{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:54:42Z","timestamp":1792634082433,"version":"4.5.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T00:00:00Z","timestamp":1486598400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s00223-017-0242-y","type":"journal-article","created":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T06:15:40Z","timestamp":1486620940000},"page":"392-401","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Stimulation of Osteogenic Differentiation by Saikosaponin-A in Bone Marrow Stromal Cells Via WNT\/\u03b2-Catenin Pathway"],"prefix":"10.1007","volume":"100","author":[{"given":"Weiqi","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shicai","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,9]]},"reference":[{"key":"242_CR1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.stemcr.2016.03.010","volume":"6","author":"J Meng","year":"2016","unstructured":"Meng J, Ma X, Wang N, Jia M, Bi L, Wang Y, Li M, Zhang H, Xue X, Hou Z, Zhou Y, Yu Z, He G, Luo X (2016) Activation of GLP-1 receptor promotes bone marrow stromal cell osteogenic differentiation through \u03b2-catenin. Stem Cell Rep 6:633","journal-title":"Stem Cell Rep"},{"key":"242_CR2","first-page":"5169","volume":"9","author":"SF Li","year":"2015","unstructured":"Li SF, Tang JJ, Chen J, Zhang P, Wang T, Chen TY, Yan B, Huang B, Wang L, Huang MJ, Zhang ZM, Jin DD (2015) Regulation of bone formation by baicalein via the mTORC1 pathway. Drug Des Dev Ther 9:5169\u20135183","journal-title":"Drug Des Dev Ther"},{"key":"242_CR3","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1159\/000430319","volume":"36","author":"D Wang","year":"2015","unstructured":"Wang D, Ma W, Wang F, Dong J, Wang D, Sun B, Wang B (2015) Stimulation of Wnt\/\u03b2-catenin signaling to improve bone development by naringin via interacting with AMPK and Akt. Cell Physiol Biochem 36:1563\u20131576","journal-title":"Cell Physiol Biochem"},{"key":"242_CR4","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.bbrc.2015.07.154","volume":"465","author":"M Li","year":"2015","unstructured":"Li M, Wu W, Tan L, Mu D, Zhu D, Wang J, Zhao B (2015) Low-magnitude mechanical vibration regulates expression of osteogenic proteins in ovariectomized rats. Biochem Biophys Res Commun 465:344\u2013348","journal-title":"Biochem Biophys Res Commun"},{"key":"242_CR5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bone.2013.03.003","volume":"55","author":"JR Curtis","year":"2013","unstructured":"Curtis JR, Cai Q, Wade SW, Stolshek BS, Adams JL, Balasubramanian A, Viswanathan HN, Kallich JD (2013) Osteoporosis medication adherence: physician perceptions vs. patients\u2019 utilization. Bone 55:1\u20136","journal-title":"Bone"},{"key":"242_CR6","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.phrs.2016.05.003","volume":"108","author":"X Tao","year":"2016","unstructured":"Tao X, Qi Y, Xu L, Yin L, Han X, Xu Y, Wang C, Sun H, Peng J (2016) Dioscin reduces ovariectomy-induced bone loss by enhancing osteoblastogenesis and inhibiting osteoclastogenesis. Pharmacol Res 108:90\u2013101","journal-title":"Pharmacol Res"},{"key":"242_CR7","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nrrheum.2011.130","volume":"7","author":"EM Lewiecki","year":"2011","unstructured":"Lewiecki EM (2011) New targets for intervention in the treatment of postmenopausal osteoporosis. Nat Rev Rheumatol 7:631\u2013638","journal-title":"Nat Rev Rheumatol"},{"key":"242_CR8","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/ncpendmet0325","volume":"2","author":"JE Mulder","year":"2006","unstructured":"Mulder JE, Kolatkar NS, LeBoff MS (2006) Drug insight: existing and emerging therapies for osteoporosis. Nat Clin Pract Endocrinol Metab 2:670\u2013680","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"242_CR9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrendo.2011.146","volume":"8","author":"JS Chen","year":"2012","unstructured":"Chen JS, Sambrook PN (2012) Antiresorptive therapies for osteoporosis: a clinical overview. Nat Rev Endocrinol 8:81\u201391","journal-title":"Nat Rev Endocrinol"},{"key":"242_CR10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.intimp.2015.01.010","volume":"25","author":"C Zhou","year":"2015","unstructured":"Zhou C, Liu W, He W, Wang H, Chen Q, Song H (2015) Saikosaponin a inhibits RANKL-induced osteoclastogenesis by suppressing NF-kappaB and