{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:26:25Z","timestamp":1791973585511,"version":"4.4.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T00:00:00Z","timestamp":1409097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1007\/s00223-014-9904-1","type":"journal-article","created":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T07:43:03Z","timestamp":1409038983000},"page":"385-392","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Clinical Presentation of Paget\u2019s Disease: Evaluation of a Contemporary Cohort and Systematic Review"],"prefix":"10.1007","volume":"95","author":[{"given":"Adrian","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart H.","family":"Ralston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,27]]},"reference":[{"key":"9904_CR1","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1056\/NEJMcp1204713","volume":"368","author":"SH Ralston","year":"2013","unstructured":"Ralston SH (2013) Clinical practice. Paget\u2019s disease of bone. N Engl J Med 368:644\u2013650","journal-title":"N Engl J Med"},{"key":"9904_CR2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1359\/jbmr.2002.17.3.465","volume":"17","author":"TP Staa van","year":"2002","unstructured":"van Staa TP, Selby P, Leufkens HG, Lyles K, Sprafka JM, Cooper C (2002) Incidence and natural history of Paget\u2019s disease of bone in England and Wales. J Bone Miner Res 17:465\u2013471","journal-title":"J Bone Miner Res"},{"key":"9904_CR3","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1359\/jbmr.060704","volume":"21","author":"G Poor","year":"2006","unstructured":"Poor G, Donath J, Fornet B, Cooper C (2006) Epidemiology of Paget\u2019s disease in Europe: the prevalence is decreasing. J Bone Miner Res 21:1545\u20131549","journal-title":"J Bone Miner Res"},{"key":"9904_CR4","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s00223-004-0281-z","volume":"75","author":"HR Cundy","year":"2004","unstructured":"Cundy HR, Gamble G, Wattie D, Rutland M, Cundy T (2004) Paget\u2019s disease of bone in New Zealand: continued decline in disease severity. Calcif Tissue Int 75:358\u2013364","journal-title":"Calcif Tissue Int"},{"key":"9904_CR5","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1359\/jbmr.060822","volume":"21","author":"D Rendina","year":"2006","unstructured":"Rendina D, de Gennari L, Filippo G, Merlotti D, de Campora E, Fazioli F, Scarano G, Nuti R, Strazzullo P, Mossetti G (2006) Evidence for increased clinical severity of familial and sporadic Paget\u2019s disease of bone in Campania, southern Italy. J Bone Miner Res 21:1828\u20131835","journal-title":"J Bone Miner Res"},{"key":"9904_CR6","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00198-012-1954-5","volume":"24","author":"L Corral-Gudino","year":"2013","unstructured":"Corral-Gudino L, Garcia-Aparicio J, Sanchez-Gonzalez MD, Miron-Canelo JA, Blanco JF, Ralston SH, Del Pino-Montes J (2013) Secular changes in Paget\u2019s disease: contrasting changes in the number of new referrals and in disease severity in two neighboring regions of Spain. Osteoporos Int 24:443\u2013450","journal-title":"Osteoporos Int"},{"key":"9904_CR7","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.bone.2013.04.024","volume":"55","author":"L Corral-Gudino","year":"2013","unstructured":"Corral-Gudino L, Borao-Cengotita-Bengoa M, Del Pino-Montes J, Ralston SH (2013) Epidemiology of Paget\u2019s disease of bone: a systematic review and meta-analysis of secular changes. Bone 55:347\u2013352","journal-title":"Bone"},{"key":"9904_CR8","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S8756-3282(02)00817-7","volume":"31","author":"PL Selby","year":"2002","unstructured":"Selby PL, Davie MW, Ralston SH, Stone MD (2002) Guidelines on the management of Paget\u2019s disease of bone. Bone 31:366\u2013373","journal-title":"Bone"},{"key":"9904_CR9","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1002\/jbmr.132","volume":"25","author":"MR Visconti","year":"2010","unstructured":"Visconti MR, Langston AL, Alonso N, Goodman K, Selby PL, Fraser WD, Ralston SH (2010) Mutations of SQSTM1 are associated with severity and clinical outcome in Paget\u2019s disease of bone. J Bone Miner Res 25:2368\u20132373","journal-title":"J Bone Miner Res"},{"key":"9904_CR10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11657-013-0135-2","volume":"8","author":"DK Dhanwal","year":"2013","unstructured":"Dhanwal DK, Siwach R, Dixit V, Mithal A, Jameson K, Cooper C (2013) Incidence of hip fracture in Rohtak district North India. Arch Osteoporos 8:135","journal-title":"Arch Osteoporos"},{"key":"9904_CR11","doi-asserted-by":"crossref","first-page":"757102","DOI":"10.4061\/2010\/757102","volume":"2010","author":"DK Dhanwal","year":"2010","unstructured":"Dhanwal DK, Cooper C, Dennison EM (2010) Geographic variation in osteoporotic hip fracture incidence: the growing importance of asian influences in coming decades. J. Osteoporos. 