{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T12:40:07Z","timestamp":1740832807203,"version":"3.38.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2011,1,6]],"date-time":"2011-01-06T00:00:00Z","timestamp":1294272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1007\/s00223-010-9456-y","type":"journal-article","created":{"date-parts":[[2011,1,5]],"date-time":"2011-01-05T05:28:36Z","timestamp":1294205316000},"page":"263-271","source":"Crossref","is-referenced-by-count":11,"title":["P2Y1 Transient Overexpression Induced Mineralization in Spinal Ligament Cells Derived from Patients with Ossification of the Posterior Longitudinal Ligament of the Cervical Spine"],"prefix":"10.1007","volume":"88","author":[{"given":"Sunao","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Asari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Motomura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Toh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-Ichi","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,1,6]]},"reference":[{"key":"9456_CR1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/0002-9343(92)90080-U","volume":"92","author":"DA Trojan","year":"1992","unstructured":"Trojan DA, Pouchot J, Pokrupa R, Ford RM, Adamsbaum C, Hill RO, Esdaile JM (1992) Diagnosis and treatment of ossification of the posterior longitudinal ligament of the spine. Am J Med 92:296\u2013306","journal-title":"Am J Med"},{"key":"9456_CR2","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1086\/378593","volume":"73","author":"T Tanaka","year":"2003","unstructured":"Tanaka T, Ikari K, Furushima K, Okada A, Tanaka H, Furukawa K, Yoshida K, Ikeda T, Ikegawa S, Hunt SC, Takeda J, Toh S, Harata S, Nakajima T, Inoue I (2003) Genomewide linkage and linkage disequilibrium analyses identify COL6A1, on chromosome 21, as the locus for ossification of the posterior longitudinal ligament of the spine. Am J Hum Genet 73:812\u2013822","journal-title":"Am J Hum Genet"},{"key":"9456_CR3","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1097\/00007632-200405010-00011","volume":"29","author":"G Kobashi","year":"2004","unstructured":"Kobashi G, Washio M, Okamoto K, Sasaki S, Yokoyama T, Miyake Y, Sakamoto N, Ohta K, Inaba Y, Tanaka H (2004) High body mass index after age 20 and diabetes mellitus are independent risk factors for ossification of the posterior longitudinal ligament of the spine in Japanese subjects: a case-control study in multiple hospitals. Spine 29:1006\u20131010","journal-title":"Spine"},{"key":"9456_CR4","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.2106\/00004623-200110000-00013","volume":"83","author":"T Akune","year":"2001","unstructured":"Akune T, Ogata N, Seichi A, Ohnishi I, Nakamura K, Kawaguchi H (2001) Insulin secretory response is positively associated with the extent of ossification of the posterior longitudinal ligament of the spine. J Bone Joint Surg Am 83:1537\u20131544","journal-title":"J Bone Joint Surg Am"},{"key":"9456_CR5","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.pharmthera.2008.03.007","volume":"118","author":"K-I Furukawa","year":"2008","unstructured":"Furukawa K-I (2008) Pharmacological aspect of ectopic ossification in spinal ligament tissues. Pharmacol Ther 118:352\u2013358","journal-title":"Pharmacol Ther"},{"issue":"2 Suppl","key":"9456_CR6","first-page":"180","volume":"96","author":"M Iwasaki","year":"2002","unstructured":"Iwasaki M, Kawaguchi Y, Kimura T, Yonenobu K (2002) Long-term results of expansive laminoplasty for ossification of the posterior longitudinal ligament of the cervical spine: more than 10\u00a0years follow up. J Neurosurg 96(2 Suppl):180\u2013189","journal-title":"J Neurosurg"},{"issue":"3 Suppl","key":"9456_CR7","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1097\/00007632-199203001-00007","volume":"17","author":"H Kawaguchi","year":"1992","unstructured":"Kawaguchi H, Kurokawa T, Hoshino Y, Kawahara H, Ogata E, Matsumoto T (1992) Immunohistochemical demonstration of bone morphogenetic protein-2 and transforming growth factor-\u03b2 in the ossification of the posterior longitudinal ligament of the cervical spine. Spine 17(3 Suppl):S33\u2013S36","journal-title":"Spine"},{"key":"9456_CR8","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3171\/SPI-07\/08\/174","volume":"7","author":"R Sato","year":"2007","unstructured":"Sato R, Uchida K, Kobayashi S, Yayama T, Kokubo Y, Nakajima H, Takamura T, Bangirana A, Itoh H, Baba H (2007) Ossification