{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:27:42Z","timestamp":1778614062734,"version":"3.51.4"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,2,16]],"date-time":"2012-02-16T00:00:00Z","timestamp":1329350400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1007\/s00223-012-9577-6","type":"journal-article","created":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T07:15:09Z","timestamp":1329290109000},"page":"279-285","source":"Crossref","is-referenced-by-count":26,"title":["Vitamin D Reduces Musculoskeletal Pain After Infusion of Zoledronic Acid for Postmenopausal Osteoporosis"],"prefix":"10.1007","volume":"90","author":[{"given":"Antonino","family":"Catalano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Morabito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Atteritano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Basile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Cucinotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Lasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,2,16]]},"reference":[{"issue":"9773","key":"9577_CR1","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","volume":"377","author":"TD Rachner","year":"2011","unstructured":"Rachner TD, Khosla S, Hofbauer LC (2011) Osteoporosis: now and the future. Lancet 377(9773):1276\u20131287","journal-title":"Lancet"},{"issue":"1","key":"9577_CR2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bone.2011.02.011","volume":"49","author":"R Eastell","year":"2011","unstructured":"Eastell R, Walsh JS, Watts NB, Siris E (2011) Bisphosphonates for postmenopausal osteoporosis. Bone 49(1):82\u201388","journal-title":"Bone"},{"key":"9577_CR3","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1056\/NEJMoa067312","volume":"356","author":"DM Black","year":"2007","unstructured":"Black DM, Delmas PD, Eastell R, Reid IR, Boonen S, Cauley JA, Cosman F, Lakatos P, Leung PC, Man Z, Mautalen C, Mesenbrink P, Hu H, Caminis J, Tong K, Rosario-Jansen T, Krasnow J, Hue TF, Sellmeyer D, Eriksen EF, Cummings SR, HORIZON Pivotal Fracture Trial (2007) Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med 356:1809\u20131822","journal-title":"N Engl J Med"},{"key":"9577_CR4","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/BF02556671","volume":"41","author":"S Adami","year":"1987","unstructured":"Adami S, Bhalla AK, Dorizzi R, Montesanti F, Rosini S, Salvagno G, Lo Cascio V (1987) The acute phase response after bisphosphonates administration. Calcif Tissue Int 41:326\u2013331","journal-title":"Calcif Tissue Int"},{"key":"9577_CR5","doi-asserted-by":"crossref","first-page":"755","DOI":"10.2165\/00002018-200730090-00003","volume":"30","author":"W Strampel","year":"2007","unstructured":"Strampel W, Emkey R, Civitelli R (2007) Safety considerations with bisphosphonates for the treatment of osteoporosis. Drug Saf 30:755\u2013763","journal-title":"Drug Saf"},{"key":"9577_CR6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00223-011-9499-8","volume":"89","author":"R Rizzoli","year":"2011","unstructured":"Rizzoli R, Reginster JY, Boonen S, Breart G, Diez-Perez A, Felsenberg D, Kaufman JM, Kanis JA, Cooper C (2011) Adverse reaction and drug\u2013drug interactions in the management of women with postmenopausal osteoporosis. Calcif Tissue Int 89:91\u2013104","journal-title":"Calcif Tissue Int"},{"key":"9577_CR7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2174\/0929866023408779","volume":"9","author":"F Ceciliani","year":"2002","unstructured":"Ceciliani F, Giordano A, Spagnolo V (2002) The systemic reaction during inflammation: the acute-phase proteins. Protein Pept Lett 9:211\u2013223","journal-title":"Protein Pept Lett"},{"key":"9577_CR8","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s002239900353","volume":"61","author":"D Thiebaud","year":"1997","unstructured":"Thiebaud D, Sauty A, Burckhardt P, Leuenberger P, Sitzler L, Green JR, Kandra A, Zieschang J, Ibarra de Palacios P (1997) An in vitro and in vivo study of cytokines in the acute-phase response associated with bisphosphonates. Calcif Tissue Int 