{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:53:58Z","timestamp":1791291238506,"version":"4.3.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T00:00:00Z","timestamp":1445644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1007\/s00223-015-0075-5","type":"journal-article","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T03:43:19Z","timestamp":1445658199000},"page":"123-128","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Denosumab Inhibition of RANKL and Insulin Resistance in Postmenopausal Women with Osteoporosis"],"prefix":"10.1007","volume":"98","author":[{"given":"Antonino","family":"Lasco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunziata","family":"Morabito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Basile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Atteritano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostino","family":"Gaudio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia Maria","family":"Giorgianni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Morini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Faraci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Bellone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Catalano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,24]]},"reference":[{"key":"75_CR1","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1101\/gad.13.8.1015","volume":"13","author":"MA Lomaga","year":"1999","unstructured":"Lomaga MA, Yeh WC, Sarosi I, Duncan GS, Furlonger C, Ho A, Morony S, Capparelli C, Van G, Kaufman S, van der HeidenA Itie A, Wakeham A, Khoo W, Sasaki T, Cao Z, Penninger JM, Paige CJ, Lacey DL, Dunstan CR, Boyle WJ, Goeddel DV, Mak TW (1999) TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev 13:1015\u20131024","journal-title":"Genes Dev"},{"key":"75_CR2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nm1203","volume":"11","author":"T Wada","year":"2005","unstructured":"Wada T, Nakashima T, Oliveira-dos-Santos AJ, Gasser J, Hara H, Schett G, Penninger JM (2005) The molecular scaffold Gab2 is acrucial component of RANK signaling and osteoclastogenesis. Nat Med 11:394\u2013399","journal-title":"Nat Med"},{"issue":"8","key":"75_CR3","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1056\/NEJMoa0809493","volume":"361","author":"SR Cummings","year":"2009","unstructured":"Cummings SR, San Martin J, McClung MR, Siris ES, Eastell R, Reid IR, Delmas P, Zoog HB, Austin M, Wang A, Kutilek S, Adami S, Zanchetta J, Libanati C, Siddhanti S, Christiansen C, Trial FREEDOM (2009) Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 361(8):756\u2013765","journal-title":"N Engl J Med"},{"issue":"2","key":"75_CR4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nm1166","volume":"11","author":"D Cai","year":"2005","unstructured":"Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE (2005) Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 11(2):183\u2013190","journal-title":"Nat Med"},{"issue":"4","key":"75_CR5","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1161\/CIRCULATIONAHA.106.686774","volume":"116","author":"S Kiechl","year":"2007","unstructured":"Kiechl S, Schett G, Schwaiger J, Seppi K, Eder P, Egger G, Santer P, Mayr A, Xu Q, Willeit J (2007) Soluble receptor activator of nuclear factor-kappa B ligand and risk for cardiovascular disease. Circulation 116(4):385\u2013391","journal-title":"Circulation"},{"issue":"9","key":"75_CR6","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1001\/jama.291.9.1108","volume":"291","author":"G Schett","year":"2004","unstructured":"Schett G, Kiechl S, Redlich K, Oberhollenzer F, Weger S, Egger G, Mayr A, Jocher J, Xu Q, Pietschmann P, Teitelbaum S, Smolen J, Willeit J (2004) Soluble RANKL and risk of non traumatic fracture. JAMA 291(9):1108\u20131113","journal-title":"JAMA"},{"issue":"3","key":"75_CR7","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1182\/blood-2003-02-0380","volume":"102","author":"E Terpos","year":"2003","unstructured":"Terpos E, Szydlo R, Apperley JF, Hatjiharissi E, Politou M, Meletis J, Viniou N, Yataganas X, Goldman JM, Rahemtulla A (2003) Soluble receptor activator of nuclear factor kappaB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index. Blood 102(3):1064\u20131069","journal-title":"Blood"},{"issue":"7","key":"75_CR8","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1002\/art.10388","volume":"46","author":"M