{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:02:38Z","timestamp":1789448558577,"version":"build-2803163510"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Brain Res"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s00221-026-07380-0","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:55:29Z","timestamp":1787219729000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["FOXM1 downregulation contributes to sevoflurane-induced microglial dysfunction via transcriptional downregulation of RGS10"],"prefix":"10.1007","volume":"244","author":[{"given":"Chen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"7380_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109765","volume":"75","author":"F Almutairi","year":"2020","unstructured":"Almutairi F, Lee J-K, Rada B (2020) Regulator of G protein signaling 10: structure, expression and functions in cellular physiology and diseases. Cell Signal 75:109765","journal-title":"Cell Signal"},{"issue":"3","key":"7380_CR2","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1124\/mol.116.106963","volume":"91","author":"M Alqinyah","year":"2017","unstructured":"Alqinyah M, Maganti N, Ali MW, Yadav R, Gao M, Cacan E, Weng HR, Greer SF, Hooks SB (2017) Regulator of G protein signaling 10 (RGS10) expression is transcriptionally silenced in activated microglia by histone deacetylase activity. Mol Pharmacol 91(3):197\u2013207","journal-title":"Mol Pharmacol"},{"issue":"4","key":"7380_CR3","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1124\/mol.118.111674","volume":"94","author":"M Alqinyah","year":"2018","unstructured":"Alqinyah M, Almutairi F, Wendimu MY, Hooks SB (2018) RGS10 regulates the expression of cyclooxygenase-2 and tumor necrosis factor alpha through a G protein\u2013independent mechanism. Mol Pharmacol 94(4):1103\u20131113","journal-title":"Mol Pharmacol"},{"key":"7380_CR4","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.semcancer.2014.07.008","volume":"29","author":"L Bella","year":"2014","unstructured":"Bella L, Zona S, Nestal de Moraes G, Lam EW (2014) FOXM1: a key oncofoetal transcription factor in health and disease. Semin Cancer Biol 29:32\u201339","journal-title":"Semin Cancer Biol"},{"key":"7380_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2023.578180","volume":"383","author":"K Biswas","year":"2023","unstructured":"Biswas K (2023) Microglia mediated neuroinflammation in neurodegenerative diseases: a review on the cell signaling pathways involved in microglial activation. J Neuroimmunol 383:578180","journal-title":"J Neuroimmunol"},{"issue":"1","key":"7380_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25728-8","volume":"12","author":"J Br\u00e4gelmann","year":"2021","unstructured":"Br\u00e4gelmann J, Lorenz C, Borchmann S, Nishii K, Wegner J, Meder L, Ostendorp J, Ast DF, Heimsoeth A, Nakasuka T et al (2021) MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I. Nat Commun 12(1):5505","journal-title":"Nat Commun"},{"key":"7380_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101589","volume":"36","author":"H-J Choi","year":"2020","unstructured":"Choi H-J, Jhe Y-L, Kim J, Lim JY, Lee JE, Shin M-K, Cheong J-H (2020) FoxM1-dependent and fatty acid oxidation-mediated ROS modulation is a cell-intrinsic drug resistance mechanism in cancer stem-like cells. Redox Biol 36:101589","journal-title":"Redox Biol"},{"key":"7380_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2024.1374298","volume":"18","author":"J Chung","year":"2024","unstructured":"Chung J, Jernigan J, Menees KB, Lee J-K (2024) RGS10 mitigates high glucose-induced microglial inflammation via the reactive oxidative stress pathway and enhances synuclein clearance in microglia. Front Cell Neurosci 18:1374298","journal-title":"Front Cell Neurosci"},{"issue":"6","key":"7380_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14060662","volume":"14","author":"E Desideri","year":"2025","unstructured":"Desideri E, Castelli S, Ciriolo MR (2025) MAPK signaling in the interplay between oxidative stress and autophagy. Antioxidants (Basel) 14(6):662","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"7380_CR10","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/s41392-023-01588-0","volume":"8","author":"C Gao","year":"2023","unstructured":"Gao C, Jiang J, Tan Y, Chen S (2023) Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets. Signal Transduct Target Ther 8(1):359","journal-title":"Signal Transduct Target Ther"},{"key":"7380_CR11","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1124\/jpet.122.558860","volume":"385","author":"S Gonzalez","year":"2023","unstructured":"Gonzalez S, Sjogren B (2023) Identification of small molecule RGS10 modulators