{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:59:14Z","timestamp":1777370354685,"version":"3.51.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,12,12]],"date-time":"2015-12-12T00:00:00Z","timestamp":1449878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Region of Southern Denmark"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1007\/s00223-015-0091-5","type":"journal-article","created":{"date-parts":[[2015,12,12]],"date-time":"2015-12-12T07:36:13Z","timestamp":1449905773000},"page":"253-262","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Bone Structural Changes and Estimated Strength After Gastric Bypass Surgery Evaluated by HR-pQCT"],"prefix":"10.1007","volume":"98","author":[{"given":"Katrine Diemer","family":"Frederiksen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stine","family":"Hanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stinus","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Brixen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeppe","family":"Gram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklas Rye","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9 Klinkby","family":"St\u00f8ving","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,12,12]]},"reference":[{"issue":"26","key":"91_CR1","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1056\/NEJMoa035622","volume":"351","author":"L Sj\u00f6str\u00f6m","year":"2004","unstructured":"Sj\u00f6str\u00f6m L, Lindroos A, Peltonen M, Torgerson J, Bouchard C, Carlsson B et al (2004) Lifestyle, diabetes and cardiovascular Risk Factors 10\u00a0years after bariatric surgery. N Engl J Med 351(26):2683\u20132693","journal-title":"N Engl J Med"},{"issue":"4","key":"91_CR2","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s00464-014-3758-5","volume":"29","author":"SW Davies","year":"2015","unstructured":"Davies SW, Efird JT, Guidry CA, Penn RI, Sawyer RG, Schirmer BD et al (2015) Twenty-first century weight loss: banding versus bypass. Surg Endosc 29(4):947\u2013954","journal-title":"Surg Endosc"},{"issue":"3","key":"91_CR3","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s11695-012-0772-3","volume":"23","author":"S Hewitt","year":"2013","unstructured":"Hewitt S, S\u00f8vik TT, Aasheim ET, Kristinsson J, Jahnsen J, Birketvedt GS et al (2013) Secondary hyperparathyroidism, vitamin D sufficiency, and serum calcium 5\u00a0years after gastric bypass and duodenal switch. Obes Surg 23(3):384\u2013390","journal-title":"Obes Surg"},{"issue":"1","key":"91_CR4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.abb.2010.06.027","volume":"503","author":"IR Reid","year":"2010","unstructured":"Reid IR (2010) Fat and bone. Arch Biochem Biophys 503(1):20\u201327","journal-title":"Arch Biochem Biophys"},{"issue":"12","key":"91_CR5","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1038\/nm1295-1311","volume":"1","author":"RC Frederich","year":"1995","unstructured":"Frederich RC, Hamann A, Anderson S, L\u00f6llmann B, Lowell BB, Flier JS (1995) Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1(12):1311\u20131314","journal-title":"Nat Med"},{"issue":"11","key":"91_CR6","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/nm1195-1155","volume":"1","author":"M Maffei","year":"1995","unstructured":"Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y et al (1995) Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1(11):1155\u20131161","journal-title":"Nat Med"},{"key":"91_CR7","doi-asserted-by":"crossref","unstructured":"Chen XX, Yang T (2015) Roles of leptin in bone metabolism and bone diseases. J Bone Miner Metab\u00a033(5):474\u2013485","DOI":"10.1007\/s00774-014-0569-7"},{"issue":"4","key":"91_CR8","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/S8756-3282(03)00237-0","volume":"33","author":"L Lenchik","year":"2003","unstructured":"Lenchik L, Register TC, Hsu FC, Lohman K, Nicklas BJ, Freedman BI et al (2003) Adiponectin as a novel determinant of bone mineral density and visceral fat. Bone 33(4):646\u2013651","journal-title":"Bone"},{"issue":"1","key":"91_CR9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11695-008-9638-0","volume":"19","author":"F Carrasco","year":"2009","unstructured":"Carrasco F, Ruz M, Rojas P, Csendes A, Rebolledo A, Codoceo J et al (2009) Changes in