Ziolkowska","year":"2002","unstructured":"Ziolkowska M, Kurowska M, Radzikowska A, Luszczykiewicz G, Wiland P, Dziewczopolski W, Filipowicz-Sosnowska A, Pazdur J, Szechinski J, Kowalczewski J, Rell-Bakalarska M, Maslinski W (2002) High levels of osteoprotegerin and soluble receptor activator of nuclear factor kappa B ligand in serum of rheumatoid arthritis patients and their normalization after anti-tumor necrosis factor alpha treatment. Arthritis Rheum 46(7):1744\u20131753","journal-title":"Arthritis Rheum"},{"issue":"4","key":"75_CR9","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1136\/gut.2004.044370","volume":"54","author":"AR Moschen","year":"2005","unstructured":"Moschen AR, Kaser A, Enrich B, Ludwiczek O, Gabriel M, Obrist P, Wolf AM, Tilg H (2005) The RANKL\/OPG system is activated in inflammatory bowel disease and relates to the state of bone loss. Gut 54(4):479\u2013487","journal-title":"Gut"},{"issue":"5","key":"75_CR10","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.metabol.2009.09.019","volume":"59","author":"I Nabipour","year":"2010","unstructured":"Nabipour I, Kalantarhormozi M, Larijani B, Assadi M, Sanjdideh Z (2010) Osteoprotegerin in relation to type 2 diabetes mellitus and the metabolic syndrome in postmenopausal women. Metabolism 59(5):742\u2013747","journal-title":"Metabolism"},{"issue":"3","key":"75_CR11","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nm.3084","volume":"19","author":"S Kiechl","year":"2013","unstructured":"Kiechl S, Wittmann J, Giaccari A, Knoflach M, Willeit P, Bozec A, Moschen AR, Muscogiuri G, Sorice GP, Kireva T, Summerer M, Wirtz S, Luther J, Mielenz D, Billmeier U, Egger G, Mayr A, Oberhollenzer F, Kronenberg F, Orthofer M, Penninger JM, Meigs JB, BonoraE Tilg H, Willeit J, Schett G (2013) Blockade of receptor activator of nuclear factor-\u03baB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus. Nat Med 19(3):358\u2013363","journal-title":"Nat Med"},{"key":"75_CR12","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cell.2007.05.047","volume":"130","author":"NK Lee","year":"2007","unstructured":"Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130:456\u2013469","journal-title":"Cell"},{"issue":"1","key":"75_CR13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/sj.ejcn.1601278","volume":"56","author":"M Montomoli","year":"2002","unstructured":"Montomoli M, Gonnelli S, Giacchi M, Mattei R, Cuda C, Rossi S, Gennari C (2002) Validation of a food frequency questionnaire for nutritional calcium intake assessment in Italian women. Eur J Clin Nutr 56(1):21\u201330","journal-title":"Eur J Clin Nutr"},{"key":"75_CR14","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2337\/diacare.23.1.57","volume":"23","author":"E Bonora","year":"2000","unstructured":"Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, Monauni T, Muggeo M (2000) Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Diabetes Care 23:57\u201363","journal-title":"Diabetes Care"},{"issue":"2","key":"75_CR15","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","volume":"39","author":"F Faul","year":"2007","unstructured":"Faul F, Erdfelder E, Lang A-G, Buchner A (2007) G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39(2):175\u2013191","journal-title":"Behav Res Methods"},{"issue":"3","key":"75_CR16","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00125-004-1328-4","volume":"47","author":"A Lasco","year":"2004","unstructured":"Lasco A, Gaudio A, Morabito N, Previti M, Mileto A, Frisina N, Cucinotta D (2004) Effects of a long-term treatment with raloxifene on insulin sensitivity in postmenopausal women. Diabetologia 47(3):571\u2013574","journal-title":"Diabetologia"},{"issue":"3","key":"75_CR17","doi-asserted-by":"crossref","first-page":"422","DOI":"10.2337\/diacare.23.3.422","volume":"23","author":"A Lasco","year":"2000","unstructured":"Lasco A, Alvaro S, Frisina N, Di Benedetto A, Denuzzo G, Cucinotta D (2000) Long-term transdermal estrogen therapy improves lipid profile but not insulin resistance in healthy postmenopausal women. Diabetes Care 23(3):422\u2013424","journal-title":"Diabetes Care"},{"issue":"1","key":"75_CR18","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00125-006-0467-1","volume":"50","author":"Y Tamura","year":"2007","unstructured":"Tamura