{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T06:32:22Z","timestamp":1721111542073},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2009,2,19]],"date-time":"2009-02-19T00:00:00Z","timestamp":1235001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1007\/s00223-009-9219-9","type":"journal-article","created":{"date-parts":[[2009,2,18]],"date-time":"2009-02-18T22:53:37Z","timestamp":1234997617000},"page":"276-285","source":"Crossref","is-referenced-by-count":13,"title":["No Association Between Hip Geometry and Four Common Polymorphisms Associated with Fracture: The Danish Osteoporosis Prevention Study"],"prefix":"10.1007","volume":"84","author":[{"given":"N.","family":"Nissen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Madsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. M.","family":"Bladbjerg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E.","family":"Beck Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. R.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Langdahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Abrahamsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Brixen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,2,19]]},"reference":[{"key":"9219_CR1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s001980200071","volume":"13","author":"C Bergot","year":"2002","unstructured":"Bergot C, Bousson V, Meunier A, Laval-Jeantet M, Laredo JD (2002) Hip fracture risk and proximal femur geometry from DXA scans. Osteoporos Int 13:542\u2013550","journal-title":"Osteoporos Int"},{"key":"9219_CR2","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1136\/bmj.312.7041.1254","volume":"312","author":"D Marshall","year":"1996","unstructured":"Marshall D, Johnell O, Wedel H (1996) Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 312:1254\u20131259","journal-title":"BMJ"},{"key":"9219_CR3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s198-002-8337-y","volume":"13","author":"NJ Crabtree","year":"2002","unstructured":"Crabtree NJ, Kroger H, Martin A, Pols HA, Lorenc R, Nijs J, Stepan JJ, Falch JA, Miazgowski T, Grazio S, Raptou P, Adams J, Collings A, Khaw KT, Rushton N, Lunt M, Dixon AK, Reeve J (2002) Improving risk assessment: hip geometry, bone mineral distribution and bone strength in hip fracture cases and controls. The EPOS study. European Prospective Osteoporosis Study. Osteoporos Int 13:48\u201354","journal-title":"Osteoporos Int"},{"key":"9219_CR4","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1359\/jbmr.1997.12.11.1895","volume":"12","author":"F Duboeuf","year":"1997","unstructured":"Duboeuf F, Hans D, Schott AM, Kotzki PO, Favier F, Marcelli C, Meunier PJ, Delmas PD (1997) Different morphometric and densitometric parameters predict cervical and trochanteric hip fracture: the EPIDOS Study. J Bone Miner Res 12:1895\u20131902","journal-title":"J Bone Miner Res"},{"key":"9219_CR5","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/jbmr.5650081008","volume":"8","author":"KG Faulkner","year":"1993","unstructured":"Faulkner KG, Cummings SR, Black D, Palermo L, Gluer CC, Genant HK (1993) Simple measurement of femoral geometry predicts hip fracture: the study of osteoporotic fractures. J Bone Miner Res 8:1211\u20131217","journal-title":"Fractu Res J Bone Miner Res"},{"key":"9219_CR6","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00198-005-0019-4","volume":"17","author":"KG Faulkner","year":"2006","unstructured":"Faulkner KG, Wacker WK, Barden HS, Simonelli C, Burke PK, Ragi S, Del RL (2006) Femur strength index predicts hip fracture independent of bone density and hip axis length. Osteoporos Int 17:593\u2013599","journal-title":"Osteoporos Int"},{"key":"9219_CR7","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.bone.2005.08.004","volume":"37","author":"A Frisoli Jr","year":"2005","unstructured":"Frisoli A Jr, Paula AP, Pinheiro M, Szejnfeld VL, Delmonte PR, Takata E, Araujo ST, Chaves PH (2005) Hip axis length as an independent risk factor for hip fracture independently of femoral bone mineral density in Caucasian elderly Brazilian women. Bone 37:871\u2013875","journal-title":"Bone"},{"key":"9219_CR8","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1007\/s001980070071","volume":"11","author":"CG Alonso","year":"2000","unstructured":"Alonso