{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T20:58:35Z","timestamp":1781125115008,"version":"3.54.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,6,17]],"date-time":"2017-06-17T00:00:00Z","timestamp":1497657600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1007\/s00223-017-0298-8","type":"journal-article","created":{"date-parts":[[2017,6,17]],"date-time":"2017-06-17T06:51:01Z","timestamp":1497682261000},"page":"433-444","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Eldecalcitol, an Active Vitamin D3 Derivative, Prevents Trabecular Bone Loss and Bone Fragility in Type I Diabetic Model Rats"],"prefix":"10.1007","volume":"101","author":[{"given":"Satoshi","family":"Takeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadaoki","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Yogo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keishi","family":"Marumo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,17]]},"reference":[{"key":"298_CR1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrendo.2011.233","volume":"8","author":"C Hamann","year":"2012","unstructured":"Hamann C, Kirschner S, G\u00fcnther KP, Hofbauer LC (2012) Bone, sweet bone\u2014osteoporotic fractures in diabetes mellitus. Nat Rev Endocrinol 8:297\u2013305","journal-title":"Nat Rev Endocrinol"},{"key":"298_CR2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00223-008-9195-5","volume":"84","author":"P Vestergaard","year":"2009","unstructured":"Vestergaard P, Rejnmark L, Mosekilde L (2009) Diabetes and its complications and their relationship with risk of fractures in type 1 and 2 diabetes. Calcif Tissue Int 84:45\u201355","journal-title":"Calcif Tissue Int"},{"key":"298_CR3","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1359\/jbmr.070510","volume":"22","author":"LC Hofbauer","year":"2007","unstructured":"Hofbauer LC, Brueck CC, Singh SK, Dobnig H (2007) Osteoporosis in patients with diabetes mellitus. J Bone Miner Res 22:1317\u20131328","journal-title":"J Bone Miner Res"},{"key":"298_CR4","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1007\/s00198-002-1345-4","volume":"14","author":"P Ammann","year":"2003","unstructured":"Ammann P, Rizzoli R (2003) Bone strength and its determinants. Osteoporos Int 14:S13\u2013S18","journal-title":"Osteoporos Int"},{"key":"298_CR5","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/01.rhu.0000208612.33819.8c","volume":"12","author":"AW Friedman","year":"2006","unstructured":"Friedman AW (2006) Important determinants of bone strength: beyond bone mineral density. J Clin Rheumatol 12:70\u201377","journal-title":"J Clin Rheumatol"},{"key":"298_CR6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00198-005-2035-9","volume":"17","author":"S Viguet-Carrin","year":"2006","unstructured":"Viguet-Carrin S, Garnero P, Delmas PD (2006) The role of collagen in bone strength. Osteoporos Int 17:319\u2013336","journal-title":"Osteoporos Int"},{"key":"298_CR7","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s11892-013-0376-x","volume":"13","author":"R Sealand","year":"2013","unstructured":"Sealand R, Razavi C, Adler RA (2013) Diabetes mellitus and osteoporosis. Curr Diabetes Rep 13:411\u2013418","journal-title":"Curr Diabetes Rep"},{"key":"298_CR8","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.2337\/diacare.24.7.1192","volume":"24","author":"KK Nicodemus","year":"2001","unstructured":"Nicodemus KK, Folsom AR (2001) Type 1 and type 2 diabetes and incident hip fractures in postmenopausal women. Diabetes Care 24:1192\u20131197","journal-title":"Diabetes Care"},{"key":"298_CR9","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.2337\/dc06-0440","volume":"29","author":"M Janghorbani","year":"2006","unstructured":"Janghorbani M, Feskanich D, Willett WC, Hu F (2006) Prospective study of diabetes and risk of hip fracture: the Nurses\u2019 Health Study. Diabetes Care 29:1573\u20131578","journal-title":"Diabetes Care"},{"key":"298_CR10","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1007\/s00198-014-2704-7","volume":"25","author":"R Dhaliwal","year":"2014","unstructured":"Dhaliwal R, Cibula D, Ghosh C, Weinstock RS, Moses AM (2014) Bone quality