in a microglial cell model of neuroinflammation. J Pharmacol Exp Ther 385:518","journal-title":"J Pharmacol Exp Ther"},{"key":"7380_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.815347","volume":"14","author":"S Guo","year":"2022","unstructured":"Guo S, Wang H, Yin Y (2022) Microglia polarization from M1 to M2 in neurodegenerative diseases. Front Aging Neurosci 14:815347","journal-title":"Front Aging Neurosci"},{"key":"7380_CR13","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.neuroscience.2024.02.014","volume":"544","author":"H Guo","year":"2024","unstructured":"Guo H, Du M, Yang Y, Lin X, Wang Y, Li H, Ren J, Xu W, Yan J, Wang N (2024) Sp1 regulates the M1 polarization of microglia through the HuR\/NF-\u03baB axis after spinal cord injury. Neuroscience 544:50\u201363","journal-title":"Neuroscience"},{"issue":"1","key":"7380_CR14","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1186\/s13046-019-1202-3","volume":"38","author":"G Hu","year":"2019","unstructured":"Hu G, Yan Z, Zhang C, Cheng M, Yan Y, Wang Y, Deng L, Lu Q, Luo S (2019) FOXM1 promotes hepatocellular carcinoma progression by regulating KIF4A expression. J Exp Clin Cancer Res 38(1):188","journal-title":"J Exp Clin Cancer Res"},{"issue":"4","key":"7380_CR15","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1016\/j.immuni.2025.02.026","volume":"58","author":"X Hu","year":"2025","unstructured":"Hu X, Wu J, Shi L, Wang F, He K, Tan P, Hu Y, Yang Y, Wang D, Ma T et al (2025) The transcription factor MEF2C restrains microglial overactivation by inhibiting kinase CDK2. Immunity 58(4):946\u2013960","journal-title":"Immunity"},{"key":"7380_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.717745","volume":"13","author":"X Huang","year":"2021","unstructured":"Huang X, Ying J, Yang D, Fang P, Wang X, Zhou B, Zhang L, Fang Y, Yu W, Liu X et al (2021) The mechanisms of sevoflurane-induced neuroinflammation. Front Aging Neurosci 13:717745","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"7380_CR17","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s12974-024-03322-1","volume":"22","author":"JE Jernigan","year":"2025","unstructured":"Jernigan JE, Staley HA (2025) RGS10 attenuates systemic immune dysregulation induced by chronic inflammatory stress. J Neuroinflammation 22(1):49","journal-title":"J Neuroinflammation"},{"issue":"1","key":"7380_CR18","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s11481-025-10201-w","volume":"20","author":"C Li","year":"2025","unstructured":"Li C, Cong Y, Song W, Wu Y, Gou X, Qi S (2025a) Irisin regulates microglia M1\/M2 polarization and promotes autophagy through the Sirt3 pathway to alleviate POCD. J Neuroimmune Pharmacol 20(1):34","journal-title":"J Neuroimmune Pharmacol"},{"issue":"7","key":"7380_CR19","doi-asserted-by":"publisher","DOI":"10.31083\/JIN36785","volume":"24","author":"Y Li","year":"2025","unstructured":"Li Y, Peng Q, Lu J, Hu L, Zhou H (2025b) Cognitive change associated with anesthesia and surgery: an introduction to POCD for neuroscientists. J Integr Neurosci 24(7):36785","journal-title":"J Integr Neurosci"},{"issue":"1","key":"7380_CR20","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1186\/s12974-021-02318-5","volume":"18","author":"G Luo","year":"2021","unstructured":"Luo G, Wang X, Cui Y, Cao Y, Zhao Z, Zhang J (2021) Metabolic reprogramming mediates hippocampal microglial M1 polarization in response to surgical trauma causing perioperative neurocognitive disorders. J Neuroinflammation 18(1):267","journal-title":"J Neuroinflammation"},{"issue":"4","key":"7380_CR21","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/bph.13139","volume":"173","author":"R Orihuela","year":"2016","unstructured":"Orihuela R, McPherson CA, Harry GJ (2016) Microglial M1\/M2 polarization and metabolic states. Br J Pharmacol 173(4):649\u2013665","journal-title":"Br J Pharmacol"},{"issue":"9","key":"7380_CR22","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202050932","volume":"22","author":"D Pelzer","year":"2021","unstructured":"Pelzer D, Phipps LS (2021) Foxm1 regulates neural progenitor fate during spinal cord regeneration. EMBO Rep 22(9):e50932","journal-title":"EMBO Rep"},{"issue":"10","key":"7380_CR23","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.2174\/1566524023666221118140523","volume":"23","author":"W Peng","year":"2023","unstructured":"Peng W, Lu W, Jiang X, Xiong C, Chai H, Cai L, Lan Z (2023) Current progress on neuroinflammation-mediated postoperative cognitive dysfunction: an update. Curr Mol Med 23(10):1077\u20131086","journal-title":"Curr Mol Med"},{"issue":"1","key":"7380_CR24","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/s41419-025-08321-5","volume":"17","author":"S