{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T06:08:00Z","timestamp":1793858880349,"version":"4.6.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T00:00:00Z","timestamp":1441324800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council (AU)","doi-asserted-by":"publisher","award":["1098991"],"award-info":[{"award-number":["1098991"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1007\/s00223-015-0054-x","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T01:53:06Z","timestamp":1441331586000},"page":"602-610","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":139,"title":["Vitamin D Receptor Ablation and Vitamin D Deficiency Result in Reduced Grip Strength, Altered Muscle Fibers, and Increased Myostatin in Mice"],"prefix":"10.1007","volume":"97","author":[{"given":"Christian M.","family":"Girgis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan Minn","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Houweling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renuka","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Mokbel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick J.","family":"Clifton-Bligh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny E.","family":"Gunton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,9,4]]},"reference":[{"key":"54_CR1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1210\/er.2012-1012","volume":"34","author":"CM Girgis","year":"2013","unstructured":"Girgis CM, Clifton-Bligh RJ, Hamrick MW, Holick MF, Gunton JE (2013) The roles of vitamin D in skeletal muscle: form, function, and metabolism. Endocr Rev 34:33\u201383","journal-title":"Endocr Rev"},{"key":"54_CR2","doi-asserted-by":"crossref","first-page":"5766","DOI":"10.1210\/jc.2003-030604","volume":"88","author":"M Visser","year":"2003","unstructured":"Visser M, Deeg DJ, Lips P (2003) Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam. J Clin Endocrinol Metab 88:5766\u20135772","journal-title":"J Clin Endocrinol Metab"},{"key":"54_CR3","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1210\/jc.2009-2725","volume":"95","author":"KA Ward","year":"2010","unstructured":"Ward KA, Das G, Roberts SA, Berry JL, Adams JE, Rawer R, Mughal MZ (2010) A randomized, controlled trial of vitamin D supplementation upon musculoskeletal health in postmenarchal females. J Clin Endocrinol Metab 95:4643\u20134651","journal-title":"J Clin Endocrinol Metab"},{"key":"54_CR4","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.1210\/jc.2012-1273","volume":"97","author":"P Szulc","year":"2012","unstructured":"Szulc P, Schoppet M, Goettsch C, Rauner M, Dschietzig T, Chapurlat R, Hofbauer LC (2012) Endocrine and clinical correlates of myostatin serum concentration in men\u2014the STRAMBO study. J Clin Endocrinol Metab 97:3700\u20133708","journal-title":"J Clin Endocrinol Metab"},{"key":"54_CR5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/cen.12368","volume":"80","author":"CM Girgis","year":"2014","unstructured":"Girgis CM, Clifton-Bligh RJ, Turner N, Lau SL, Gunton JE (2014) Effects of vitamin D in skeletal muscle: falls, strength, athletic performance and insulin sensitivity. Clin Endocrinol (Oxf) 80:169\u2013181","journal-title":"Clin Endocrinol (Oxf)"},{"key":"54_CR6","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1210\/en.2010-1109","volume":"152","author":"Y Wang","year":"2011","unstructured":"Wang Y, DeLuca HF (2011) Is the vitamin D receptor found in muscle? Endocrinology 152:354\u2013363","journal-title":"Endocrinology"},{"key":"54_CR7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1023\/A:1017535728844","volume":"33","author":"HA Bischoff","year":"2001","unstructured":"Bischoff HA, Borchers M, Gudat F, Duermueller U, Theiler R, Stahelin HB, Dick W (2001) In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue. Histochem J 33:19\u201324","journal-title":"Histochem J"},{"key":"54_CR8","doi-asserted-by":"crossref","first-page":"C396","DOI":"10.1152\/ajpcell.00014.2012","volume":"303","author":"R Srikuea","year":"2012","unstructured":"Srikuea R, Zhang X, Park-Sarge OK, Esser KA (2012) VDR and CYP27B1 are expressed in C2C12 cells and regenerating skeletal muscle: potential role in suppression of myoblast proliferation. Am J Physiol Cell Physiol 303:C396\u2013C405","journal-title":"Am