bone mineral density, body composition and adiponectin levels in morbidly obese patients after bariatric surgery. Obes Surg 19(1):41\u201346","journal-title":"Obes Surg"},{"issue":"5","key":"91_CR10","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s00198-007-0492-z","volume":"19","author":"IR Reid","year":"2008","unstructured":"Reid IR (2008) Relationships between fat and bone. Osteoporos Int 19(5):595\u2013606","journal-title":"Osteoporos Int"},{"issue":"5","key":"91_CR11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3357\/ASEM.BR02.2009","volume":"80","author":"ER Spector","year":"2009","unstructured":"Spector ER, Smith SM, Sibonga JD (2009) Skeletal effects of long-duration head-down bed rest. Aviat Space Environ Med 80(5):23\u201328","journal-title":"Aviat Space Environ Med"},{"issue":"1","key":"91_CR12","first-page":"33","volume":"7","author":"AD LeBlanc","year":"2007","unstructured":"LeBlanc AD, Spector ER, Evans HJ, Sibonga JD (2007) Skeletal responses to space flight and the bed rest analog: a review. J Musculoskelet Neuronal Interact 7(1):33\u201347","journal-title":"J Musculoskelet Neuronal Interact"},{"issue":"8","key":"91_CR13","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1359\/jbmr.090307","volume":"24","author":"TJ Beck","year":"2009","unstructured":"Beck TJ, Petit MA, Wu G, LeBoff MS, Cauley JA, Chen Z (2009) Does obesity really make the femur stronger? BMD, geometry, and fracture incidence in the women\u2019s health initiative-observational study. J Bone Miner Res 24(8):1369\u20131379","journal-title":"J Bone Miner Res"},{"issue":"2","key":"91_CR14","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/jbmr.1466","volume":"27","author":"D Prieto-Alhambra","year":"2012","unstructured":"Prieto-Alhambra D, Premaor MO, Fina Avil\u00e9s F, Hermosilla E, Martinez-Laguna D, Carbonell-Abella C et al (2012) The association between fracture and obesity is site-dependent: a population-based study in postmenopausal women. J Bone Miner Res 27(2):294\u2013300","journal-title":"J Bone Miner Res"},{"issue":"4","key":"91_CR15","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00774-009-0056-8","volume":"27","author":"S Gnudi","year":"2009","unstructured":"Gnudi S, Sitta E, Lisi L (2009) Relationship of body mass index with main limb fragility fractures in postmenopausal women. J Bone Miner Metab 27(4):479\u2013484","journal-title":"J Bone Miner Metab"},{"issue":"3","key":"91_CR16","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/jbmr.235","volume":"26","author":"CM Nielson","year":"2011","unstructured":"Nielson CM, Marshall LM, Adams AL, LeBlanc ES, Cawthon PM, Ensrud K et al (2011) BMI and fracture risk in older men: the osteoporotic fractures in men study (MrOS). J Bone Miner Res 26(3):496\u2013502","journal-title":"J Bone Miner Res"},{"key":"91_CR17","doi-asserted-by":"crossref","first-page":"e5085","DOI":"10.1136\/bmj.e5085","volume":"345","author":"A Lalmohamed","year":"2012","unstructured":"Lalmohamed A, de Vries F, Bazelier MT, Cooper A, van Staa T-P, Cooper C et al (2012) Risk of fracture after bariatric surgery in the United Kingdom: population based, retrospective cohort study. BMJ 345:e5085","journal-title":"BMJ"},{"issue":"1","key":"91_CR18","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00198-013-2463-x","volume":"25","author":"KM Nakamura","year":"2014","unstructured":"Nakamura KM, Haglind EGC, Clowes JA, Achenbach SJ, Atkinson EJ, Melton LJ et al (2014) Fracture risk following bariatric surgery: a population-based study. Osteoporos Int 25(1):151\u2013158","journal-title":"Osteoporos Int"},{"issue":"12","key":"91_CR19","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1007\/s11695-008-9653-1","volume":"18","author":"T Mahdy","year":"2008","unstructured":"Mahdy T, Atia S, Farid M, Adulatif A (2008) Effect of Roux-en Y gastric bypass on bone metabolism in patients with morbid obesity: mansoura experiences. Obes Surg 18(12):1526\u20131531","journal-title":"Obes Surg"},{"issue":"7","key":"91_CR20","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1007\/s11695-009-9843-5","volume":"19","author":"N Vilarrasa","year":"2009","unstructured":"Vilarrasa N, G\u00f3mez JM, Elio I, G\u00f3mez-Vaquero C, Masdevall C, Pujol J et al (2009) Evaluation of bone disease in morbidly