Raghuwanshi","year":"2026","unstructured":"Raghuwanshi S, Gartel AL (2026) FOXM1 induces therapy resistance and inhibits apoptosis in a variety of human cancers. Cell Death Dis 17(1):230","journal-title":"Cell Death Dis"},{"issue":"5","key":"7380_CR25","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1136\/gutjnl-2025-335163","volume":"75","author":"M Sasaki","year":"2026","unstructured":"Sasaki M, Wang JX (2026) FOXM1 inhibition reduces IL-13-induced epithelial remodelling and inflammation in eosinophilic oesophagitis. Gut 75(5):857\u2013871","journal-title":"Gut"},{"issue":"1","key":"7380_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18276-0","volume":"11","author":"AP Sawaya","year":"2020","unstructured":"Sawaya AP, Stone RC, Brooks SR, Pastar I, Jozic I, Hasneen K, O\u2019Neill K, Mehdizadeh S, Head CR, Strbo N et al (2020) Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing. Nat Commun 11(1):4678","journal-title":"Nat Commun"},{"issue":"4","key":"7380_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14040457","volume":"14","author":"Z Sebghatollahi","year":"2025","unstructured":"Sebghatollahi Z, Yogesh R, Mahato N, Kumar V, Mohanta YK, Baek K-H, Mishra AK (2025) Signaling pathways in oxidative stress-induced neurodegenerative diseases: a review of phytochemical therapeutic interventions. Antioxidants (Basel) 14(4):457","journal-title":"Antioxidants (Basel)"},{"key":"7380_CR28","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1124\/jpet.122.194210","volume":"385","author":"S Talele","year":"2023","unstructured":"Talele S, Gonzalez S, Saldarriaga V, Hooks S, Sjogren B (2023) Transcriptional analysis of RGS10 function in microglia. J Pharmacol Exp Ther 385:283","journal-title":"J Pharmacol Exp Ther"},{"issue":"5","key":"7380_CR29","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/s41577-022-00792-3","volume":"23","author":"G van Loo","year":"2023","unstructured":"van Loo G, Bertrand MJM (2023) Death by TNF: a road to inflammation. Nat Rev Immunol 23(5):289\u2013303","journal-title":"Nat Rev Immunol"},{"issue":"10","key":"7380_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/biology14101368","volume":"14","author":"D Wang","year":"2025","unstructured":"Wang D, Liu J (2025) Transcriptomic investigation of FoxM1-mediated neuroprotection by hAEC-derived exosomes in an in vitro ischemic stroke model. Biology 14(10):1368","journal-title":"Biology"},{"issue":"4","key":"7380_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.curpro.2025.100029","volume":"22","author":"L Wang","year":"2025","unstructured":"Wang L, Zhou D, Ou Y (2025) NSUN2\/FOXM1 positive feedback pathway promotes the malignant development of non-small cell lung cancer. Curr Proteomics 22(4):100029","journal-title":"Curr Proteomics"},{"issue":"1","key":"7380_CR32","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/s41065-025-00525-1","volume":"162","author":"Y Wei","year":"2025","unstructured":"Wei Y, Zhang X, Zuo R, Dang W, Chen L, Liu F, Yao J, Ran W, Chen Z, Wang X et al (2025) Screening, identification, and experimental validation of SUMOylation biomarkers in Parkinson\u2019s disease. Hereditas 162(1):154","journal-title":"Hereditas"},{"key":"7380_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2021.109974","volume":"83","author":"MY Wendimu","year":"2021","unstructured":"Wendimu MY, Alqinyah M, Vella S, Dean P, Almutairi F, Davila-Rivera R, Rayatpisheh S, Wohlschlegel J, Moreno S, Hooks SB (2021) RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia. Cell Signal 83:109974","journal-title":"Cell Signal"},{"issue":"19","key":"7380_CR34","first-page":"4756","volume":"21","author":"H Xiaopeng","year":"2024","unstructured":"Xiaopeng H, Peijiang P, Lijuan Z, Jiemei C, Hailong W, Yanyan L, Yueqi L, Yao L, Junjun J, Li Y et al (2024) Deep learning-driven identification and evaluation of potential therapeutic agents for COVID-19 co-infection diseases targeting METTL3. Lett Drug des Discov 21(19):4756\u20134781","journal-title":"Lett Drug des Discov"},{"issue":"2","key":"7380_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112863","volume":"408","author":"X Xu","year":"2021","unstructured":"Xu X, Zhang L, Hua F, Zhang C, Zhang C, Mi X, Qin N, Wang J, Zhu A, Qin Z et al (2021) FOXM1-activated SIRT4 inhibits NF-\u03baB signaling and NLRP3 inflammasome to alleviate kidney injury and podocyte pyroptosis in diabetic nephropathy. Exp Cell Res 408(2):112863","journal-title":"Exp Cell Res"},{"issue":"2","key":"7380_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112860","volume":"408","author":"D Yang","year":"2021","unstructured":"Yang D, Ma Y, Zhao P, Ma J, He C (2021) HMMR