{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:34:39Z","timestamp":1791023679998,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T00:00:00Z","timestamp":1223510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1007\/s00223-008-9180-z","type":"journal-article","created":{"date-parts":[[2008,10,8]],"date-time":"2008-10-08T15:30:18Z","timestamp":1223479818000},"page":"308-314","source":"Crossref","is-referenced-by-count":16,"title":["The Effects of Strontium Ranelate in Asian Women with Postmenopausal Osteoporosis"],"prefix":"10.1007","volume":"83","author":[{"given":"J. S.","family":"Hwang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. F.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. S.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. S.","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. H.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. L.","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. T.","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,10,9]]},"reference":[{"key":"9180_CR1","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","volume":"359","author":"SR Cummings","year":"2002","unstructured":"Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359:1761\u20131767","journal-title":"Lancet"},{"key":"9180_CR2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/jbmr.5650100202","volume":"10","author":"LJ Melton III","year":"1995","unstructured":"Melton LJ III (1995) How many women have osteoporosis now? J Bone Miner Res 10:175\u2013177","journal-title":"J Bone Miner Res"},{"issue":"Suppl 3","key":"9180_CR3","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1007\/BF03194352","volume":"7","author":"KS Tsai","year":"1997","unstructured":"Tsai KS, Tai TY (1997) Epidemiology of osteoporosis in Taiwan. Osteoporos Int 7(Suppl 3):S96\u2013S98","journal-title":"Osteoporos Int"},{"key":"9180_CR4","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00198-003-1509-x","volume":"15","author":"TS Yang","year":"2004","unstructured":"Yang TS, Chen YR, Chen YJ, Chang CY, Ng HT (2004) Osteoporosis: prevalence in Taiwanese women. Osteoporos Int 15:345\u2013347","journal-title":"Osteoporos Int"},{"key":"9180_CR5","doi-asserted-by":"crossref","first-page":"12S","DOI":"10.1016\/S0002-9343(97)90022-X","volume":"103","author":"C Cooper","year":"1997","unstructured":"Cooper C (1997) The crippling consequences of fractures and their impact on quality of life. Am J Med 103:12S\u201319S","journal-title":"Am J Med"},{"key":"9180_CR6","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0140-6736(98)09075-8","volume":"353","author":"JR Center","year":"1999","unstructured":"Center JR, Nguyen TV, Schneider D, Sambrook PN, Eisman JA (1999) Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet 353:878\u2013882","journal-title":"Lancet"},{"key":"9180_CR7","first-page":"1535","volume":"348","author":"DM Black","year":"1996","unstructured":"Black DM, Cummings SR, Karpf DB, Cauley JA, Thompson DE, Nevitt MC, Bauer DC, Genant HK, Haskell WL, Marcus R, Ott SM, Torner JC, Quandt SA, Reiss TF, Ensrud KE (1996) Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group. Lancet 348:1535\u20131541","journal-title":"Fracture Intervention Trial Research Group. Lancet"},{"key":"9180_CR8","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1001\/jama.282.14.1344","volume":"282","author":"ST Harris","year":"1999","unstructured":"Harris ST, Watts NB, Genant HK, McKeever CD, Hangartner T, Keller M, Chesnut CH III, Brown J, Eriksen EF, Hoseyni MS, Axelrod DW, Miller PD (1999) Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group. JAMA 282:1344\u20131352","journal-title":"JAMA"},{"key":"9180_CR9","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM200105103441904","volume":"344","author":"RM Neer","year":"2001","unstructured":"Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster JY, Hodsman AB, Eriksen EF, Ish-Shalom S, Genant HK, Wang O, Mitlak BH (2001) Effect of parathyroid hormone (1\u201334) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med 344:1434\u20131441","journal-title":"N Engl J Med"},{"key":"9180_CR10","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1056\/NEJM199803123381107","volume":"338","author":"R