J Physiol Cell Physiol"},{"key":"54_CR9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s10735-010-9270-x","volume":"41","author":"L Ceglia","year":"2010","unstructured":"Ceglia L, da Silva Morais M, Park LK, Morris E, Harris SS, Bischoff-Ferrari HA, Fielding RA, Dawson-Hughes B (2010) Multi-step immunofluorescent analysis of vitamin D receptor loci and myosin heavy chain isoforms in human skeletal muscle. J Mol Histol 41:137\u2013142","journal-title":"J Mol Histol"},{"key":"54_CR10","doi-asserted-by":"crossref","first-page":"E1927","DOI":"10.1210\/jc.2013-2820","volume":"98","author":"L Ceglia","year":"2013","unstructured":"Ceglia L, Niramitmahapanya S, Morais MD, Rivas DA, Harris SS, Bischoff-Ferrari H, Fielding RA, Dawson-Hughes B (2013) A randomized study on the effect of vitamin D3 supplementation on skeletal muscle morphology and vitamin D receptor concentration in older women. J Clin Endocrinol Metab 98:E1927\u2013E1935","journal-title":"J Clin Endocrinol Metab"},{"key":"54_CR11","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1210\/en.2014-1016","volume":"155","author":"CM Girgis","year":"2014","unstructured":"Girgis CM, Mokbel N, Minn Cha K, Houweling PJ, Abboud M, Fraser DR, Mason RS, Clifton-Bligh RJ, Gunton JE (2014) The vitamin D receptor (VDR) is expressed in skeletal muscle of male mice and modulates 25-hydroxyvitamin D (25OHD) uptake in myofibers. Endocrinology 155:3227\u20133237","journal-title":"Endocrinology"},{"key":"54_CR12","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s00223-014-9932-x","volume":"96","author":"RM Pojednic","year":"2014","unstructured":"Pojednic RM, Ceglia L, Olsson K, Gustafsson T, Lichtenstein AH, Dawson-Hughes B, Fielding RA (2014) Effects of 1,25-dihydroxyvitamin D and vitamin D on the expression of the vitamin D receptor in human skeletal muscle cells. Calcif Tissue Int 96:256\u2013263","journal-title":"Calcif Tissue Int"},{"key":"54_CR13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.mce.2011.05.021","volume":"347","author":"RL Boland","year":"2011","unstructured":"Boland RL (2011) VDR activation of intracellular signaling pathways in skeletal muscle. Mol Cell Endocrinol 347:11\u201316","journal-title":"Mol Cell Endocrinol"},{"key":"54_CR14","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1210\/en.2012-2245","volume":"154","author":"M Abboud","year":"2013","unstructured":"Abboud M, Puglisi DA, Davies BN, Rybchyn M, Whitehead NP, Brock KE, Cole L, Gordon-Thomson C, Fraser DR, Mason RS (2013) Evidence for a specific uptake and retention mechanism for 25-hydroxyvitamin D (25OHD) in skeletal muscle cells. Endocrinology 154:3022\u20133030","journal-title":"Endocrinology"},{"key":"54_CR15","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1210\/en.2013-1205","volume":"155","author":"CM Girgis","year":"2014","unstructured":"Girgis CM, Clifton-Bligh RJ, Mokbel N, Cheng K, Gunton JE (2014) Vitamin D signaling regulates proliferation, differentiation, and myotube size in C2C12 skeletal muscle cells. Endocrinology 155:347\u2013357","journal-title":"Endocrinology"},{"key":"54_CR16","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/mus.23950","volume":"49","author":"M Tanaka","year":"2014","unstructured":"Tanaka M, Kishimoto KN, Okuno H, Saito H, Itoi E (2014) Vitamin D receptor gene silencing effects on differentiation of myogenic cell lines. Muscle Nerve 49:700\u2013708","journal-title":"Muscle Nerve"},{"key":"54_CR17","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1210\/en.2011-0159","volume":"152","author":"LA Garcia","year":"2011","unstructured":"Garcia LA, King KK, Ferrini MG, Norris KC, Artaza JN (2011) 1,25(OH)2vitamin D3 stimulates myogenic differentiation by inhibiting cell proliferation and modulating the expression of promyogenic growth factors and myostatin in C2C12 skeletal muscle cells. Endocrinology 152:2976\u20132986","journal-title":"Endocrinology"},{"key":"54_CR18","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.1210\/endo.140.11.7110","volume":"140","author":"M Amling","year":"1999","unstructured":"Amling M, Priemel M, Holzmann T, Chapin K, Rueger JM, Baron R, Demay MB (1999) Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endocrinology 