CG, Curiel MD, Carranza FH, Cano RP, Perez AD (2000) Femoral bone mineral density, neck-shaft angle and mean femoral neck width as predictors of hip fracture in men and women. Multicenter Project for Research in Osteoporosis. Osteoporos Int 11:714\u2013720","journal-title":"Osteoporos Int"},{"key":"9219_CR9","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s00198-005-1988-z","volume":"16","author":"S El-Kaissi","year":"2005","unstructured":"El-Kaissi S, Pasco JA, Henry MJ, Panahi S, Nicholson JG, Nicholson GC, Kotowicz MA (2005) Femoral neck geometry and hip fracture risk: the Geelong osteoporosis study. Osteoporos Int 16:1299\u20131303","journal-title":"Osteoporos Int"},{"key":"9219_CR10","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/00004424-199001000-00004","volume":"25","author":"TJ Beck","year":"1990","unstructured":"Beck TJ, Ruff CB, Warden KE, Scott WW Jr, Rao GU (1990) Predicting femoral neck strength from bone mineral data. A structural approach. Invest Radiol 25:6\u201318","journal-title":"Invest Radiol"},{"key":"9219_CR11","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1385\/JCD:8:4:488","volume":"8","author":"HF Boehm","year":"2005","unstructured":"Boehm HF, Eckstein F, Wunderer C, Kuhn V, Lochmueller EM, Schreiber K, Mueller D, Rummeny EJ, Link TM (2005) Improved performance of hip DXA using a novel region of interest in the upper part of the femoral neck: in vitro study using bone strength as a standard of reference. J Clin Densitom 8:488\u2013494","journal-title":"J Clin Densitom"},{"key":"9219_CR12","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/jbmr.5650090714","volume":"9","author":"KG Faulkner","year":"1994","unstructured":"Faulkner KG, McClung M, Cummings SR (1994) Automated evaluation of hip axis length for predicting hip fracture. J Bone Miner Res 9:1065\u20131070","journal-title":"J Bone Miner Res"},{"key":"9219_CR13","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1359\/jbmr.2003.18.4.723","volume":"18","author":"B Abrahamsen","year":"2003","unstructured":"Abrahamsen B, Madsen JS, Tofteng CL, Stilgren L, Bladbjerg EM, Kristensen SR, Brixen K, Mosekilde L (2003) A common methylenetetrahydrofolate reductase (C677T) polymorphism is associated with low bone mineral density and increased fracture incidence after menopause: longitudinal data from the Danish Osteoporosis Prevention Study. J Bone Miner Res 18:723\u2013729","journal-title":"J Bone Miner Res"},{"key":"9219_CR14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/8756-3282(95)00418-1","volume":"18","author":"L Flicker","year":"1996","unstructured":"Flicker L, Faulkner KG, Hopper JL, Green RM, Kaymacki B, Nowson CA, Young D, Wark JD (1996) Determinants of hip axis length in women aged 10\u201389\u00a0years: a twin study. Bone 18:41\u201345","journal-title":"Bone"},{"key":"9219_CR15","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1172\/JCI113125","volume":"80","author":"NA Pocock","year":"1987","unstructured":"Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sambrook PN, Eberl S (1987) Genetic determinants of bone mass in adults. A twin study. J Clin Invest 80:706\u2013710","journal-title":"J Clin Invest"},{"key":"9219_CR16","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00223-004-0198-6","volume":"75","author":"AC Looker","year":"2004","unstructured":"Looker AC, Beck TJ (2004) Maternal history of osteoporosis and femur geometry. Calcif Tissue Int 75:277\u2013285","journal-title":"Calcif Tissue Int"},{"key":"9219_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2265.2001.01149.x","volume":"54","author":"EE Hobson","year":"2001","unstructured":"Hobson EE, Ralston SH (2001) Role of genetic factors in the pathophysiology and management of osteoporosis. Clin Endocrinol (Oxf) 54:1\u20139","journal-title":"Clin Endocrinol (Oxf)"},{"key":"9219_CR18","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s00223-001-2126-3","volume":"71","author":"HL Jorgensen","year":"2002","unstructured":"Jorgensen HL, Madsen JS, Madsen B, Saleh MM, Abrahamsen B, Fenger M, Lauritzen JB (2002) Association of a common allelic polymorphism (C677T) in the methylene tetrahydrofolate reductase gene with a reduced risk of osteoporotic fractuRes A case control study in Danish postmenopausal women. Calcif Tissue