{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:50:21Z","timestamp":1762505421761},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2008,11,20]],"date-time":"2008-11-20T00:00:00Z","timestamp":1227139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1007\/s00223-008-9191-9","type":"journal-article","created":{"date-parts":[[2008,11,19]],"date-time":"2008-11-19T17:42:11Z","timestamp":1227116531000},"page":"404-413","source":"Crossref","is-referenced-by-count":8,"title":["Primary Hyperparathyroidism: Role of the Preoperative Oral Calcium Loading Test in the Differential Diagnosis Between Adenoma and Hyperplasia"],"prefix":"10.1007","volume":"83","author":[{"given":"P.","family":"Hagag","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Kummer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,11,20]]},"reference":[{"key":"9191_CR1","first-page":"1071","volume-title":"Williams textbook of endocrinology","author":"FR Bringhurst","year":"2003","unstructured":"Bringhurst FR, Demay MB, Kronenberg HM (2003) Hormones and disorders of mineral metabolism. In: Larsen PR, Kronenberg HM, Melmed S, Polonsky KS (eds) Williams textbook of endocrinology, 10th edn. WB Saunders, Philadelphia, pp 1071\u20131303","edition":"10"},{"key":"9191_CR2","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1067\/msy.2099.101579","volume":"126","author":"F Pattou","year":"1999","unstructured":"Pattou F, Torres G, Mondragon-Sanchez A, Huglo D, N\u2019Guyen H, Carnaille B, Proye C (1999) Correlation of parathyroid scanning and anatomy in 261 unselected patients with sporadic primary hyperparathyroidism. Surgery 126:1123\u20131131","journal-title":"Surgery"},{"key":"9191_CR3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1043-2760(00)00345-3","volume":"12","author":"T Carling","year":"2001","unstructured":"Carling T (2001) Molecular pathology of parathyroid tumors. Trends Endocrinol Metab 12:53\u201358","journal-title":"Trends Endocrinol Metab"},{"key":"9191_CR4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF02739689","volume":"9","author":"X Sanjuan","year":"1998","unstructured":"Sanjuan X, Bryant BR, Sobel ME, Merino MI (1998) Clonality analysis of benign parathyroid lesions by human androgen receptor (HUMARA) gene assay. Endocr Pathol 9:293\u2013300","journal-title":"Endocr Pathol"},{"key":"9191_CR5","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/gcc.20565","volume":"47","author":"Y Yi","year":"2008","unstructured":"Yi Y, Nowak NJ, Pacchia AL, Morrison C (2008) Chromosome 11 genomic changes in parathyroid adenoma and hyperplasis: array CGH, FISH, and tissue microarrays. Genes Chromosomes Cancer 47:639\u2013648","journal-title":"Genes Chromosomes Cancer"},{"key":"9191_CR6","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00268-005-0708-3","volume":"30","author":"D Vel\u00e1zquez-Fern\u00e1ndez","year":"2006","unstructured":"Vel\u00e1zquez-Fern\u00e1ndez D, Laurell C, Saqui-Salces M, Pantoja JP, Candanedo-Gonzalez F, Reza-Albarr\u00e1n A, Gamboa-Dominguez A, Herrera MF (2006) Differential RNA expression profile by cDNA microarray in sporadic primary hyperparathyroidism (pHPT): primary parathyroid hyperplasia versus adenoma. World J Surg 30:705\u2013713","journal-title":"World J Surg"},{"key":"9191_CR7","first-page":"423","volume-title":"The parathyroids: basic and clinical concepts","author":"LE Mallette","year":"1994","unstructured":"Mallette LE (1994) The functional and pathological spectrum of parathyroid abnormalities in hyperparathyroidism. In: Bilezikian JP, Marcus R, Levine MA (eds) The parathyroids: basic and clinical concepts. Raven Press, New York, pp 423\u2013455"},{"key":"9191_CR8","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1046\/j.1365-2265.2000.00933.x","volume":"52","author":"S Corbetta","year":"2000","unstructured":"Corbetta S, Mantovani G, Lania A, Borgato S, Vicentini L, Beretta E, Faglia G, Di Blasis AM, Spada A (2000) Calcium-sensing receptor expression and signaling in human parathyroid adenomas and primary hyperplasia. Clin Endocrinol (Oxf) 52:339\u2013348","journal-title":"Clin Endocrinol (Oxf)"},{"key":"9191_CR9","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/0002-9343(79)90446-7","volume":"66","author":"EM Brown","year":"1979","unstructured":"Brown EM, Gardner DG, Brennan MF, Marx SJ, Spiegel AM, Attie MF, Downs RW Jr, Doppman JL, Aurbach CD (1979) Calcium-regulated parathyroid hormone release in primary