{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:54:07Z","timestamp":1790258047562,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Psychiatric Research Foundation in the Region of Southern Denmark"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1007\/s00223-017-0254-7","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T05:11:24Z","timestamp":1487653884000},"page":"24-33","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The Role of Body Weight on Bone in Anorexia Nervosa: A HR-pQCT Study"],"prefix":"10.1007","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8156-2424","authenticated-orcid":false,"given":"Jacob","family":"Fr\u00f8lich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stinus","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Al-Dakhiel","family":"Winkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas K.","family":"Andresen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Pernille","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 K.","family":"St\u00f8ving","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"issue":"4","key":"254_CR1","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1007\/s11920-012-0282-y","volume":"14","author":"FR Smink","year":"2012","unstructured":"Smink FR, van Hoeken D, Hoek HW (2012) Epidemiology of eating disorders: incidence, prevalence and mortality rates. Curr Psychiatry Rep 14(4):406\u2013414. doi: 10.1007\/s11920-012-0282-y","journal-title":"Curr Psychiatry Rep"},{"issue":"7","key":"254_CR2","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/s2213-8587(13)70180-3","volume":"2","author":"M Misra","year":"2014","unstructured":"Misra M, Klibanski A (2014) Endocrine consequences of anorexia nervosa. Lancet Diabetes Endocrinol 2(7):581\u2013592. doi: 10.1016\/s2213-8587(13)70180-3","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"10","key":"254_CR3","doi-asserted-by":"crossref","first-page":"790","DOI":"10.7326\/0003-4819-133-10-200011210-00011","volume":"133","author":"S Grinspoon","year":"2000","unstructured":"Grinspoon S, Thomas E, Pitts S, Gross E, Mickley D, Miller K, Herzog D, Klibanski A (2000) Prevalence and predictive factors for regional osteopenia in women with anorexia nervosa. Ann Intern Med 133(10):790\u2013794","journal-title":"Ann Intern Med"},{"issue":"3","key":"254_CR4","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1148\/radiol.2492080173","volume":"249","author":"MA Bredella","year":"2008","unstructured":"Bredella MA, Misra M, Miller KK, Madisch I, Sarwar A, Cheung A, Klibanski A, Gupta R (2008) Distal radius in adolescent girls with anorexia nervosa: trabecular structure analysis with high-resolution flat-panel volume CT. Radiology 249(3):938\u2013946. doi: 10.1148\/radiol.2492080173","journal-title":"Radiology"},{"issue":"7","key":"254_CR5","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/s00198-004-1759-2","volume":"16","author":"G Milos","year":"2005","unstructured":"Milos G, Spindler A, Ruegsegger P, Seifert B, Muhlebach S, Uebelhart D, Hauselmann HJ (2005) Cortical and trabecular bone density and structure in anorexia nervosa. Osteoporos Int 16 (7):783\u2013790. doi: 10.1007\/s00198-004-1759-2","journal-title":"Osteoporos Int"},{"issue":"3","key":"254_CR6","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.biopsych.2006.03.040","volume":"61","author":"JI Hudson","year":"2007","unstructured":"Hudson JI, Hiripi E, Pope HG, Kessler RC (2007) The prevalence and correlates of eating disorders in the national comorbidity survey replication. Biol Psychiatry 61(3):348\u2013358. doi: 10.1016\/j.biopsych.2006.03.040","journal-title":"Biol Psychiatry"},{"issue":"1","key":"254_CR7","doi-asserted-by":"publisher","first-page":"100105.e101","DOI":"10.1016\/j.jpeds.2010.06.054","volume":"158\u2013","author":"V Gilsanz","year":"2011","unstructured":"Gilsanz V, Chalfant J, Kalkwarf H, Zemel B, Lappe J, Oberfield S, Shepherd J, Wren T, Winer K (2011) Age at onset of puberty predicts bone mass in young adulthood. J Pediatr 158(1):100\u2013105.e101\u2013102. doi: 10.1016\/j.jpeds.2010.06.054","journal-title":"J