Int 71:386\u2013392","journal-title":"Calcif Tissue Int"},{"key":"9219_CR19","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.bone.2004.12.014","volume":"36","author":"B Abrahamsen","year":"2005","unstructured":"Abrahamsen B, Madsen JS, Tofteng CL, Stilgren L, Bladbjerg EM, Kristensen SR, Brixen K, Mosekilde L (2005) Are effects of MTHFR (C677T) genotype on BMD confined to women with low folate and riboflavin intake? Analysis of food records from the Danish Osteoporosis Prevention Study. Bone 36:577\u2013583","journal-title":"Bone"},{"key":"9219_CR20","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s00774-005-0676-6","volume":"24","author":"HH Lau","year":"2006","unstructured":"Lau HH, Ng MY, Cheung WM, Paterson AD, Sham PC, Luk KD, Chan V, Kung AW (2006) Assessment of linkage and association of 13 genetic loci with bone mineral density. J Bone Miner Metab 24:226\u2013234","journal-title":"J Bone Miner Metab"},{"key":"9219_CR21","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S1471-4892(03)00033-X","volume":"3","author":"SH Ralston","year":"2003","unstructured":"Ralston SH (2003) Genetic determinants of susceptibility to osteoporosis. Curr Opin Pharmacol 3:286\u2013290","journal-title":"Curr Opin Pharmacol"},{"key":"9219_CR22","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF01626540","volume":"6","author":"LM Salamone","year":"1996","unstructured":"Salamone LM, Ferrell R, Black DM, Palermo L, Epstein RS, Petro N, Steadman N, Kuller LH, Cauley JA (1996) The association between vitamin D receptor gene polymorphisms and bone mineral density at the spine, hip and whole-body in premenopausal women. Osteoporos Int 6:63\u201368","journal-title":"Osteoporos Int"},{"key":"9219_CR23","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/j.1365-2796.2005.01568.x","volume":"258","author":"C Valero","year":"2005","unstructured":"Valero C, Zarrabeitia MT, Hernandez JL, Zarrabeitia A, Gonzalez-Macias J, Riancho JA (2005) Bone mass in young adults: relationship with gender, weight and genetic factors. J Intern Med 258:554\u2013562","journal-title":"J Intern Med"},{"key":"9219_CR24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s002230010037","volume":"69","author":"AM Qureshi","year":"2001","unstructured":"Qureshi AM, McGuigan FE, Seymour DG, Hutchison JD, Reid DM, Ralston SH (2001) Association between COLIA1 Sp1 alleles and femoral neck geometry. Calcif Tissue Int 69:67\u201372","journal-title":"Calcif Tissue Int"},{"key":"9219_CR25","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/jbmr.5650110414","volume":"11","author":"NK Arden","year":"1996","unstructured":"Arden NK, Baker J, Hogg C, Baan K, Spector TD (1996) The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins. J Bone Miner Res 11:530\u2013534","journal-title":"J Bone Miner Res"},{"issue":"Suppl 1","key":"9219_CR26","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1186\/1471-2350-8-S1-S14","volume":"8","author":"DP Kiel","year":"2007","unstructured":"Kiel DP, Demissie S, Dupuis J, Lunetta KL, Murabito JM, Karasik D (2007) Genome-wide association with bone mass and geometry in the Framingham Heart Study. BMC Med Genet 8(Suppl 1):S14","journal-title":"BMC Med Genet"},{"key":"9219_CR27","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/BF01623395","volume":"6","author":"NK Arden","year":"1996","unstructured":"Arden NK, Keen RW, Lanchbury JS, Spector TD (1996) Polymorphisms of the vitamin D receptor gene do not predict quantitative ultrasound of the calcaneus or hip axis length. Osteoporos Int 6:334\u2013337","journal-title":"Osteoporos Int"},{"key":"9219_CR28","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s002230010038","volume":"66","author":"M Miyao","year":"2000","unstructured":"Miyao M, Morita H, Hosoi T, Kurihara H, Inoue S, Hoshino S, Shiraki M, Yazaki Y, Ouchi Y (2000) Association of methylenetetrahydrofolate reductase (MTHFR) polymorphism with bone mineral density in postmenopausal Japanese women. Calcif Tissue Int 66:190\u2013194","journal-title":"Calcif Tissue Int"},{"key":"9219_CR29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0021-9150(00)00696-1","volume":"157","author":"A Passaro","year":"2001","unstructured":"Passaro A, Vanini A, Calzoni F, Alberti L, Zamboni PF, Fellin R, Solini A (2001) Plasma