2010:757102","journal-title":"J. Osteoporos."},{"key":"9904_CR12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11657-013-0137-0","volume":"8","author":"A Svedbom","year":"2013","unstructured":"Svedbom A, Hernlund E, Ivergard M, Compston J, Cooper C, Stenmark J, McCloskey EV, Jonsson B, Kanis JA (2013) Osteoporosis in the European Union: a compendium of country-specific reports. Arch Osteoporos 8:137","journal-title":"Arch Osteoporos"},{"key":"9904_CR13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11657-012-0082-3","volume":"7","author":"O Lesnyak","year":"2012","unstructured":"Lesnyak O, Ershova O, Belova K, Gladkova E, Sinitsina O, Ganert O, Romanova M, Khodirev V, JOhansson H, McCloskey E, Kanis JA (2012) Epidemiology of fracture in the Russian Federation and the development of a FRAX model. Arch Osteoporos 7:67\u201373","journal-title":"Arch Osteoporos"},{"key":"9904_CR14","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00198-004-1596-3","volume":"15","author":"J Morales-Torres","year":"2004","unstructured":"Morales-Torres J, Gutierrez-Urena S (2004) The burden of osteoporosis in Latin America. Osteoporos Int 15:625\u2013632","journal-title":"Osteoporos Int"},{"key":"9904_CR15","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1002\/art.1780231008","volume":"23","author":"RD Altman","year":"1980","unstructured":"Altman RD (1980) Musculoskeletal manifestations of Paget\u2019s disease of bone. Arthritis Rheum 23:1121\u20131127","journal-title":"Arthritis Rheum"},{"key":"9904_CR16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.reuma.2008.11.005","volume":"5","author":"J Del Pino-Montes","year":"2009","unstructured":"Del Pino-Montes J, de Garcia Yebenes Prous MA, Torrijos Eslava A, Morales Piga A, Carbonell Abello J, Farrerons Minguela J, Garrido Garcia J, Gobbo Montoya M, Rodriguez Perez M, Tornero Molina J, Guanabens Gay N, Carmona L (2009) [Characteristics of Paget\u2019s disease in Spain. Data from the National Paget\u2019s Register]. Reumatol Clin 5:109\u2013114","journal-title":"Reumatol Clin"},{"key":"9904_CR17","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00296-010-1648-2","volume":"32","author":"GR Werner Castro de","year":"2012","unstructured":"de Werner Castro GR, Heiden GI, Zimmermann AF, Morato EF, Neves FS, Toscano MA, de Magalhaes Souza Fialho SC, Pereira IA (2012) Paget\u2019s disease of bone: analysis of 134 cases from an island in Southern Brazil: another cluster of Paget\u2019s disease of bone in South America. Rheumatol Int 32:627\u2013631","journal-title":"Rheumatol Int"},{"key":"9904_CR18","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00774-012-0352-6","volume":"30","author":"JM Gu","year":"2012","unstructured":"Gu JM, Zhang ZL, Zhang H, Hu WW, Wang C, Yue H, Ke YH, He JW, Hu YQ, Li M, Liu YJ, Fu WZ (2012) Thirteen Chinese patients with sporadic Paget\u2019s disease of bone: clinical features, SQSTM1 mutation identification, and functional analysis. J Bone Miner Metab 30:525\u2013533","journal-title":"J Bone Miner Metab"},{"key":"9904_CR19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/jbmr.507","volume":"27","author":"S Sankaran","year":"2012","unstructured":"Sankaran S, Naot D, Grey A, Cundy T (2012) Paget\u2019s disease in patients of Asian descent in New Zealand. J Bone Miner Res 27:223\u2013226","journal-title":"J Bone Miner Res"},{"key":"9904_CR20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3899\/jrheum.090674","volume":"37","author":"M Varenna","year":"2010","unstructured":"Varenna M, Zucchi F, Galli L, Manara M, De Marco G, Sinigaglia L (2010) Demographic and clinical features related to a symptomatic onset of Paget\u2019s disease of bone. J Rheumatol 37:155\u2013160","journal-title":"J