Pediatr"},{"issue":"10","key":"254_CR8","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1007\/s00198-003-1454-8","volume":"14","author":"CJ Hernandez","year":"2003","unstructured":"Hernandez CJ, Beaupre GS, Carter DR (2003) A theoretical analysis of the relative influences of peak BMD, age-related bone loss and menopause on the development of osteoporosis. Osteoporos Int 14(10):843\u2013847. doi: 10.1007\/s00198-003-1454-8","journal-title":"Osteoporos Int"},{"issue":"3","key":"254_CR9","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/eat.10101","volume":"32","author":"P Vestergaard","year":"2002","unstructured":"Vestergaard P, Emborg C, Stoving RK, Hagen C, Mosekilde L, Brixen K (2002) Fractures in patients with anorexia nervosa, bulimia nervosa, and other eating disorders\u2013a nationwide register study. Int J Eat Disord 32(3):301\u2013308. doi: 10.1002\/eat.10101","journal-title":"Int J Eat Disord"},{"key":"254_CR10","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.bone.2015.03.019","volume":"76","author":"N Lara-Castillo","year":"2015","unstructured":"Lara-Castillo N, Kim-Weroha NA, Kamel MA, Javaheri B, Ellies DL, Krumlauf RE, Thiagarajan G, Johnson ML (2015) In vivo mechanical loading rapidly activates beta-catenin signaling in osteocytes through a prostaglandin mediated mechanism. Bone 76:58\u201366. doi: 10.1016\/j.bone.2015.03.019","journal-title":"Bone"},{"issue":"4","key":"254_CR11","doi-asserted-by":"publisher","first-page":"E582","DOI":"10.1210\/jc.2013-2565","volume":"99","author":"L Maimoun","year":"2014","unstructured":"Maimoun L, Guillaume S, Lefebvre P, Philibert P, Bertet H, Picot MC, Gaspari L, Paris F, Courtet P, Thomas E, Mariano-Goulart D, Bringer J, Renard E, Sultan C (2014) Role of sclerostin and dickkopf-1 in the dramatic alteration in bone mass acquisition in adolescents and young women with recent anorexia nervosa. J Clin Endocrinol Metab 99(4):E582\u2013E590. doi: 10.1210\/jc.2013-2565","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"254_CR12","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s00223-014-9857-4","volume":"95","author":"S Andersen","year":"2014","unstructured":"Andersen S, Frederiksen KD, Hansen S, Brixen K, Gram J, Stoving RK (2014) Bone structure and estimated bone strength in obese patients evaluated by high-resolution peripheral quantitative computed tomography. Calcif Tissue Int 95(1):19\u201328. doi: 10.1007\/s00223-014-9857-4","journal-title":"Calcif Tissue Int"},{"issue":"6","key":"254_CR13","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/j.bone.2009.01.369","volume":"44","author":"HH Bolotin","year":"2009","unstructured":"Bolotin HH (2009) Bone loss without the loss of bone mineral material? A new perspective on anorexia nervosa. Bone 44(6):1034\u20131042. doi: 10.1016\/j.bone.2009.01.369","journal-title":"Bone"},{"issue":"1","key":"254_CR14","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1002\/jbmr.506","volume":"27","author":"EW Yu","year":"2012","unstructured":"Yu EW, Thomas BJ, Brown JK, Finkelstein JS (2012) Simulated increases in body fat and errors in bone mineral density measurements by DXA and QCT. J Bone Miner Res 27(1):119\u2013124. doi: 10.1002\/jbmr.506","journal-title":"J Bone Miner Res"},{"key":"254_CR15","unstructured":"World Health Organization (1995) Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee (1995). World Health Organization technical report series 854:1\u2013452"},{"issue":"10","key":"254_CR16","doi-asserted-by":"publisher","first-page":"3123","DOI":"10.1210\/jc.2011-1614","volume":"96","author":"KE Ackerman","year":"2011","unstructured":"Ackerman KE, Nazem T, Chapko D, Russell M, Mendes N, Taylor AP, Bouxsein ML, Misra M (2011) Bone microarchitecture is impaired in adolescent amenorrheic athletes compared with eumenorrheic athletes and nonathletic controls. J Clin Endocrinol Metab 96(10):3123\u20133133. doi: 10.1210\/jc.2011-1614","journal-title":"J Clin Endocrinol Metab"},{"issue":"5\u20136","key":"254_CR17","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3233\/THC-1998-65-606","volume":"6","author":"A