obese women after gastric bypass and risk factors implicated in bone loss. Obes Surg 19(7):860\u2013866","journal-title":"Obes Surg"},{"issue":"1","key":"91_CR21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jocd.2009.10.001","volume":"13","author":"L Nelson","year":"2010","unstructured":"Nelson L, Gulenchyn KY, Atthey M, Webber CE (2010) Is a fixed value for the least significant change appropriate? J Clin Densitom 13(1):18\u201323","journal-title":"J Clin Densitom"},{"issue":"1","key":"91_CR22","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bone.2007.02.022","volume":"41","author":"HH Bolotin","year":"2007","unstructured":"Bolotin HH (2007) DXA in vivo BMD methodology: an erroneous and misleading research and clinical gauge of bone mineral status, bone fragility, and bone remodelling. Bone 41(1):138\u2013154","journal-title":"Bone"},{"issue":"1","key":"91_CR23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/jbmr.506","volume":"27","author":"EW Yu","year":"2012","unstructured":"Yu EW, Thomas BJ, Brown JK, Finkelstein JS (2012) Simulated increases in body fat and errors in bone mineral density measurements by DXA and QCT. J Bone Miner Res 27(1):119\u2013124","journal-title":"J Bone Miner Res"},{"issue":"3","key":"91_CR24","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/jbmr.2063","volume":"29","author":"EW Yu","year":"2014","unstructured":"Yu EW, Bouxsein ML, Roy AE, Baldwin C, Cange A, Neer RM et al (2014) Bone loss after bariatric surgery: discordant results between DXA and QCT bone density. J Bone Miner Res 29(3):542\u2013550","journal-title":"J Bone Miner Res"},{"issue":"3","key":"91_CR25","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jocd.2006.04.117","volume":"9","author":"EM Evans","year":"2006","unstructured":"Evans EM, Mojtahedi MC, Kessinger RB, Misic MM (2006) Simulated change in body fatness affects Hologic QDR 4500A whole body and central DXA bone measures. J Clin Densitom. 9(3):315\u2013322","journal-title":"J Clin Densitom."},{"issue":"2","key":"91_CR26","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1210\/jc.2012-2394","volume":"98","author":"EM Stein","year":"2013","unstructured":"Stein EM, Carrelli A, Young P, Bucozsky M, Zhang C, Schrope B et al (2013) Bariatric Surgery Results in Cortical Bone Loss. J Clin Endocrinol Metab 98(2):541\u2013549","journal-title":"J Clin Endocrinol Metab"},{"key":"91_CR27","unstructured":"Yu EW, Bouxsein ML, Putman MS, Monis EL, Roy AE, Pratt JS a., et al. (2015) Two-year changes in bone density after Roux-en-Y gastric bypass surgery. J Clin Endocrinol Metab\u00a0100(4):1452\u20131459"},{"issue":"1","key":"91_CR28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S8756-3282(98)00159-8","volume":"24","author":"A Laib","year":"1999","unstructured":"Laib A, R\u00fcegsegger P (1999) Calibration of trabecular bone structure measurements of in vivo three-dimensional peripheral quantitative computed tomography with 28-microm-resolution microcomputed tomography. Bone 24(1):35\u201339","journal-title":"Bone"},{"issue":"6","key":"91_CR29","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S8756-3282(97)00205-6","volume":"21","author":"A Laib","year":"1997","unstructured":"Laib A, Hildebrand T, H\u00e4uselmann HJ, R\u00fcegsegger P (1997) Ridge number density: a new parameter for in vivo bone structure analysis. Bone 21(6):541\u2013546","journal-title":"Bone"},{"issue":"11","key":"91_CR30","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1002\/jbmr.5650111118","volume":"11","author":"R M\u00fcller","year":"1996","unstructured":"M\u00fcller R, Hildebrand T, H\u00e4uselmann HJ, R\u00fcegsegger P (1996) In vivo reproducibility of three-dimensional structural properties of noninvasive bone biopsies using 3D-pQCT. J Bone Miner Res 11(11):1745\u20131750","journal-title":"J Bone Miner Res"},{"issue":"12","key":"91_CR31","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1210\/jc.2005-1258","volume":"90","author":"S Boutroy","year":"2005","unstructured":"Boutroy S, Bouxsein ML, Munoz F, Delmas PD (2005) In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab 90(12):6508\u20136515","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"91_CR32","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.bone.2012.03.003","volume":"50","author":"Y