of the posterior longitudinal ligament of the cervical spine: histopathological findings around the calcification and ossification front. J Neurosurg Spine 7:174\u2013183","journal-title":"J Neurosurg Spine"},{"key":"9456_CR9","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S8756-3282(03)00204-7","volume":"22","author":"M Tanno","year":"2003","unstructured":"Tanno M, Furukawa K, Ueyama K, Harata S, Motomura S (2003) Uniaxial cyclic stretch induces osteogenic differentiation and synthesis of bone morphogenetic proteins of spinal ligament cells derived from patients with ossification of the posterior longitudinal ligaments. Bone 22:475\u2013484","journal-title":"Bone"},{"key":"9456_CR10","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1124\/jpet.102.047142","volume":"305","author":"H Ohishi","year":"2003","unstructured":"Ohishi H, Furukawa K, Iwasaki K, Ueyama K, Okada A, Motomura S, Harata S, Toh S (2003) Role of prostaglandin I2 in the gene expression induced by mechanical stress in spinal ligament cells derived from patients with ossification of the posterior longitudinal ligament. J Pharmacol Exp Ther 305:818\u2013824","journal-title":"J Pharmacol Exp Ther"},{"key":"9456_CR11","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s00223-002-0021-1","volume":"74","author":"K Iwasaki","year":"2004","unstructured":"Iwasaki K, Furukawa K, Tanno M, Kusumi T, Ueyama K, Tanaka M, Kudo H, Toh S, Harata S, Motomura S (2004) Uni-axial cyclic stretch induces Cbfa1 expression in spinal ligament cells derived from patients with ossification of the posterior longitudinal ligament. Calcif Tissue Int 74:448\u2013457","journal-title":"Calcif Tissue Int"},{"key":"9456_CR12","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s00223-006-0147-7","volume":"79","author":"T Iwasawa","year":"2006","unstructured":"Iwasawa T, Iwasaki K, Sawada T, Okada A, Ueyama K, Motomura S, Harata S, Inoue I, Toh S, Furukawa K (2006) Pathophysiological role of endothelin in ectopic ossification of human spinal ligaments induced by mechanical stress. Calcif Tissue Int 79:422\u2013430","journal-title":"Calcif Tissue Int"},{"key":"9456_CR13","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1002\/1529-0131(200007)43:7<1571::AID-ANR22>3.0.CO;2-L","volume":"43","author":"RD Graff","year":"2000","unstructured":"Graff RD, Lazerowski ER, Banes AJ, Lee GM (2000) ATP release by mechanically loaded porcine chondrons in pellet culture. Arthritis Rheum 43:1571\u20131579","journal-title":"Arthritis Rheum"},{"key":"9456_CR14","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1006\/bbrc.2001.6124","volume":"289","author":"M Romanello","year":"2001","unstructured":"Romanello M, Pani B, Bicego M, D\u2019Andrea P (2001) Mechanically induced ATP release from human osteoblastic cells. Biochem Biophys Res Commun 289:1275\u20131281","journal-title":"Biochem Biophys Res Commun"},{"key":"9456_CR15","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1359\/jbmr.070113","volume":"22","author":"RC Riddle","year":"2007","unstructured":"Riddle RC, Taylor AF, Rogers JR, Donahue HJ (2007) ATP release mediates fluid flow-induced proliferation of human bone marrow stromal cells. J Bone Miner Res 22:589\u2013600","journal-title":"J Bone Miner Res"},{"key":"9456_CR16","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0031-6997(24)01373-5","volume":"50","author":"V Ralevic","year":"1998","unstructured":"Ralevic V, Burnstock G (1998) Receptors for purines and pyrimidines. Pharmacol Rev 50:413\u2013492","journal-title":"Pharmacol Rev"},{"key":"9456_CR17","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1152\/physrev.00015.2002","volume":"82","author":"RA North","year":"2002","unstructured":"North RA (2002) Molecular physiology of P2X receptors. Physiol Rev 82:1013\u20131067","journal-title":"Physiol Rev"},{"key":"9456_CR18","doi-asserted-by":"crossref","first-page":"793","DOI":"10.2174\/1568026043451014","volume":"4","author":"G Burnstock","year":"2004","unstructured":"Burnstock G (2004) Introduction: P2 receptors. Curr Top Med Chem 4:793\u2013803","journal-title":"Curr Top Med Chem"},{"key":"9456_CR19","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.pharmthera.2005.08.014","volume":"110","author":"I K\u00fcgelgen von","year":"2006","unstructured":"von K\u00fcgelgen I (2006) Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther 110:415\u2013432","journal-title":"Pharmacol Ther"},{"key":"9456_CR20","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1002\/jcb.21249","volume":"101","author":"T