140:4982\u20134987","journal-title":"Endocrinology"},{"key":"54_CR19","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1210\/en.2013-1369","volume":"154","author":"M Bhat","year":"2013","unstructured":"Bhat M, Kalam R, Qadri SS, Madabushi S, Ismail A (2013) Vitamin D deficiency induced muscle wasting occurs through the ubiquitin proteasome pathway and is partially corrected by calcium in male rats. Endocrinology 154:4018\u20134029","journal-title":"Endocrinology"},{"key":"54_CR20","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1002\/jcp.24628","volume":"229","author":"N Mokbel","year":"2014","unstructured":"Mokbel N, Hoffman NJ, Girgis CM, Small L, Turner N, Daly RJ, Cooney GJ, Holt LJ (2014) Grb10 deletion enhances muscle cell proliferation, differentiation and GLUT4 plasma membrane translocation. J Cell Physiol 229:1753\u20131764","journal-title":"J Cell Physiol"},{"key":"54_CR21","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.brainresbull.2005.10.014","volume":"69","author":"TH Burne","year":"2006","unstructured":"Burne TH, Johnston AN, McGrath JJ, Mackay-Sim A (2006) Swimming behaviour and post-swimming activity in vitamin D receptor knockout mice. Brain Res Bull 69:74\u201378","journal-title":"Brain Res Bull"},{"key":"54_CR22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.brainresbull.2004.04.015","volume":"64","author":"AV Kalueff","year":"2004","unstructured":"Kalueff AV, Lou YR, Laaksi I, Tuohimaa P (2004) Impaired motor performance in mice lacking neurosteroid vitamin D receptors. Brain Res Bull 64:25\u201329","journal-title":"Brain Res Bull"},{"key":"54_CR23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jsbmb.2009.01.020","volume":"114","author":"A Minasyan","year":"2009","unstructured":"Minasyan A, Keisala T, Zou J, Zhang Y, Toppila E, Syvala H, Lou YR, Kalueff AV, Pyykko I, Tuohimaa P (2009) Vestibular dysfunction in vitamin D receptor mutant mice. J Steroid Biochem Mol Biol 114:161\u2013166","journal-title":"J Steroid Biochem Mol Biol"},{"key":"54_CR24","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ki.1978.28","volume":"13","author":"JS Rodman","year":"1978","unstructured":"Rodman JS, Baker T (1978) Changes in the kinetics of muscle contraction in vitamin D-depleted rats. Kidney Int 13:189\u2013193","journal-title":"Kidney Int"},{"key":"54_CR25","doi-asserted-by":"crossref","first-page":"13728","DOI":"10.1523\/JNEUROSCI.3637-11.2011","volume":"31","author":"SE Tague","year":"2011","unstructured":"Tague SE, Clarke GL, Winter MK, McCarson KE, Wright DE, Smith PG (2011) Vitamin D deficiency promotes skeletal muscle hypersensitivity and sensory hyperinnervation. J Neurosci 31:13728\u201313738","journal-title":"J Neurosci"},{"key":"54_CR26","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1172\/JCI109569","volume":"64","author":"D Pleasure","year":"1979","unstructured":"Pleasure D, Wyszynski B, Sumner A, Schotland D, Feldman B, Nugent N, Hitz K, Goodman DB (1979) Skeletal muscle calcium metabolism and contractile force in vitamin D-deficient chicks. J Clin Invest 64:1157\u20131167","journal-title":"J Clin Invest"},{"key":"54_CR27","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.abb.2010.05.029","volume":"500","author":"L Schubert","year":"2010","unstructured":"Schubert L, DeLuca HF (2010) Hypophosphatemia is responsible for skeletal muscle weakness of vitamin D deficiency. Arch Biochem Biophys 500:157\u2013161","journal-title":"Arch Biochem Biophys"},{"key":"54_CR28","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/BF02405030","volume":"35","author":"R Boland","year":"1983","unstructured":"Boland R, de Boland AR, Ritz E, Hasselbach W (1983) Effect of 1,25-dihydroxycholecalciferol on sarcoplasmic reticulum calcium transport in strontium-fed chicks. Calcif Tissue Int 35:190\u2013194","journal-title":"Calcif Tissue Int"},{"key":"54_CR29","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF02405031","volume":"35","author":"R Boland","year":"1983","unstructured":"Boland R, Matthews C, de Boland AR, Ritz E, Hasselbach W (1983) Reversal of decreased phosphorylation of sarcoplasmic reticulum calcium transport ATPase by 1,25-dihydroxycholecalciferol in experimental uremia. Calcif Tissue Int 35:195\u2013201","journal-title":"Calcif Tissue Int"},{"key":"54_CR30","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1210\/endo.139.3.5803","volume":"139","author":"YC