{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:17:41Z","timestamp":1790047061597,"version":"4.0.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T00:00:00Z","timestamp":1448323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"General Research Fund","award":["CUHK470813"],"award-info":[{"award-number":["CUHK470813"]}]},{"name":"China Shenzhen City Science and Technology Bureau under the Shenzhen City Knowledge Innovation Plan","award":["JCYJ20130401171935811"],"award-info":[{"award-number":["JCYJ20130401171935811"]}]},{"name":"Amgen Inc. and UCB Pharma"},{"name":"SMART program, CUHK"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1007\/s00223-015-0085-3","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T08:24:27Z","timestamp":1448353467000},"page":"263-274","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Effects of Sclerostin Antibody on the Healing of Femoral Fractures in Ovariectomised Rats"],"prefix":"10.1007","volume":"98","author":[{"given":"Yang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Rui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tin Yan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanbiao","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne Yuk Wai","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huazhu","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,24]]},"reference":[{"issue":"9319","key":"85_CR1","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","volume":"359","author":"SR Cummings","year":"2002","unstructured":"Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359(9319):1761\u20131767","journal-title":"Lancet"},{"issue":"Suppl 2","key":"85_CR2","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1007\/s00198-004-1702-6","volume":"16","author":"O Johnell","year":"2005","unstructured":"Johnell O, Kanis J (2005) Epidemiology of osteoporotic fractures. Osteoporos Int 16(Suppl 2):S3\u2013S7","journal-title":"Osteoporos Int"},{"issue":"5","key":"85_CR3","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1210\/er.2011-1060","volume":"33","author":"HZ Ke","year":"2012","unstructured":"Ke HZ et al (2012) Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases. Endocr Rev 33(5):747\u2013783","journal-title":"Endocr Rev"},{"issue":"2","key":"85_CR4","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1302\/0301-620X.60B2.350882","volume":"60-B","author":"B McKibbin","year":"1978","unstructured":"McKibbin B (1978) The biology of fracture healing in long bones. J Bone Joint Surg Br 60-B(2):150\u2013162","journal-title":"J Bone Joint Surg Br"},{"key":"85_CR5","first-page":"283","volume":"248","author":"HM Frost","year":"1989","unstructured":"Frost HM (1989) The biology of fracture healing. An overview for clinicians. Part I. Clin Orthop Relat Res 248:283\u2013293","journal-title":"Clin Orthop Relat Res"},{"issue":"4","key":"85_CR6","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1359\/jbmr.081206","volume":"24","author":"X Li","year":"2009","unstructured":"Li X et al (2009) Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis. J Bone Miner Res 24(4):578\u2013588","journal-title":"J Bone Miner Res"},{"key":"85_CR7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/01.blo.0000131484.27501.4b","volume":"425","author":"D Ring","year":"2004","unstructured":"Ring D et al (2004) Locking compression plates for osteoporotic nonunions of the diaphyseal humerus. Clin Orthop Relat Res 425:50\u201354","journal-title":"Clin Orthop Relat Res"},{"issue":"5","key":"85_CR8","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.devcel.2005.02.013","volume":"8","author":"TP Hill","year":"2005","unstructured":"Hill TP et al (2005) Canonical Wnt\/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell 8(5):727\u2013738","journal-title":"Dev Cell"},{"issue":"4","key":"85_CR9","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1517\/14728220902841961","volume":"13","author":"LH Hoeppner","year":"2009","unstructured":"Hoeppner LH, Secreto FJ, Westendorf JJ (2009) Wnt signaling as a therapeutic target for bone diseases. Expert Opin Ther Targets 13(4):485\u2013496","journal-title":"Expert Opin Ther Targets"},{"issue":"7","key":"85_CR10","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/jor.21078","volume":"28","author":"DE Komatsu","year":"2010","unstructured":"Komatsu DE et al (2010) Modulation of Wnt signaling influences fracture repair. J Orthop Res 28(7):928\u2013936","journal-title":"J Orthop Res"},{"issue":"1","key":"85_CR11","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.bone.2012.09.029","volume":"52","author":"R Zhang","year":"2013","unstructured":"Zhang R et al (2013) Wnt\/beta-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts. Bone 52(1):145\u2013156","journal-title":"Bone"},{"issue":"22","key":"85_CR12","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1242\/dev.025825","volume":"135","author":"N Kamiya","year":"2008","unstructured":"Kamiya N et al (2008) BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. Development 