61:386\u2013392","journal-title":"Calcif Tissue Int"},{"key":"9577_CR9","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1517\/14728222.11.7.941","volume":"11","author":"S Galluzzo","year":"2007","unstructured":"Galluzzo S, Santini D, Vincenzi B, Caccamo N, Meraviglia F, Salerno A, Dieli F, Tonini G (2007) Immunomodulating role of bisphosphonates on human \u03b3, \u03b4 T cells: an intriguing and promising aspect of their antitumour activity. Expert Opin Ther Targets 11:941\u2013954","journal-title":"Expert Opin Ther Targets"},{"key":"9577_CR10","doi-asserted-by":"crossref","first-page":"6222","DOI":"10.1158\/1078-0432.CCR-06-0843","volume":"12","author":"AJ Roelofs","year":"2006","unstructured":"Roelofs AJ, Thompson K, Gordon S, Rogers MJ (2006) Molecular mechanisms of action of bisphosphonates: current status. Clin Cancer Res 12:6222\u20136230","journal-title":"Clin Cancer Res"},{"key":"9577_CR11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1365-2249.2005.02665.x","volume":"139","author":"RE Hewitt","year":"2005","unstructured":"Hewitt RE, Lissina A, Green AE, Slay ES, Price DA, Sewell AK (2005) The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood \u03b3, \u03b4 T cells in response to aminobisphosphonates is inhibited by statins. Clin Exp Immunol 139:101\u2013111","journal-title":"Clin Exp Immunol"},{"key":"9577_CR12","doi-asserted-by":"crossref","first-page":"4380","DOI":"10.1210\/jc.2010-0597","volume":"95","author":"IR Reid","year":"2010","unstructured":"Reid IR, Gamble GD, Mesenbrink P, Lakatos P, Black DM (2010) Characterization of and risk factors for the acute-phase response after zoledronic acid. J Clin Endocrinol Metab 95:4380\u20134387","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"9577_CR13","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1359\/jbmr.090819","volume":"25","author":"F Bertoldo","year":"2010","unstructured":"Bertoldo F, Pancheri S, Zenari S, Boldini S, Giovanazzi B, Zanatta M, Valenti MT, Dalle Carbonare L, Lo Cascio V (2010) Serum 25-hydroxyvitamin D levels modulate the acute-phase response associated with the first nitrogen-containing bisphosphonate infusion. J Bone Miner Res 25(3):447\u2013454","journal-title":"J Bone Miner Res"},{"issue":"2","key":"9577_CR14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/jbmr.290","volume":"26","author":"T Srivastava","year":"2011","unstructured":"Srivastava T, Dai H, Haney CJ, Alon US (2011) Serum 25-hydroxyvitamin D level and acute-phase reaction following initial intravenous bisphosphonate. J Bone Miner Res 26(2):437\u2013438","journal-title":"J Bone Miner Res"},{"key":"9577_CR15","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.4049\/jimmunol.173.5.2909","volume":"173","author":"T-T Wang","year":"2004","unstructured":"Wang T-T, Nestel FP, Bourdeau V, Nagai Y, Wang Q, Liao J, Tavera-Mendoza L, Lin R, Hanrahan JH, Mader S, White JH (2004) Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol 173:2909\u20132912","journal-title":"J Immunol"},{"key":"9577_CR16","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1359\/jbmr.2001.16.11.2057","volume":"16","author":"C Mathieu","year":"2001","unstructured":"Mathieu C, Van Etten E, Gysemans C, Gysemans C, Decallonne B, Kato S, Laurevs J, Depovere J, Valckx D, Verstuyf A, Bouillon R (2001) In vitro and in vivo analysis of the immune system of vitamin D receptor knockout mice. J Bone Miner Res 16:2057\u20132065","journal-title":"J Bone Miner Res"},{"key":"9577_CR17","doi-asserted-by":"crossref","first-page":"4974","DOI":"10.4049\/jimmunol.167.9.4974","volume":"167","author":"A Boonstra","year":"2001","unstructured":"Boonstra A, Barrat FJ, Crain C, Health VL, Savelkoul HF, O\u2019Garra A (2001) 1\u03b1,25-Dihydroxyvitamin D3 has a direct effect on naive CD4+ T cells to enhance the development of Th2 cells. J Immunol 167:4974\u20134980","journal-title":"J Immunol"},{"key":"9577_CR18","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.2337\/diabetes.51.5.1367","volume":"51","author":"S Gregori","year":"2002","unstructured":"Gregori S, Giarratana N, Smiroldo S, Uskokovic M, Adorini L (2002) A 1\u03b1,25-dihydroxyvitamin D3 analog enhances regulatory T cells and arrests autoimmune diabetes in NOD mice. Diabetes 51:1367\u20131374","journal-title":"Diabetes"},{"issue":"24","key":"9577_CR19","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.3748\/wjg.14.3897","volume":"14","author":"X-P Qi","year":"2008","unstructured":"Qi X-P, Pei L, Gang L, Sun Z, Li J-S (2008) 1,25-Dihydroxyvitamin D3 regulates LPS-induced cytokine production and reduces mortality in rats. World J Gastroenterol 14(24):3897\u20133902","journal-title":"World J Gastroenterol"},{"issue":"10","key":"9577_CR20","doi-asserted-by":"crossref","first-page":"6144","DOI":"10.4049\/jimmunol.174.10.6144","volume":"174","author":"L Chen","year":"2005","unstructured":"Chen L, Cencioni MT, Angelini DF, Borsellino G, Battistini L, Brosnan CF (2005) Transcriptional profiling of \u03b3, \u03b4 T cells identifies a role for vitamin D in the immunoregulation of the Vg9Vd2 response to phosphonate containing ligands. J Immunol 174(10):6144\u20136152","journal-title":"J Immunol"},{"key":"9577_CR21","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","volume":"357","author":"MF Holick","year":"2007","unstructured":"Holick MF (2007) Vitamin D deficiency. N Engl J Med 357:266\u2013281","journal-title":"N Engl J Med"},{"issue":"9","key":"9577_CR22","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650080915","volume":"8","author":"HK Genant","year":"1993","unstructured":"Genant HK, Wu CY, van Kuijk C, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 8(9):1137\u20131148","journal-title":"J Bone Miner Res"},{"issue":"2","key":"9577_CR23","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1359\/JBMR.0301230","volume":"19","author":"K Thompson","year":"2004","unstructured":"Thompson K, Rogers MJ (2004) Statins prevent bisphosphonate-induced \u03b3, \u03b4 T-cell proliferation and activation in vitro. J Bone Miner Res 19(2):278\u2013288","journal-title":"J Bone Miner Res"},{"issue":"52","key":"9577_CR24","doi-asserted-by":"crossref","first-page":"22593","DOI":"10.1073\/pnas.1011624108","volume":"107","author":"K Edfeldt","year":"2010","unstructured":"Edfeldt K, Liu PT, Chun R, Fabri M, Schenk M, Wheelwright M, Keegan C, Krutzik SR, Adams JS, Hewison M, Modlin RL (2010) T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism. Proc Natl Acad Sci USA 107(52):22593\u201322598","journal-title":"Proc Natl Acad Sci USA"},{"issue":"10","key":"9577_CR25","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.1210\/jc.2010-0502","volume":"95","author":"C Cipriani","year":"2010","unstructured":"Cipriani C, Romagnoli E, Scillitani A, Chiodini I, Clerico R, Carnevale V, Mascia ML, Battista C, Viti R, Pileri M, Eller-Vainicher C, Minisola S (2010) Effect of a single oral dose of 600,000 IU of cholecalciferol on serum calciotropic hormones in young subjects with vitamin D deficiency: a prospective intervention study. J Clin Endocrinol Metab 95(10):4771\u20134777","journal-title":"J Clin Endocrinol Metab"},{"key":"9577_CR26","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1210\/jc.2008-0350","volume":"93","author":"E Romagnoli","year":"2008","unstructured":"Romagnoli E, Mascia ML, Cipriani C, Fassino V, Mazzei F, D\u2019Erasmo E, Carnevale V, Scillitani A, Minisola S (2008) Short and long term variations in serum calciotropic hormones after a single very large dose of ergocolecalciferol (vitamin D2) or cholecalciferol (vitamin D3) in the elderly. J Clin Endocrinol Metab 93:3015\u20133020","journal-title":"J Clin Endocrinol Metab"},{"key":"9577_CR27","doi-asserted-by":"crossref","unstructured":"Araki T, Holick MF, Alfonso BD, Charlap E, Romero CM, Rizk D, Newman LG (2011) Vitamin D intoxication with severe hypercalcemia due to manufacturing and labeling errors of two dietary supplements made in the United States. J Clin Endocrinol Metab. doi: 10.1210\/jc.2011-1443","DOI":"10.1210\/jc.2011-1443"},{"key":"9577_CR28","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.4049\/jimmunol.164.5.2405","volume":"164","author":"G Penna","year":"2000","unstructured":"Penna