{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:48:01Z","timestamp":1784958481119,"version":"3.55.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T00:00:00Z","timestamp":1222214400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1007\/s00223-008-9170-1","type":"journal-article","created":{"date-parts":[[2008,9,23]],"date-time":"2008-09-23T14:13:57Z","timestamp":1222179237000},"page":"251-259","source":"Crossref","is-referenced-by-count":178,"title":["Acid-Suppressive Medications and Risk of Bone Loss and Fracture in Older Adults"],"prefix":"10.1007","volume":"83","author":[{"given":"Elaine W.","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri","family":"Blackwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine E.","family":"Ensrud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa A.","family":"Hillier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy E.","family":"Lane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Orwoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas C.","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,9,24]]},"reference":[{"key":"9170_CR1","unstructured":"IMS Health (2005) Leading therapy classes by pharmaceutical sales. http:\/\/www.imshealth.com\/portal\/site\/imshealth . Accessed January 2008"},{"key":"9170_CR2","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1440-1746.2007.04871.x","volume":"22","author":"M Miyamoto","year":"2007","unstructured":"Miyamoto M, Haruma K, Kuwabara M, Nagano M, Okamoto T, Tanaka M (2007) Long-term gastroesophageal reflux disease therapy improves reflux symptoms in elderly patients: five-year prospective study in community medicine. J Gastroenterol Hepatol 22:639\u2013644","journal-title":"J Gastroenterol Hepatol"},{"key":"9170_CR3","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1046\/j.1365-2036.2000.00768.x","volume":"14","author":"L Laine","year":"2000","unstructured":"Laine L, Ahnen D, McClain C, Solcia E, Walsh JH (2000) Potential gastrointestinal effects of long-term acid suppression with proton pump inhibitors. Aliment Pharmacol Ther 14:651\u2013668","journal-title":"Aliment Pharmacol Ther"},{"key":"9170_CR4","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1001\/jama.292.16.1955","volume":"292","author":"RJ Laheij","year":"2004","unstructured":"Laheij RJ, Sturkenboom MC, Hassing RJ, Dieleman J, Stricker BH, Jansen JB (2004) Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs. JAMA 292:1955\u20131960","journal-title":"JAMA"},{"key":"9170_CR5","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1159\/000064290","volume":"91","author":"G Graziani","year":"2002","unstructured":"Graziani G, Badalamenti S, Como G, Gallieni M, Finazzi S, Angelini C, Brancaccio D, Ponticelli C (2002) Calcium and phosphate plasma levels in dialysis patients after dietary Ca-P overload. Role of gastric acid secretion. Nephron 91:474\u2013479","journal-title":"Nephron"},{"key":"9170_CR6","first-page":"1376","volume":"10","author":"G Graziani","year":"1995","unstructured":"Graziani G, Como G, Badalamenti S, Finazzi S, Malesci A, Gallieni M, Brancaccio D, Ponticelli C (1995) Effect of gastric acid secretion on intestinal phosphate and calcium absorption in normal subjects. Nephrol Dial Transplant 10:1376\u20131380","journal-title":"Nephrol Dial Transplant"},{"key":"9170_CR7","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.amjmed.2005.02.007","volume":"118","author":"MB O\u2019Connell","year":"2005","unstructured":"O\u2019Connell MB, Madden DM, Murray AM, Heaney RP, Kerzner LJ (2005) Effects of proton pump inhibitors on calcium carbonate absorption in women: a randomized crossover trial. Am J Med 118:778\u2013781","journal-title":"Am J Med"},{"key":"9170_CR8","doi-asserted-by":"crossref","first-page":"345","DOI":"10.7326\/0003-4819-132-5-200003070-00003","volume":"132","author":"KE Ensrud","year":"2000","unstructured":"Ensrud KE, Duong T, Cauley JA, Heaney RP, Wolf RL, Harris E, Cummings SR (2000) Low fractional calcium absorption increases the risk for hip fracture in women with low calcium intake. Study of Osteoporotic Fractures Research Group. Ann Intern Med 132:345\u2013353","journal-title":"Ann Intern