hyperparathyroidism: studies in vitro with dispersed parathyroid cells. Am J Med 66:923\u2013931","journal-title":"Am J Med"},{"key":"9191_CR10","first-page":"1026","volume":"108","author":"CR McHenry","year":"1990","unstructured":"McHenry CR, Rosen IB, Walfish PG, Pollard A (1990) Oral calcium loading test: diagnostic and physiologic implications in hyperparathyroidism. Surgery 108:1026\u20131032","journal-title":"Surgery"},{"key":"9191_CR11","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1056\/NEJM196906192802504","volume":"280","author":"E Reiss","year":"1969","unstructured":"Reiss E, Canterbury JM (1969) Application of radioimmunoassay to differentiation of adenoma and hyperplasia and to preoperative localization of hyperfunctioning parathyroid glands. N Engl J Med 280:1381\u20131385","journal-title":"N Engl J Med"},{"key":"9191_CR12","doi-asserted-by":"crossref","first-page":"126","DOI":"10.5858\/2007-131-126-DEOKGI","volume":"131","author":"PP Schachter","year":"2007","unstructured":"Schachter PP, Ayesh S, Matouk I, Schneider T, Czerniak A, Hochberg A (2007) Differential expression of kinase genes in primary hyperparathyroidism: adenoma versus normal and hyperplastic parathyroid tissue. Arch Pathol Lab Med 131:126\u2013130","journal-title":"Arch Pathol Lab Med"},{"key":"9191_CR13","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1210\/jcem.87.5.8492","volume":"87","author":"S Corbetta","year":"2002","unstructured":"Corbetta S, Lania A, Filopanti M, Vicentini L, Ballar\u00e9 E, Spada A (2002) Mitogen-activated protein kinase cascade in human normal and tumoral parathyroid cells. J Clin Endocrinol Metab 87:2201\u20132205","journal-title":"J Clin Endocrinol Metab"},{"key":"9191_CR14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1365-2265.1991.tb03493.x","volume":"35","author":"P Lips","year":"1991","unstructured":"Lips P, Netelenbos JC, van Doorn L, Hackeng WHL, Lips CJM (1991) Stimulation and suppression of intact parathyroid hormone (PTH 1\u201384) in normal subjects and hyperparathyroid patients. Clin Endocrinol (Oxf) 35:35\u201340","journal-title":"Clin Endocrinol (Oxf)"},{"key":"9191_CR15","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1359\/JBMR.051210","volume":"21","author":"M Bevilacqua","year":"2006","unstructured":"Bevilacqua M, Dominguez LJ, Righini V, Valdes V, Vago T, Leopaldi E, Baldi G, Barrella M, Barbagallo M (2006) Dissimilar PTH, gastrin, and calcitonin responses to oral calcium and peptones in hypocalciuric hypercalcemia, primary hyperparathyroidism, and normal subjects: a useful tool for differential diagnosis. J Bone Miner Res 21:406\u2013412","journal-title":"J Bone Miner Res"},{"key":"9191_CR16","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1172\/JCI119413","volume":"99","author":"JM Ray","year":"1997","unstructured":"Ray JM, Squires PE, Curtis SB, Meloche MR, Buchan AM (1997) Expression of the calcium-sensing receptor on human antral gastrin cells in cultures. J Clin Invest 99:2328\u20132333","journal-title":"J Clin Invest"},{"key":"9191_CR17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev.physiol.65.072302.114200","volume":"65","author":"X Yao","year":"2003","unstructured":"Yao X, Forte JG (2003) Cell biology of acid secretion by the parietal cell. Annu Rev Physiol 65:103\u2013131","journal-title":"Annu Rev Physiol"},{"key":"9191_CR18","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1073\/pnas.86.8.2834","volume":"86","author":"P Persson","year":"1989","unstructured":"Persson P, Hakanson R, Axelson J, Sundler F (1989) Gastrin releases a blood calcium lowering peptide from the acid-producing part of the rat stomach. Proc Natl Acad Sci USA 86:2834\u20132838","journal-title":"Proc Natl Acad Sci USA"},{"key":"9191_CR19","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/BF03345180","volume":"26","author":"P Hagag","year":"2003","unstructured":"Hagag P, Revet-Zak I, Hod N, Horne T, Weiss M (2003) Diagnosis of normocalcemic hyperparathyroidism by oral calcium loading test. J Endocrinol Invest 26:327\u2013332","journal-title":"J Endocrinol Invest"},{"key":"9191_CR20","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.otc.2004.02.008","volume":"37","author":"JW Meilstrup","year":"2004","unstructured":"Meilstrup JW (2004) Ultrasound examination of the parathyroid glands. Otolaryngol Clin North Am 37:763\u2013778","journal-title":"Otolaryngol Clin North