is a downstream target of FOXM1 in enhancing proliferation and partial epithelial-to-mesenchymal transition of bladder cancer cells. Exp Cell Res 408(2):112860","journal-title":"Exp Cell Res"},{"issue":"1","key":"7380_CR37","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/imm.13869","volume":"174","author":"Y Yang","year":"2025","unstructured":"Yang Y, Shao Y, Gao X, Hu Z, Wang Y, Ma C, Jin G, Zhu F, Dong G, Zhou G (2025) RGS10 deficiency alleviated intestinal mucosal inflammation through suppression of Th1\/Th17 cell immune responses in ulcerative colitis. Immunology 174(1):139\u2013152","journal-title":"Immunology"},{"issue":"18","key":"7380_CR38","doi-asserted-by":"publisher","first-page":"4429","DOI":"10.2174\/0115701808340483241119064321","volume":"21","author":"G Yuan","year":"2024","unstructured":"Yuan G, Lei M, Dedong X (2024) Mechanism of pyroptosis in postoperative cognitive dysfunction rats and & #945;7-nicotinic receptor agonist regulating NLRP3 inflammasome activation. Lett Drug des Discovery 21(18):4429\u20134438","journal-title":"Lett Drug des Discovery"},{"key":"7380_CR39","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00531","volume":"12","author":"B Zhang","year":"2018","unstructured":"Zhang B, Wei YZ, Wang GQ, Li DD, Shi JS, Zhang F (2018) Targeting MAPK pathways by naringenin modulates microglia M1\/M2 polarization in lipopolysaccharide-stimulated cultures. Front Cell Neurosci 12:531","journal-title":"Front Cell Neurosci"},{"issue":"5","key":"7380_CR40","doi-asserted-by":"publisher","first-page":"857","DOI":"10.3390\/biom13050857","volume":"13","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, Li M, Sun T, Zhang Z, Liu C (2023) FOXM1: functional roles of FOXM1 in non-malignant diseases. Biomolecules 13(5):857","journal-title":"Biomolecules"},{"key":"7380_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1466681","volume":"11","author":"L Zhang","year":"2024","unstructured":"Zhang L, Qiu Y, Zhang ZF, Zhao YF, Ding YM (2024a) Current perspectives on postoperative cognitive dysfunction in geriatric patients: insights from clinical practice. Front Med 11:1466681","journal-title":"Front Med"},{"key":"7380_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fresc.2024.1525813","volume":"5","author":"ZR Zhang","year":"2024","unstructured":"Zhang ZR, Li YZ, Wu XQ, Chen WJ, Xu J, Zhao WH, Gong XY (2024b) Postoperative cognitive dysfunction in elderly postcardiac surgery patients: progress in rehabilitation application research. Front Rehabil Sci 5:1525813","journal-title":"Front Rehabil Sci"},{"key":"7380_CR43","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2024.1328790","volume":"18","author":"Q Zhao","year":"2024","unstructured":"Zhao Q, Wan H, Pan H, Xu Y (2024) Postoperative cognitive dysfunction-current research progress. Front Behav Neurosci 18:1328790","journal-title":"Front Behav Neurosci"},{"key":"7380_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2024.111467","volume":"124","author":"L Zheng","year":"2024","unstructured":"Zheng L, Rajamanickam V, Wang M, Zhang H, Fang S, Linnebacher M, Abd El-Aty AM, Zhang X, Zhang Y, Wang J et al (2024) Fangchinoline inhibits metastasis and reduces inflammation-induced epithelial-mesenchymal transition by targeting the FOXM1-ADAM17 axis in hepatocellular carcinoma. Cell Signal 124:111467","journal-title":"Cell Signal"},{"issue":"11","key":"7380_CR45","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1016\/j.bbagrm.2014.09.016","volume":"1839","author":"S Zona","year":"2014","unstructured":"Zona S, Bella L, Burton MJ, Nestal de Moraes G, Lam EW (2014) FOXM1: an emerging master regulator of DNA damage response and genotoxic agent resistance. Biochim Et Biophys Acta (BBA) - Gene Regul Mech 1839(11):1316\u20131322","journal-title":"Biochim Et Biophys Acta (BBA) - Gene Regul Mech"}],"container-title":["Experimental Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-026-07380-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00221-026-07380-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00221-026-07380-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:21:25Z","timestamp":1789446085000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00221-026-07380-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["7380"],"URL":"https:\/\/doi.org\/10.1007\/s00221-026-07380-0","relation":{},"ISSN":["0014-4819","1432-1106"],"issn-type":[{"value":"0014-4819","type":"print"},{"value":"1432-1106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,20]]},"assertion":[{"value":"14 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors have no interests to disclose.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"176"}}