Med"},{"key":"9170_CR9","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/S0899-9007(97)83011-0","volume":"13","author":"BE Nordin","year":"1997","unstructured":"Nordin BE (1997) Calcium and osteoporosis. Nutrition 13:664\u2013686","journal-title":"Nutrition"},{"key":"9170_CR10","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1080\/003655201750422585","volume":"36","author":"GL Cui","year":"2001","unstructured":"Cui GL, Syversen U, Zhao CM, Chen D, Waldum HL (2001) Long-term omeprazole treatment suppresses body weight gain and bone mineralization in young male rats. Scand J Gastroenterol 36:1011\u20131015","journal-title":"Scand J Gastroenterol"},{"key":"9170_CR11","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/jbmr.5650060812","volume":"6","author":"JA Grisso","year":"1991","unstructured":"Grisso JA, Chiu GY, Maislin G, Steinmann WC, Portale J (1991) Risk factors for hip fractures in men: a preliminary study. J Bone Miner Res 6:865\u2013868","journal-title":"J Bone Miner Res"},{"key":"9170_CR12","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s00223-006-0021-7","volume":"79","author":"P Vestergaard","year":"2006","unstructured":"Vestergaard P, Rejnmark L, Mosekilde L (2006) Proton pump inhibitors, histamine h(2) receptor antagonists, and other antacid medications and the risk of fracture. Calcif Tissue Int 79:76\u201383","journal-title":"Calcif Tissue Int"},{"key":"9170_CR13","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1001\/jama.296.24.2947","volume":"296","author":"YX Yang","year":"2006","unstructured":"Yang YX, Lewis JD, Epstein S, Metz DC (2006) Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA 296:2947\u20132953","journal-title":"JAMA"},{"key":"9170_CR14","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1001\/jama.1990.03440050059033","volume":"263","author":"SR Cummings","year":"1990","unstructured":"Cummings SR, Black DM, Nevitt MC, Browner WS, Cauley JA, Genant HK, Mascioli SR, Scott JC, Seeley DG, Steiger P et al (1990) Appendicular bone density and age predict hip fracture in women. The Study of Osteoporotic Fractures Research Group. JAMA 263:665\u2013668","journal-title":"JAMA"},{"key":"9170_CR15","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S1529-9430(03)00024-X","volume":"3","author":"MT Vogt","year":"2003","unstructured":"Vogt MT, Rubin DA, Palermo L, Christianson L, Kang JD, Nevitt MC, Cauley JA (2003) Lumbar spine listhesis in older African American women. Spine J 3:255\u2013261","journal-title":"Spine J"},{"key":"9170_CR16","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.cct.2005.05.005","volume":"26","author":"JB Blank","year":"2005","unstructured":"Blank JB, Cawthon PM, Carrion-Petersen ML, Harper L, Johnson JP, Mitson E, Delay RR (2005) Overview of recruitment for the osteoporotic fractures in men study (MrOS). Contemp Clin Trials 26:557\u2013568","journal-title":"Contemp Clin Trials"},{"key":"9170_CR17","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.cct.2005.05.006","volume":"26","author":"E Orwoll","year":"2005","unstructured":"Orwoll E, Blank JB, Barrett-Connor E, Cauley J, Cummings S, Ensrud K, Lewis C, Cawthon PM, Marcus R, Marshall LM, McGowan J, Phipps K, Sherman S, Stefanick ML, Stone K (2005) Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study\u2014a large observational study of the determinants of fracture in older men. Contemp Clin Trials 26:569\u2013585","journal-title":"Contemp Clin Trials"},{"key":"9170_CR18","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/BF01719664","volume":"10","author":"M Pahor","year":"1994","unstructured":"Pahor M, Chrischilles EA, Guralnik JM, Brown SL, Wallace RB, Carbonin P (1994) Drug data coding and analysis in epidemiologic studies. Eur J Epidemiol 10:405\u2013411","journal-title":"Eur J Epidemiol"},{"key":"9170_CR19","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1002\/jbmr.5650101122","volume":"10","author":"KE Ensrud","year":"1995","unstructured":"Ensrud KE, Palermo L, Black DM, Cauley J, Jergas M, Orwoll ES, Nevitt MC, Fox KM, Cummings SR (1995) Hip and calcaneal bone loss increase with advancing age: longitudinal results from the Study of Osteoporotic Fractures. J Bone Miner Res 10:1778\u20131787","journal-title":"J Bone Miner