135(22):3801\u20133811","journal-title":"Development"},{"issue":"5","key":"85_CR13","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1172\/JCI28551","volume":"116","author":"V Krishnan","year":"2006","unstructured":"Krishnan V, Bryant HU, Macdougald OA (2006) Regulation of bone mass by Wnt signaling. J Clin Invest 116(5):1202\u20131209","journal-title":"J Clin Invest"},{"issue":"Suppl 1","key":"85_CR14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2106\/JBJS.G.01183","volume":"90","author":"P Dijke Ten","year":"2008","unstructured":"Ten Dijke P et al (2008) Osteocyte-derived sclerostin inhibits bone formation: its role in bone morphogenetic protein and Wnt signaling. J Bone Joint Surg Am 90(Suppl 1):31\u201335","journal-title":"J Bone Joint Surg Am"},{"issue":"1","key":"85_CR15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1359\/jbmr.061002","volume":"22","author":"RL Bezooijen Van","year":"2007","unstructured":"Van Bezooijen RL et al (2007) Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation. J Bone Miner Res 22(1):19\u201328","journal-title":"J Bone Miner Res"},{"key":"85_CR16","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1086\/318811","volume":"68","author":"ME Brunkow","year":"2001","unstructured":"Brunkow ME, Gardner JC, Van Ness J, Paeper BW, Kovacevich BR (2001) Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Am J Hum Genet 68:577\u2013589","journal-title":"Am J Hum Genet"},{"issue":"5","key":"85_CR17","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/hmg\/10.5.537","volume":"10","author":"W Balemans","year":"2001","unstructured":"Balemans W, Ebeling M, Patel N (2001) Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST). Hum Mol Genet 10(5):537\u2013543","journal-title":"Hum Mol Genet"},{"issue":"2","key":"85_CR18","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1359\/jbmr.090730","volume":"25","author":"I Kramer","year":"2010","unstructured":"Kramer I et al (2010) Parathyroid hormone (PTH)-induced bone gain is blunted in SOST overexpressing and deficient mice. J Bone Miner Res 25(2):178\u2013189","journal-title":"J Bone Miner Res"},{"issue":"10","key":"85_CR19","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/jor.22109","volume":"30","author":"MM McDonald","year":"2012","unstructured":"McDonald MM et al (2012) Inhibition of sclerostin by systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectomized rats. J Orthop Res 30(10):1541\u20131548","journal-title":"J Orthop Res"},{"issue":"1","key":"85_CR20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/jbmr.173","volume":"26","author":"D Padhi","year":"2011","unstructured":"Padhi D et al (2011) Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody. J Bone Miner Res 26(1):19\u201326","journal-title":"J Bone Miner Res"},{"issue":"1","key":"85_CR21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/jor.1100020115","volume":"2","author":"Frank Bonnarens","year":"1984","unstructured":"Bonnarens Frank, Einhorn TA (1984) Production of a standard closed fracture in laboratory animal bone. J Orthop Res 2(1):97\u2013102","journal-title":"J Orthop Res"},{"issue":"2","key":"85_CR22","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jbiomech.2007.09.003","volume":"41","author":"E Mittra","year":"2008","unstructured":"Mittra E et al (2008) Evaluation of trabecular mechanical and microstructural properties in human calcaneal bone of advanced age using mechanical testing, microCT, and DXA. J Biomech 41(2):368\u2013375","journal-title":"J Biomech"},{"issue":"8","key":"85_CR23","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/jor.22636","volume":"32","author":"PK Suen","year":"2014","unstructured":"Suen PK et al (2014) Sclerostin monoclonal antibody enhanced bone fracture healing in an open osteotomy model in rats. J Orthop Res 32(8):997\u20131005","journal-title":"J Orthop Res"},{"issue":"1","key":"85_CR24","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","volume":"28","author":"DW Dempster","year":"2013","unstructured":"Dempster DW et al (2013) Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 28(1):2\u201317","journal-title":"J Bone Miner Res"},{"issue":"6","key":"85_CR25","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.bone.2011.03.720","volume":"48","author":"YX He","year":"2011","unstructured":"He YX et al (2011) Impaired bone healing pattern in mice with ovariectomy-induced osteoporosis: a drill-hole defect model. Bone 48(6):1388\u20131400","journal-title":"Bone"},{"issue":"1","key":"85_CR26","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00198-011-1812-x","volume":"23","author":"YX He","year":"2012","unstructured":"He YX et al (2012) Deletion of estrogen receptor beta accelerates early stage of bone healing in a mouse osteotomy model. Osteoporos Int 23(1):377\u2013389","journal-title":"Osteoporos Int"},{"issue":"4","key":"85_CR27","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.biocel.2011.12.018","volume":"44","author":"L Xu","year":"2012","unstructured":"Xu L et al (2012) Cellular retinol-binding protein 1 (CRBP-1) regulates osteogenenesis and adipogenesis of mesenchymal stem cells through inhibiting