homocysteine, methylenetetrahydrofolate reductase mutation and carotid damage in elderly healthy women. Atherosclerosis 157:175\u2013180","journal-title":"Atherosclerosis"},{"key":"9219_CR30","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1515\/CCLM.2001.115","volume":"39","author":"J Geisel","year":"2001","unstructured":"Geisel J, Zimbelmann I, Schorr H, Knapp JP, Bodis M, Hubner U, Herrmann W (2001) Genetic defects as important factors for moderate hyperhomocysteinemia. Clin Chem Lab Med 39:698\u2013704","journal-title":"Clin Chem Lab Med"},{"key":"9219_CR31","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0021-9150(00)00522-0","volume":"154","author":"V Dekou","year":"2001","unstructured":"Dekou V, Whincup P, Papacosta O, Ebrahim S, Lennon L, Ueland PM, Refsum H, Humphries SE, Gudnason V (2001) The effect of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase gene on homocysteine levels in elderly men and women from the British Regional Heart Study. Atherosclerosis 154:659\u2013666","journal-title":"Atherosclerosis"},{"key":"9219_CR32","doi-asserted-by":"crossref","first-page":"7574","DOI":"10.1074\/jbc.M104608200","volume":"277","author":"NR Jorgensen","year":"2002","unstructured":"Jorgensen NR, Henriksen Z, Sorensen OH, Eriksen EF, Civitelli R, Steinberg TH (2002) Intercellular calcium signaling occurs between human osteoblasts and osteoclasts and requires activation of osteoclast P2X7 receptors. J Biol Chem 277:7574\u20137580","journal-title":"J Biol Chem"},{"key":"9219_CR33","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/FPC.0b013e3280951625","volume":"17","author":"SD Ohlendorff","year":"2007","unstructured":"Ohlendorff SD, Tofteng CL, Jensen JE, Petersen S, Civitelli R, Fenger M, Abrahamsen B, Hermann AP, Eiken P, Jorgensen NR (2007) Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatment. Pharmacogenet Genomics 17:555\u2013567","journal-title":"Pharmacogenet Genomics"},{"key":"9219_CR34","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.bone.2005.01.006","volume":"36","author":"J Bollerslev","year":"2005","unstructured":"Bollerslev J, Wilson SG, Dick IM, Islam FM, Ueland T, Palmer L, Devine A, Prince RL (2005) LRP5 gene polymorphisms predict bone mass and incident fractures in elderly Australian women. Bone 36:599\u2013606","journal-title":"Bone"},{"key":"9219_CR35","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00223-007-9088-z","volume":"81","author":"K Brixen","year":"2007","unstructured":"Brixen K, Beckers S, Peeters A, Piters E, Balemans W, Nielsen TL, Wraae K, Bathum L, Brasen C, Hagen C, Andersen M, Van Hul W, Abrahamsen B (2007) Polymorphisms in the low-density lipoprotein receptor\u2013related protein 5 (LRP5) gene are associated with peak bone mass in non-sedentary men\u2014results from the Odense Androgen Study. Calcif Tissue Int 81:421\u2013429","journal-title":"Calcif Tissue Int"},{"key":"9219_CR36","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11926-005-0011-1","volume":"7","author":"H Jin","year":"2005","unstructured":"Jin H, Ralston SH (2005) Genetics of osteoporosis. Curr Rheumatol Rep 7:66\u201370","journal-title":"Curr Rheumatol Rep"},{"key":"9219_CR37","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.molmed.2005.01.004","volume":"11","author":"MA Koay","year":"2005","unstructured":"Koay MA, Brown MA (2005) Genetic disorders of the LRP5-Wnt signalling pathway affecting the skeleton. Trends Mol Med 11:129\u2013137","journal-title":"Trends Mol Med"},{"key":"9219_CR38","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1086\/420771","volume":"74","author":"SL Ferrari","year":"2004","unstructured":"Ferrari SL, Deutsch S, Choudhury U, Chevalley T, Bonjour JP, Dermitzakis ET, Rizzoli R, Antonarakis SE (2004) Polymorphisms in the low-density lipoprotein receptor\u2013related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites. Am J Hum Genet 74:866\u2013875","journal-title":"Am J Hum Genet"},{"key":"9219_CR39","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.bone.2005.01.014","volume":"36","author":"HH Lau","year":"2005","unstructured":"Lau HH, Ng MY, Ho AY, Luk KD, Kung AW (2005) Genetic and environmental determinants of bone mineral density in Chinese women. Bone 