Li","year":"1998","unstructured":"Li YC, Pirro AE, Demay MB (1998) Analysis of vitamin D-dependent calcium-binding protein messenger ribonucleic acid expression in mice lacking the vitamin D receptor. Endocrinology 139:847\u2013851","journal-title":"Endocrinology"},{"key":"54_CR31","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1172\/JCI65726","volume":"123","author":"K Funai","year":"2013","unstructured":"Funai K, Song H, Yin L, Lodhi IJ, Wei X, Yoshino J, Coleman T, Semenkovich CF (2013) Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling. J Clin Invest 123:1229\u20131240","journal-title":"J Clin Invest"},{"key":"54_CR32","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.1210\/en.2003-0502","volume":"144","author":"I Endo","year":"2003","unstructured":"Endo I, Inoue D, Mitsui T, Umaki Y, Akaike M, Yoshizawa T, Kato S, Matsumoto T (2003) Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors. Endocrinology 144:5138\u20135144","journal-title":"Endocrinology"},{"key":"54_CR33","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.jmb.2007.11.049","volume":"376","author":"S Koyama","year":"2008","unstructured":"Koyama S, Hata S, Witt CC, Ono Y, Lerche S, Ojima K, Chiba T, Doi N, Kitamura F, Tanaka K, Abe K, Witt SH, Rybin V, Gasch A, Franz T, Labeit S, Sorimachi H (2008) Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis. J Mol Biol 376:1224\u20131236","journal-title":"J Mol Biol"},{"key":"54_CR34","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/387083a0","volume":"387","author":"AC McPherron","year":"1997","unstructured":"McPherron AC, Lawler AM, Lee SJ (1997) Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature 387:83\u201390","journal-title":"Nature"},{"key":"54_CR35","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s11914-014-0204-5","volume":"12","author":"C Girgis","year":"2014","unstructured":"Girgis C, Mokbel N, Digirolamo DJ (2014) Therapies for musculoskeletal disease: can we treat two birds with one stone? Curr Osteoporos Rep 12:142\u2013153","journal-title":"Curr Osteoporos Rep"},{"key":"54_CR36","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1210\/jc.2014-3290","volume":"99","author":"M Grossmann","year":"2014","unstructured":"Grossmann M (2014) Myostatin inhibition: a new treatment for androgen deprivation-induced sarcopenia? J Clin Endocrinol Metab 99:3625\u20133628","journal-title":"J Clin Endocrinol Metab"},{"key":"54_CR37","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1359\/jbmr.2004.19.2.265","volume":"19","author":"HA Bischoff-Ferrari","year":"2004","unstructured":"Bischoff-Ferrari HA, Borchers M, Gudat F, Durmuller U, Stahelin HB, Dick W (2004) Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res 19:265\u2013269","journal-title":"J Bone Miner Res"},{"key":"54_CR38","first-page":"973","volume":"48","author":"D Max","year":"2013","unstructured":"Max D, Brandsch C, Schumann S, Kuhne H, Frommhagen M, Schutkowski A, Hirche F, Staege MS, Stangl GI (2013) Maternal vitamin D deficiency causes smaller muscle fibers and altered transcript levels of genes involved in protein degradation, myogenesis, and cytoskeleton organization in the newborn rat. Mol Nutr Food Res 48:973\u2013984","journal-title":"Mol Nutr Food Res"},{"key":"54_CR39","doi-asserted-by":"crossref","first-page":"628","DOI":"10.3945\/ajcn.110.003921","volume":"93","author":"GV Krishnaveni","year":"2011","unstructured":"Krishnaveni GV, Veena SR, Winder NR, Hill JC, Noonan K, Boucher BJ, Karat SC, Fall CH (2011) Maternal vitamin D status during pregnancy and body composition and cardiovascular risk markers in Indian children: the Mysore Parthenon Study. Am J Clin Nutr 93:628\u2013635","journal-title":"Am J Clin Nutr"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-015-0054-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-015-0054-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-015-0054-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T01:23:43Z","timestamp":1567128223000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-015-0054-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,4]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["54"],"URL":"https:\/\/doi.org\/10.1007\/s00223-015-0054-x","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,4]]}}}