Y, Ogihara T, Uchida T, Ikeda F, Kumashiro N, Nomiyama T, Sato F, Hirose T, Tanaka Y, Mochizuki H, Kawamori R, Watada H (2007) Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB indb\/db mice. Diabetologia 50(1):131\u2013141","journal-title":"Diabetologia"},{"issue":"6","key":"75_CR19","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1002\/jbmr.1865","volume":"28","author":"AV Schwartz","year":"2013","unstructured":"Schwartz AV, Schafer AL, Grey A, Vittinghoff E, Palermo L, Lui LY, Wallace RB, Cummings SR, Black DM, Bauer DC, Reid IR (2013) Effects of antiresorptive therapies on glucose metabolism: results from the FIT, HORIZON-PFT, and FREEDOM trials. J Bone Miner Res 28(6):1348\u20131354","journal-title":"J Bone Miner Res"},{"issue":"Suppl 1","key":"75_CR20","first-page":"S36","volume":"29","author":"N Napoli","year":"2014","unstructured":"Napoli N, Vittinghoff E, Pannacciulli N, Crittenden D, Yun J, Wang A, Wagman R, Schwartz A (2014) Effect of Denosumab on Fasting Glucose Concentrations in Postmenopausal Women with Osteoporosis: Results From Subjects With Diabetes or Prediabetes From the FREEDOM Trial. J Bone Miner Res 29(Suppl 1):S36 1104 (Oral Presentation)","journal-title":"J Bone Miner Res"},{"key":"75_CR21","doi-asserted-by":"crossref","first-page":"352858","DOI":"10.1155\/2015\/352858","volume":"2015","author":"E Passeri","year":"2015","unstructured":"Passeri E, Benedini S, Costa E, Corbetta S (2015) A Single 60\u00a0mg Dose of Denosumab Might Improve Hepatic Insulin Sensitivity in Postmenopausal Non diabetic Severe Osteoporotic Women. Int J Endocrinol 2015:352858. doi: 10.1155\/2015\/352858","journal-title":"Int J Endocrinol"},{"key":"75_CR22","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1210\/jc.2011-0587","volume":"96","author":"AL Schafer","year":"2011","unstructured":"Schafer AL, Sellmeyer DE, Schwartz AV, Rosen CJ, Vittinghoff E, Palermo L, Bilezikian JP, Shoback DM, Black DM (2011) Change in undercarboxylated osteocalcin is associated with changes in body weight, fat mass, and adiponectin: parathyroid hormone (1\u201384) or alendronate therapy in postmenopausal women with osteoporosis (the PaTH Study). J Clin Endocrinol Metab 96:1982\u20131989","journal-title":"J Clin Endocrinol Metab"},{"key":"75_CR23","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1210\/jc.2008-1422","volume":"94","author":"AG Pittas","year":"2009","unstructured":"Pittas AG, Harris SS, Eliades M, Stark P, Dawson-Hughes B (2009) Association between serum osteocalcin and markers of metabolic phenotype. J Clin Endocrinol Metab 94:827\u2013832","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"75_CR24","first-page":"347","volume":"36","author":"A Catalano","year":"2013","unstructured":"Catalano A, Morabito N, Di Vieste G, Pintaudi B, Cucinotta D, Lasco A, Di Benedetto A (2013) Phalangeal quantitative ultrasound and metabolic control in pre-menopausal women with type 1 diabetes mellitus. J Endocrinol Invest 36(5):347\u2013351","journal-title":"J Endocrinol Invest"},{"key":"75_CR25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1210\/jc.2008-1455","volume":"94","author":"I Kanazawa","year":"2009","unstructured":"Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Kurioka S, Yano S, Sugimoto T (2009) Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus. J Clin Endocrinol Metab 94:45\u201349","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"75_CR26","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/eci.12390","volume":"45","author":"A Catalano","year":"2015","unstructured":"Catalano A, Morabito N, Basile G, Cucinotta D, Lasco A (2015) Calcifediol improves lipid profile in osteopenic atorvastatin-treated postmenopausal women. Eur J Clin Invest 45(2):144\u2013149","journal-title":"Eur J Clin Invest"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-015-0075-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-015-0075-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-015-0075-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T11:41:13Z","timestamp":1558698073000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-015-0075-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,24]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["75"],"URL":"https:\/\/doi.org\/10.1007\/s00223-015-0075-5","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,24]]}}}