36:700\u2013709","journal-title":"Bone"},{"key":"9219_CR40","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0378-5122(99)00006-7","volume":"31","author":"L Mosekilde","year":"1999","unstructured":"Mosekilde L, Hermann AP, Beck-Nielsen H, Charles P, Nielsen SP, Sorensen OH (1999) The Danish Osteoporosis Prevention Study (DOPS): project design and inclusion of 2000 normal perimenopausal women. Maturitas 31:207\u2013219","journal-title":"Maturitas"},{"key":"9219_CR41","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jocd.2006.12.002","volume":"10","author":"JA Riancho","year":"2007","unstructured":"Riancho JA, Valero C, Hernandez JL, Olmos JM, Paule B, Zarrabeitia A, Gonzalez-Macias J (2007) Biomechanical indices of the femoral neck estimated from the standard DXA output: age- and sex-related differences. J Clin Densitom 10:39\u201345","journal-title":"J Clin Densitom"},{"key":"9219_CR42","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1080\/02841850510021562","volume":"46","author":"N Nissen","year":"2005","unstructured":"Nissen N, Hauge EM, Abrahamsen B, Jensen JE, Mosekilde L, Brixen K (2005) Geometry of the proximal femur in relation to age and sex: a cross-sectional study in healthy adult Danes. Acta Radiol 46:514\u2013518","journal-title":"Acta Radiol"},{"key":"9219_CR43","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1055\/s-0037-1613089","volume":"87","author":"EM Bladbjerg","year":"2002","unstructured":"Bladbjerg EM, Gram J, Jespersen J, de Maat MP (2002) Internal quality control of PCR-based genotyping methods in research studies and patient diagnostics. Thromb Haemost 87:812\u2013816","journal-title":"Thromb Haemost"},{"key":"9219_CR44","first-page":"309","volume":"29","author":"H Morita","year":"1997","unstructured":"Morita H, Taguchi J, Kurihara H, Kitaoka M, Kaneda H, Kurihara Y, Maemura K, Shindo T, Minamino T, Ohno M, Yamaoki K, Ogasawara K, Aizawa T, Suzuki S, Yazaki Y (1997) Gene Polymorphism of 5, 10-methylenetetrahydrofolate reductase as a coronary risk factor [in Japanese]. J Cardiol 29:309\u2013315","journal-title":"J Cardiol"},{"key":"9219_CR45","unstructured":"Gonzales-Bofill N, Husted LB, Vestergaard P, Tofteng CL, Abrahamsen B, Eiken P, Langdahl BL (2006) LRP5 and LRP6 polymorphisms affect peak bone mass but not early postmenopausal bone loss. J Bone Miner Res (Abstract, ASBMR)"},{"key":"9219_CR46","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.bone.2006.09.020","volume":"40","author":"S Demissie","year":"2007","unstructured":"Demissie S, Dupuis J, Cupples LA, Beck TJ, Kiel DP, Karasik D (2007) Proximal hip geometry is linked to several chromosomal regions: genome-wide linkage results from the Framingham Osteoporosis Study. Bone 40:743\u2013750","journal-title":"Bone"},{"key":"9219_CR47","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1359\/jbmr.2001.16.9.1634","volume":"16","author":"HM Macdonald","year":"2001","unstructured":"Macdonald HM, McGuigan FA, New SA, Campbell MK, Golden MH, Ralston SH, Reid DM (2001) COL1A1 Sp1 polymorphism predicts perimenopausal and early postmenopausal spinal bone loss. J Bone Miner Res 16:1634\u20131641","journal-title":"J Bone Miner Res"},{"key":"9219_CR48","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s002230010010","volume":"68","author":"RU Ashford","year":"2001","unstructured":"Ashford RU, Luchetti M, McCloskey EV, Gray RL, Pande KC, Dey A, Kayan K, Ralston SH, Kanis JA (2001) Studies of bone density, quantitative ultrasound, and vertebral fractures in relation to collagen type I alpha 1 alleles in elderly women. Calcif Tissue Int 68:348\u2013351","journal-title":"Calcif Tissue Int"},{"key":"9219_CR49","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00223-002-2006-5","volume":"72","author":"R Sapir-Koren","year":"2003","unstructured":"Sapir-Koren R, Livshits G, Kobyliansky E (2003) Association and linkage disequilibrium analyses suggest genetic effects of estrogen receptor alpha and collagen IA1 genes on bone mineral density in Caucasian women. Calcif Tissue Int 72:643\u2013650","journal-title":"Calcif Tissue Int"},{"key":"9219_CR50","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1371\/journal.pmed.0030090","volume":"3","author":"SH Ralston","year":"2006","unstructured":"Ralston SH, Uitterlinden AG, Brandi ML, Balcells S, Langdahl BL, Lips P, Lorenc R, Obermayer-Pietsch