Eastell","year":"1998","unstructured":"Eastell R (1998) Treatment of postmenopausal osteoporosis. N Engl J Med 338:736\u2013746","journal-title":"N Engl J Med"},{"key":"9180_CR11","first-page":"267","volume":"109","author":"CH Chesnut III","year":"2000","unstructured":"Chesnut CH III, Silverman S, Andriano K, Genant H, Gimona A, Harris S, Kiel D, LeBoff M, Maricic M, Miller P, Moniz C, Peacock M, Richardson P, Watts N, Baylink D (2000) A randomized trial of nasal spray salmon calcitonin in postmenopausal women with established osteoporosis: the Prevent Recurrence of Osteoporotic Fractures Study. PROOF Study Group. Am J Med 109:267\u2013276","journal-title":"PROOF Study Group. Am J Med"},{"key":"9180_CR12","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1210\/er.2001-9002","volume":"23","author":"A Cranney","year":"2002","unstructured":"Cranney A, Guyatt G, Griffith L, Wells G, Tugwell P, Rosen C, Osteoporosis Methodology Group, Osteoporosis Research Advisory Group (2002) Meta-analyses of therapies for postmenopausal osteoporosis IX: summary of meta-analyses of therapies for postmenopausal osteoporosis. Endocr Rev 23:570\u2013578","journal-title":"Endocr Rev"},{"key":"9180_CR13","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00198-005-2002-5","volume":"17","author":"JS Hwang","year":"2006","unstructured":"Hwang JS, Tu ST, Yang TS, Chen JF, Wang CJ, Tsai KS (2006) Teriparatide vs calcitonin in the treatment of Asian postmenopausal women with established osteoporosis. Osteoporos Int 17:373\u2013378","journal-title":"Osteoporos Int"},{"key":"9180_CR14","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S8756-3282(00)00384-7","volume":"27","author":"ML Yen","year":"2000","unstructured":"Yen ML, Yen BL, Jang MH, Hsu SH, Cheng WC, Tsai KS (2000) Effects of alendronate on osteopenic postmenopausal Chinese women. Bone 27:681\u2013685","journal-title":"Bone"},{"key":"9180_CR15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/01.blo.0000200247.27253.e9","volume":"443","author":"N Burlet","year":"2006","unstructured":"Burlet N, Reginster JY (2006) Strontium ranelate: the first dual acting treatment for postmenopausal osteoporosis. Clin Orthop Relat Res 443:55\u201360","journal-title":"Clin Orthop Relat Res"},{"key":"9180_CR16","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s002230010055","volume":"69","author":"PJ Marie","year":"2001","unstructured":"Marie PJ, Ammann P, Boivin G, Rey C (2001) Mechanisms of action and therapeutic potential of strontium in bone. Calcif Tissue Int 69:121\u2013129","journal-title":"Calcif Tissue Int"},{"key":"9180_CR17","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1210\/jc.2004-1774","volume":"90","author":"JY Reginster","year":"2005","unstructured":"Reginster JY, Seeman E, De Vernejoul MC, Adami S, Compston J, Phenekos C, Devogelaer JP, Curiel MD, Sawicki A, Goemaere S, Sorensen OH, Felsenberg D, Meunier PJ (2005) Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study. J Clin Endocrinol Metab 90:2816\u20132822","journal-title":"J Clin Endocrinol Metab"},{"key":"9180_CR18","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1056\/NEJMoa022436","volume":"350","author":"PJ Meunier","year":"2004","unstructured":"Meunier PJ, Roux C, Seeman E, Ortolani S, Badurski JE, Spector TD, Cannata J, Balogh A, Lemmel EM, Pors-Nielsen S, Rizzoli R, Genant HK, Reginster JY (2004) The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 350:459\u2013468","journal-title":"N Engl J Med"},{"key":"9180_CR19","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650080915","volume":"8","author":"HK Genant","year":"1993","unstructured":"Genant HK, Wu CY, van KC, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 8:1137\u20131148","journal-title":"J Bone Miner Res"},{"key":"9180_CR20","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.metabol.2003.10.022","volume":"53","author":"A Barbara","year":"2004","unstructured":"Barbara A, Delannoy P, Denis BG, Marie PJ (2004) Normal matrix mineralization induced by strontium ranelate in MC3T3\u2013E1 osteogenic cells. Metabolism 53:532\u2013537","journal-title":"Metabolism"},{"key":"9180_CR21","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/8756-3282(96)00080-4","volume":"18","author":"E