assessment in type 2 diabetes mellitus. Osteoporos Int 25:1969\u20131973","journal-title":"Osteoporos Int"},{"key":"298_CR11","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/jdi.12372","volume":"6","author":"K Ishikawa","year":"2015","unstructured":"Ishikawa K, Fukui T, Nagai T, Kuroda T, Hara N, Yamamoto T, Inagaki K, Hirano T (2015) Type 1 diabetes patients have lower strength in femoral bone determined by quantitative computed tomography: a cross-sectional study. J Diabetes Investig 6:726\u2013733","journal-title":"J Diabetes Investig"},{"key":"298_CR12","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jbmr.1763","volume":"28","author":"JM Patsch","year":"2013","unstructured":"Patsch JM, Burghardt AJ, Yap SP, Baum T, Schwartz AV, Joseph GB, Link TM (2013) Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures. J Bone Miner Res 28:313\u2013324","journal-title":"J Bone Miner Res"},{"key":"298_CR13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s11914-014-0202-7","volume":"12","author":"M Saito","year":"2014","unstructured":"Saito M, Kida Y, Kato S, Marumo K (2014) Diabetes, collagen, and bone quality. Curr Osteoporos Rep 12:181\u2013188","journal-title":"Curr Osteoporos Rep"},{"key":"298_CR14","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.bone.2011.07.011","volume":"49","author":"T Matsumoto","year":"2011","unstructured":"Matsumoto T, Ito M, Hayashi Y, Hirota T, Tanigawara Y, Sone T, Fukunaga M, Shiraki M, Nakamura T (2011) A new active vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures\u2014a randomized, active comparator, double-blind study. Bone 49:605\u2013612","journal-title":"Bone"},{"key":"298_CR15","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.bone.2011.05.002","volume":"49","author":"M Ito","year":"2011","unstructured":"Ito M, Nakamura T, Fukunaga M, Shiraki M, Matsumoto T (2011) Effect of eldecalcitol, an active vitamin D analog, on hip structure and biomechanical properties: 3D assessment by clinical CT. Bone 49:328\u2013334","journal-title":"Bone"},{"key":"298_CR16","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S8756-3282(02)00682-8","volume":"30","author":"Y Uchiyama","year":"2002","unstructured":"Uchiyama Y, Higuchi Y, Takeda S, Masaki T, Shira-ishi A, Sato K, Kubodera N, Ikeda K, Ogata E (2002) ED-71, a vitamin D analog, is a more potent inhibitor of bone resorption than alfacalcidol in an estrogen-deficient rat model of osteoporosis. Bone 30:582\u2013588","journal-title":"Bone"},{"key":"298_CR17","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.bone.2011.05.022","volume":"49","author":"PH Freitas de","year":"2011","unstructured":"de Freitas PH, Hasegawa T, Takeda S, Sasaki M, Tabata C, Oda K, Li M, Saito H, Amizuka N (2011) Eldecalcitol, a second-generation vitamin D analog, drives bone minimodeling and reduces osteoclastic number in trabecular bone of ovariectomized rats. Bone 49:335\u2013342","journal-title":"Bone"},{"key":"298_CR18","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jsbmb.2012.10.004","volume":"136","author":"H Saito","year":"2013","unstructured":"Saito H, Takeda S, Amizuka N (2013) Eldecalcitol and calcitriol stimulates \u2018bone minimodeling\u2019, focal bone formation without prior bone resorption, in rat trabecular bone. J Steroid Biochem Mol Biol 136:178\u2013182","journal-title":"J Steroid Biochem Mol Biol"},{"key":"298_CR19","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.bone.2015.08.004","volume":"81","author":"S Sakai","year":"2015","unstructured":"Sakai S, Takeda S, Sugimoto M, Shimizu M, Shimonaka Y, Yogo K, Hashimoto J, Bauss F, Endo K (2015) Treatment with the combination of ibandronate plus eldecalcitol has a synergistic effect on inhibition of bone resorption without suppressing bone formation in ovariectomized rats. Bone 81:449\u2013458","journal-title":"Bone"},{"key":"298_CR20","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bone.2014.11.025","volume":"73","author":"M Saito","year":"2015","unstructured":"Saito M, Grynpas MD, Burr DB, Allen MR, Smith SY, Doyle N, Amizuka N, Hasegawa T, Kida Y, Marumo K, Saito H (2015) Treatment with eldecalcitol positively affects mineralization, microdamage, and