B, Scollen S, Bustamante M, Husted LB, Carey AH, Ez-Perez A, Dunning AM, Falchetti A, Karczmarewicz E, Kruk M, van Leeuwen JP, van Meurs JB, Mangion J, McGuigan FE, Mellibovsky L, Del MF, Pols HA, Reeve J, Reid DM, Renner W, Rivadeneira F, van Schoor NM, Sherlock RE, Ioannidis JP (2006) Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study. PLoS Med 3:e90","journal-title":"PLoS Med"},{"key":"9219_CR51","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1210\/jc.2005-2651","volume":"91","author":"TL Stewart","year":"2006","unstructured":"Stewart TL, Jin H, McGuigan FE, Albagha OM, Garcia-Giralt N, Bassiti A, Grinberg D, Balcells S, Reid DM, Ralston SH (2006) Haplotypes defined by promoter and intron 1 polymorphisms of the COLIA1 gene regulate bone mineral density in women. J Clin Endocrinol Metab 91:3575\u20133583","journal-title":"J Clin Endocrinol Metab"},{"key":"9219_CR52","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00198-004-1704-4","volume":"16","author":"MM Villadsen","year":"2005","unstructured":"Villadsen MM, Bunger MH, Carstens M, Stenkjaer L, Langdahl BL (2005) Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with osteoporotic vertebral fractures, but is a weak predictor of BMD. Osteoporos Int 16:411\u2013416","journal-title":"Osteoporos Int"},{"key":"9219_CR53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00223-007-9087-0","volume":"82","author":"L Rejnmark","year":"2008","unstructured":"Rejnmark L, Vestergaard P, Hermann AP, Brot C, Eiken P, Mosekilde L (2008) Dietary intake of folate, but not vitamin B2 or B12, is associated with increased bone mineral density 5\u00a0years after the menopause: results from a 10-year follow-up study in early postmenopausal women. Calcif Tissue Int 82:1\u201311","journal-title":"Calcif Tissue Int"},{"key":"9219_CR54","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.bone.2006.09.029","volume":"40","author":"DP Kiel","year":"2007","unstructured":"Kiel DP, Ferrari SL, Cupples LA, Karasik D, Manen D, Imamovic A, Herbert AG, Dupuis J (2007) Genetic variation at the low-density lipoprotein receptor\u2013related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men. Bone 40:587\u2013596","journal-title":"Bone"},{"key":"9219_CR55","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.bone.2006.11.010","volume":"40","author":"A Saarinen","year":"2007","unstructured":"Saarinen A, Valimaki VV, Valimaki MJ, Loyttyniemi E, Auro K, Uusen P, Kuris M, Lehesjoki AE, Makitie O (2007) The A1330\u00a0V polymorphism of the low-density lipoprotein receptor\u2013related protein 5 gene (LRP5) associates with low peak bone mass in young healthy men. Bone 40:1006\u20131012","journal-title":"Bone"},{"key":"9219_CR56","first-page":"166","volume":"7","author":"SA Dubrow","year":"2007","unstructured":"Dubrow SA, Hruby PM, Akhter MP (2007) Gender specific LRP5 influences on trabecular bone structure and strength. J Musculoskelet Neuronal Interact 7:166\u2013173","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"9219_CR57","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1359\/jbmr.061116","volume":"22","author":"DH Xiong","year":"2007","unstructured":"Xiong DH, Lei SF, Yang F, Wang L, Peng YM, Wang W, Recker RR, Deng HW (2007) Low-density lipoprotein receptor\u2013related protein 5 (LRP5) gene polymorphisms are associated with bone mass in both Chinese and whites. J Bone Miner Res 22:385\u2013393","journal-title":"J Bone Miner Res"},{"key":"9219_CR58","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1359\/JBMR.040704","volume":"19","author":"MA Koay","year":"2004","unstructured":"Koay MA, Woon PY, Zhang Y, Miles LJ, Duncan EL, Ralston SH, Compston JE, Cooper C, Keen R, Langdahl BL, MacLelland A, O\u2019Riordan J, Pols HA, Reid DM, Uitterlinden AG, Wass JA, Brown MA (2004) Influence of LRP5 polymorphisms on normal variation in BMD. J Bone Miner Res 19:1619\u20131627","journal-title":"J Bone Miner Res"},{"key":"9219_CR59","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1359\/JBMR.050904","volume":"21","author":"JB Meurs van","year":"2006","unstructured":"van Meurs JB, Rivadeneira F, Jhamai M, Hugens W, Hofman A, van Leeuwen JP, Pols HA, Uitterlinden AG (2006) Common genetic variation of the low-density lipoprotein receptor\u2013related protein 5 and 6 genes