{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T23:58:25Z","timestamp":1768780705731,"version":"3.49.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,4,29]],"date-time":"2012-04-29T00:00:00Z","timestamp":1335657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1007\/s00223-012-9602-9","type":"journal-article","created":{"date-parts":[[2012,4,28]],"date-time":"2012-04-28T02:00:01Z","timestamp":1335578401000},"page":"15-23","source":"Crossref","is-referenced-by-count":7,"title":["Novel Sequence Variations in the CER1 Gene Are Strongly Associated with Low Bone Mineral Density and Risk of Osteoporotic Fracture in Postmenopausal Women"],"prefix":"10.1007","volume":"91","author":[{"given":"Theodora","family":"Koromila","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe","family":"Dailiana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stavroula","family":"Samara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Chassanidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chara","family":"Tzavara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George P.","family":"Patrinos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vassiliki","family":"Aleporou-Marinou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagoula","family":"Kollia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,4,29]]},"reference":[{"key":"9602_CR1","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.bone.2007.11.007","volume":"42","author":"BL Langdahl","year":"2008","unstructured":"Langdahl BL (2008) Large-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene (TGFB1) and osteoporosis: the GENOMOS study. Bone 42:969\u2013981","journal-title":"Bone"},{"key":"9602_CR2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0889-8529(02)00059-2","volume":"32","author":"PO Albagha","year":"2003","unstructured":"Albagha PO, Ralston SH (2003) Genetic determinants of susceptibility to osteoporosis. Endocrinol Metab Clin North Am 32:65\u201381","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"5","key":"9602_CR3","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.beem.2008.08.007","volume":"22","author":"SM Ferrari","year":"2008","unstructured":"Ferrari SM (2008) Human genetics of osteoporosis. Best Pract Res Clin Endocrinol Metab 22(5):723\u2013735","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"17","key":"9602_CR4","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1056\/NEJMra0808700","volume":"360","author":"J Hardy","year":"2009","unstructured":"Hardy J, Singleton A (2009) Genomewide association studies and human disease. N Engl J Med 360(17):1759\u20131768","journal-title":"N Engl J Med"},{"issue":"22","key":"9602_CR5","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1056\/NEJMoa0801197","volume":"358","author":"U Styrkarsdottir","year":"2008","unstructured":"Styrkarsdottir U, Halldorsson BV, Gretarsdottir S et al (2008) Multiple genetic loci for bone mineral density and fractures. N Engl J Med 358(22):2355\u20132365","journal-title":"N Engl J Med"},{"issue":"11","key":"9602_CR6","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/ng.446","volume":"41","author":"F Rivadeneira","year":"2009","unstructured":"Rivadeneira F, Styrkarsdottir U, Estrada K et al (2009) Twenty bone\u2010mineral\u2010density loci identified by large\u2010scale meta\u2010analysis of genome\u2010wide association studies. Nat Genet 41(11):1199\u20131206","journal-title":"Nat Genet"},{"issue":"1","key":"9602_CR7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/ng.284","volume":"41","author":"U Styrkarsdottir","year":"2009","unstructured":"Styrkarsdottir U, Halldorsson BV, Gretarsdottir S et al (2009) New sequence variants associated with bone mineral density. Nat Genet 41(1):15\u201317","journal-title":"Nat Genet"},{"issue":"6","key":"9602_CR8","doi-asserted-by":"crossref","first-page":"e1000977","DOI":"10.1371\/journal.pgen.1000977","volume":"6","author":"YH Hsu","year":"2010","unstructured":"Hsu YH, Zillikens MC, Wilson SG et al (2010) An integration of genome\u2010wide association study and gene expression profiling to prioritize the discovery of novel susceptibility loci for osteoporosis related traits. PLoS Genet 6(6):e1000977","journal-title":"PLoS Genet"},{"issue":"2","key":"9602_CR9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ajhg.2009.12.014","volume":"86","author":"AW Kung","year":"2010","unstructured":"Kung AW, Xiao SM, Cherny S et al (2010) Association of JAG1 with bone mineral density and osteoporotic fractures: a genome\u2010wide association study and follow\u2010up replication studies. Am J Hum Genet 86(2):229\u2013239","journal-title":"Am J Hum Genet"},{"issue":"4","key":"9602_CR10","doi-asserted-by":"crossref","first-page":"e1001372","DOI":"10.1371\/journal.pgen.1001372","volume":"7","author":"EL Duncan","year":"2011","unstructured":"Duncan EL, Danoy P, Kemp JP et al (2011) Genome\u2010wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk. PLoS Genet 7(4):e1001372","journal-title":"PLoS