Laib","year":"1998","unstructured":"Laib A, Hauselmann HJ, Ruegsegger P (1998) In vivo high resolution 3D-QCT of the human forearm. Technol Health Care 6(5\u20136):329\u2013337","journal-title":"Technol Health Care"},{"issue":"6","key":"254_CR18","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S8756-3282(97)00205-6","volume":"21","author":"A Laib","year":"1997","unstructured":"Laib A, Hildebrand T, Hauselmann HJ, Ruegsegger P (1997) Ridge number density: a new parameter for in vivo bone structure analysis. Bone 21(6):541\u2013546","journal-title":"Bone"},{"issue":"1","key":"254_CR19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S8756-3282(98)00159-8","volume":"24","author":"A Laib","year":"1999","unstructured":"Laib A, Ruegsegger P (1999) Calibration of trabecular bone structure measurements of in vivo three-dimensional peripheral quantitative computed tomography with 28-microm-resolution microcomputed tomography. Bone 24(1):35\u201339","journal-title":"Bone"},{"issue":"12","key":"254_CR20","doi-asserted-by":"publisher","first-page":"6508","DOI":"10.1210\/jc.2005-1258","volume":"90","author":"S Boutroy","year":"2005","unstructured":"Boutroy S, Bouxsein ML, Munoz F, Delmas PD (2005) In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab 90(12):6508\u20136515. doi: 10.1210\/jc.2005-1258","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"254_CR21","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.bone.2010.05.034","volume":"47","author":"AJ Burghardt","year":"2010","unstructured":"Burghardt AJ, Buie HR, Laib A, Majumdar S, Boyd SK (2010) Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCT. Bone 47(3):519\u2013528. doi: 10.1016\/j.bone.2010.05.034","journal-title":"Bone"},{"issue":"4","key":"254_CR22","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1002\/jbmr.1784","volume":"28","author":"S Hansen","year":"2013","unstructured":"Hansen S, Hauge EM, Beck Jensen JE, Brixen K (2013) Differing effects of PTH 1\u201334, PTH 1\u201384, and zoledronic acid on bone microarchitecture and estimated strength in postmenopausal women with osteoporosis: an 18-month open-labeled observational study using HR-pQCT. J Bone Miner Res 28(4):736\u2013745. doi: 10.1002\/jbmr.1784","journal-title":"J Bone Miner Res"},{"issue":"298","key":"254_CR23","doi-asserted-by":"publisher","first-page":"348","DOI":"10.2307\/2281644","volume":"57","author":"A Zellner","year":"1962","unstructured":"Zellner A (1962) An efficient method of estimating seemingly unrelated regressions and tests for aggregation bias. J Am Stat Assoc 57(298):348\u2013368. doi: 10.2307\/2281644","journal-title":"J Am Stat Assoc"},{"issue":"3","key":"254_CR24","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1002\/eat.20687","volume":"43","author":"LA Sim","year":"2010","unstructured":"Sim LA, McGovern L, Elamin MB, Swiglo BA, Erwin PJ, Montori VM (2010) Effect on bone health of estrogen preparations in premenopausal women with anorexia nervosa: a systematic review and meta-analyses. Int J Eat Disord 43(3):218\u2013225. doi: 10.1002\/eat.20687","journal-title":"Int J Eat Disord"},{"issue":"7","key":"254_CR25","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1007\/s001980170074","volume":"12","author":"CM Neu","year":"2001","unstructured":"Neu CM, Rauch F, Manz F, Schoenau E (2001) Modeling of cross-sectional bone size, mass and geometry at the proximal radius: a study of normal bone development using peripheral quantitative computed tomography. Osteoporos Int 12(7):538\u2013547. doi: 10.1007\/s001980170074","journal-title":"Osteoporos Int"},{"issue":"5","key":"254_CR26","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1210\/jc.2012-4153","volume":"98","author":"AT Faje","year":"2013","unstructured":"Faje AT, Karim L, Taylor A, Lee H, Miller KK, Mendes N, Meenaghan E, Goldstein MA, Bouxsein ML, Misra M, Klibanski A (2013) Adolescent girls with anorexia nervosa have impaired cortical and trabecular microarchitecture and lower estimated bone strength at the distal radius. J Clin Endocrinol Metab 98(5):1923\u20131929. doi: 