G, Adorini L (2000) 1\u03b1,25-Dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J Immunol 164:2405\u20132411","journal-title":"J Immunol"},{"key":"9577_CR29","doi-asserted-by":"crossref","first-page":"6800","DOI":"10.1073\/pnas.121172198","volume":"98","author":"MD Griffin","year":"2001","unstructured":"Griffin MD, Lutz W, Phan VA, Bachman LA, McKean DJ, Kumar R (2001) Dendritic cell modulation by 1\u03b1,25 dihydroxyvitamin D3 and its analogs: a vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo. Proc Natl Acad Sci USA 98:6800\u20136805","journal-title":"Proc Natl Acad Sci USA"},{"key":"9577_CR30","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.2337\/diabetes.49.8.1301","volume":"49","author":"L Overbergh","year":"2000","unstructured":"Overbergh L, Decallonne B, Waer M, Rutgeerts O, Valckx D, Casteels KM, Laureys J, Bouillon R, Mathieu C (2000) 1\u03b1,25-Dihydroxyvitamin D3 induces an autoantigen-specific T-helper 1\/T-helper 2 immune shift in NOD mice immunized withGAD65 (p524\u2013543). Diabetes 49:1301\u20131307","journal-title":"Diabetes"},{"key":"9577_CR31","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0140-6736(94)92689-1","volume":"343","author":"PR Woodhouse","year":"1994","unstructured":"Woodhouse PR, Khaw KT, Plummer M, Foley A, Meade TW (1994) Seasonal variations of plasma fibrinogen and factor VII activity in the elderly: winter infections and death from cardiovascular disease. Lancet 343:435\u2013439","journal-title":"Lancet"},{"key":"9577_CR32","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1001\/archinte.163.10.1200","volume":"163","author":"D Rothenbacher","year":"2003","unstructured":"Rothenbacher D, Hoffmeister A, Brenner H, Koenig W (2003) Physical activity, coronary heart disease, and inflammatory response. Arch Intern Med 163:1200\u20131205","journal-title":"Arch Intern Med"},{"key":"9577_CR33","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1046\/j.1532-5415.2003.51380.x","volume":"51","author":"DB Reuben","year":"2003","unstructured":"Reuben DB, Judd-Hamilton L, Harris TB, Seeman TE (2003) The associations between physical activity and inflammatory markers in high functioning older persons: McArthur studies of successful aging. J Am Geriatr Soc 51:1125\u20131130","journal-title":"J Am Geriatr Soc"},{"key":"9577_CR34","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/01.CIR.95.2.335","volume":"95","author":"W Koenig","year":"1997","unstructured":"Koenig W, Sund M, Doring A, Ernst E (1997) Leisure time physical activity but not work related physical activity is associated with decreased plasma viscosity: results from a large population sample. Circulation 95:335\u2013341","journal-title":"Circulation"},{"key":"9577_CR35","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1161\/01.ATV.20.1.271","volume":"20","author":"JW Yarnell","year":"2000","unstructured":"Yarnell JW, Sweetnam PM, Rumley A, Lowe GD (2000) Lifestyle and hemostatic risk factors for ischemic heart disease: the Caerphilly study. Arterioscler Thromb Vasc Biol 20:271\u2013279","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"17","key":"9577_CR36","doi-asserted-by":"crossref","first-page":"7917","DOI":"10.1158\/0008-5472.CAN-05-1435","volume":"65","author":"J Moreno","year":"2005","unstructured":"Moreno J, Krishnan AV, Swami S, Nonn L, Peehl DM, Feldman D (2005) Regulation of prostaglandin metabolism by calcitriol attenuates growth stimulation in prostate cancer cells. Cancer Res 65(17):7917\u20137925","journal-title":"Cancer Res"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-012-9577-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-012-9577-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-012-9577-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T18:47:07Z","timestamp":1561315627000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-012-9577-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,16]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["9577"],"URL":"https:\/\/doi.org\/10.1007\/s00223-012-9577-6","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,16]]}}}