collagen crosslinks in primate bone. Bone 73:8\u201315","journal-title":"Bone"},{"key":"298_CR21","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/j.1476-5381.2012.01911.x","volume":"166","author":"AJ King","year":"2012","unstructured":"King AJ (2012) The use of animal models in diabetes research. Br J Pharmacol 166:877\u2013894","journal-title":"Br J Pharmacol"},{"key":"298_CR22","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s00223-010-9441-5","volume":"88","author":"J Iwamoto","year":"2011","unstructured":"Iwamoto J, Seki A, Sato Y, Matsumoto H, Takeda T, Yeh JK (2011) Vitamin K2 prevents hyperglycemia and cancellous osteopenia in rats with streptozotocin-induced type 1 diabetes. Calcif Tissue Int 88:162\u2013168","journal-title":"Calcif Tissue Int"},{"key":"298_CR23","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1359\/jbmr.2001.16.5.958","volume":"16","author":"MN Horcajada-Molteni","year":"2001","unstructured":"Horcajada-Molteni MN, Chanteranne B, Lebecque P, Davicco MJ, Coxam V, Young A, Barlet JP (2001) Amylin and bone metabolism in streptozotocin-induced diabetic rats. J Bone Miner Res 16:958\u2013965","journal-title":"J Bone Miner Res"},{"key":"298_CR24","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/PL00005838","volume":"66","author":"T Tsuchida","year":"2000","unstructured":"Tsuchida T, Sato K, Miyakoshi N, Abe T, Kudo T, Tamura Y, Kasukawa Y, Suzuki K (2000) Histomorphometric evaluation of the recovering effect of human parathyroid hormone (1-34) on bone structure and turnover in streptozotocin-induced diabetic rats. Calcif Tissue Int 66:229\u2013233","journal-title":"Calcif Tissue Int"},{"key":"298_CR25","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","volume":"28","author":"DW Dempster","year":"2013","unstructured":"Dempster DW, Compston JE, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR, Parfitt AM (2013) Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 28:2\u201317","journal-title":"J Bone Miner Res"},{"key":"298_CR26","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/8756-3282(93)90081-K","volume":"14","author":"CH Turner","year":"1993","unstructured":"Turner CH, Burr DB (1993) Basic biomechanical measurements of bone: a tutorial. Bone 14:595\u2013608","journal-title":"Bone"},{"key":"298_CR27","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1006\/abio.1997.2350","volume":"253","author":"M Saito","year":"1997","unstructured":"Saito M, Marumo K, Fujii K, Ishioka N (1997) Single-column high-performance liquid chromatographic-fluorescence detection of immature, mature, and senescent cross-links of collagen. Anal Biochem 253:26\u201332","journal-title":"Anal Biochem"},{"key":"298_CR28","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1056\/NEJMra053077","volume":"354","author":"E Seeman","year":"2006","unstructured":"Seeman E, Delmas PD (2006) Bone quality\u2014the material and structural basis of bone strength and fragility. N Engl J Med 354:2250\u20132261","journal-title":"N Engl J Med"},{"key":"298_CR29","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00198-009-1066-z","volume":"21","author":"M Saito","year":"2010","unstructured":"Saito M, Marumo K (2010) Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus. Osteoporos Int 21:195\u2013214","journal-title":"Osteoporos Int"},{"key":"298_CR30","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1359\/jbmr.090316","volume":"24","author":"MJ Silva","year":"2009","unstructured":"Silva MJ, Brodt MD, Lynch MA, McKenzie JA, Tanouye KM, Nyman JS, Wang X (2009) Type 1 diabetes in young rats leads to progressive trabecular bone loss, cessation of cortical bone growth, and diminished whole bone strength and fatigue life. J Bone Miner Res 24:1618\u20131627","journal-title":"J Bone Miner Res"},{"key":"298_CR31","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S8756-3282(03)00169-8","volume":"33","author":"K Suzuki","year":"2003","unstructured":"Suzuki K, Miyakoshi N, Tsuchida T, Kasukawa Y, Sato K, Itoi E (2003) Effects of combined treatment of insulin and human parathyroid hormone(1-34) on cancellous bone mass and structure in streptozotocin-induced diabetic rats. Bone 