Genet"},{"key":"9602_CR11","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/08977190412331279890","volume":"22","author":"D Chen","year":"2004","unstructured":"Chen D, Zhao M, Mundy GR (2004) Bone morphogenetic proteins. Growth Factors 22:233\u2013241","journal-title":"Growth Factors"},{"key":"9602_CR12","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/39092","volume":"389","author":"A Glinka","year":"1997","unstructured":"Glinka A, Wu W, Onichtchouk D, Blumenstock C, Niehrs C (1997) Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus. Nature 389:517\u2013519","journal-title":"Nature"},{"key":"9602_CR13","first-page":"795","volume":"17","author":"M Katoh","year":"2006","unstructured":"Katoh M, Katoh M (2006) CER1 is a common target of WNT and NODAL signaling pathways in human embryonic stem cells. Int J Mol Med 17:795\u2013799","journal-title":"Int J Mol Med"},{"key":"9602_CR14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0925-4773(97)00125-1","volume":"68","author":"JA Belo","year":"1997","unstructured":"Belo JA, Bouwmeester T, Leyns L et al (1997) Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula. Mech Dev 68:45\u201357","journal-title":"Mech Dev"},{"key":"9602_CR15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1006\/dbio.1997.8812","volume":"194","author":"C Biben","year":"1998","unstructured":"Biben C, Stanley E, Fabri L et al (1998) Murine cerberus homologue mCer-1: a candidate anterior patterning molecule. Dev Biol 194:135\u2013151","journal-title":"Dev Biol"},{"key":"9602_CR16","doi-asserted-by":"crossref","first-page":"6198","DOI":"10.1073\/pnas.95.11.6198","volume":"95","author":"W Shawlot","year":"1998","unstructured":"Shawlot W, Deng JM, Behringer RR (1998) Expression of the mouse cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somitogenesis. Proc Natl Acad Sci USA 95:6198\u20136203","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6721","key":"9602_CR17","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/17820","volume":"397","author":"S Piccolo","year":"1999","unstructured":"Piccolo S, Agius E, Leyns L et al (1999) The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature 397(6721):707\u2013710","journal-title":"Nature"},{"issue":"7","key":"9602_CR18","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0092-8674(00)00211-7","volume":"103","author":"Y Yoshida","year":"2000","unstructured":"Yoshida Y, Tanaka S, Umemori H et al (2000) Negative regulation of BMP\/Smad signaling by Tob in osteoblasts. Cell 103(7):1085\u20131097","journal-title":"Cell"},{"issue":"6","key":"9602_CR19","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1359\/jbmr.2002.17.6.1026","volume":"17","author":"M Usui","year":"2002","unstructured":"Usui M, Yoshida Y, Yamashita T et al (2002) Enhancing effect of Tob deficiency on bone formation is specific to bone morphogenetic protein\u2013induced osteogenesis. J Bone Miner Res 17(6):1026\u20131033","journal-title":"J Bone Miner Res"},{"issue":"1\u20132","key":"9602_CR20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.mce.2004.10.009","volume":"230","author":"H Kawate","year":"2005","unstructured":"Kawate H, Wu Y, Ohnaka K et al (2005) Tob proteins suppress steroid hormone receptor\u2013mediated transcriptional activation. Mol Cell Endocrinol 230(1\u20132):77\u201386","journal-title":"Mol Cell Endocrinol"},{"key":"9602_CR21","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/j.1469-1809.2008.00447.x","volume":"72","author":"D Karasik","year":"2008","unstructured":"Karasik D, Ferrari SL (2008) Contribution of gender-specific genetic factors to osteoporosis risk. Ann Hum Genet 72:696\u2013714","journal-title":"Ann Hum Genet"},{"key":"9602_CR22","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000103005","volume":"51","author":"JP Bonjour","year":"2007","unstructured":"Bonjour JP, Chevalley T, Rizzoli R, Ferrari S (2007) Gene\u2013environment interactions in the skeletal response to nutrition and exercise during growth. Med Sport Sci 51:64\u201380","journal-title":"Med Sport Sci"},{"issue":"5","key":"9602_CR23","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S8756-3282(00)00381-1","volume":"27","author":"JA Kanis","year":"2000","unstructured":"Kanis JA, Johnell O, Oden A et al (2000) Risk of hip fracture according to the World Health Organization criteria for osteopenia and osteoporosis. Bone 27(5):585\u2013590","journal-title":"Bone"},{"issue":"2","key":"9602_CR24","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1359\/JBMR.051013","volume":"21","author":"JD Doecke","year":"2006","unstructured":"Doecke JD, Day CJ, Stephens AS et al (2006) Association of functionally different RUNX2 P2 promoter alleles with BMD. J Bone Miner Res 21(2):265\u2013273","journal-title":"J Bone Miner Res"},{"issue":"22","key":"9602_CR25","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1002\/sim.4004","volume":"29","author":"H Finner","year":"2010","unstructured":"Finner H, Strassburger K, Heid IM et al (2010) How to link call rate and p-values for Hardy-Weinberg