Kanno","year":"2007","unstructured":"Kanno T, Takahashi T, Tsujusawa T, Ariyoshi W, Nishihara T (2007) Mechanical stress-mediated Runx2 activation is dependent on Ras\/ERK1\/2 MAPK signaling in osteoblasts. J Cell Biochem 101:1266\u20131277","journal-title":"J Cell Biochem"},{"key":"9456_CR21","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.bone.2007.09.058","volume":"42","author":"D Liu","year":"2008","unstructured":"Liu D, Genetos DC, Shao Y, Geist DJ, Li J, Ke HZ, Turner CH, Duncan RL (2008) Activation of extracellular-signal regulated kinase (ERK1\/2) by fluid shear is Ca2+- and ATP-dependent in MC3T3-E1 osteoblasts. Bone 42:644\u2013652","journal-title":"Bone"},{"key":"9456_CR22","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.ijom.2007.12.008","volume":"37","author":"MC Qi","year":"2008","unstructured":"Qi MC, Hu J, Zou SJ, Chen HQ, Zhou HX, Han LC (2008) Mechanical strain induces osteogenic differentiation: Cbfa1 and Ets-1 expression in stretched rat mesenchymal stem cells. Int J Oral Maxillofac Surg 37:453\u2013458","journal-title":"Int J Oral Maxillofac Surg"},{"key":"9456_CR23","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1254\/jphs.FP0071224","volume":"106","author":"T Sawada","year":"2008","unstructured":"Sawada T, Kishiya M, Kanemaru K, Seya K, Yokoyama T, Ueyama K, Motomura S, Toh S, Furukawa K (2008) Possible role of extracellular nucleotides in ectopic ossification of human spinal ligaments. J Pharmacol Sci 106:152\u2013161","journal-title":"J Pharmacol Sci"},{"key":"9456_CR24","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1161\/CIRCRESAHA.107.165795","volume":"102","author":"J Shen","year":"2008","unstructured":"Shen J, DiCorleto PE (2008) ADP stimulates human endothelial cell migration via P2Y1 nucleotide receptor-mediated mitogen-activated protein kinase pathways. Circ Res 102:448\u2013456","journal-title":"Circ Res"},{"key":"9456_CR25","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/cne.21066","volume":"498","author":"K Kobayashi","year":"2006","unstructured":"Kobayashi K, Fukuoka T, Yamanaka H, Dai Y, Obata K, Tokunaga A, Noguchi K (2006) Neurons and glial cells differentially express P2Y receptor mRNAs in the rat dorsal root ganglion and spinal cord. J Comp Neurol 498:443\u2013454","journal-title":"J Comp Neurol"},{"key":"9456_CR26","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1527-3466.2003.tb00106.x","volume":"21","author":"A Baurand","year":"2003","unstructured":"Baurand A, Gachet C (2003) The P2Y1 receptor as a target for new antithrombotic drugs: a review of the P2Y1 antagonist MRS-2179. Cardiovasc Drug Rev 21:67\u201376","journal-title":"Cardiovasc Drug Rev"},{"key":"9456_CR27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s11302-005-6209-x","volume":"1","author":"C L\u00e9on","year":"2005","unstructured":"L\u00e9on C, Freund M, Latchoumanin O, Farret A, Petit P, Cazenave JP, Gachet C (2005) The P2Y1 receptor is involved in the maintenance of glucose homeostasis and insulin secretion in mice. Purinergic Signal 1:145\u2013151","journal-title":"Purinergic Signal"},{"key":"9456_CR28","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.bone.2006.02.063","volume":"39","author":"IR Orriss","year":"2006","unstructured":"Orriss IR, Knight GE, Ranasinghe S, Burnstock G, Arnett TR (2006) Osteoblast responses to nucleotides increase during differentiation. Bone 39:300\u2013309","journal-title":"Bone"},{"key":"9456_CR29","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1124\/mol.65.2.426","volume":"65","author":"GL Waldo","year":"2004","unstructured":"Waldo GL, Harden TK (2004) Agonist binding and Gq-stimulating activities of the purified human P2Y1 receptor. Mol Pharmacol 65:426\u2013436","journal-title":"Mol Pharmacol"},{"key":"9456_CR30","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.bone.2009.09.017","volume":"46","author":"EC Alvarenga","year":"2010","unstructured":"Alvarenga EC, Rodrigues R, Caricati-Neto A, Silva-Filho FC, Paredes-Gamero EJ, Ferreira AT (2010) Low-intensity pulsed ultrasound-dependent osteoblast proliferation occurs by via activation of the P2Y receptor: role of the P2Y1 receptor. Bone 46:355\u2013362","journal-title":"Bone"},{"key":"9456_CR31","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1126\/science.3201241","volume":"242","author":"JM Wozney","year":"1988","unstructured":"Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, Wang EA (1988) Novel regulators of bone formation: molecular clones and activities. Science 242:1528\u20131534","journal-title":"Science"},{"key":"9456_CR32","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1002\/jcp.20988","volume":"211","author":"T Liu","year":"2007","unstructured":"Liu T, Gao Y, Sakamoto K, Minamizato T, Furukawa K, Tsukazaki T, Shibata Y, Bessho K, Komori T, Yamaguchi A (2007) BMP-2 promotes differentiation of osteoblasts and chondroblasts in Runx2-deficient cell lines. J Cell Physiol 211:728\u2013735","journal-title":"J Cell Physiol"},{"key":"9456_CR33","doi-asserted-by":"crossref","first-page":"29119","DOI":"10.1074\/jbc.M801774200","volume":"283","author":"T Matsubara","year":"2008","unstructured":"Matsubara T, Kida K, Yamaguchi A, Hata K, Ichida F, Meguro H, Aburatani H, Nishimura R, Yoneda T (2008) BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation. J Biol Chem 283:29119\u201329125","journal-title":"J Biol Chem"},{"key":"9456_CR34","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1097\/00007632-200405010-00003","volume":"29","author":"SH Moon","year":"2004","unstructured":"Moon SH, Park SR, Kim H, Kwon UH, Kim KH, Kim HS, Lee HM (2004) Biologic modification of ligamentum flavum cells by marker gene transfer and recombinant human bone morphogenetic protein-2. Spine 29:960\u2013965","journal-title":"Spine"},{"key":"9456_CR35","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s002239900231","volume":"60","author":"T Kon","year":"1997","unstructured":"Kon T, Yamazaki M, Tagawa M, Goto S, Terakado A, Moriya H, Fujimura S (1997) Bone morphogenetic protein-2 stimulates differentiation of cultured spinal ligament cells from patients with ossification of the posterior longitudinal ligament. Calcif Tissue Int 60:291\u2013296","journal-title":"Calcif Tissue Int"},{"key":"9456_CR36","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1101\/gad.1017802","volume":"16","author":"H Akiyama","year":"2002","unstructured":"Akiyama H, Chaboissier MC, Martin JF, Schedl A, de Crombrugghe B (2002) The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev 16:2813\u20132828","journal-title":"Genes Dev"},{"key":"9456_CR37","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1359\/jbmr.1999.14.10.1734","volume":"14","author":"BK Zehentner","year":"1999","unstructured":"Zehentner BK, Dony C, Burtscher H (1999) The transcription factor Sox9 is involved in BMP-2 signaling. J Bone Miner Res 14:1734\u20131741","journal-title":"J Bone Miner Res"},{"key":"9456_CR38","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/jcp.21496","volume":"217","author":"Q Pan","year":"2008","unstructured":"Pan Q, Yu Y, Chen Q, Li C, Wu H, Wan Y, Ma J, Sun F (2008) Sox9, a key transcription factor of bone morphogenetic protein-2-induced chondrogenesis, is activated through BMP pathway and a CCAAT box in the proximal promoter. J Cell Physiol 217:228\u2013241","journal-title":"J Cell Physiol"},{"key":"9456_CR39","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.bone.2009.04.239","volume":"45","author":"MV Bais","year":"2009","unstructured":"Bais MV, Wigner N, Young M, Toholka R, Graves DT, Morgan EF, Gerstenfeld LC, Einhorn TA (2009) BMP2 is essential for post natal osteogenesis but not for recruitment of osteogenic stem cells. Bone 45:254\u2013266","journal-title":"Bone"},{"key":"9456_CR40","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1091\/mbc.E09-03-0227","volume":"20","author":"K Amano","year":"2009","unstructured":"Amano K, Hata K, Sugita A, Takigawa Y, Ono K, Wakabayashi M, Kogo M, Nishimura R, Yoneda T (2009) Sox9 family members negatively regulate maturation and calcification of chondrocytes through up-regulation of parathyroid hormone-related protein. Mol Biol Cell 20:4541\u20134551","journal-title":"Mol Biol Cell"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-010-9456-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-010-9456-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-010-9456-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T11:46:11Z","timestamp":1740829571000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-010-9456-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,6]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["9456"],"URL":"https:\/\/doi.org\/10.1007\/s00223-010-9456-y","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"type":"print","value":"0171-967X"},{"type":"electronic","value":"1432-0827"}],"subject":[],"published":{"date-parts":[[2011,1,6]]}}}