10.1210\/jc.2012-4153","journal-title":"J Clin Endocrinol Metab"},{"key":"254_CR27","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.bone.2015.04.001","volume":"77","author":"PK Fazeli","year":"2015","unstructured":"Fazeli PK, Faje AT, Cross EJ, Lee H, Rosen CJ, Bouxsein ML, Klibanski A (2015) Serum FGF-21 levels are associated with worsened radial trabecular bone microarchitecture and decreased radial bone strength in women with anorexia nervosa. Bone 77:6\u201311. doi: 10.1016\/j.bone.2015.04.001","journal-title":"Bone"},{"issue":"12","key":"254_CR28","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1359\/jbmr.060904","volume":"21","author":"P Szulc","year":"2006","unstructured":"Szulc P, Seeman E, Duboeuf F, Sornay-Rendu E, Delmas PD (2006) Bone fragility: failure of periosteal apposition to compensate for increased endocortical resorption in postmenopausal women. J Bone Miner Res 21(12):1856\u20131863. doi: 10.1359\/jbmr.060904","journal-title":"J Bone Miner Res"},{"key":"254_CR29","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2817","author":"VV Shanbhogue","year":"2016","unstructured":"Shanbhogue VV, Brixen K, Hansen S (2016) Age- and sex-related changes in bone microarchitecture and estimated strength. A three-year prospective study using HR-pQCT. J Bone Miner Res. doi: 10.1002\/jbmr.2817","journal-title":"J Bone Miner Res"},{"issue":"6947","key":"254_CR30","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/424389a","volume":"424","author":"K Lee","year":"2003","unstructured":"Lee K, Jessop H, Suswillo R, Zaman G, Lanyon L (2003) Endocrinology: bone adaptation requires oestrogen receptor-alpha. Nature 424(6947):389. doi: 10.1038\/424389a","journal-title":"Nature"},{"issue":"11","key":"254_CR31","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1359\/jbmr.040918","volume":"19","author":"M Suuriniemi","year":"2004","unstructured":"Suuriniemi M, Mahonen A, Kovanen V, Alen M, Lyytikainen A, Wang Q, Kroger H, Cheng S (2004) Association between exercise and pubertal BMD is modulated by estrogen receptor alpha genotype. J Bone Miner Res 19(11):1758\u20131765. doi: 10.1359\/jbmr.040918","journal-title":"J Bone Miner Res"},{"key":"254_CR32","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2796","author":"S Boutroy","year":"2016","unstructured":"Boutroy S, Khosla S, Sornay-Rendu E, Zanchetta MB, McMahon DJ, Zhang CA, Chapurlat RD, Zanchetta J, Stein EM, Bogado C, Majumdar S, Burghardt AJ, Shane E (2016) Microarchitecture and peripheral BMD are impaired in postmenopausal caucasian women with fracture independently of total hip T-score\u2014an international multicenter study. J Bone Miner Res. doi: 10.1002\/jbmr.2796","journal-title":"J Bone Miner Res"},{"issue":"2","key":"254_CR33","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.jocd.2014.12.002","volume":"18","author":"VV Shanbhogue","year":"2015","unstructured":"Shanbhogue VV, Hansen S, Halekoh U, Brixen K (2015) Use of relative vs fixed offset distance to define region of interest at the distal radius and tibia in high-resolution peripheral quantitative computed tomography. J Clin Densitom 18(2):217\u2013225. doi: 10.1016\/j.jocd.2014.12.002","journal-title":"J Clin Densitom"},{"issue":"5","key":"254_CR34","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1007\/s11914-015-0278-8","volume":"13","author":"NE Cusano","year":"2015","unstructured":"Cusano NE (2015) Skeletal effects of smoking. Curr Osteoporos Rep 13(5):302\u2013309. doi: 10.1007\/s11914-015-0278-8","journal-title":"Curr Osteoporos Rep"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-017-0254-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-017-0254-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-017-0254-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T19:15:12Z","timestamp":1601666112000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-017-0254-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,21]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["254"],"URL":"https:\/\/doi.org\/10.1007\/s00223-017-0254-7","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,21]]}}}