Pauchard","year":"2012","unstructured":"Pauchard Y, Liphardt A-M, Macdonald HM, Hanley DA, Boyd SK (2012) Quality control for bone quality parameters affected by subject motion in high-resolution peripheral quantitative computed tomography. Bone 50(6):1304\u20131310","journal-title":"Bone"},{"issue":"5\u20136","key":"91_CR33","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3233\/THC-1998-65-606","volume":"6","author":"A Laib","year":"1998","unstructured":"Laib A, H\u00e4uselmann HJ, R\u00fcegsegger P (1998) In vivo high resolution 3D-QCT of the human forearm. Technol Heal care 6(5\u20136):329\u2013337","journal-title":"Technol Heal care"},{"issue":"3","key":"91_CR34","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.bone.2010.05.034","volume":"47","author":"AJ Burghardt","year":"2010","unstructured":"Burghardt AJ, Buie HR, Laib A, Majumdar S, Boyd SK (2010) Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCT. Bone 47(3):519\u2013528","journal-title":"Bone"},{"issue":"4","key":"91_CR35","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1359\/jbmr.091020","volume":"25","author":"KK Nishiyama","year":"2010","unstructured":"Nishiyama KK, Macdonald HM, Buie HR, Hanley DA, Boyd SK (2010) Postmenopausal women with osteopenia have higher cortical porosity and thinner cortices at the distal radius and tibia than women with normal aBMD: an in vivo HR-pQCT study. J Bone Miner Res. 25(4):882\u2013890","journal-title":"J Bone Miner Res."},{"issue":"6","key":"91_CR36","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S8756-3282(02)00736-6","volume":"30","author":"W Pistoia","year":"2002","unstructured":"Pistoia W, van Rietbergen B, Lochm\u00fcller E-M, Lill CA, Eckstein F, R\u00fcegsegger P (2002) Estimation of distal radius failure load with micro-finite element analysis models based on three-dimensional peripheral quantitative computed tomography images. Bone. 30(6):842\u2013848","journal-title":"Bone."},{"issue":"4","key":"91_CR37","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/jbmr.1784","volume":"28","author":"S Hansen","year":"2013","unstructured":"Hansen S, Hauge EM (2013) Beck Jensen JE, Brixen K. Differing effects of PTH 1-34, PTH 1-84, and zoledronic acid on bone microarchitecture and estimated strength in postmenopausal women with osteoporosis: an 18-month open-labeled observational study using HR-pQCT. J Bone Miner Res 28(4):736\u2013745","journal-title":"J Bone Miner Res"},{"issue":"10","key":"91_CR38","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1210\/jc.2008-0481","volume":"93","author":"J Fleischer","year":"2008","unstructured":"Fleischer J, Stein EM, Bessler M, Della Badia M, Restuccia N, Olivero-Rivera L et al (2008) The decline in hip bone density after gastric bypass surgery is associated with extent of weight loss. J Clin Endocrinol Metab 93(10):3735\u20133740","journal-title":"J Clin Endocrinol Metab"},{"key":"91_CR39","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1590\/S0100-879X2007000400009","volume":"40","author":"FA Pereira","year":"2007","unstructured":"Pereira FA, Foss MC (2007) Impact of marked weight loss induced by bariatric surgery on bone mineral density and remodeling. Braz J Med Biol Res 40:509\u2013517","journal-title":"Braz J Med Biol Res"},{"issue":"4","key":"91_CR40","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s11695-010-0338-1","volume":"21","author":"N Vilarrasa","year":"2011","unstructured":"Vilarrasa N, San Jos\u00e9 P, Garc\u00eda I, G\u00f3mez-Vaquero C, Miras PM, de Gordejuela AGR et al (2011) Evaluation of bone mineral density loss in morbidly obese women after gastric bypass: 3-year follow-up. Obes Surg 21(4):465\u2013472","journal-title":"Obes Surg"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-015-0091-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-015-0091-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-015-0091-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:38:22Z","timestamp":1718239102000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-015-0091-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,12]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["91"],"URL":"https:\/\/doi.org\/10.1007\/s00223-015-0091-5","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,12]]}}}