MAPK pathways. Int Immunopharmacol 25:49\u201354","journal-title":"Int Immunopharmacol"},{"key":"242_CR11","first-page":"582437","volume":"2015","author":"JE Shin","year":"2015","unstructured":"Shin JE, Kim HJ, Kim KR, Lee SK, Park J, Kim H, Park KK, Chung WY (2015) Type I saikosaponins a and d inhibit osteoclastogenesis in bone marrow-derived macrophages and osteolytic activity of metastatic breast cancer cells. Evid Based Complement Alternat Med 2015:582437","journal-title":"Evid Based Complement Alternat Med"},{"key":"242_CR12","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.biopha.2016.04.012","volume":"81","author":"M Ye","year":"2016","unstructured":"Ye M, Bi YF, Ding L, Zhu WW, Gao W (2016) Saikosaponin a functions as anti-epileptic effect in pentylenetetrazol induced rats through inhibiting mTOR signaling pathway. Biomed Pharmacother 81:281\u2013287","journal-title":"Biomed Pharmacother"},{"key":"242_CR13","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3109\/03639040903264371","volume":"36","author":"E Chen","year":"2010","unstructured":"Chen E, Chen J, Cao SL, Zhang QZ, Jiang XG (2010) Preparation of nasal temperature-sensitive in situ gel of Radix Bupleuri and evaluation of the febrile response mechanism. Drug Dev Ind Pharm 36:490\u2013496","journal-title":"Drug Dev Ind Pharm"},{"key":"242_CR14","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1055\/s-2002-20238","volume":"68","author":"P Bermejo","year":"2002","unstructured":"Bermejo P, Abad MJ, Diaz AM, Fernandez L, De Santos J, Sanchez S, Villaescusa L, Carrasco L, Irurzun A (2002) Antiviral activity of seven iridoids, three saikosaponins and one phenylpropanoid glycoside extracted from Bupleurum rigidum and Scrophularia scorodonia. Planta Med 68:106\u2013110","journal-title":"Planta Med"},{"key":"242_CR15","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.intimp.2009.04.006","volume":"9","author":"Y Sun","year":"2009","unstructured":"Sun Y, Cai TT, Zhou XB, Xu Q (2009) Saikosaponin a inhibits the proliferation and activation of T cells through cell cycle arrest and induction of apoptosis. Int Immunopharmacol 9:978\u2013983","journal-title":"Int Immunopharmacol"},{"key":"242_CR16","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1007\/s10753-016-0377-4","volume":"39","author":"Y Ma","year":"2016","unstructured":"Ma Y, Bao Y, Wang S, Li T, Chang X, Yang G, Meng X (2016) Anti-inflammation effects and potential mechanism of saikosaponins by regulating nicotinate and nicotinamide metabolism and arachidonic acid metabolism. Inflammation 39:1453\u20131461","journal-title":"Inflammation"},{"key":"242_CR17","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.freeradbiomed.2015.10.407","volume":"89","author":"Y Fu","year":"2015","unstructured":"Fu Y, Hu X, Cao Y, Zhang Z, Zhang N (2015) Saikosaponin a inhibits lipopolysaccharide-oxidative stress and inflammation in Human umbilical vein endothelial cells via preventing TLR4 translocation into lipid rafts. Free Radic Biol Med 89:777\u2013785","journal-title":"Free Radic Biol Med"},{"key":"242_CR18","doi-asserted-by":"crossref","first-page":"e50694","DOI":"10.1371\/journal.pone.0050694","volume":"7","author":"YH Yu","year":"2012","unstructured":"Yu YH, Xie W, Bao Y, Li HM, Hu SJ, Xing JL (2012) Saikosaponin a mediates the anticonvulsant properties in the HNC models of AE and SE by inhibiting NMDA receptor current and persistent sodium current. PLoS One 7:e50694","journal-title":"PLoS One"},{"key":"242_CR19","doi-asserted-by":"crossref","first-page":"32260","DOI":"10.1038\/srep32260","volume":"6","author":"YQ Liu","year":"2016","unstructured":"Liu YQ, Hong ZL, Zhan LB, Chu HY, Zhang XZ, Li GH (2016) Wedelolactone enhances osteoblastogenesis by regulating Wnt\/beta-catenin signaling pathway but suppresses osteoclastogenesis by NF-kappaB\/c-fos\/NFATc1 pathway. Sci Rep 6:32260","journal-title":"Sci Rep"},{"key":"242_CR20","doi-asserted-by":"crossref","first-page":"32261","DOI":"10.1038\/srep32261","volume":"6","author":"L Du","year":"2016","unstructured":"Du L, Nong MN, Zhao JM, Peng XM, Zong SH, Zeng GF (2016) Polygonatum sibiricum polysaccharide inhibits osteoporosis by promoting osteoblast formation and blocking osteoclastogenesis through Wnt\/\u03b2-catenin signalling pathway. Sci Rep 6:32261","journal-title":"Sci Rep"},{"key":"242_CR21","doi-asserted-by":"crossref","first-page":"e1851","DOI":"10.1038\/cddis.2015.221","volume":"6","author":"X