determines fracture risk in elderly white men. J Bone Miner Res 21:141\u2013150","journal-title":"J Bone Miner Res"},{"key":"9219_CR60","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1016\/S0021-9258(18)61477-2","volume":"262","author":"TH Steinberg","year":"1987","unstructured":"Steinberg TH, Silverstein SC (1987) Extracellular ATP4- promotes cation fluxes in the J774 mouse macrophage cell line. J Biol Chem 262:3118\u20133122","journal-title":"J Biol Chem"},{"key":"9219_CR61","doi-asserted-by":"crossref","first-page":"8884","DOI":"10.1016\/S0021-9258(18)47497-2","volume":"262","author":"TH Steinberg","year":"1987","unstructured":"Steinberg TH, Newman AS, Swanson JA, Silverstein SC (1987) ATP4- permeabilizes the plasma membrane of mouse macrophages to fluorescent dyes. J Biol Chem 262:8884\u20138888","journal-title":"J Biol Chem"},{"key":"9219_CR62","doi-asserted-by":"crossref","first-page":"7574","DOI":"10.1074\/jbc.M104608200","volume":"277","author":"NR Jorgensen","year":"2002","unstructured":"Jorgensen NR, Henriksen Z, Sorensen OH, Eriksen EF, Civitelli R, Steinberg TH (2002) Intercellular calcium signaling occurs between human osteoblasts and osteoclasts and requires activation of osteoclast P2X7 receptors. J Biol Chem 277:7574\u20137580","journal-title":"J Biol Chem"},{"key":"9219_CR63","doi-asserted-by":"crossref","first-page":"39107","DOI":"10.1074\/jbc.M105881200","volume":"276","author":"LN Naemsch","year":"2001","unstructured":"Naemsch LN, Dixon SJ, Sims SM (2001) Activity-dependent development of P2X7 current and Ca2+ entry in rabbit osteoclasts. J Biol Chem 276:39107\u201339114","journal-title":"J Biol Chem"},{"key":"9219_CR64","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S8756-3282(00)00351-3","volume":"27","author":"A Hoebertz","year":"2000","unstructured":"Hoebertz A, Townsend-Nicholson A, Glass R, Burnstock G, Arnett TR (2000) Expression of P2 receptors in bone and cultured bone cells. Bone 27:503\u2013510","journal-title":"Bone"},{"key":"9219_CR65","doi-asserted-by":"crossref","first-page":"7574","DOI":"10.1074\/jbc.M104608200","volume":"277","author":"NR Jorgensen","year":"2002","unstructured":"Jorgensen NR, Henriksen Z, Sorensen OH, Eriksen EF, Civitelli R, Steinberg TH (2002) Intercellular calcium signaling occurs between human osteoblasts and osteoclasts and requires activation of osteoclast P2X7 receptors. J Biol Chem 277:7574\u20137580","journal-title":"J Biol Chem"},{"key":"9219_CR66","doi-asserted-by":"crossref","first-page":"C403","DOI":"10.1152\/ajpcell.00361.2003","volume":"287","author":"JF Hiken","year":"2004","unstructured":"Hiken JF, Steinberg TH (2004) ATP downregulates P2X7 and inhibits osteoclast formation in RAW cells. Am J Physiol Cell Physiol 287:C403\u2013C412","journal-title":"Am J Physiol Cell Physiol"},{"key":"9219_CR67","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1359\/jbmr.2001.16.5.846","volume":"16","author":"A Gartland","year":"2001","unstructured":"Gartland A, Hipskind RA, Gallagher JA, Bowler WB (2001) Expression of a P2X7 receptor by a subpopulation of human osteoblasts. J Bone Miner Res 16:846\u2013856","journal-title":"J Bone Miner Res"},{"key":"9219_CR68","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00223-002-2098-y","volume":"73","author":"A Gartland","year":"2003","unstructured":"Gartland A, Buckley KA, Bowler WB, Gallagher JA (2003) Blockade of the pore-forming P2X7 receptor inhibits formation of multinucleated human osteoclasts in vitro. Calcif Tissue Int 73:361\u2013369","journal-title":"Calcif Tissue Int"},{"key":"9219_CR69","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1074\/jbc.M006781200","volume":"276","author":"M Solle","year":"2001","unstructured":"Solle M, Labasi J, Perregaux DG, Stam E, Petrushova N, Koller BH, Griffiths RJ, Gabel CA (2001) Altered cytokine production in mice lacking P2X7 receptors. J Biol Chem 276:125\u2013132","journal-title":"J Biol Chem"},{"key":"9219_CR70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00223-007-9024-2","volume":"81","author":"MA Koay","year":"2007","unstructured":"Koay MA, Tobias JH, Leary SD, Steer CD, Vilarino-Guell C, Brown MA (2007) The effect of LRP5 polymorphisms on bone mineral density is apparent in childhood. Calcif Tissue Int 81:1\u20139","journal-title":"Calcif