Res"},{"key":"9170_CR20","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/jbmr.5650070606","volume":"7","author":"P Steiger","year":"1992","unstructured":"Steiger P, Cummings SR, Black DM, Spencer NE, Genant HK (1992) Age-related decrements in bone mineral density in women over 65. J Bone Miner Res 7:625\u2013632","journal-title":"J Bone Miner Res"},{"key":"9170_CR21","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1001\/jama.298.20.2381","volume":"298","author":"DC Mackey","year":"2007","unstructured":"Mackey DC, Lui LY, Cawthon PM, Bauer DC, Nevitt MC, Cauley JA, Hillier TA, Lewis CE, Barrett-Connor E, Cummings SR (2007) High-trauma fractures and low bone mineral density in older women and men. JAMA 298:2381\u20132388","journal-title":"JAMA"},{"key":"9170_CR22","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0895-4356(93)90053-4","volume":"46","author":"RA Washburn","year":"1993","unstructured":"Washburn RA, Smith KW, Jette AM, Janney CA (1993) The Physical Activity Scale for the Elderly (PASE): development and evaluation. J Clin Epidemiol 46:153\u2013162","journal-title":"J Clin Epidemiol"},{"key":"9170_CR23","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S0002-8223(21)00836-1","volume":"92","author":"G Block","year":"1992","unstructured":"Block G, Subar AF (1992) Estimates of nutrient intake from a food frequency questionnaire: the 1987 National Health Interview Survey. J Am Diet Assoc 92:969\u2013977","journal-title":"J Am Diet Assoc"},{"key":"9170_CR24","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4899-3115-3_7","volume-title":"Time-dependent variables","author":"D Collett","year":"1994","unstructured":"Collett D (1994) Time-dependent variables. Chapman & Hall, London"},{"key":"9170_CR25","volume-title":"Estimating Cox regression models with PROC PHREG","author":"P Allison","year":"1995","unstructured":"Allison P (1995) Estimating Cox regression models with PROC PHREG. SAS Institute, Cary, NC"},{"key":"9170_CR26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/096228029900800102","volume":"8","author":"JL Schafer","year":"1999","unstructured":"Schafer JL (1999) Multiple imputation: a primer. Stat Methods Med Res 8:3\u201315","journal-title":"Stat Methods Med Res"},{"key":"9170_CR27","doi-asserted-by":"crossref","first-page":"757","DOI":"10.7326\/0003-4819-127-8_Part_2-199710151-00064","volume":"127","author":"DB Rubin","year":"1997","unstructured":"Rubin DB (1997) Estimating causal effects from large data sets using propensity scores. Ann Intern Med 127:757\u2013763","journal-title":"Ann Intern Med"},{"key":"9170_CR28","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF02556841","volume":"38","author":"J Tuukkanen","year":"1986","unstructured":"Tuukkanen J, Vaananen HK (1986) Omeprazole, a specific inhibitor of H+-K+-ATPase, inhibits bone resorption in vitro. Calcif Tissue Int 38:123\u2013125","journal-title":"Calcif Tissue Int"},{"key":"9170_CR29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF01352010","volume":"53","author":"K Mizunashi","year":"1993","unstructured":"Mizunashi K, Furukawa Y, Katano K, Abe K (1993) Effect of omeprazole, an inhibitor of H+, K+-ATPase, on bone resorption in humans. Calcif Tissue Int 53:21\u201325","journal-title":"Calcif Tissue Int"},{"key":"9170_CR30","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1056\/NEJM198507113130202","volume":"313","author":"RR Recker","year":"1985","unstructured":"Recker RR (1985) Calcium absorption and achlorhydria. N Engl J Med 313:70\u201373","journal-title":"N Engl J Med"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-008-9170-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-008-9170-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-008-9170-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T21:22:47Z","timestamp":1631827367000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-008-9170-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,24]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["9170"],"URL":"https:\/\/doi.org\/10.1007\/s00223-008-9170-1","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1137954.595058","asserted-by":"object"}]},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,24]]}}}