","first-page":"1150135","DOI":"10.3389\/fneur.2023.1150135","volume":"14","author":"A Tsivitis","year":"2023","unstructured":"Tsivitis A, Wang A, Murphy J, Khan A, Jin Z, Moore R, Tateosian V, Bergese S (2023) Anesthesia, the developing brain, and dexmedetomidine for neuroprotection. Front Neurol 14:1150135","journal-title":"Front Neurol"},{"issue":"1","key":"7332_CR23","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s40520-024-02779-7","volume":"36","author":"HA Varpaei","year":"2024","unstructured":"Varpaei HA, Farhadi K, Mohammadi M, Khafaee Pour Khamseh A, Mokhtari T (2024) Postoperative cognitive dysfunction: a concept analysis. Aging Clin Exp Res 36(1):133","journal-title":"Aging Clin Exp Res"},{"key":"7332_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.884907","volume":"13","author":"T Vu","year":"2022","unstructured":"Vu T, Smith JA (2022) An update on postoperative cognitive dysfunction following cardiac surgery. Front Psych 13:884907","journal-title":"Front Psych"},{"key":"7332_CR25","doi-asserted-by":"publisher","first-page":"4961","DOI":"10.12659\/MSM.908133","volume":"24","author":"Y Wang","year":"2018","unstructured":"Wang Y, Wang C, Zhang D, Wang H, Bo L, Deng X (2018) Dexmedetomidine protects against traumatic brain injury-induced acute lung injury in mice. Med Sci Monit 24:4961\u20134967","journal-title":"Med Sci Monit"},{"issue":"15","key":"7332_CR26","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1021\/acschemneuro.2c00173","volume":"13","author":"W Wang","year":"2022","unstructured":"Wang W, Ma Y, Liu Y, Wang P, Liu Y (2022) Effects of dexmedetomidine anesthesia on early postoperative cognitive dysfunction in elderly patients. ACS Chem Neurosci 13(15):2309\u20132314","journal-title":"ACS Chem Neurosci"},{"key":"7332_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2023.110387","volume":"375","author":"M Wang","year":"2023","unstructured":"Wang M, Tang G, Zhou C, Guo H, Hu Z, Hu Q, Li G (2023a) Revisiting the intersection of microglial activation and neuroinflammation in Alzheimer\u2019s disease from the perspective of ferroptosis. Chem Biol Interact 375:110387","journal-title":"Chem Biol Interact"},{"issue":"7","key":"7332_CR28","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1097\/CM9.0000000000002392","volume":"136","author":"Y Wang","year":"2023","unstructured":"Wang Y, Bai H, Jiang M, Zhou C, Gong Z (2023b) Emerging role of long non-coding RNA JPX in malignant processes and potential applications in cancers. Chin Med J 136(7):757\u2013766","journal-title":"Chin Med J"},{"issue":"10","key":"7332_CR29","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70066","volume":"30","author":"S Wang","year":"2024","unstructured":"Wang S, Wu Z, Bu X, Peng X, Zhou Q, Song W, Gao W, Wang W, Xia Z (2024) MEF2C alleviates postoperative cognitive dysfunction by repressing ferroptosis. CNS Neurosci Ther 30(10):e70066","journal-title":"CNS Neurosci Ther"},{"issue":"6","key":"7332_CR30","doi-asserted-by":"publisher","first-page":"2812","DOI":"10.1007\/s12035-020-02277-7","volume":"58","author":"N Zhang","year":"2021","unstructured":"Zhang N, Yu X, Xie J, Xu H (2021) New Insights into the role of Ferritin in iron homeostasis and neurodegenerative diseases. Mol Neurobiol 58(6):2812\u20132823","journal-title":"Mol Neurobiol"},{"key":"7332_CR31","volume":"130","author":"Q Zhu","year":"2024","unstructured":"Zhu Q, Han Y, He Y, Meng P, Fu Y, Yang H, He G, Long M, Shi Y (2024) Quercetin inhibits neuronal Ferroptosis and promotes immune response by targeting lipid metabolism-related gene PTGS2 to alleviate breast cancer-related depression. Phytomed Int J Phytother Phytopharmacol 130:155560","journal-title":"Phytomed Int J Phytother Phytopharmacol"}],"container-title":["Experimental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-026-07332-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00221-026-07332-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-026-07332-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:01:27Z","timestamp":1782943287000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00221-026-07332-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,15]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["7332"],"URL":"https:\/\/doi.org\/10.1007\/s00221-026-07332-8","relation":{},"ISSN":["0014-4819","1432-1106"],"issn-type":[{"value":"0014-4819","type":"print"},{"value":"1432-1106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,15]]},"assertion":[{"value":"12 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The author declare that they have no competing interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All animal experiments were approved by the Animal Experiment Ethics Committee of Wuhan No.1 Hospital (Approval No. WOH202412231). The study complied with institutional and international guidelines for ethical conduct in animal research (NIH Guide for the Care and Use of Laboratory Animals, 8th edition).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"135"}}