Su","year":"2015","unstructured":"Su X, Liao L, Shuai Y, Jing H, Liu S, Zhou H, Liu Y, Jin Y (2015) MiR-26a functions oppositely in osteogenic differentiation of BMSCs and ADSCs depending on distinct activation and roles of Wnt and BMP signaling pathway. Cell Death Dis 6:e1851","journal-title":"Cell Death Dis"},{"key":"242_CR22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.5966\/sctm.2011-0024","volume":"1","author":"WM Jackson","year":"2012","unstructured":"Jackson WM, Nesti LJ, Tuan RS (2012) Concise review: clinical translation of wound healing therapies based on mesenchymal stem cells. Stem Cells Transl Med 1:44\u201350","journal-title":"Stem Cells Transl Med"},{"key":"242_CR23","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1634\/stemcells.2007-0197","volume":"25","author":"G Chamberlain","year":"2007","unstructured":"Chamberlain G, Fox J, Ashton B, Middleton J (2007) Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 25:2739\u20132749","journal-title":"Stem Cells"},{"key":"242_CR24","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00441-015-2115-x","volume":"361","author":"ZP Ma","year":"2015","unstructured":"Ma ZP, Liao JC, Zhao C, Cai DZ (2015) Effects of the 1, 4-dihydropyridine L-type calcium channel blocker benidipine on bone marrow stromal cells. Cell Tissue Res 361:467\u2013476","journal-title":"Cell Tissue Res"},{"key":"242_CR25","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1002\/stem.1461","volume":"31","author":"W Yao","year":"2013","unstructured":"Yao W, Guan M, Jia J, Dai W, Lay YA, Amugongo S, Liu R, Olivos D, Saunders M, Lam KS, Nolta J, Olvera D, Ritchie RO, Lane NE (2013) Reversing bone loss by directing mesenchymal stem cells to bone. Stem Cells 31:2003\u20132014","journal-title":"Stem Cells"},{"key":"242_CR26","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/nm.2665","volume":"18","author":"M Guan","year":"2012","unstructured":"Guan M, Yao W, Liu R, Lam KS, Nolta J, Jia J, Panganiban B, Meng L, Zhou P, Shahnazari M, Ritchie RO, Lane NE (2012) Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass. Nat Med 18:456\u2013462","journal-title":"Nat Med"},{"key":"242_CR27","doi-asserted-by":"crossref","first-page":"18690","DOI":"10.3390\/molecules191118690","volume":"19","author":"J Jiang","year":"2014","unstructured":"Jiang J, Li J, Jia X (2014) The antiosteoporotic activity of central-icaritin (CIT) on bone metabolism of ovariectomized rats. Molecules 19:18690\u201318704","journal-title":"Molecules"},{"key":"242_CR28","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s11596-014-1241-0","volume":"34","author":"W Sun","year":"2014","unstructured":"Sun W, Wang YQ, Yan Q, Lu R, Shi B (2014) Effects of Er-Zhi-Wan on microarchitecture and regulation of Wnt\/beta-catenin signaling pathway in alveolar bone of ovariectomized rats. J Huazhong Univ Sci Technolog Med Sci 34:114\u2013119","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"key":"242_CR29","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s12013-014-9942-3","volume":"70","author":"G He","year":"2014","unstructured":"He G, Guo W, Lou Z, Zhang H (2014) Achyranthes bidentata saponins promote osteogenic differentiation of bone marrow stromal cells through the ERK MAPK signaling pathway. Cell Biochem Biophys 70:467\u2013473","journal-title":"Cell Biochem Biophys"},{"key":"242_CR30","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/s12906-016-1304-9","volume":"16","author":"Y Wang","year":"2016","unstructured":"Wang Y, Huang X, Tang Y, Lin H, Zhou N (2016) Effects of panax notoginseng saponins on the osteogenic differentiation of rabbit bone mesenchymal stem cells through TGF-\u03b21 signaling pathway. BMC Complement Altern Med 16:319","journal-title":"BMC Complement Altern Med"},{"key":"242_CR31","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jsbmb.2012.12.006","volume":"139","author":"T Schilling","year":"2014","unstructured":"Schilling T, Ebert R, Raaijmakers N, Schutze N, Jakob F (2014) Effects of phytoestrogens and other plant-derived compounds on mesenchymal stem cells, bone maintenance and regeneration. J Steroid Biochem Mol Biol 139:252\u2013261","journal-title":"J Steroid Biochem Mol Biol"},{"key":"242_CR32","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1111\/jphp.12306","volume":"66","author":"MH Siddiqi","year":"2014","unstructured":"Siddiqi