equilibrium as measures of genome-wide SNP data quality. Stat Med 29(22):2347\u20132358","journal-title":"Stat Med"},{"issue":"8","key":"9602_CR26","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1093\/aje\/kwq234","volume":"172","author":"OA Panagiotou","year":"2010","unstructured":"Panagiotou OA, Evangelou E, Ioannidis JP (2010) Genome-wide significant associations for variants with minor allele frequency of 5\u00a0% or less\u2014an overview: a HuGE review. Am J Epidemiol 172(8):869\u2013889","journal-title":"Am J Epidemiol"},{"issue":"6","key":"9602_CR27","first-page":"101","volume":"24","author":"PL Tang","year":"2009","unstructured":"Tang PL, Cheung CL, Sham PC et al (2009) Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with BMD and fracture in southern Chinese women. J Bone Miner Res 24(6):101\u20131021","journal-title":"J Bone Miner Res"},{"key":"9602_CR28","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1359\/jbmr.051002","volume":"21","author":"YJ Liu","year":"2006","unstructured":"Liu YJ, Shen H, Xiao P et al (2006) Molecular genetic studies of gene identification for osteoporosis: a 2004 update. J Bone Miner Res 21:1511\u20131535","journal-title":"J Bone Miner Res"},{"issue":"5","key":"9602_CR29","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1210\/er.2009-0044","volume":"31","author":"SH Ralston","year":"2010","unstructured":"Ralston SH, Uitterlinden AG (2010) Genetics of osteoporosis. Endocr Rev 31(5):629\u2013662","journal-title":"Endocr Rev"},{"issue":"1\u20132","key":"9602_CR30","first-page":"51","volume":"7","author":"E Gazzerro","year":"2006","unstructured":"Gazzerro E, Canalis E (2006) Bone morphogenetic proteins and their antagonists. Rev Endocr Metab Disord 7(1\u20132):51\u201365","journal-title":"Rev Endocr Metab Disord"},{"issue":"6","key":"9602_CR31","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1086\/426458","volume":"75","author":"AG Uitterlinden","year":"2004","unstructured":"Uitterlinden AG, Arp PP, Paeper BW et al (2004) Polymorphisms in the sclerosteosis\/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites. Am J Hum Genet 75(6):1032\u20131045","journal-title":"Am J Hum Genet"},{"key":"9602_CR32","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S1097-2765(00)80067-2","volume":"1","author":"DR Hsu","year":"1998","unstructured":"Hsu DR, Economides AN, Wang X, Eimon PM, Harland RM (1998) The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol Cell 1:673\u2013683","journal-title":"Mol Cell"},{"key":"9602_CR33","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1006\/dbio.1999.9240","volume":"2009","author":"JJ Pearce","year":"1999","unstructured":"Pearce JJ, Penny G, Rossant J (1999) A mouse cerberus\/Dan-related gene family. Dev Biol 2009:98\u2013110","journal-title":"Dev Biol"},{"key":"9602_CR34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1196\/annals.1346.005","volume":"1068","author":"V Rosen","year":"2006","unstructured":"Rosen V (2006) BMP and BMP inhibitors in bone. Ann NY Acad Sci 1068:19\u201325","journal-title":"Ann NY Acad Sci"},{"issue":"1","key":"9602_CR35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000106057","volume":"65","author":"CL Cheung","year":"2008","unstructured":"Cheung CL, Chan V, Kung AW (2008) A differential association of ALOX15 polymorphisms with bone mineral density in pre- and post-menopausal women. Hum Hered 65(1):1\u20138","journal-title":"Hum Hered"},{"key":"9602_CR36","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1101\/gr.2155004","volume":"14","author":"BM Smits","year":"2004","unstructured":"Smits BM, van Zutphen BF, Plasterk RH, Cuppen E (2004) Genetic variation in coding regions between and within commonly used inbred rat strains. Genome Res 14:1285\u20131290","journal-title":"Genome Res"},{"issue":"10","key":"9602_CR37","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nrg1451","volume":"5","author":"G Ast","year":"2004","unstructured":"Ast G (2004) How did alternative splicing evolve? Nat Rev Genet 5(10):773\u2013782","journal-title":"Nat Rev Genet"},{"issue":"1","key":"9602_CR38","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s00223-011-9545-6","volume":"90","author":"H Hagino","year":"2012","unstructured":"Hagino H, Sawaguchi T, Endo N, Ito Y, Nakano T, Watanabe Y (2012) The risk of a second hip fracture in patients after their first hip fracture. Calcif Tissue Int 90(1):14\u201321","journal-title":"Calcif Tissue Int"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-012-9602-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-012-9602-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-012-9602-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T11:41:03Z","timestamp":1558698063000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-012-9602-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,29]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["9602"],"URL":"https:\/\/doi.org\/10.1007\/s00223-012-9602-9","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,29]]}}}