Canalis","year":"1996","unstructured":"Canalis E, Hott M, Deloffre P, Tsouderos Y, Marie PJ (1996) The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro. Bone 18:517\u2013523","journal-title":"Bone"},{"key":"9180_CR22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0014-2999(02)02040-X","volume":"450","author":"R Baron","year":"2002","unstructured":"Baron R, Tsouderos Y (2002) In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation. Eur J Pharmacol 450:11\u201317","journal-title":"Eur J Pharmacol"},{"key":"9180_CR23","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1359\/jbmr.2003.18.6.1082","volume":"18","author":"N Takahashi","year":"2003","unstructured":"Takahashi N, Sasaki T, Tsouderos Y, Suda T (2003) S12911-2 inhibits osteoclastic bone resorption in vitro. J Bone Miner Res 18:1082\u20131087","journal-title":"J Bone Miner Res"},{"key":"9180_CR24","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S8756-3282(01)00484-7","volume":"29","author":"J Buehler","year":"2001","unstructured":"Buehler J, Chappuis P, Saffar JL, Tsouderos Y, Vignery A (2001) Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis). Bone 29:176\u2013179","journal-title":"Bone"},{"key":"9180_CR25","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1053\/meta.2002.33360","volume":"51","author":"P Delannoy","year":"2002","unstructured":"Delannoy P, Bazot D, Marie PJ (2002) Long-term treatment with strontium ranelate increases vertebral bone mass without deleterious effect in mice. Metabolism 51:906\u2013911","journal-title":"Metabolism"},{"key":"9180_CR26","doi-asserted-by":"crossref","unstructured":"Ammann P, Shen V, Robin B, Mauras Y, Bonjour JP, Rizzoli R (2004) Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats [erratum appears in J Bone Miner Res 2005;20:548]. J Bone Miner Res 19:2012\u20132020","DOI":"10.1359\/jbmr.040906"},{"key":"9180_CR27","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.bone.2004.04.026","volume":"35","author":"NS Pors","year":"2004","unstructured":"Pors NS (2004) The biological role of strontium. Bone 35:583\u2013588","journal-title":"Bone"},{"key":"9180_CR28","first-page":"2060","volume":"87","author":"PJ Meunier","year":"2002","unstructured":"Meunier PJ, Slosman DO, Delmas PD, Sebert JL, Brandi ML, Albanese C, Lorenc R, Pors-Nielsen S, De Vernejoul MC, Roces A, Reginster JY (2002) Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis\u2014a 2-year randomized placebo controlled trial. J Clin Endocrinol Metab 87:2060\u20132066","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 1","key":"9180_CR29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bone.2005.10.030","volume":"38","author":"S Ortolani","year":"2006","unstructured":"Ortolani S, Vai S (2006) Strontium ranelate: an increased bone quality leading to vertebral antifracture efficacy at all stages. Bone 38(Suppl 1):19\u201322","journal-title":"Bone"},{"key":"9180_CR30","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S1094-6950(06)60402-2","volume":"2","author":"SP Nielsen","year":"1999","unstructured":"Nielsen SP, Slosman D, Sorensen OH, Basse-Cathalinat B, De CP, Roux CR, Meunier PJ (1999) Influence of strontium on bone mineral density and bone mineral content measurements by dual X-ray absorptiometry. J Clin Densitom 2:371\u2013379","journal-title":"J Clin Densitom"},{"key":"9180_CR31","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jocd.2006.10.004","volume":"10","author":"GM Blake","year":"2007","unstructured":"Blake GM, Fogelman I (2007) Effect of bone strontium on BMD measurements. J Clin Densitom 10:34\u201338","journal-title":"J Clin Densitom"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-008-9180-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-008-9180-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-008-9180-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T11:37:55Z","timestamp":1558697875000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-008-9180-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,9]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["9180"],"URL":"https:\/\/doi.org\/10.1007\/s00223-008-9180-z","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,9]]}}}