MH, Siddiqi MZ, Ahn S, Kim YJ, Yang DC (2014) Ginsenoside Rh1 induces mouse osteoblast growth and differentiation through the bone morphogenetic protein 2\/runt-related gene 2 signalling pathway. J Pharm Pharmacol 66:1763\u20131773","journal-title":"J Pharm Pharmacol"},{"key":"242_CR33","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1002\/ptr.3414","volume":"25","author":"Y Niu","year":"2011","unstructured":"Niu Y, Li Y, Huang H, Kong X, Zhang R, Liu L, Sun Y, Wang T, Mei Q (2011) Asperosaponin VI, a saponin component from Dipsacus asper wall, induces osteoblast differentiation through bone morphogenetic protein-2\/p38 and extracellular signal-regulated kinase 1\/2 pathway. Phytother Res 25:1700\u20131706","journal-title":"Phytother Res"},{"key":"242_CR34","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bone.2015.01.002","volume":"74","author":"Q Huang","year":"2015","unstructured":"Huang Q, Gao B, Wang L, Zhang HY, Li XJ, Shi J, Wang Z, Zhang JK, Yang L, Luo ZJ, Liu J (2015) Ophiopogonin D: a new herbal agent against osteoporosis. Bone 74:18\u201328","journal-title":"Bone"},{"key":"242_CR35","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cbi.2015.10.010","volume":"242","author":"L Wang","year":"2015","unstructured":"Wang L, Zhang YG, Wang XM, Ma LF, Zhang YM (2015) Naringin protects human adipose-derived mesenchymal stem cells against hydrogen peroxide-induced inhibition of osteogenic differentiation. Chem Biol Interact 242:255\u2013261","journal-title":"Chem Biol Interact"},{"key":"242_CR36","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1002\/jor.21147","volume":"28","author":"K Serigano","year":"2010","unstructured":"Serigano K, Sakai D, Hiyama A, Tamura F, Tanaka M, Mochida J (2010) Effect of cell number on mesenchymal stem cell transplantation in a canine disc degeneration model. J Orthop Res 28:1267\u20131275","journal-title":"J Orthop Res"},{"key":"242_CR37","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ejphar.2014.04.049","volume":"738","author":"X Ying","year":"2014","unstructured":"Ying X, Chen X, Feng Y, Xu HZ, Chen H, Yu K, Cheng S, Peng L (2014) Myricetin enhances osteogenic differentiation through the activation of canonical Wnt\/\u03b2-catenin signaling in human bone marrow stromal cells. Eur J Pharmacol 738:22\u201330","journal-title":"Eur J Pharmacol"},{"key":"242_CR38","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.toxlet.2015.10.007","volume":"240","author":"K Tao","year":"2016","unstructured":"Tao K, Xiao D, Weng J, Xiong A, Kang B, Zeng H (2016) Berberine promotes bone marrow-derived mesenchymal stem cells osteogenic differentiation via canonical Wnt\/\u03b2-catenin signaling pathway. Toxicol Lett 240:68\u201380","journal-title":"Toxicol Lett"},{"key":"242_CR39","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s11010-015-2517-9","volume":"409","author":"JJ Xiao","year":"2015","unstructured":"Xiao JJ, Zhao WJ, Zhang XT, Zhao WL, Wang XX, Yin SH, Jiang F, Zhao YX, Chen FN, Li SL (2015) Bergapten promotes bone marrow stromal cell differentiation into osteoblasts in vitro and in vivo. Mol Cell Biochem 409:113\u2013122","journal-title":"Mol Cell Biochem"},{"key":"242_CR40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/EJE-11-0132","volume":"165","author":"PJ Marie","year":"2011","unstructured":"Marie PJ, Kassem M (2011) Osteoblasts in osteoporosis: past, emerging, and future anabolic targets. Eur J Endocrinol 165:1\u201310","journal-title":"Eur J Endocrinol"},{"key":"242_CR41","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.1128\/MCB.25.12.4946-4955.2005","volume":"25","author":"M Ai","year":"2005","unstructured":"Ai M, Holmen SL, Van Hul W, Williams BO, Warman ML (2005) Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling. Mol Cell Biol 25:4946\u20134955","journal-title":"Mol Cell Biol"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-017-0242-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-017-0242-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-017-0242-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T06:10:45Z","timestamp":1498371045000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-017-0242-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,9]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["242"],"URL":"https:\/\/doi.org\/10.1007\/s00223-017-0242-y","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,9]]}}}