RXRalpha-induced beta-catenin degradation. Int J Biochem Cell Biol 44(4):612\u2013619","journal-title":"Int J Biochem Cell Biol"},{"issue":"Suppl 2","key":"85_CR28","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1007\/s00198-004-1728-9","volume":"16","author":"P Augat","year":"2005","unstructured":"Augat P et al (2005) Mechanics and mechano-biology of fracture healing in normal and osteoporotic bone. Osteoporos Int 16(Suppl 2):S36\u2013S43","journal-title":"Osteoporos Int"},{"issue":"5","key":"85_CR29","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1002\/jbmr.307","volume":"26","author":"MS Ominsky","year":"2011","unstructured":"Ominsky MS et al (2011) Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones. J Bone Miner Res 26(5):1012\u20131021","journal-title":"J Bone Miner Res"},{"key":"85_CR30","first-page":"S37","volume":"S1","author":"D Padhi","year":"2007","unstructured":"Padhi D, Stouch B, Jang G, Fang L, Darling M, Glise H, Robinson M, Harris S, Posvar E (2007) Anti-sclerostin antibody increases markers of bone formation in healthy postmenopausal women. J Bone Miner Res S1:S37","journal-title":"J Bone Miner Res"},{"issue":"3","key":"85_CR31","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/jbmr.1803","volume":"28","author":"C Hamann","year":"2013","unstructured":"Hamann C et al (2013) Sclerostin antibody treatment improves bone mass, bone strength, and bone defect regeneration in rats with type 2 diabetes mellitus. J Bone Miner Res 28(3):627\u2013638","journal-title":"J Bone Miner Res"},{"issue":"4","key":"85_CR32","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.bone.2009.12.008","volume":"46","author":"M Saito","year":"2010","unstructured":"Saito M et al (2010) Comparison of effects of alfacalcidol and alendronate on mechanical properties and bone collagen cross-links of callus in the fracture repair rat model. Bone 46(4):1170\u20131179","journal-title":"Bone"},{"issue":"4","key":"85_CR33","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1001\/jama.297.4.387","volume":"297","author":"JR Center","year":"2007","unstructured":"Center JR, Bliuc D, Nguyen TV, Eisman JA (2007) Risk of subsequent fracture after low trauma fracture in men and women. JAMA 297(4):387\u2013394","journal-title":"JAMA"},{"issue":"2","key":"85_CR34","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2174\/157488808784223032","volume":"3","author":"TJ Heino","year":"2008","unstructured":"Heino TJ, Hentunen TA (2008) Differentiation of osteoblasts and osteocytes from mesenchymal stem cells. Curr Stem Cell Res Ther 3(2):131\u2013145","journal-title":"Curr Stem Cell Res Ther"},{"issue":"6","key":"85_CR35","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0026-0495(86)90016-8","volume":"35","author":"JR Farley","year":"1986","unstructured":"Farley JR, Baylink DJ (1986) Skeletal alkaline phosphatase activity as a bone formation index in vitro. Metabolism 35(6):563\u2013572","journal-title":"Metabolism"},{"issue":"4","key":"85_CR36","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.bone.2004.05.023","volume":"35","author":"MK Sutherland","year":"2004","unstructured":"Sutherland MK et al (2004) Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation. Bone 35(4):828\u2013835","journal-title":"Bone"},{"issue":"23","key":"85_CR37","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1093\/emboj\/cdg599","volume":"22","author":"DG Winkler","year":"2003","unstructured":"Winkler DG, Sutherland MK, Geoghegan JC (2003) Osteocyte control of bone formation via sclerostin. EMBO J 22(23):6267\u20136276","journal-title":"EMBO J"},{"issue":"5","key":"85_CR38","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1359\/jbmr.080103","volume":"23","author":"KA Jacobsen","year":"2008","unstructured":"Jacobsen KA et al (2008) Bone formation during distraction osteogenesis is dependent on both VEGFR1 and VEGFR2 signaling. J Bone Miner Res 23(5):596\u2013609","journal-title":"J Bone Miner Res"},{"issue":"15","key":"85_CR39","doi-asserted-by":"crossref","first-page":"9656","DOI":"10.1073\/pnas.152324099","volume":"99","author":"J Street","year":"2002","unstructured":"Street J et al (2002) Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci USA 99(15):9656\u20139661","journal-title":"Proc Natl Acad Sci USA"},{"key":"85_CR40","first-page":"17","volume":"26","author":"C Lu","year":"2006","unstructured":"Lu C, Marcucio R, Miclau T (2006) Assessing angiogenesis during fracture healing. Iowa Orthop J 26:17\u201326","journal-title":"Iowa Orthop J"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-015-0085-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-015-0085-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-015-0085-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T19:39:54Z","timestamp":1599853194000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-015-0085-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,24]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["85"],"URL":"https:\/\/doi.org\/10.1007\/s00223-015-0085-3","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,24]]}}}