Am"},{"key":"9191_CR21","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1365-2796.2004.01422.x","volume":"257","author":"JP Bilezikian","year":"2005","unstructured":"Bilezikian JP, Brandi ML, Rubin M, Silverberg SJ (2005) Primary hyperparathyroidism: new concepts in clinical, densitometric and biochemical features. J Intern Med 257:6\u201317","journal-title":"J Intern Med"},{"key":"9191_CR22","first-page":"1436","volume":"78","author":"A St John","year":"1994","unstructured":"St John A, Thomas M, Dick I, Young P, Prince RL (1994) Parathyroid function in mild to moderate renal failure: evaluation by oral calcium suppression test. J Clin Endocrinol Metab 78:1436\u20131438","journal-title":"J Clin Endocrinol Metab"},{"key":"9191_CR23","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1365-2265.1982.tb02760.x","volume":"16","author":"S Adami","year":"1982","unstructured":"Adami S, Muirhead N, Manning RM, Gleed JJ, Papapoulos SE, Sandler LM, Catto GR, O\u2019Riordan JL (1982) Control of secretion of parathyroid hormone in secondary hyperparathyroidism. Clin Endocrinol (Oxf) 16:463\u2013473","journal-title":"Clin Endocrinol (Oxf)"},{"key":"9191_CR24","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00223-003-0070-0","volume":"74","author":"J Guillemant","year":"2004","unstructured":"Guillemant J, Accarie C, Peres G, Guillemant S (2004) Acute effects of an oral calcium load on markers of bone metabolism during endurance cycling exercise in male athletes. Calcif Tissue Int 74:407\u2013414","journal-title":"Calcif Tissue Int"},{"key":"9191_CR25","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF03347313","volume":"21","author":"JP Praet","year":"1998","unstructured":"Praet JP, Peretz A, Mets T, Rozenberg S (1998) Comparative study of the intestinal absorption of three salts of calcium in young and elderly women. J Endocrinol Invest 21:263\u2013267","journal-title":"J Endocrinol Invest"},{"key":"9191_CR26","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1136\/jcp.49.11.881","volume":"49","author":"CP Williams","year":"1996","unstructured":"Williams CP, Child DF, Hudson PR, Soysa LD, Davies GK, Davies MG, De Bolla AR (1996) Inappropriate phosphate excretion in idiopathic hypercalciuria: the key to a common cause and future treatment? J Clin Pathol 49:881\u2013888","journal-title":"J Clin Pathol"},{"key":"9191_CR27","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1210\/jcem-70-4-951","volume":"70","author":"JF Tohme","year":"1990","unstructured":"Tohme JF, Bilezikian JP, Clemens TL, Silgerberg SJ, Shane E, Lindsay R (1990) Suppression of parathyroid hormone secretion with oral calcium in normal subjects and patients with primary hyperparathyroidism. J Clin Endocrinol Metab 70:951\u2013956","journal-title":"J Clin Endocrinol Metab"},{"key":"9191_CR28","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1172\/JCI108324","volume":"57","author":"GP Mayer","year":"1976","unstructured":"Mayer GP, Habener JF, Potts JT Jr (1976) Parathyroid hormone secretion in vivo. Demonstration of a calcium-independent, nonsuppressible component of secretion. J Clin Invest 57:678\u2013683","journal-title":"J Clin Invest"},{"key":"9191_CR29","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-2265.1980.tb02704.x","volume":"12","author":"AE Broadus","year":"1980","unstructured":"Broadus AE, Horst RL, Littledike ET, Mahaffey JE, Rasmussen H (1980) Primary hyperparathyroidism with intermittent hypercalcaemia: serial observations and simple diagnosis by means of an oral calcium tolerance test. Clin Endocrinol (Oxf) 12:225\u2013235","journal-title":"Clin Endocrinol (Oxf)"},{"key":"9191_CR30","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1210\/jcem-58-3-480","volume":"58","author":"P Madvig","year":"1984","unstructured":"Madvig P, Young G, Marcus R (1984) Assessment of adenosine 3\u2032,5\u2032-monophosphate excretion and an oral calcium tolerance test in the diagnosis of mild primary hyperparathyroidism. J Clin Endocrinol Metab 58:480\u2013487","journal-title":"J Clin Endocrinol Metab"},{"key":"9191_CR31","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1365-2265.1972.tb00394.x","volume":"1","author":"TM Murray","year":"1972","unstructured":"Murray TM, Peacock M, Powell D, Monchik JM, Potts JT Jr (1972) Non-autonomy of hormone secretion in primary hyperparathyroidism. Clin Endocrinol (Oxf) 1:235\u2013246","journal-title":"Clin Endocrinol (Oxf)"},{"key":"9191_CR32","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1210\/jcem-48-4-604","volume":"48","author":"EM Brown","year":"1979","unstructured":"Brown EM, Broadus AE, Brennan MF, Gardner DG, Marx SJ, Spiegel AM, Downs RW Jr, Attie M, Aurbach AD (1979) Direct comparison in vivo and in vitro of suppressibility of parathyroid function by calcium in primary hyperparathyroidism. J Clin Endocrinol Metab 48:604\u2013610","journal-title":"J Clin Endocrinol Metab"},{"key":"9191_CR33","first-page":"1103","volume":"112","author":"JM Monchik","year":"1992","unstructured":"Monchik JM, Lamberton RP, Roth U (1992) Role of the oral calcium-loading test with measurement of intact parathyroid hormone in the diagnosis of symptomatic subtle primary hyperparathyroidism. Surgery 112:1103\u20131110","journal-title":"Surgery"},{"key":"9191_CR34","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1001\/archsurg.139.11.1175","volume":"139","author":"O Ugur","year":"2004","unstructured":"Ugur O, Bozkurt MF, Hamaloglu E, Sokmensuer C, Etikan I, Ugur Y, Sayek I, Gulec SA (2004) Clinicopathologic and radiopharmacokinetic factors affecting gamma probe-guided parathyroidectomy. Arch Surg 139:1175\u20131179","journal-title":"Arch Surg"},{"key":"9191_CR35","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1365-2265.2006.02601.x","volume":"65","author":"A Bhansali","year":"2006","unstructured":"Bhansali A, Masodi SR, Bhadada S, Mittal BR, Belura A, Singh P (2006) Ultrasonography in detection of single and multiple abnormal parathyroid glands in primary hyperparathyroidism: comparison with radionuclide scintigraphy and surgery. Clin Endocrinol (Oxf) 65:340\u2013345","journal-title":"Clin Endocrinol (Oxf)"},{"key":"9191_CR36","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s00268-004-7601-3","volume":"28","author":"JF Henry","year":"2004","unstructured":"Henry JF, Sebag F, Tamagnini P, Forman C, Silaghi H (2004) Endoscopic parathyroid surgery: results of 365 consecutive procedures. World J Surg 28:1219\u20131223","journal-title":"World J Surg"},{"key":"9191_CR37","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1097\/00000658-200205000-00008","volume":"235","author":"R Udelsman","year":"2002","unstructured":"Udelsman R (2002) Six hundred fifty six consecutive explorations for primary hyperparathyroidism. Ann Surg 235:665\u2013672","journal-title":"Ann Surg"},{"key":"9191_CR38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1072-7515(02)01178-X","volume":"195","author":"RA Saaristo","year":"2002","unstructured":"Saaristo RA, Salmi JJ, Koobi T, Turjanmaa V, Sand JA, Nordback IH (2002) Intraoperative localization of parathyroid glands with gamma counter probe in primary hyperparathyroidism: a prospective study. J Am Coll Surg 195:19\u201322","journal-title":"J Am Coll Surg"},{"key":"9191_CR39","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1056\/NEJM200012213432508","volume":"343","author":"SJ Marx","year":"2000","unstructured":"Marx SJ (2000) Hyperparathyroid and hypoparathyroid disorders. N Engl J Med 343:1863\u20131875","journal-title":"N Engl J Med"},{"key":"9191_CR40","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1007\/s00268-002-6620-1","volume":"26","author":"D Miura","year":"2002","unstructured":"Miura D, Wada N, Arici C, Morita E, Duh QY, Clark OH (2002) Does intraoperative quick parathyroid hormone assay improve the results of parathyroidectomy? World J Surg 26:926\u2013930","journal-title":"World J Surg"},{"key":"9191_CR41","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jamcollsurg.2008.01.066","volume":"207","author":"J McGill","year":"2008","unstructured":"McGill J, Sturgeon C, Kaplan SP, Chiu B, Kaplan EL, Angelos P (2008) How does the operative strategy for primary hyperparathyroidism impact the findings and cure rate? A comparison of 800 parathyroidectomies. J Am Coll Surg 207:246\u2013249","journal-title":"J Am Coll Surg"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-008-9191-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-008-9191-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-008-9191-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T19:32:53Z","timestamp":1632252773000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-008-9191-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,20]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["9191"],"URL":"https:\/\/doi.org\/10.1007\/s00223-008-9191-9","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,20]]}}}