33:108\u2013114","journal-title":"Bone"},{"key":"298_CR32","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.bone.2006.12.057","volume":"40","author":"Y Hamada","year":"2007","unstructured":"Hamada Y, Kitazawa S, Kitazawa R, Fujii H, Kasuga M, Fukagawa M (2007) Histomorphometric analysis of diabetic osteopenia in streptozotocin-induced diabetic mice: a possible role of oxidative stress. Bone 40:1408\u20131414","journal-title":"Bone"},{"key":"298_CR33","first-page":"611","volume":"26","author":"M Hie","year":"2010","unstructured":"Hie M, Tsukamoto I (2010) Increased expression of the receptor for activation of NF-kappaB and decreased runt-related transcription factor 2 expression in bone of rats with streptozotocin-induced diabetes. Int J Mol Med 26:611\u2013618","journal-title":"Int J Mol Med"},{"key":"298_CR34","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ejphar.2011.08.014","volume":"670","author":"W Liang","year":"2011","unstructured":"Liang W, Luo Z, Ge S, Li M, Du J, Yang M, Yan M, Ye Z, Luo Z (2011) Oral administration of quercetin inhibits bone loss in rat model of diabetic osteopenia. Eur J Pharmacol 670:317\u2013324","journal-title":"Eur J Pharmacol"},{"key":"298_CR35","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/s00223-004-0118-9","volume":"75","author":"J Pino-Montes Del","year":"2004","unstructured":"Del Pino-Montes J, Benito GE, Fern\u00e1ndez-Salazar MP, Cove\u00f1as R, Calvo JJ, Bouillon R, Quesada JM (2004) Calcitriol improves streptozotocin-induced diabetes and recovers bone mineral density in diabetic rats. Calcif Tissue Int 75:526\u2013532","journal-title":"Calcif Tissue Int"},{"key":"298_CR36","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/ncpneuro0504","volume":"3","author":"G Said","year":"2007","unstructured":"Said G (2007) Diabetic neuropathy\u2014a review. Nat Clin Pract Neurol 3:331\u2013340","journal-title":"Nat Clin Pract Neurol"},{"key":"298_CR37","doi-asserted-by":"crossref","first-page":"17106","DOI":"10.1074\/jbc.M114.631291","volume":"290","author":"W Hao","year":"2015","unstructured":"Hao W, Tashiro S, Hasegawa T, Sato Y, Kobayashi T, Tando T, Katsuyama E, Fujie A, Watanabe R, Morita M, Miyamoto K, Morioka H, Nakamura M, Matsumoto M, Amizuka N, Toyama Y, Miyamoto T (2015) Hyperglycemia promotes Schwann cell de-differentiation and de-myelination via sorbitol accumulation and Igf1 protein down-regulation. J Biol Chem 290:17106\u201317115","journal-title":"J Biol Chem"},{"key":"298_CR38","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.2174\/13816128113196660690","volume":"20","author":"L Ferrucci","year":"2014","unstructured":"Ferrucci L, Baroni M, Ranchelli A, Lauretani F, Maggio M, Mecocci P, Ruggiero C (2014) Interaction between bone and muscle in older persons with mobility limitations. Curr Pharm Des 20:3178\u20133197","journal-title":"Curr Pharm Des"},{"key":"298_CR39","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s00223-015-9985-5","volume":"97","author":"M Saito","year":"2015","unstructured":"Saito M, Marumo K (2015) Effects of collagen crosslinking on bone material properties in health and disease. Calcif Tissue Int 97:242\u2013261","journal-title":"Calcif Tissue Int"},{"key":"298_CR40","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1007\/s00198-006-0155-5","volume":"17","author":"M Saito","year":"2006","unstructured":"Saito M, Fujii K, Mori Y, Marumo K (2006) Role of collagen enzymatic and glycation induced cross-links as a determinant of bone quality in spontaneously diabetic WBN\/Kob rats. Osteoporos Int 17:1514\u20131523","journal-title":"Osteoporos Int"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-017-0298-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-017-0298-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-017-0298-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T22:52:56Z","timestamp":1504738376000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-017-0298-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,17]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["298"],"URL":"https:\/\/doi.org\/10.1007\/s00223-017-0298-8","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,17]]}}}