Rheumatol"},{"key":"9904_CR21","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s00296-009-1103-4","volume":"30","author":"F Bandeira","year":"2010","unstructured":"Bandeira F, Assuncao V, Diniz ET, Lucena CS, Griz L (2010) Characteristics of Paget\u2019s disease of bone in the city of Recife, Brazil. Rheumatol Int 30:1055\u20131061","journal-title":"Rheumatol Int"},{"key":"9904_CR22","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1359\/jbmr.080215","volume":"23","author":"RA Wermers","year":"2008","unstructured":"Wermers RA, Tiegs RD, Atkinson EJ, Achenbach SJ, Melton LJ III (2008) Morbidity and mortality associated with Paget\u2019s disease of bone: a population-based study. J Bone Miner Res 23:819\u2013825","journal-title":"J Bone Miner Res"},{"key":"9904_CR23","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s00774-005-0670-z","volume":"24","author":"J Hashimoto","year":"2006","unstructured":"Hashimoto J, Ohno I, Nakatsuka K, Yoshimura N, Takata S, Zamma M, Yabe H, Abe S, Terada M, Yoh K, Fukunaga M, Cooper C, Morii H, Yoshikawa H (2006) Prevalence and clinical features of Paget\u2019s disease of bone in Japan. J Bone Miner Metab 24:186\u2013190","journal-title":"J Bone Miner Metab"},{"key":"9904_CR24","first-page":"525","volume":"54","author":"Thomas, N Anjali","year":"2006","unstructured":"Anjali Thomas, N, Rajaratnam S, Shanthly N, Oommen R, Seshadri MS (2006) Paget\u2019s disease of bone: experience from a centre in southern India. J Assoc Physicians India 54:525\u2013529","journal-title":"J Assoc Physicians India"},{"key":"9904_CR25","first-page":"530","volume":"54","author":"S Bhadada","year":"2006","unstructured":"Bhadada S, Bhansali A, Unnikrishnan AG, Khadgawat R, Singh SK, Mithal A, Saikia UN (2006) Does Paget\u2019s disease exist in India?: a series of 21 patients. J Assoc Physicians India 54:530\u2013534","journal-title":"J Assoc Physicians India"},{"key":"9904_CR26","first-page":"535","volume":"54","author":"SR Joshi","year":"2006","unstructured":"Joshi SR, Ambhore S, Butala N, Patwardhan M, Kulkarni M, Pai B, Karne R (2006) Paget\u2019s disease from Western India. J Assoc Physicians India 54:535\u2013538","journal-title":"J Assoc Physicians India"},{"key":"9904_CR27","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1136\/ard.2004.021139","volume":"64","author":"S Holgado","year":"2005","unstructured":"Holgado S, Rotes D, Guma M, Monfort J, Olive A, Carbonell J, Tena X (2005) Paget\u2019s disease of bone in early adult life. Ann Rheum Dis 64:306\u2013308","journal-title":"Ann Rheum Dis"},{"key":"9904_CR28","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1359\/JBMR.050322","volume":"20","author":"D Merlotti","year":"2005","unstructured":"Merlotti D, Gennari L, Galli B, Martini G, Calabro A, de Paola V, Ceccarelli E, Nardi P, Avanzati A, Nuti R (2005) Characteristics and familial aggregation of Paget\u2019s disease of bone in Italy. J Bone Miner Res 20:1356\u20131364","journal-title":"J Bone Miner Res"},{"key":"9904_CR29","first-page":"491","volume":"131","author":"G Gonzalez","year":"2003","unstructured":"Gonzalez G, Brusco F, Arteaga L, Rodriguez J, Jacobelli S, Massardo L, Ortiz C, Contreras O (2003) Paget disease of bone in Chile: report of 15 cases. Rev Med Chil 131:491\u2013497","journal-title":"Rev Med Chil"},{"key":"9904_CR30","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0025-7753(02)73487-8","volume":"119","author":"M Guma","year":"2002","unstructured":"Guma M, Rotes D, Holgado S, Monfort J, Olive A, Carbonell J, Tena X (2002) Paget\u2019s disease of bone: study of 314 patients. Med Clin (Barc) 119:537\u2013540","journal-title":"Med Clin (Barc)"},{"issue":"244","key":"9904_CR31","first-page":"246","volume":"95","author":"LM Wang","year":"2002","unstructured":"Wang LM, Au-Yeong ML, McKenna MJ (2002) Paget\u2019s disease of bone: presentation, extent and response to bisphosphonates. Ir Med J 95(244):246","journal-title":"Ir Med J"},{"key":"9904_CR32","doi-asserted-by":"crossref","first-page":"11S","DOI":"10.1016\/S8756-3282(99)00027-7","volume":"24","author":"M Davie","year":"1999","unstructured":"Davie M, Davies M, Francis R, Fraser W, Hosking D, Tansley R (1999) Paget\u2019s disease of bone: a review of 889 patients. Bone 24:11S\u201312S","journal-title":"Bone"},{"key":"9904_CR33","doi-asserted-by":"crossref","first-page":"13S","DOI":"10.1016\/S8756-3282(99)00028-9","volume":"24","author":"J