Tissue Int"},{"key":"9219_CR71","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1359\/jbmr.040907","volume":"19","author":"SL Holmen","year":"2004","unstructured":"Holmen SL, Giambernardi TA, Zylstra CR, Buckner-Berghuis BD, Resau JH, Hess JF, Glatt V, Bouxsein ML, Ai M, Warman ML, Williams BO (2004) Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J Bone Miner Res 19:2033\u20132040","journal-title":"J Bone Miner Res"},{"key":"9219_CR72","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1359\/jbmr.061118","volume":"22","author":"UT Iwaniec","year":"2007","unstructured":"Iwaniec UT, Wronski TJ, Liu J, Rivera MF, Arzaga RR, Hansen G, Brommage R (2007) PTH stimulates bone formation in mice deficient in Lrp5. J Bone Miner Res 22:394\u2013402","journal-title":"J Bone Miner Res"},{"key":"9219_CR73","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s002239900177","volume":"60","author":"NA Pocock","year":"1997","unstructured":"Pocock NA, Noakes KA, Majerovic Y, Griffiths MR (1997) Magnification error of femoral geometry using fan beam densitometers. Calcif Tissue Int 60:8\u201310","journal-title":"Calcif Tissue Int"},{"key":"9219_CR74","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1302\/0301-620X.74B1.1732260","volume":"74","author":"PJ Rubin","year":"1992","unstructured":"Rubin PJ, Leyvraz PF, Aubaniac JM, Argenson JN, Esteve P, de Roguin B (1992) The morphology of the proximal femur. A three-dimensional radiographic analysis. J Bone Joint Surg Br 74:28\u201332","journal-title":"J Bone Joint Surg Br"},{"key":"9219_CR75","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s198-002-8337-y","volume":"13","author":"NJ Crabtree","year":"2002","unstructured":"Crabtree NJ, Kroger H, Martin A, Pols HA, Lorenc R, Nijs J, Stepan JJ, Falch JA, Miazgowski T, Grazio S, Raptou P, Adams J, Collings A, Khaw KT, Rushton N, Lunt M, Dixon AK, Reeve J (2002) Improving risk assessment: hip geometry, bone mineral distribution and bone strength in hip fracture cases and controls. The EPOS study. European Prospective Osteoporosis Study. Osteoporos Int 13:48\u201354","journal-title":"Osteoporos Int"},{"key":"9219_CR76","first-page":"62","volume":"15","author":"AS Karlamangla","year":"2003","unstructured":"Karlamangla AS, Barrett-Connor E, Young J, Greendale GA (2003) Hip fracture risk assessment using composite indices of femoral neck strength: the Rancho Bernardo Study. Osteoporos Int 15:62\u201370","journal-title":"Osteoporos Int"},{"key":"9219_CR77","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1056\/NEJM199503233321202","volume":"332","author":"SR Cummings","year":"1995","unstructured":"Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE, Cauley J, Black D, Vogt TM (1995) Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med 332:767\u2013773","journal-title":"N Engl J Med"},{"key":"9219_CR78","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/jbmr.5650090715","volume":"9","author":"T Nakamura","year":"1994","unstructured":"Nakamura T, Turner CH, Yoshikawa T, Slemenda CW, Peacock M, Burr DB, Mizuno Y, Orimo H, Ouchi Y, Johnston CC Jr (1994) Do variations in hip geometry explain differences in hip fracture risk between Japanese and white Americans? J Bone Miner Res 9:1071\u20131076","journal-title":"J Bone Miner Res"},{"key":"9219_CR79","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1002\/jbmr.5650100515","volume":"10","author":"DA Nelson","year":"1995","unstructured":"Nelson DA, Jacobsen G, Barondess DA, Parfitt AM (1995) Ethnic differences in regional bone density, hip axis length, and lifestyle variables among healthy black and white men. J Bone Miner Res 10:782\u2013787","journal-title":"J Bone Miner Res"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-009-9219-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-009-9219-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-009-9219-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T01:04:38Z","timestamp":1633136678000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-009-9219-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,19]]},"references-count":79,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["9219"],"URL":"https:\/\/doi.org\/10.1007\/s00223-009-9219-9","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,19]]}}}