Monfort","year":"1999","unstructured":"Monfort J, Sala DR, Romero AB, Duro JC, Maymo J, Carbonell J (1999) Epidemiological, clinical, biochemical, and imaging characteristics of monostotic and polyostotic Paget\u2019s disease. Bone 24:13S\u201314S","journal-title":"Bone"},{"key":"9904_CR34","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1097\/00007611-199310000-00003","volume":"86","author":"RC Hamdy","year":"1993","unstructured":"Hamdy RC, Moore S, Leroy J (1993) Clinical presentation of Paget\u2019s disease of the bone in older patients. South Med J 86:1097\u20131100","journal-title":"South Med J"},{"key":"9904_CR35","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1136\/ard.43.6.769","volume":"43","author":"J Winfield","year":"1984","unstructured":"Winfield J, Stamp TC (1984) Bone and joint symptoms in Paget\u2019s disease. Ann Rheum Dis 43:769\u2013773","journal-title":"Ann Rheum Dis"},{"key":"9904_CR36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1136\/pgmj.53.615.33","volume":"53","author":"HJB Galbraith","year":"1977","unstructured":"Galbraith HJB, Evans EC, Lacey J (1977) Paget\u2019s disease of bone: a clinical and genetic study. Postgrad Med J 53:33\u201339","journal-title":"Postgrad Med J"},{"key":"9904_CR37","first-page":"29","volume":"33","author":"MK Klimova","year":"1958","unstructured":"Klimova MK (1958) Osteitis deformans-Paget\u2019s disease analysis of clinical and X-ray studies on 238 subjects. Vestn Rentgenol Radiol 33:29\u201336","journal-title":"Vestn Rentgenol Radiol"},{"key":"9904_CR38","first-page":"894","volume":"1","author":"RG Russell","year":"1974","unstructured":"Russell RG, Smith R, Preston C, Walton RJ, Woods CG (1974) Diphosphonates in Paget\u2019s disease. Lancet 1:894\u2013898","journal-title":"Lancet"},{"key":"9904_CR39","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0002-9343(96)00227-6","volume":"101","author":"IR Reid","year":"1996","unstructured":"Reid IR, Nicholson GC, Weinstein RS, Hosking DJ, Cundy T, Kotowicz MA, Murphy WA Jr, Yeap S, Dufresne S, Lombardi A, Musliner TA, Thompson DE, Yates AJ (1996) Biochemical and radiologic improvement in Paget\u2019s disease of bone treated with alendronate: a randomized, placebo-controlled trial. Am J Med 101:341\u2013348","journal-title":"Am J Med"},{"key":"9904_CR40","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1359\/jbmr.090709","volume":"25","author":"AL Langston","year":"2010","unstructured":"Langston AL, Campbell MK, Fraser WD, MacLennan GS, Selby PL, Ralston SH (2010) Randomised trial of intensive bisphosphonate treatment versus symptomatic management in Paget\u2019s disease of bone. J Bone Miner Res 25:20\u201331","journal-title":"J Bone Miner Res"},{"key":"9904_CR41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00223-006-0184-2","volume":"80","author":"AL Langston","year":"2007","unstructured":"Langston AL, Campbell MK, Fraser WD, Maclennan G, Selby P, Ralston SH (2007) Clinical determinants of quality of life in Paget\u2019s disease of bone. Calcif Tissue Int 80:1\u20139","journal-title":"Calcif Tissue Int"},{"key":"9904_CR42","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1002\/jbmr.1975","volume":"28","author":"OM Albagha","year":"2013","unstructured":"Albagha OM, Visconti MR, Alonso N, Wani S, Goodman K, Fraser WD, Gennari L, Merlotti D, Gianfrancesco F, Esposito T, Rendina D, Di Stefano M, Isaia G, Brandi ML, Guisti F, Del Pino-Montes J, Corral-Gudino L, Gonzalez-Sarmiento R, Ward L, Rea SL, Ratajczak T, Walsh JP, Ralston SH (2013) Common susceptibility alleles and SQSTM1 mutations predict disease extent and severity in a multinational study of patients with Paget\u2019s disease. J Bone Miner Res 28:2238\u20132246","journal-title":"J Bone Miner Res"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-014-9904-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-014-9904-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-014-9904-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T11:41:10Z","timestamp":1558698070000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-014-9904-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,27]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["9904"],"URL":"https:\/\/doi.org\/10.1007\/s00223-014-9904-1","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,27]]}}}